SG191610A1 - Monoclonal antibodies having homosubtype cross-neutralization properties against influenza a viruses subtype h1 - Google Patents
Monoclonal antibodies having homosubtype cross-neutralization properties against influenza a viruses subtype h1 Download PDFInfo
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- SG191610A1 SG191610A1 SG2013040647A SG2013040647A SG191610A1 SG 191610 A1 SG191610 A1 SG 191610A1 SG 2013040647 A SG2013040647 A SG 2013040647A SG 2013040647 A SG2013040647 A SG 2013040647A SG 191610 A1 SG191610 A1 SG 191610A1
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- influenza
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000398A ITTO20080398A1 (it) | 2008-05-27 | 2008-05-27 | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG191610A1 true SG191610A1 (en) | 2013-07-31 |
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Family Applications (1)
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| SG2013040647A SG191610A1 (en) | 2008-05-27 | 2009-05-27 | Monoclonal antibodies having homosubtype cross-neutralization properties against influenza a viruses subtype h1 |
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| CN (1) | CN102124028B (enExample) |
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| CA (1) | CA2725627C (enExample) |
| EA (1) | EA022855B1 (enExample) |
| ES (1) | ES2555486T5 (enExample) |
| IL (1) | IL209499A (enExample) |
| IT (1) | ITTO20080398A1 (enExample) |
| MX (1) | MX2010012974A (enExample) |
| NZ (1) | NZ590115A (enExample) |
| SG (1) | SG191610A1 (enExample) |
| WO (1) | WO2009144667A1 (enExample) |
| ZA (1) | ZA201009273B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| IT1395961B1 (it) * | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| ITTO20110067A1 (it) * | 2011-01-26 | 2012-07-27 | Pomona Ricerca Srl | Immunoglobuline intere di isotipo igg atte a riconoscere un epitopo di neutralizzazione eterosubtipica sulla regione stelo (stem region) dell'emoagglutinina e loro uso come medicamento antinfluenzale |
| WO2011117848A1 (en) * | 2010-03-26 | 2011-09-29 | Pomona Ricerca S.R.L. | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
| CN102241768B (zh) * | 2010-05-14 | 2013-12-25 | 中国科学院上海生命科学研究院 | 一种抗甲型h1n1流感病毒血凝素蛋白的抗体 |
| EP2603237A4 (en) * | 2010-08-12 | 2014-05-21 | Theraclone Sciences Inc | ANTI-HEMAGGLUTININE ANTIBODY COMPOSITIONS AND METHOD FOR THEIR USE |
| CN101988050B (zh) * | 2010-12-09 | 2012-06-27 | 湖南出入境检验检疫局检验检疫技术中心 | 抗h1n1猪流感病毒血凝素蛋白单克隆抗体，杂交瘤细胞株及抗原捕获elisa试剂盒 |
| RU2457243C1 (ru) * | 2011-01-11 | 2012-07-27 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вирусологии им. Д.И. Ивановского" Министерства здравоохранения и социального развития Российской Федерации | ШТАММ ГИБРИДНЫХ КУЛЬТИВИРУЕМЫХ КЛЕТОК МЫШИ Mus. Musculus - 1E7, ПРОДУЦИРУЮЩИЙ МОНОКЛОНАЛЬНОЕ АНТИТЕЛО, ИММУНОРЕАКТИВНОЕ С БЕЛКОМ ГЕМАГГЛЮТИНИНА ПАНДЕМИЧЕСКОГО ВИРУСА ГРИППА А/IIV-Moscow/01/09(H1N1)sw1 |
| EP2699688A1 (en) | 2011-04-20 | 2014-02-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| WO2013119793A1 (en) * | 2012-02-07 | 2013-08-15 | University Of Kansas | Chemiluminescent nanoparticles and uses thereof |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| CN113667013B (zh) | 2013-10-02 | 2024-04-09 | 免疫医疗有限责任公司 | 中和抗甲型流感抗体及其用途 |
| KR101628331B1 (ko) * | 2014-03-28 | 2016-06-08 | 주식회사 녹십자엠에스 | 인플루엔자 a 바이러스 특이적 단클론 항체 및 이를 이용한 인플루엔자 감염 치료 및 진단 방법 |
| ES2833230T3 (es) | 2014-05-13 | 2021-06-14 | Univ Pennsylvania | Composiciones que comprenden AVV que expresan construcciones y usos de doble anticuerpo del mismo |
| CA2954780A1 (en) | 2014-07-15 | 2016-01-21 | Medimmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3307310A2 (en) | 2015-05-13 | 2018-04-18 | The Trustees Of The University Of Pennsylvania | Aav-mediated expression of anti-influenza antibodies and methods of use thereof |
| HUE056407T2 (hu) | 2015-06-01 | 2022-02-28 | Medimmune Llc | Neutralizáló influenzaellenes kötõmolekulák és alkalmazásaik |
| US10513553B2 (en) | 2015-11-13 | 2019-12-24 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| US20190015509A1 (en) | 2016-01-13 | 2019-01-17 | Medimmune, Llc | Method of treating influenza a |
| CA3015347A1 (en) | 2016-02-24 | 2017-08-31 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| AU2018229293A1 (en) | 2017-02-28 | 2019-08-29 | Janssen Biotech, Inc. | Influenza vaccines based on AAV vectors |
| US11827906B2 (en) | 2017-02-28 | 2023-11-28 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (AAV) clade f vector and uses therefor |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| KR101972238B1 (ko) * | 2017-11-22 | 2019-04-24 | 한국생명공학연구원 | 인플루엔자 a 바이러스 특이적 항체 또는 그의 항원 결합 단편 |
| JP2022521819A (ja) | 2019-03-25 | 2022-04-12 | ビステラ， インコーポレイテッド | インフルエンザを処置および予防するための組成物および方法 |
| MX2023006444A (es) | 2020-12-01 | 2023-08-10 | Univ Pennsylvania | Composiciones novedosas con motivos dirigidos a tejido específico y composiciones que los contienen. |
| WO2022232289A1 (en) | 2021-04-27 | 2022-11-03 | Generation Bio Co. | Non-viral dna vectors expressing therapeutic antibodies and uses thereof |
| WO2023177655A1 (en) | 2022-03-14 | 2023-09-21 | Generation Bio Co. | Heterologous prime boost vaccine compositions and methods of use |
| WO2024243249A1 (en) * | 2023-05-23 | 2024-11-28 | The Scripps Research Institute | Stabilized hemagglutinin (ha) trimers as influenza vaccine antigens |
| CN121021682A (zh) * | 2025-10-29 | 2025-11-28 | 山东第一医科大学(山东省医学科学院) | 一种抗甲型h1n1亚型猪流感病毒的重组纳米抗体及其制备方法和应用 |
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| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
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| US5245015A (en) | 1991-04-26 | 1993-09-14 | Tanox Biosystems, Inc. | Monoclonal antibodies which neutralize HIV-1 through reaction with a conformational epitope in vitro |
| WO1992015885A1 (en) | 1991-03-11 | 1992-09-17 | Idec Pharmaceuticals Corporation | Methods for selecting antibody reagents; anti-idiotype antibodies; and aids vaccine formulations |
| DE69333348T2 (de) | 1992-03-09 | 2004-09-16 | San Diego Regional Cancer Center, San Diego | Anti-idiotypischer Antikörper und seine Verwendung zur Diagnose und Therapie bei HIV-bezogenen Krankheiten |
| EP0621339B1 (en) | 1992-09-17 | 2001-10-24 | Takara Shuzo Co. Ltd. | Immunogenic human influenza A virus haemagglutinin polypeptides |
| JP3061960B2 (ja) * | 1992-09-17 | 2000-07-10 | 寳酒造株式会社 | 抗ヒトインフルエンザウイルス抗体 |
| GB9221654D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
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| AU5285899A (en) | 1998-07-21 | 2000-02-14 | Connex Gesellschaft Zur Optimierung Von Forschung Und Entwicklung Mbh | Anti hepatitis c virus antibody and uses thereof |
| JP2004524829A (ja) | 2000-12-01 | 2004-08-19 | アメリカ合衆国 | Ｃ型肝炎ウイルスのｅ２糖タンパク質に特異的なモノクローナル抗体、ならびにｃ型肝炎の診断、治療、および予防におけるそれらの使用 |
| FR2817869B1 (fr) | 2000-12-07 | 2005-01-14 | Technopharm | Anticorps monoclonal humain dirige contre le virus influenza ou un fragment de celui-ci |
| US6768004B2 (en) | 2001-01-11 | 2004-07-27 | Mueller Sybille | Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies |
| US6964199B2 (en) | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
| WO2003059953A2 (en) | 2002-01-17 | 2003-07-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Anti-idiotypic antibody inducing hiv-1 neutralizing antibodies |
| ITRM20020049A1 (it) | 2002-01-30 | 2003-07-30 | Biostrands S R L | Frammenti fab di anticorpi monoclonali umani diretti contro la glicoproteina e2 di hcv e dotati di potere neutralizzante in vitro. |
| JP2009537147A (ja) | 2006-05-15 | 2009-10-29 | シー レーン バイオテクノロジーズ， エルエルシー | インフルエンザウイルスに対する中和抗体 |
| EP2059532B1 (en) | 2006-09-07 | 2012-12-26 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| WO2008033159A1 (en) | 2006-09-15 | 2008-03-20 | Fraunhofer Usa, Inc. | Influenza antibodies, compositions, and related methods |
| ITTO20070066A1 (it) | 2007-01-30 | 2008-07-31 | Pomona Biotechnologies Llc | Anticorpi monoclonali anti-idiotipo mimotopi dell'antigene gp 120 di hiv |
| JP2010538667A (ja) | 2007-09-20 | 2010-12-16 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | 新規オリゴクローナル抗体の製造方法 |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| ITTO20080398A1 (it) | 2008-05-27 | 2009-11-28 | Pomona Biotechnologies Llc | Anticorpi monoclonali aventi proprieta' di cross-neutralizzazione omosubtipica per virus influenzali di tipo a sottotipo h1 |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| IT1395961B1 (it) | 2009-06-01 | 2012-11-02 | Pomona Biotechnologies Llc | Anticorpi monoclonali come medicamento per il trattamento terapeutico e/o profilattico delle infezioni da virus influenzale a (h1n1) di origine suina (s-oiv) |
| WO2011117848A1 (en) | 2010-03-26 | 2011-09-29 | Pomona Ricerca S.R.L. | Full-length immunoglobulins of the igg isotvpe capable of recognizing a heterosubtvpe neutralizing epitope on the hemagglutinin stem region and their use as anti-influenza medicament |
-
2008
- 2008-05-27 IT IT000398A patent/ITTO20080398A1/it unknown
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2009
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- 2009-05-27 EA EA201071365A patent/EA022855B1/ru not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| EA022855B1 (ru) | 2016-03-31 |
| ITTO20080398A1 (it) | 2009-11-28 |
| ES2555486T5 (es) | 2019-02-15 |
| CA2725627A1 (en) | 2009-12-03 |
| CN102124028A (zh) | 2011-07-13 |
| US9243054B2 (en) | 2016-01-26 |
| CN102124028B (zh) | 2015-05-20 |
| EP2294084B2 (en) | 2018-09-05 |
| EP2294084B1 (en) | 2015-09-09 |
| EP2294084A1 (en) | 2011-03-16 |
| AU2009252758B2 (en) | 2014-07-31 |
| EA201071365A1 (ru) | 2011-08-30 |
| BRPI0912285A2 (pt) | 2015-10-20 |
| US20110076265A1 (en) | 2011-03-31 |
| ZA201009273B (en) | 2012-05-01 |
| CA2725627C (en) | 2019-08-06 |
| KR20110020865A (ko) | 2011-03-03 |
| JP2011524161A (ja) | 2011-09-01 |
| JP5792060B2 (ja) | 2015-10-07 |
| NZ590115A (en) | 2012-08-31 |
| MX2010012974A (es) | 2011-01-21 |
| IL209499A0 (en) | 2011-01-31 |
| WO2009144667A1 (en) | 2009-12-03 |
| ES2555486T3 (es) | 2016-01-04 |
| IL209499A (en) | 2016-10-31 |
| AU2009252758A1 (en) | 2009-12-03 |
| KR101665146B1 (ko) | 2016-10-11 |
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