JP2011522070A5 - - Google Patents
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- JP2011522070A5 JP2011522070A5 JP2011509671A JP2011509671A JP2011522070A5 JP 2011522070 A5 JP2011522070 A5 JP 2011522070A5 JP 2011509671 A JP2011509671 A JP 2011509671A JP 2011509671 A JP2011509671 A JP 2011509671A JP 2011522070 A5 JP2011522070 A5 JP 2011522070A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- micelle
- micelle assembly
- block
- assembly according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000693 micelle Substances 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 229920001400 block copolymer Polymers 0.000 claims 7
- 230000000368 destabilizing effect Effects 0.000 claims 6
- 239000012528 membrane Substances 0.000 claims 6
- 239000000178 monomer Substances 0.000 claims 6
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 108091023037 Aptamer Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 125000005250 alkyl acrylate group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 239000000074 antisense oligonucleotide Substances 0.000 claims 1
- 238000012230 antisense oligonucleotides Methods 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002091 cationic group Chemical group 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229920000359 diblock copolymer Polymers 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000005588 protonation Effects 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5291408P | 2008-05-13 | 2008-05-13 | |
| US5290808P | 2008-05-13 | 2008-05-13 | |
| US61/052,914 | 2008-05-13 | ||
| US61/052,908 | 2008-05-13 | ||
| US9129408P | 2008-08-22 | 2008-08-22 | |
| US61/091,294 | 2008-08-22 | ||
| US11204808P | 2008-11-06 | 2008-11-06 | |
| US61/112,048 | 2008-11-06 | ||
| US14077408P | 2008-12-24 | 2008-12-24 | |
| US61/140,774 | 2008-12-24 | ||
| US17136909P | 2009-04-21 | 2009-04-21 | |
| US61/171,369 | 2009-04-21 | ||
| PCT/US2009/043849 WO2009140429A2 (en) | 2008-05-13 | 2009-05-13 | Micellic assemblies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015107802A Division JP2015221898A (ja) | 2008-05-13 | 2015-05-27 | ミセル集合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011522070A JP2011522070A (ja) | 2011-07-28 |
| JP2011522070A5 true JP2011522070A5 (cg-RX-API-DMAC10.html) | 2012-06-28 |
| JP5755563B2 JP5755563B2 (ja) | 2015-07-29 |
Family
ID=41319324
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509671A Expired - Fee Related JP5755563B2 (ja) | 2008-05-13 | 2009-05-13 | ミセル集合体 |
| JP2015107802A Pending JP2015221898A (ja) | 2008-05-13 | 2015-05-27 | ミセル集合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015107802A Pending JP2015221898A (ja) | 2008-05-13 | 2015-05-27 | ミセル集合体 |
Country Status (13)
Families Citing this family (65)
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| US8426214B2 (en) | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
| US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
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| JP2008050506A (ja) | 2006-08-25 | 2008-03-06 | Canon Inc | 組成物 |
| WO2008085556A2 (en) | 2006-09-12 | 2008-07-17 | University Of South Florida | Surfactant-free nanoparticles for drug delivery |
| US20080081075A1 (en) | 2006-10-02 | 2008-04-03 | National Tsing Hua University | Multifunctional mixed micelle of graft and block copolymers and preparation thereof |
| GB0624729D0 (en) * | 2006-12-12 | 2007-01-17 | Univ Leeds | Reversible micelles and applications for their use |
| WO2008071009A1 (en) | 2006-12-15 | 2008-06-19 | The Governors Of The University Of Alberta | Novel ligand guided block copolymers for targeted drug delivery |
| US20080311045A1 (en) | 2007-06-06 | 2008-12-18 | Biovaluation & Analysis, Inc. | Polymersomes for Use in Acoustically Mediated Intracellular Drug Delivery in vivo |
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| WO2009140423A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Targeted polymer bioconjugates |
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| US20100150952A1 (en) | 2008-11-07 | 2010-06-17 | University Of Washington | pH-RESPONSIVE POLYMER CARRIER COMPOSITIONS FOR CYTOSOLIC PROTEIN DELIVERY |
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- 2009-05-13 CA CA2724014A patent/CA2724014C/en active Active
- 2009-05-13 ES ES09747512T patent/ES2404136T3/es active Active
- 2009-05-13 KR KR1020107027809A patent/KR101764427B1/ko not_active Expired - Fee Related
- 2009-05-13 BR BRPI0911989A patent/BRPI0911989A2/pt not_active IP Right Cessation
- 2009-05-13 EP EP09747512A patent/EP2285853B1/en not_active Not-in-force
- 2009-05-13 CN CN2009801234403A patent/CN102066444A/zh active Pending
- 2009-05-13 WO PCT/US2009/043849 patent/WO2009140429A2/en not_active Ceased
- 2009-05-13 MX MX2010012239A patent/MX2010012239A/es active IP Right Grant
- 2009-05-13 AU AU2009246329A patent/AU2009246329B8/en not_active Ceased
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