ITTO20110067A1 - Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale - Google Patents
Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzaleInfo
- Publication number
- ITTO20110067A1 ITTO20110067A1 IT000067A ITTO20110067A ITTO20110067A1 IT TO20110067 A1 ITTO20110067 A1 IT TO20110067A1 IT 000067 A IT000067 A IT 000067A IT TO20110067 A ITTO20110067 A IT TO20110067A IT TO20110067 A1 ITTO20110067 A1 IT TO20110067A1
- Authority
- IT
- Italy
- Prior art keywords
- stem
- isotipo
- eterosubtipic
- emoagglutinine
- antinfluenual
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000006386 neutralization reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000067A ITTO20110067A1 (it) | 2011-01-26 | 2011-01-26 | Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale |
CN201180015849.0A CN102958539B (zh) | 2010-03-26 | 2011-03-25 | 能够识别血凝素干区上的杂亚型中和表位的IgG同种型全长免疫球蛋白和其作为抗-流感药物的应用 |
PCT/IB2011/051284 WO2011117848A1 (en) | 2010-03-26 | 2011-03-25 | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
US13/637,030 US20130022608A1 (en) | 2010-03-26 | 2011-03-25 | FULL-LENGTH IgG IMMUNOGLOBULINS CAPABLE OF RECOGNIZING A HETEROSUBTYPE NEUTRALIZING EPITOPE ON THE HEMAGGLUTININ STEM REGION AND USES THEREOF |
SI201131130A SI2552485T1 (sl) | 2010-03-26 | 2011-03-25 | Imunoglobulini polne dolžine igg izotipa, sposobni prepoznave heteropodtipskega nevtralizacijskega epitopa na hemagglutininskem izvornem področju in njih uporaba kot zdravilo proti gripi |
EP11721645.7A EP2552485B1 (en) | 2010-03-26 | 2011-03-25 | Full-length immunoglobulins of the igg isotype capable of recognizing a heterosubtype neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
EA201290955A EA029198B1 (ru) | 2010-03-26 | 2011-03-25 | Полноразмерные иммуноглобулины изотипа igg, способные к распознаванию нейтрализующего эпитопа в области стебля гемагглютинина различных подтипов и их использование в качестве лекарственного средства против гриппа |
HRP20170490TT HRP20170490T1 (hr) | 2010-03-26 | 2017-03-24 | Imunoglobulini pune dužine igg izotipa sposobni za prepoznavanje heterosubtipnog epitopa neutralizacije na području stabljike hemaglutinina i njihova uporaba kao lijek protiv gripe |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000067A ITTO20110067A1 (it) | 2011-01-26 | 2011-01-26 | Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale |
Publications (1)
Publication Number | Publication Date |
---|---|
ITTO20110067A1 true ITTO20110067A1 (it) | 2012-07-27 |
Family
ID=43975646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT000067A ITTO20110067A1 (it) | 2010-03-26 | 2011-01-26 | Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale |
Country Status (1)
Country | Link |
---|---|
IT (1) | ITTO20110067A1 (it) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009115972A1 (en) * | 2008-03-17 | 2009-09-24 | Pomona Biotechnologies Llc | Monoclonal antibodies capable of reacting with a plurality of influenza virus a subtypes |
WO2009144667A1 (en) * | 2008-05-27 | 2009-12-03 | Pomona Biotechnologies Llc | Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1 |
WO2010140114A1 (en) * | 2009-06-01 | 2010-12-09 | Pomona Biotechnologies Llc | Monoclonal antibodies as a medicament for the therapeutic and/or prophylactic treatment of swine -origin influenza a (h1n1) virus (s-oiv) infections |
-
2011
- 2011-01-26 IT IT000067A patent/ITTO20110067A1/it unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009115972A1 (en) * | 2008-03-17 | 2009-09-24 | Pomona Biotechnologies Llc | Monoclonal antibodies capable of reacting with a plurality of influenza virus a subtypes |
WO2009144667A1 (en) * | 2008-05-27 | 2009-12-03 | Pomona Biotechnologies Llc | Monoclonal antibodies having homosubtype cross -neutralization properties against influenza a viruses subtype h1 |
WO2010140114A1 (en) * | 2009-06-01 | 2010-12-09 | Pomona Biotechnologies Llc | Monoclonal antibodies as a medicament for the therapeutic and/or prophylactic treatment of swine -origin influenza a (h1n1) virus (s-oiv) infections |
Non-Patent Citations (5)
Title |
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BECK ALAIN ET AL: "Therapeutic antibodies and related products: choosing the right structure for success", M-S (MEDECINE SCIENCES), vol. 25, no. 12, December 2009 (2009-12-01), pages 1024 - 1032, XP008138357, ISSN: 0767-0974 * |
BURIONI R ET AL: "Monoclonal antibodies isolated from human B cells neutralize a broad range of H1 subtype influenza A viruses including swine-origin Influenza virus (S-OIV)", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 399, no. 1, 30 March 2010 (2010-03-30), pages 144 - 152, XP026923963, ISSN: 0042-6822, [retrieved on 20100224], DOI: DOI:10.1016/J.VIROL.2009.12.014 * |
BURIONI ROBERTO ET AL: "Molecular cloning of the first human monoclonal antibodies neutralizing with high potency Swine-origin Influenza A pandemic virus (S-OIV)", NEW MICROBIOLOGICA, vol. 32, no. 4, October 2009 (2009-10-01), pages 319 - 324, XP002644800, ISSN: 1121-7138 * |
HENDERIKX PAULA ET AL: "A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized", AMERICAN JOURNAL OF PATHOLOGY, vol. 160, no. 5, May 2002 (2002-05-01), pages 1597 - 1608, XP002644798, ISSN: 0002-9440 * |
JOSTOCK T ET AL: "Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 289, no. 1-2, 1 June 2004 (2004-06-01), pages 65 - 80, XP004520880, ISSN: 0022-1759, DOI: DOI:10.1016/J.JIM.2004.03.014 * |
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