JP2012070758A5 - - Google Patents
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- JP2012070758A5 JP2012070758A5 JP2011285435A JP2011285435A JP2012070758A5 JP 2012070758 A5 JP2012070758 A5 JP 2012070758A5 JP 2011285435 A JP2011285435 A JP 2011285435A JP 2011285435 A JP2011285435 A JP 2011285435A JP 2012070758 A5 JP2012070758 A5 JP 2012070758A5
- Authority
- JP
- Japan
- Prior art keywords
- collagenase
- derived
- measured
- area
- performance liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102000029816 Collagenase Human genes 0.000 claims 27
- 108060005980 Collagenase Proteins 0.000 claims 27
- YRQNKMKHABXEJZ-UVQQGXFZSA-N chembl176323 Chemical compound C1C[C@]2(C)[C@@]3(C)CC(N=C4C[C@]5(C)CCC6[C@]7(C)CC[C@@H]([C@]7(CC[C@]6(C)[C@@]5(C)CC4=N4)C)CCCCCCCC)=C4C[C@]3(C)CCC2[C@]2(C)CC[C@H](CCCCCCCC)[C@]21C YRQNKMKHABXEJZ-UVQQGXFZSA-N 0.000 claims 27
- 229960002424 collagenase Drugs 0.000 claims 27
- 238000004007 reversed phase HPLC Methods 0.000 claims 17
- 102000004169 proteins and genes Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 15
- 230000000409 histolytic effect Effects 0.000 claims 11
- 241000894006 Bacteria Species 0.000 claims 10
- 241000193159 Hathewaya histolytica Species 0.000 claims 9
- 238000001042 affinity chromatography Methods 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 238000004440 column chromatography Methods 0.000 claims 4
- 239000002158 endotoxin Substances 0.000 claims 4
- 238000000855 fermentation Methods 0.000 claims 4
- 230000004151 fermentation Effects 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 3
- 102000013382 Gelatinases Human genes 0.000 claims 2
- 108010026132 Gelatinases Proteins 0.000 claims 2
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 229930006000 Sucrose Natural products 0.000 claims 2
- 239000007983 Tris buffer Substances 0.000 claims 2
- 238000005571 anion exchange chromatography Methods 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 108090001092 clostripain Proteins 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims 2
- 108010052968 leupeptin Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000011084 recovery Methods 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000011109 contamination Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76347006P | 2006-01-30 | 2006-01-30 | |
| US60/763,470 | 2006-01-30 | ||
| US78413506P | 2006-03-20 | 2006-03-20 | |
| US60/784,135 | 2006-03-20 | ||
| US11/699,302 US7811560B2 (en) | 2006-01-30 | 2007-01-29 | Compositions and methods for treating collagen-mediated diseases |
| US11/699,302 | 2007-01-29 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552504A Division JP5309289B2 (ja) | 2006-01-30 | 2007-01-30 | コラーゲン媒介疾患を処置するための組成物および方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015072261A Division JP6230200B2 (ja) | 2006-01-30 | 2015-03-31 | コラーゲン媒介疾患を処置するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012070758A JP2012070758A (ja) | 2012-04-12 |
| JP2012070758A5 true JP2012070758A5 (cg-RX-API-DMAC7.html) | 2013-08-01 |
Family
ID=38328033
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552504A Active JP5309289B2 (ja) | 2006-01-30 | 2007-01-30 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2011285435A Withdrawn JP2012070758A (ja) | 2006-01-30 | 2011-12-27 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2015072261A Active JP6230200B2 (ja) | 2006-01-30 | 2015-03-31 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2016196519A Active JP6389493B2 (ja) | 2006-01-30 | 2016-10-04 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2017173236A Active JP6851943B2 (ja) | 2006-01-30 | 2017-09-08 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2018126943A Active JP6792596B2 (ja) | 2006-01-30 | 2018-07-03 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2019229674A Active JP6944989B2 (ja) | 2006-01-30 | 2019-12-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2021070232A Active JP7191152B2 (ja) | 2006-01-30 | 2021-04-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552504A Active JP5309289B2 (ja) | 2006-01-30 | 2007-01-30 | コラーゲン媒介疾患を処置するための組成物および方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015072261A Active JP6230200B2 (ja) | 2006-01-30 | 2015-03-31 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2016196519A Active JP6389493B2 (ja) | 2006-01-30 | 2016-10-04 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2017173236A Active JP6851943B2 (ja) | 2006-01-30 | 2017-09-08 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2018126943A Active JP6792596B2 (ja) | 2006-01-30 | 2018-07-03 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2019229674A Active JP6944989B2 (ja) | 2006-01-30 | 2019-12-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
| JP2021070232A Active JP7191152B2 (ja) | 2006-01-30 | 2021-04-19 | コラーゲン媒介疾患を処置するための組成物および方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (16) | US7811560B2 (cg-RX-API-DMAC7.html) |
| EP (6) | EP2474319A1 (cg-RX-API-DMAC7.html) |
| JP (8) | JP5309289B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20110046537A (cg-RX-API-DMAC7.html) |
| CN (2) | CN101400788B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2007211313C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0708017A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2637262C (cg-RX-API-DMAC7.html) |
| DK (2) | DK2474321T3 (cg-RX-API-DMAC7.html) |
| ES (3) | ES2709202T3 (cg-RX-API-DMAC7.html) |
| HU (2) | HUE041764T2 (cg-RX-API-DMAC7.html) |
| IL (6) | IL291175B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008009756A (cg-RX-API-DMAC7.html) |
| NZ (2) | NZ569882A (cg-RX-API-DMAC7.html) |
| PT (2) | PT1987141T (cg-RX-API-DMAC7.html) |
| TR (1) | TR201903008T4 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007089851A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6958150B2 (en) | 1994-12-15 | 2005-10-25 | Advance Biofactures Of Curacao, N.V. | Reduction of adipose tissue |
| US20070224184A1 (en) * | 2006-02-22 | 2007-09-27 | The Research Foundation Of The State University Of New York | Method for treating cellulite |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
| US10071143B1 (en) | 2007-05-03 | 2018-09-11 | The Research Foundation For The State University Of New York | Methods for non-surgical treatment of carpal tunnel syndrome |
| WO2009046168A1 (en) | 2007-10-02 | 2009-04-09 | Avaxia Biologics, Inc. | Antibody therapy for use in the digestive tract |
| US20100159564A1 (en) * | 2007-11-30 | 2010-06-24 | Dwulet Francis E | Protease resistant recombinant bacterial collagenases |
| TWI395593B (zh) | 2008-03-06 | 2013-05-11 | Halozyme Inc | 可活化的基質降解酵素之活體內暫時性控制 |
| EP2130551B1 (en) * | 2008-06-02 | 2012-06-06 | Roche Diagnostics GmbH | Improved purification of collagenases from clostridium histolyticum liquid culture |
| US8236356B2 (en) * | 2008-06-11 | 2012-08-07 | Roche Diagnostics Operations, Inc. | Growth medium for Clostridium histolyticum |
| US20110229451A2 (en) * | 2009-03-06 | 2011-09-22 | Halozyme, Inc. | Temperature sensitive mutants of matrix metalloproteases and uses thereof |
| ES2385239B1 (es) | 2010-09-30 | 2013-06-19 | Proteos Biotech S.L.U. | Uso de colagenasa g recombinante, colagenasa h recombinante y pz-peptidasa recombinante para el tratamiento de enfermedades que cursan con alteraciones del colágeno. |
| WO2012125948A1 (en) | 2011-03-16 | 2012-09-20 | Biospecifics Technologies Corp. | Compositions and methods for producing clostridial collagenases |
| ES2690568T3 (es) | 2011-07-20 | 2018-11-21 | Mediwound, Ltd. | Extracto proteolítico de bromelaína para el tratamiento de trastornos del tejido conectivo |
| HUE044650T2 (hu) * | 2011-10-21 | 2019-11-28 | Endo Global Ventures | Eljárás EFP kezelésére vagy csökkentésére |
| HUE046160T2 (hu) * | 2012-01-12 | 2020-02-28 | Endo Global Ventures | Clostridium histolyticum enzim |
| ITPD20120118A1 (it) | 2012-04-18 | 2013-10-19 | Fidia Farmaceutici | "nuovo processo di produzione e purificazione dell'enzima collagenasi da vibrio alginolyticus" |
| EP2844276B1 (en) | 2012-05-01 | 2019-10-02 | Proteolease Ltd. | Methods for extracting a tooth |
| BR102012013110A2 (pt) | 2012-05-31 | 2014-05-27 | Cristalia Prod Quimicos Farm | Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica |
| WO2014066622A2 (en) | 2012-10-24 | 2014-05-01 | The Research Foundation For The State University Of New York | Use of collagenase to treat glaucoma |
| US20150196625A9 (en) | 2013-01-07 | 2015-07-16 | Rudolph D. Paladini | Metal Sensitive Mutants of Matrix Metalloproteases and uses thereof |
| US9744138B2 (en) * | 2013-03-15 | 2017-08-29 | Biospecifics Technologies Corp. | Treatment method and product for uterine fibroids using purified collagenase |
| US20160000890A1 (en) | 2013-03-15 | 2016-01-07 | Biospecifics Technologies Corp. | Thermosensitive hydrogel collagenase formulations |
| US10383875B2 (en) | 2013-06-18 | 2019-08-20 | Harrow Ip, Llc | Pharmaceutical formulations of xanthine or xanthine derivatives, and their use |
| US9849133B2 (en) * | 2013-06-18 | 2017-12-26 | Eton Pharmaceuticals, Inc. | Pharmaceutical formulations of xanthine or xanthine derivatives, and their use |
| US10117892B2 (en) * | 2013-08-29 | 2018-11-06 | Allergan, Inc. | Devices and methods for reducing the appearance of cellulite |
| CN103751102A (zh) | 2014-01-15 | 2014-04-30 | 上海交通大学 | 一种胶原酶温敏水凝胶及其制备方法和应用 |
| CN105477627B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 治疗前列腺癌的组合物及其用途 |
| CN105412916B (zh) * | 2014-09-19 | 2021-04-30 | 达森生物药业有限公司 | 治疗乳腺癌的组合物及其用途 |
| CN105412917B (zh) * | 2014-09-19 | 2021-04-30 | 达森生物药业有限公司 | 治疗实体瘤的抗癌组合物及其用途 |
| CN105477628B (zh) * | 2014-09-19 | 2021-04-30 | 山东蓝金生物工程有限公司 | 抗癌组合物及其用途 |
| DE202014105440U1 (de) * | 2014-11-12 | 2016-02-15 | Bilz Werkzeugfabrik Gmbh & Co. Kg | Werkzeugaufnahme |
| KR101723168B1 (ko) | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| US10303245B2 (en) * | 2015-05-04 | 2019-05-28 | Adobe Inc. | Methods and devices for detecting and responding to changes in eye conditions during presentation of video on electronic devices |
| ES3036011T3 (en) | 2017-03-01 | 2025-09-11 | Endo Operations Ltd | Apparatus and method for assessing and treating cellulite |
| CN118325876A (zh) | 2017-03-28 | 2024-07-12 | 恩多风投有限公司 | 生产胶原酶的改进方法 |
| WO2020021330A2 (en) * | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| WO2020021332A2 (en) | 2018-07-12 | 2020-01-30 | Endo Global Aesthetics Limited | Injection techniques for the treatment of cellulite |
| KR20210079291A (ko) | 2018-09-18 | 2021-06-29 | 엔도 글로벌 에스테틱스 리미티드 | 셀룰라이트를 치료하기 위한 조성물 및 방법 |
| CN113382714A (zh) | 2019-01-06 | 2021-09-10 | 恩多全球美学有限公司 | 胶原酶制剂及其制备方法 |
| WO2021076618A1 (en) | 2019-10-15 | 2021-04-22 | The Johns Hopkins University | Treatment of uterine fibroids using purified collagenase |
| WO2023131588A1 (en) | 2022-01-05 | 2023-07-13 | Nordmark Pharma Gmbh | Culture medium for cultivating hathewaya histolytica (or clostridium histolyticum) and the production of one or more proteases |
| CN116102638B (zh) * | 2023-01-09 | 2025-05-16 | 中国农业科学院农产品加工研究所 | 基于亲和吸附富集骨胶原蛋白成骨活性肽的方法 |
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| JPS61289885A (ja) * | 1985-06-14 | 1986-12-19 | Nitta Zerachin Kk | コラゲナ−ゼおよびコラゲナ−ゼの製造方法 |
| JP2898022B2 (ja) * | 1989-09-05 | 1999-05-31 | 株式会社ニッピ | コラーゲン分解酵素の製造方法 |
| CA2047306A1 (en) * | 1990-07-23 | 1992-01-24 | Milan Holjevac | Mutant bacterium clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase |
| US5393792A (en) * | 1991-11-20 | 1995-02-28 | Advance Biofactures Of Curacao, N.V. | High dosage topical forms of collagenase |
| US5462739A (en) * | 1991-11-21 | 1995-10-31 | Yeda Research And Development Co., Ltd. | Microdelivery device and method for enhanced drug administration to the eye |
| WO1994000580A1 (en) * | 1992-06-22 | 1994-01-06 | Trigen, Inc. | Molecular cloning of the genes reponsible for collagenase production from clostridium histolyticum |
| JP3186881B2 (ja) * | 1993-02-18 | 2001-07-11 | 倉敷紡績株式会社 | 肝細胞の分離方法 |
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| CA2189646C (en) * | 1994-06-24 | 1999-05-25 | Francis E. Dwulet | A purified mixture of collagenases and two other proteases obtained from clostridium histolyticum |
| US5589171A (en) | 1994-08-22 | 1996-12-31 | Advance Biofactures Of Curacao | Treatment of Dupuytren's disease with collagenase |
| HUP9901188A2 (hu) * | 1995-03-16 | 1999-08-30 | Knoll Aktiengesellschaft | Új, meghatározott enzimkeverékek sejtkinyeréshez és sebkezeléshez |
| US5989888A (en) * | 1996-01-24 | 1999-11-23 | Roche Diagnostics Corporation | Purified mixture of collagenase I, collagenase II and two other proteases |
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| US6086872A (en) | 1997-03-27 | 2000-07-11 | Advance Biofactures Of Curacao, Nv | Amelioration of dupuytren's disease |
| JPH10262658A (ja) * | 1997-03-28 | 1998-10-06 | Kikkoman Corp | ザルコシン・オキシダーゼの結晶、その製造方法及び三次元構造 |
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| AU2002354696A1 (en) * | 2001-07-02 | 2003-01-21 | Nordmark Arzneinmittel Gmbh And Co. Kg | Method for purifying an enzyme, a purified enzyme produced thereby, and use of this enzyme |
| EP1462519A1 (en) * | 2003-03-24 | 2004-09-29 | Boehringer Ingelheim Austria GmbH | Method and devices for producing biomolecules |
| JP4205496B2 (ja) * | 2003-06-19 | 2009-01-07 | 三菱化学株式会社 | 新規カルボニル還元酵素及びこれをコードするｄｎａ、ならびにこれらを利用した光学活性アルコールの製造方法 |
| NZ548871A (en) * | 2004-01-30 | 2009-06-26 | Shire Pharmaceuticals Ireland | Use of arylsulfatase A for treating metachromatic leukodystrophy |
| US7355027B2 (en) * | 2004-06-16 | 2008-04-08 | Dynport Vaccine Company Llc | Bacillus anthracis protective antigen |
| EP1781697B1 (en) * | 2004-07-07 | 2009-04-22 | H.Lundbeck A/S | Novel carbamylated epo and method for its production |
| WO2006010057A2 (en) * | 2004-07-08 | 2006-01-26 | Amgen Inc. | Therapeutic peptides |
| NZ556160A (en) * | 2005-01-21 | 2009-11-27 | Univ New York State Res Found | Methods for treating adhesive capsulitis |
| US7811560B2 (en) * | 2006-01-30 | 2010-10-12 | Auxilium Us Holdings, Llc | Compositions and methods for treating collagen-mediated diseases |
-
2007
- 2007-01-29 US US11/699,302 patent/US7811560B2/en active Active
- 2007-01-30 EP EP12155228A patent/EP2474319A1/en not_active Withdrawn
- 2007-01-30 AU AU2007211313A patent/AU2007211313C1/en active Active
- 2007-01-30 WO PCT/US2007/002654 patent/WO2007089851A2/en not_active Ceased
- 2007-01-30 JP JP2008552504A patent/JP5309289B2/ja active Active
- 2007-01-30 EP EP24194815.7A patent/EP4483952A3/en active Pending
- 2007-01-30 HU HUE07762860A patent/HUE041764T2/hu unknown
- 2007-01-30 EP EP12155233.5A patent/EP2474321B1/en active Active
- 2007-01-30 ES ES07762860T patent/ES2709202T3/es active Active
- 2007-01-30 EP EP18209918.4A patent/EP3508571B1/en active Active
- 2007-01-30 IL IL291175A patent/IL291175B2/en unknown
- 2007-01-30 CN CN200780008746.5A patent/CN101400788B/zh active Active
- 2007-01-30 DK DK12155233.5T patent/DK2474321T3/da active
- 2007-01-30 HU HUE12155233 patent/HUE044220T2/hu unknown
- 2007-01-30 PT PT07762860T patent/PT1987141T/pt unknown
- 2007-01-30 ES ES12155233T patent/ES2729941T3/es active Active
- 2007-01-30 DK DK07762860.0T patent/DK1987141T3/en active
- 2007-01-30 EP EP07762860.0A patent/EP1987141B8/en active Active
- 2007-01-30 ES ES18209918T patent/ES2992881T3/es active Active
- 2007-01-30 MX MX2008009756A patent/MX2008009756A/es active IP Right Grant
- 2007-01-30 EP EP12155230A patent/EP2474320A1/en not_active Withdrawn
- 2007-01-30 KR KR1020117006197A patent/KR20110046537A/ko not_active Ceased
- 2007-01-30 NZ NZ569882A patent/NZ569882A/en unknown
- 2007-01-30 KR KR1020087021302A patent/KR20080093142A/ko not_active Ceased
- 2007-01-30 CA CA2637262A patent/CA2637262C/en active Active
- 2007-01-30 PT PT12155233T patent/PT2474321T/pt unknown
- 2007-01-30 NZ NZ593907A patent/NZ593907A/xx unknown
- 2007-01-30 TR TR2019/03008T patent/TR201903008T4/tr unknown
- 2007-01-30 BR BRPI0708017-4A patent/BRPI0708017A2/pt not_active Application Discontinuation
- 2007-01-30 CN CN201610369324.1A patent/CN105999244B/zh active Active
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2008
- 2008-07-17 IL IL192878A patent/IL192878A/en active IP Right Grant
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2010
- 2010-04-13 US US12/759,065 patent/US20100233151A1/en not_active Abandoned
- 2010-07-16 US US12/837,933 patent/US20100330065A1/en not_active Abandoned
- 2010-08-30 US US12/871,159 patent/US20110158972A1/en not_active Abandoned
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2011
- 2011-04-12 US US13/084,734 patent/US20110243909A1/en not_active Abandoned
- 2011-04-12 US US13/084,735 patent/US20110243920A1/en not_active Abandoned
- 2011-04-12 US US13/084,722 patent/US20110243908A1/en not_active Abandoned
- 2011-04-12 US US13/084,719 patent/US20110189163A1/en not_active Abandoned
- 2011-04-12 US US13/084,720 patent/US20110243919A1/en not_active Abandoned
- 2011-04-12 US US13/084,716 patent/US20110189153A1/en not_active Abandoned
- 2011-12-27 JP JP2011285435A patent/JP2012070758A/ja not_active Withdrawn
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2012
- 2012-02-15 AU AU2012200863A patent/AU2012200863B2/en active Active
- 2012-12-13 US US13/713,019 patent/US20140004094A1/en not_active Abandoned
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2015
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2016
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2017
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2018
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2019
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2020
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2021
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2022
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2024
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