JP2011524161A5 - - Google Patents
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- Publication number
- JP2011524161A5 JP2011524161A5 JP2011511147A JP2011511147A JP2011524161A5 JP 2011524161 A5 JP2011524161 A5 JP 2011524161A5 JP 2011511147 A JP2011511147 A JP 2011511147A JP 2011511147 A JP2011511147 A JP 2011511147A JP 2011524161 A5 JP2011524161 A5 JP 2011524161A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza
- virus
- monoclonal antibody
- seq
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000712431 Influenza A virus Species 0.000 claims 14
- 101710154606 Hemagglutinin Proteins 0.000 claims 9
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 9
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 9
- 101710176177 Protein A56 Proteins 0.000 claims 9
- 239000000185 hemagglutinin Substances 0.000 claims 9
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 238000003556 assay Methods 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- 241001358279 Malaya Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 208000037797 influenza A Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000003472 neutralizing effect Effects 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 206010069767 H1N1 influenza Diseases 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000725681 Swine influenza virus Species 0.000 claims 1
- 230000003302 anti-idiotype Effects 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 201000010740 swine influenza Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITTO2008A000398 | 2008-05-27 | ||
| IT000398A ITTO20080398A1 (it) | 2008-05-27 | 2008-05-27 | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| PCT/IB2009/052212 WO2009144667A1 (en) | 2008-05-27 | 2009-05-27 | Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524161A JP2011524161A (ja) | 2011-09-01 |
| JP2011524161A5 true JP2011524161A5 (enExample) | 2012-07-12 |
| JP5792060B2 JP5792060B2 (ja) | 2015-10-07 |
Family
ID=40303127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511147A Active JP5792060B2 (ja) | 2008-05-27 | 2009-05-27 | Ａ型インフルエンザウイルスサブタイプｈ１に対するホモサブタイプ交差中和特性を有するモノクローナル抗体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9243054B2 (enExample) |
| EP (1) | EP2294084B2 (enExample) |
| JP (1) | JP5792060B2 (enExample) |
| KR (1) | KR101665146B1 (enExample) |
| CN (1) | CN102124028B (enExample) |
| AU (1) | AU2009252758B2 (enExample) |
| BR (1) | BRPI0912285A2 (enExample) |
| CA (1) | CA2725627C (enExample) |
| EA (1) | EA022855B1 (enExample) |
| ES (1) | ES2555486T5 (enExample) |
| IL (1) | IL209499A (enExample) |
| IT (1) | ITTO20080398A1 (enExample) |
| MX (1) | MX2010012974A (enExample) |
| NZ (1) | NZ590115A (enExample) |
| SG (1) | SG191610A1 (enExample) |
| WO (1) | WO2009144667A1 (enExample) |
| ZA (1) | ZA201009273B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| IT1395961B1 (it) * | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| ITTO20110067A1 (it) * | 2011-01-26 | 2012-07-27 | Pomona Ricerca Srl | Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale |
| WO2011117848A1 (en) * | 2010-03-26 | 2011-09-29 | Pomona Ricerca S.R.L. | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
| CN102241768B (zh) * | 2010-05-14 | 2013-12-25 | 中国科学院上海生命科学研究院 | 一种抗甲型h1n1流感病毒血凝素蛋白的抗体 |
| EP2603237A4 (en) * | 2010-08-12 | 2014-05-21 | Theraclone Sciences Inc | ANTI-HEMAGGLUTININE ANTIBODY COMPOSITIONS AND METHOD FOR THEIR USE |
| CN101988050B (zh) * | 2010-12-09 | 2012-06-27 | 湖南出入境检验检疫局检验检疫技术中心 | 抗h1n1猪流感病毒血凝素蛋白单克隆抗体，杂交瘤细胞株及抗原捕获elisa试剂盒 |
| RU2457243C1 (ru) * | 2011-01-11 | 2012-07-27 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вирусологии им. Д.И. Ивановского" Министерства здравоохранения и социального развития Российской Федерации | ШТАММ ГИБРИДНЫХ КУЛЬТИВИРУЕМЫХ КЛЕТОК МЫШИ Mus. Musculus - 1E7, ПРОДУЦИРУЮЩИЙ МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, ИММУНОРЕАКТИВНОЕ С БЕЛКОМ ГЕМАГГЛЮТИНИНА ПАНДЕМИЧЕСКОГО ВИРУСА ГРИППА А/IIV-Moscow/01/09(H1N1)sw1 |
| EP2699688A1 (en) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| WO2013119793A1 (en) * | 2012-02-07 | 2013-08-15 | University Of Kansas | Chemiluminescent nanoparticles and uses thereof |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| CN113667013B (zh) | 2013-10-02 | 2024-04-09 | 免疫医疗有限责任公司 | 中和抗甲型流感抗体及其用途 |
| KR101628331B1 (ko) * | 2014-03-28 | 2016-06-08 | 주식회사 녹십자엠에스 | 인플루엔자 a 바이러스 특이적 단클론 항체 및 이를 이용한 인플루엔자 감염 치료 및 진단 방법 |
| ES2833230T3 (es) | 2014-05-13 | 2021-06-14 | Univ Pennsylvania | Composiciones que comprenden AVV que expresan construcciones y usos de doble anticuerpo del mismo |
| CA2954780A1 (en) | 2014-07-15 | 2016-01-21 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3307310A2 (en) | 2015-05-13 | 2018-04-18 | The Trustees Of The University Of Pennsylvania | Aav-mediated expression of anti-influenza antibodies and methods of use thereof |
| HUE056407T2 (hu) | 2015-06-01 | 2022-02-28 | Medimmune Llc | Neutralizáló influenzaellenes kötõmolekulák és alkalmazásaik |
| US10513553B2 (en) | 2015-11-13 | 2019-12-24 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| US20190015509A1 (en) | 2016-01-13 | 2019-01-17 | Medimmune, Llc | Method of treating influenza a |
| CA3015347A1 (en) | 2016-02-24 | 2017-08-31 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| AU2018229293A1 (en) | 2017-02-28 | 2019-08-29 | Janssen Biotech, Inc. | Influenza vaccines based on AAV vectors |
| US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| KR101972238B1 (ko) * | 2017-11-22 | 2019-04-24 | 한국생명공학연구원 | 인플루엔자 a 바이러스 특이적 항체 또는 그의 항원 결합 단편 |
| JP2022521819A (ja) | 2019-03-25 | 2022-04-12 | ビステラ， インコーポレイテッド | インフルエンザを処置および予防するための組成物および方法 |
| MX2023006444A (es) | 2020-12-01 | 2023-08-10 | Univ Pennsylvania | Composiciones novedosas con motivos dirigidos a tejido específico y composiciones que los contienen. |
| WO2022232289A1 (en) | 2021-04-27 | 2022-11-03 | Generation Bio Co. | Non-viral dna vectors expressing therapeutic antibodies and uses thereof |
| WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
| WO2024243249A1 (en) * | 2023-05-23 | 2024-11-28 | The Scripps Research Institute | Stabilized hemagglutinin (ha) trimers as influenza vaccine antigens |
| CN121021682A (zh) * | 2025-10-29 | 2025-11-28 | 山东第一医科大学(山东省医学科学院) | 一种抗甲型h1n1亚型猪流感病毒的重组纳米抗体及其制备方法和应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6812024B2 (en) | 1987-03-16 | 2004-11-02 | Mcgready Roland Keith | Anti-paratopic antibody as an immunogen |
| US5245015A (en) | 1991-04-26 | 1993-09-14 | Tanox Biosystems, Inc. | Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro |
| WO1992015885A1 (en) | 1991-03-11 | 1992-09-17 | Idec Pharmaceuticals Corporation | Methods for selecting antibody reagents; anti-idiotype antibodies; and aids vaccine formulations |
| DE69333348T2 (de) | 1992-03-09 | 2004-09-16 | San Diego Regional Cancer Center, San Diego | Anti-idiotypischer Antikörper und seine Verwendung zur Diagnose und Therapie bei HIV-bezogenen Krankheiten |
| EP0621339B1 (en) | 1992-09-17 | 2001-10-24 | Takara Shuzo Co. Ltd. | Immunogenic human influenza A virus haemagglutinin polypeptides |
| JP3061960B2 (ja) * | 1992-09-17 | 2000-07-10 | 寳酒造株式会社 | 抗ヒトインフルエンザウイルス抗体 |
| GB9221654D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
| JP2996864B2 (ja) * | 1994-03-30 | 2000-01-11 | 寳酒造株式会社 | 抗体可変領域ｄｎａ |
| US6057421A (en) | 1994-11-30 | 2000-05-02 | Immpheron, Inc. | Variable heavy and light chain regions of murine monoclonal antibody 1F7 |
| AU5285899A (en) | 1998-07-21 | 2000-02-14 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| JP2004524829A (ja) | 2000-12-01 | 2004-08-19 | アメリカ合衆国 | Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用 |
| FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
| US6768004B2 (en) | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
| US6964199B2 (en) | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
| WO2003059953A2 (en) | 2002-01-17 | 2003-07-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Anti-idiotypic antibody inducing hiv-1 neutralizing antibodies |
| ITRM20020049A1 (it) | 2002-01-30 | 2003-07-30 | Biostrands S R L | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
| JP2009537147A (ja) | 2006-05-15 | 2009-10-29 | シー レーン バイオテクノロジーズ， エルエルシー | インフルエンザウイルスに対する中和抗体 |
| EP2059532B1 (en) | 2006-09-07 | 2012-12-26 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| WO2008033159A1 (en) | 2006-09-15 | 2008-03-20 | Fraunhofer Usa, Inc. | Influenza antibodies, compositions, and related methods |
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| JP2010538667A (ja) | 2007-09-20 | 2010-12-16 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 新規オリゴクローナル抗体の製造方法 |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| WO2011117848A1 (en) | 2010-03-26 | 2011-09-29 | Pomona Ricerca S.R.L. | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
-
2008
- 2008-05-27 IT IT000398A patent/ITTO20080398A1/it unknown
-
2009
- 2009-05-27 ES ES09754293T patent/ES2555486T5/es active Active
- 2009-05-27 EA EA201071365A patent/EA022855B1/ru not_active IP Right Cessation
- 2009-05-27 US US12/994,746 patent/US9243054B2/en active Active
- 2009-05-27 CA CA2725627A patent/CA2725627C/en active Active
- 2009-05-27 NZ NZ590115A patent/NZ590115A/xx not_active IP Right Cessation
- 2009-05-27 MX MX2010012974A patent/MX2010012974A/es active IP Right Grant
- 2009-05-27 AU AU2009252758A patent/AU2009252758B2/en not_active Ceased
- 2009-05-27 BR BRPI0912285A patent/BRPI0912285A2/pt not_active Application Discontinuation
- 2009-05-27 WO PCT/IB2009/052212 patent/WO2009144667A1/en not_active Ceased
- 2009-05-27 EP EP09754293.0A patent/EP2294084B2/en active Active
- 2009-05-27 KR KR1020107029309A patent/KR101665146B1/ko active Active
- 2009-05-27 SG SG2013040647A patent/SG191610A1/en unknown
- 2009-05-27 CN CN200980130479.8A patent/CN102124028B/zh active Active
- 2009-05-27 JP JP2011511147A patent/JP5792060B2/ja active Active
-
2010
- 2010-11-22 IL IL209499A patent/IL209499A/en active IP Right Grant
- 2010-12-23 ZA ZA2010/09273A patent/ZA201009273B/en unknown
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