JP2012139246A5 - - Google Patents
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- JP2012139246A5 JP2012139246A5 JP2012104994A JP2012104994A JP2012139246A5 JP 2012139246 A5 JP2012139246 A5 JP 2012139246A5 JP 2012104994 A JP2012104994 A JP 2012104994A JP 2012104994 A JP2012104994 A JP 2012104994A JP 2012139246 A5 JP2012139246 A5 JP 2012139246A5
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- Prior art keywords
- negative
- pluripotent stem
- culture
- cells
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 20
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 19
- 108091005804 Peptidases Proteins 0.000 claims 12
- 239000004365 Protease Substances 0.000 claims 12
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 8
- 230000006355 external stress Effects 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108010017842 Telomerase Proteins 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 210000001654 germ layer Anatomy 0.000 claims 3
- 235000015097 nutrients Nutrition 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 230000000638 stimulation Effects 0.000 claims 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 239000012141 concentrate Substances 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- 108091005508 Acid proteases Proteins 0.000 claims 1
- 102000035101 Aspartic proteases Human genes 0.000 claims 1
- 108091005502 Aspartic proteases Proteins 0.000 claims 1
- 102000029816 Collagenase Human genes 0.000 claims 1
- 108060005980 Collagenase Proteins 0.000 claims 1
- 102000005927 Cysteine Proteases Human genes 0.000 claims 1
- 108010005843 Cysteine Proteases Proteins 0.000 claims 1
- 241000237858 Gastropoda Species 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 101100154912 Mus musculus Tyrp1 gene Proteins 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 102000035100 Threonine proteases Human genes 0.000 claims 1
- 108091005501 Threonine proteases Proteins 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960002424 collagenase Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 108010007093 dispase Proteins 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 101150077014 sox10 gene Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21378809P | 2009-07-15 | 2009-07-15 | |
| US61/213,788 | 2009-07-15 | ||
| US29015909P | 2009-12-24 | 2009-12-24 | |
| US61/290,159 | 2009-12-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Division JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015237186A Division JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012139246A JP2012139246A (ja) | 2012-07-26 |
| JP2012139246A5 true JP2012139246A5 (https=) | 2013-08-29 |
| JP5852503B2 JP5852503B2 (ja) | 2016-02-03 |
Family
ID=43449509
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Active JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
| JP2012104994A Active JP5852503B2 (ja) | 2009-07-15 | 2012-05-01 | 生体組織から単離できる多能性幹細胞 |
| JP2015237186A Active JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
| JP2017021036A Active JP6416298B2 (ja) | 2009-07-15 | 2017-02-08 | 生体組織から単離できる多能性幹細胞 |
| JP2018188234A Active JP6641441B2 (ja) | 2009-07-15 | 2018-10-03 | 生体組織から単離できる多能性幹細胞 |
| JP2019239248A Active JP6937821B2 (ja) | 2009-07-15 | 2019-12-27 | 生体組織から単離できる多能性幹細胞 |
| JP2021140656A Active JP7134317B2 (ja) | 2009-07-15 | 2021-08-31 | 生体組織から単離できる多能性幹細胞 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522886A Active JP5185443B2 (ja) | 2009-07-15 | 2010-07-15 | 生体組織から分離できる多能性幹細胞画分 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015237186A Active JP6092357B2 (ja) | 2009-07-15 | 2015-12-04 | 生体組織から単離できる多能性幹細胞 |
| JP2017021036A Active JP6416298B2 (ja) | 2009-07-15 | 2017-02-08 | 生体組織から単離できる多能性幹細胞 |
| JP2018188234A Active JP6641441B2 (ja) | 2009-07-15 | 2018-10-03 | 生体組織から単離できる多能性幹細胞 |
| JP2019239248A Active JP6937821B2 (ja) | 2009-07-15 | 2019-12-27 | 生体組織から単離できる多能性幹細胞 |
| JP2021140656A Active JP7134317B2 (ja) | 2009-07-15 | 2021-08-31 | 生体組織から単離できる多能性幹細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9550975B2 (https=) |
| EP (3) | EP3214170B1 (https=) |
| JP (7) | JP5185443B2 (https=) |
| KR (4) | KR20120069663A (https=) |
| CN (2) | CN102858951B (https=) |
| AU (1) | AU2010271722B8 (https=) |
| CA (1) | CA2768238C (https=) |
| DK (2) | DK2455452T4 (https=) |
| ES (3) | ES3015175T3 (https=) |
| HR (1) | HRP20250245T1 (https=) |
| HU (3) | HUE052559T2 (https=) |
| NO (1) | NO2455452T3 (https=) |
| PL (3) | PL2455452T5 (https=) |
| PT (2) | PT2455452T (https=) |
| SG (1) | SG177705A1 (https=) |
| WO (1) | WO2011007900A1 (https=) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014133703A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体組織から単離できるｓｓｅａ−３陽性の多能性幹細胞を含む他家移植用細胞治療用組成物 |
| JP2014132830A (ja) * | 2011-03-30 | 2014-07-24 | Clio Inc | 生体の臍帯又は脂肪組織から単離できる多能性幹細胞 |
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
| US9399758B2 (en) | 2009-07-15 | 2016-07-26 | Mari Dezawa | SSEA3(+) pluripotent stem cell that can be isolated from body tissue |
| US8883430B2 (en) | 2009-08-21 | 2014-11-11 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced efficiency of induced pluripotent stem cell generation from human somatic cells |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| PL2718416T3 (pl) * | 2011-06-06 | 2020-05-18 | ReGenesys BVBA | Namnażanie komórek macierzystych w bioreaktorach włóknisto-kapilarnych |
| JP6090937B2 (ja) | 2011-07-27 | 2017-03-08 | 国立大学法人京都大学 | 新規ドーパミン産生神経前駆細胞マーカー |
| KR101751355B1 (ko) * | 2011-08-24 | 2017-07-04 | (주)아모레퍼시픽 | 인간 피부 진피 유래 성체 줄기세포 |
| WO2013058403A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
| WO2013131192A1 (en) * | 2012-03-06 | 2013-09-12 | Aris Aziz | Placental stem cells, methods for isolating same and use thereof |
| SG11201407768QA (en) * | 2012-04-24 | 2015-01-29 | Brigham & Womens Hospital | Generating pluripotent cells de novo |
| WO2014018663A1 (en) * | 2012-07-27 | 2014-01-30 | Bioquark, Inc. | Extracts isolated from electroporated ambhibian oocytes and use thereof in treating diseases and disorders |
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| WO2014100806A1 (en) * | 2012-12-21 | 2014-06-26 | Rutgers, The State University Of New Jersey | Muse cells isolation and expansion |
| US9709554B2 (en) | 2013-01-31 | 2017-07-18 | Rutgers, The State University Of New Jersey | In vitro model of macrosteatotic (fatty) liver |
| JP6495658B2 (ja) | 2013-02-08 | 2019-04-03 | 国立大学法人京都大学 | 巨核球及び血小板の製造方法 |
| WO2014133090A1 (ja) * | 2013-02-28 | 2014-09-04 | 国立大学法人浜松医科大学 | 脳腫瘍治療のための多能性幹細胞 |
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| CA2906643A1 (en) * | 2013-03-15 | 2014-09-25 | The Jackson Laboratory | Isolation of non-embryonic stem cells and uses thereof |
| JP6473077B2 (ja) | 2013-03-21 | 2019-02-20 | 国立大学法人京都大学 | 神経分化誘導用の多能性幹細胞 |
| EP2980207B1 (en) | 2013-03-25 | 2018-12-05 | Foundation for Biomedical Research and Innovation at Kobe | Cell sorting method |
| JP6461787B2 (ja) | 2013-04-12 | 2019-01-30 | 国立大学法人京都大学 | 肺胞上皮前駆細胞の誘導方法 |
| JP6429280B2 (ja) | 2013-05-14 | 2018-11-28 | 国立大学法人京都大学 | 効率的な心筋細胞の誘導方法 |
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| EP3031905A4 (en) | 2013-08-07 | 2017-04-26 | Kyoto University | Method for producing pancreatic hormone-producing cell |
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| CN118679244A (zh) | 2022-02-09 | 2024-09-20 | 住友制药株式会社 | 判定培养液中的细胞在由多能干细胞向中脑底板区域的神经系统细胞的分化中的分化能力的方法 |
| EP4530344A1 (en) | 2022-05-23 | 2025-04-02 | Kyoto University | Production method for renal collecting duct cells and pelvic epithelial cells |
| TW202444899A (zh) | 2023-04-03 | 2024-11-16 | 日商大塚製藥股份有限公司 | 巨核細胞之製造方法 |
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
| CN117187174B (zh) * | 2023-11-08 | 2024-02-06 | 广州正源生物技术有限公司 | 一种Muse细胞培养基以及一种脂肪Muse细胞的提取方法 |
| JP2025123077A (ja) * | 2024-02-09 | 2025-08-22 | 国立大学法人東北大学 | 脊髄梗塞治療のための多能性幹細胞 |
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| WO2001011011A2 (en) | 1999-08-05 | 2001-02-15 | Mcl Llc | Multipotent adult stem cells and methods for isolation |
| US7575921B2 (en) * | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| US20020151050A1 (en) * | 2000-10-30 | 2002-10-17 | Vacanti Charles A. | Isolation of spore-like cells from tissues exposed to extreme conditions |
| JP4182742B2 (ja) | 2002-12-12 | 2008-11-19 | 日産自動車株式会社 | 自動車の前部車体構造 |
| US7569385B2 (en) | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| AU2004269409A1 (en) * | 2003-08-29 | 2005-03-10 | Regents Of The University Of Minnesota | Kidney derived stem cells and methods for their isolation, differentiation and use |
| US20060216821A1 (en) * | 2004-02-26 | 2006-09-28 | Reliance Life Sciences Pvt. Ltd. | Pluripotent embryonic-like stem cells derived from corneal limbus, methods of isolation and uses thereof |
| EP1893748A1 (en) * | 2005-05-17 | 2008-03-05 | Reliance Life Sciences Pvt., Ltd. | Establishment of a human embryonic stem cell line using mammalian cells |
| US9388382B2 (en) * | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| AU2006304390A1 (en) | 2005-10-17 | 2007-04-26 | Academia Sinica | Pulmonary stem cells, related methods and kits |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US20090155225A1 (en) * | 2006-11-02 | 2009-06-18 | Mariusz Ratajczak | Uses and isolation of very small of embryonic-like (vsel) stem cells |
| WO2008080200A1 (en) | 2006-12-29 | 2008-07-10 | Irina Kerkis | Process for obtaining stem cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US20090172832A1 (en) * | 2007-12-28 | 2009-07-02 | Timothy Caspar | Expression of rubisco enzyme from a non-rubisco locus |
| ITRM20080342A1 (it) * | 2008-06-26 | 2009-12-27 | Univ Degli Studi Udine | Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso. |
| US9550975B2 (en) * | 2009-07-15 | 2017-01-24 | Mari Dezawa | SSEA-3 pluripotent stem cell isolated from body tissue |
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