JP2011530592A5 - - Google Patents
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- Publication number
- JP2011530592A5 JP2011530592A5 JP2011522953A JP2011522953A JP2011530592A5 JP 2011530592 A5 JP2011530592 A5 JP 2011530592A5 JP 2011522953 A JP2011522953 A JP 2011522953A JP 2011522953 A JP2011522953 A JP 2011522953A JP 2011530592 A5 JP2011530592 A5 JP 2011530592A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- membrane
- composition
- conductivity
- ion exchange
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 34
- 239000012528 membrane Substances 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 239000000872 buffer Substances 0.000 claims description 8
- 239000003014 ion exchange membrane Substances 0.000 claims description 4
- 239000003011 anion exchange membrane Substances 0.000 claims description 2
- 238000005341 cation exchange Methods 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims 6
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 238000004255 ion exchange chromatography Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 102100038080 B-cell receptor CD22 Human genes 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 claims 1
- 102000002259 TNF-Related Apoptosis-Inducing Ligand Receptors Human genes 0.000 claims 1
- 108010000449 TNF-Related Apoptosis-Inducing Ligand Receptors Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 108091008605 VEGF receptors Proteins 0.000 claims 1
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 1
- 239000003463 adsorbent Substances 0.000 claims 1
- 238000001042 affinity chromatography Methods 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 229960000470 omalizumab Drugs 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 229960002087 pertuzumab Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 description 19
- 102000004196 processed proteins & peptides Human genes 0.000 description 19
- 108090000765 processed proteins & peptides Proteins 0.000 description 19
- 239000000356 contaminant Substances 0.000 description 6
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2008/073179 WO2010019148A1 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530592A JP2011530592A (ja) | 2011-12-22 |
| JP2011530592A5 true JP2011530592A5 (https=) | 2014-06-26 |
| JP5666447B2 JP5666447B2 (ja) | 2015-02-12 |
Family
ID=39899038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522953A Active JP5666447B2 (ja) | 2008-08-14 | 2008-08-14 | 常在性タンパク質置換イオン交換メンブレンクロマトグラフィを用いた混入物除去方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10927144B2 (https=) |
| EP (3) | EP2321337B2 (https=) |
| JP (1) | JP5666447B2 (https=) |
| KR (3) | KR20180033311A (https=) |
| CN (1) | CN102149724B (https=) |
| AU (1) | AU2008360625C1 (https=) |
| BR (1) | BRPI0823046B1 (https=) |
| CA (1) | CA2731943C (https=) |
| CY (1) | CY1122221T1 (https=) |
| DK (2) | DK2848625T3 (https=) |
| ES (3) | ES2527943T5 (https=) |
| FI (1) | FI3604324T3 (https=) |
| HR (2) | HRP20240472T1 (https=) |
| HU (2) | HUE047316T2 (https=) |
| IL (2) | IL210912B (https=) |
| LT (2) | LT2848625T (https=) |
| MX (1) | MX2011001506A (https=) |
| PL (2) | PL2848625T3 (https=) |
| PT (2) | PT2848625T (https=) |
| RS (1) | RS59232B1 (https=) |
| SI (2) | SI3604324T1 (https=) |
| WO (1) | WO2010019148A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI456062B (zh) | 2006-09-13 | 2014-10-11 | Abbvie Inc | 細胞培養改良 |
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| MX2011004201A (es) | 2008-10-20 | 2011-05-24 | Abbott Lab | Desactivacion viral durante purificacion de anticuerpos. |
| AU2009347206C1 (en) | 2008-10-20 | 2016-12-08 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
| EP4492053A3 (en) † | 2010-05-25 | 2025-03-19 | F. Hoffmann-La Roche AG | Methods of purifying polypeptides |
| WO2012030512A1 (en) * | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
| SG191089A1 (en) * | 2010-12-10 | 2013-07-31 | Tracy Thompson | Compositions for separation methods |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| RU2648999C2 (ru) * | 2011-12-22 | 2018-03-29 | Дженентек, Инк. | Способы повышения эффективности этапов очистки белка, находящихся ниже по потоку, с использованием мембранной ионообменной хроматографии |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| SG11201505203XA (en) * | 2013-02-26 | 2015-08-28 | Agency Science Tech & Res | Protein purification in the presence of nonionic organic polymers and electropositive surfaces |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| JP6163541B2 (ja) * | 2013-04-16 | 2017-07-12 | 旭化成メディカル株式会社 | 抗体タンパク質の精製方法 |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| EP2986307A4 (en) | 2014-01-03 | 2017-04-12 | Bio-rad Laboratories, Inc. | Removal of impurities from protein a eluates |
| EP3510042B1 (en) * | 2016-09-07 | 2024-05-22 | GlaxoSmithKline Intellectual Property Development Limited | Methods for purifying antibodies |
| US11446613B2 (en) | 2016-09-09 | 2022-09-20 | 3M Innovative Properties Company | Functionalized copolymers and use thereof |
| US10053368B1 (en) * | 2017-09-07 | 2018-08-21 | Chevron U.S.A. Inc. | Synthesis of AFX framework type molecular sieves |
| EP3546475A1 (en) * | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| TWI903214B (zh) * | 2018-05-02 | 2025-11-01 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
| CN112566930A (zh) * | 2018-06-19 | 2021-03-26 | 百时美施贵宝公司 | 使用色谱纯化蛋白质的方法 |
| CN109324143B (zh) * | 2018-10-19 | 2021-10-29 | 张骐 | 利用二维液相分离制备抗体类产品相关杂质的方法 |
| CN109806916B (zh) * | 2019-03-15 | 2021-12-21 | 中科森辉微球技术（苏州）有限公司 | 高性能阴离子交换介质及其制备方法 |
| GB201911685D0 (en) * | 2019-08-15 | 2019-10-02 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process for purifying monoclonal antibodies |
| KR20220112014A (ko) | 2021-02-03 | 2022-08-10 | 고인석 | 십전대보탕을 이용하여 만든 오리목뼈 간식 |
| AU2021471146A1 (en) * | 2021-10-27 | 2024-06-13 | Plasma Technologies, Llc | Compositions and methods for isolating proteins |
| WO2025221920A1 (en) * | 2024-04-18 | 2025-10-23 | Makana Therapeutics, Inc. | Products and methods relating to transplant recipient antibodies bound to donor cell membrane fragments |
| CN118290514B (zh) * | 2024-06-05 | 2025-04-04 | 东曜药业有限公司 | 基于阴离子膜的抗体偶联药物的纯化方法及抗体偶联药物 |
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2008
- 2008-08-14 MX MX2011001506A patent/MX2011001506A/es active IP Right Grant
- 2008-08-14 LT LTEP14189582.1T patent/LT2848625T/lt unknown
- 2008-08-14 PL PL14189582T patent/PL2848625T3/pl unknown
- 2008-08-14 EP EP08797895.3A patent/EP2321337B2/en active Active
- 2008-08-14 FI FIEP19181531.5T patent/FI3604324T3/fi active
- 2008-08-14 EP EP14189582.1A patent/EP2848625B1/en active Active
- 2008-08-14 CA CA2731943A patent/CA2731943C/en active Active
- 2008-08-14 KR KR1020187008461A patent/KR20180033311A/ko not_active Ceased
- 2008-08-14 PL PL19181531.5T patent/PL3604324T3/pl unknown
- 2008-08-14 PT PT141895821T patent/PT2848625T/pt unknown
- 2008-08-14 KR KR1020187036563A patent/KR102196883B1/ko active Active
- 2008-08-14 SI SI200832219T patent/SI3604324T1/sl unknown
- 2008-08-14 DK DK14189582.1T patent/DK2848625T3/da active
- 2008-08-14 ES ES08797895T patent/ES2527943T5/es active Active
- 2008-08-14 JP JP2011522953A patent/JP5666447B2/ja active Active
- 2008-08-14 SI SI200832092T patent/SI2848625T1/sl unknown
- 2008-08-14 RS RSP20191119 patent/RS59232B1/sr unknown
- 2008-08-14 DK DK19181531.5T patent/DK3604324T3/da active
- 2008-08-14 HU HUE14189582A patent/HUE047316T2/hu unknown
- 2008-08-14 WO PCT/US2008/073179 patent/WO2010019148A1/en not_active Ceased
- 2008-08-14 US US13/058,796 patent/US10927144B2/en active Active
- 2008-08-14 AU AU2008360625A patent/AU2008360625C1/en active Active
- 2008-08-14 HU HUE19181531A patent/HUE066562T2/hu unknown
- 2008-08-14 ES ES19181531T patent/ES2978373T3/es active Active
- 2008-08-14 EP EP19181531.5A patent/EP3604324B1/en active Active
- 2008-08-14 CN CN200880131059.7A patent/CN102149724B/zh active Active
- 2008-08-14 KR KR1020117005824A patent/KR101843915B1/ko active Active
- 2008-08-14 BR BRPI0823046-3A patent/BRPI0823046B1/pt active IP Right Grant
- 2008-08-14 PT PT191815315T patent/PT3604324T/pt unknown
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2011
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2021
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