JP2011513307A5 - - Google Patents
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- Publication number
- JP2011513307A5 JP2011513307A5 JP2010548745A JP2010548745A JP2011513307A5 JP 2011513307 A5 JP2011513307 A5 JP 2011513307A5 JP 2010548745 A JP2010548745 A JP 2010548745A JP 2010548745 A JP2010548745 A JP 2010548745A JP 2011513307 A5 JP2011513307 A5 JP 2011513307A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- pharmaceutical composition
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 21
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 229910052805 deuterium Inorganic materials 0.000 claims description 14
- 229910052739 hydrogen Inorganic materials 0.000 claims description 14
- 239000001257 hydrogen Substances 0.000 claims description 14
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 208000020832 chronic kidney disease Diseases 0.000 claims description 5
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- 206010022489 Insulin Resistance Diseases 0.000 claims description 4
- 206010022562 Intermittent claudication Diseases 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 230000007850 degeneration Effects 0.000 claims description 4
- 208000021156 intermittent vascular claudication Diseases 0.000 claims description 4
- 208000017667 Chronic Disease Diseases 0.000 claims description 3
- 210000004185 liver Anatomy 0.000 claims description 3
- 208000009304 Acute Kidney Injury Diseases 0.000 claims description 2
- 200000000007 Arterial disease Diseases 0.000 claims description 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims description 2
- 206010056340 Diabetic ulcer Diseases 0.000 claims description 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- 208000004930 Fatty Liver Diseases 0.000 claims description 2
- 206010016654 Fibrosis Diseases 0.000 claims description 2
- 206010018364 Glomerulonephritis Diseases 0.000 claims description 2
- 208000002705 Glucose Intolerance Diseases 0.000 claims description 2
- 206010019663 Hepatic failure Diseases 0.000 claims description 2
- 206010019708 Hepatic steatosis Diseases 0.000 claims description 2
- 206010019728 Hepatitis alcoholic Diseases 0.000 claims description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 206010055171 Hypertensive nephropathy Diseases 0.000 claims description 2
- 201000001431 Hyperuricemia Diseases 0.000 claims description 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 2
- 206010029164 Nephrotic syndrome Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 206010067362 Radiation necrosis Diseases 0.000 claims description 2
- 208000033626 Renal failure acute Diseases 0.000 claims description 2
- 208000017442 Retinal disease Diseases 0.000 claims description 2
- 206010038923 Retinopathy Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 208000026723 Urinary tract disease Diseases 0.000 claims description 2
- 208000012931 Urologic disease Diseases 0.000 claims description 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 2
- 201000011040 acute kidney failure Diseases 0.000 claims description 2
- 208000012998 acute renal failure Diseases 0.000 claims description 2
- 208000002353 alcoholic hepatitis Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 230000007882 cirrhosis Effects 0.000 claims description 2
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims description 2
- 230000037213 diet Effects 0.000 claims description 2
- 235000005911 diet Nutrition 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000010706 fatty liver disease Diseases 0.000 claims description 2
- 201000005206 focal segmental glomerulosclerosis Diseases 0.000 claims description 2
- 231100000854 focal segmental glomerulosclerosis Toxicity 0.000 claims description 2
- 231100000268 induced nephrotoxicity Toxicity 0.000 claims description 2
- 230000000155 isotopic effect Effects 0.000 claims description 2
- 208000007903 liver failure Diseases 0.000 claims description 2
- 231100000835 liver failure Toxicity 0.000 claims description 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims description 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 230000000414 obstructive effect Effects 0.000 claims description 2
- 208000030761 polycystic kidney disease Diseases 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- 231100000240 steatosis hepatitis Toxicity 0.000 claims description 2
- 208000014001 urinary system disease Diseases 0.000 claims description 2
- 201000005569 Gout Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 201000009104 prediabetes syndrome Diseases 0.000 claims 1
- 201000005665 thrombophilia Diseases 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 239000000203 mixture Substances 0.000 description 9
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical compound O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 description 2
- 229960001476 pentoxifylline Drugs 0.000 description 2
- 0 *C(*)(*)C(*)(*)C(*)(*)C(*)(*)C(*)(*)N(C(c1c(N2*)nc(*)[n]1*)=O)C2=O Chemical compound *C(*)(*)C(*)(*)C(*)(*)C(*)(*)C(*)(*)N(C(c1c(N2*)nc(*)[n]1*)=O)C2=O 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6773608P | 2008-02-29 | 2008-02-29 | |
| US61/067,736 | 2008-02-29 | ||
| US13456808P | 2008-07-11 | 2008-07-11 | |
| US61/134,568 | 2008-07-11 | ||
| US19871508P | 2008-11-07 | 2008-11-07 | |
| US61/198,715 | 2008-11-07 | ||
| PCT/US2009/001294 WO2009108375A1 (en) | 2008-02-29 | 2009-02-27 | Substituted xanthine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011513307A JP2011513307A (ja) | 2011-04-28 |
| JP2011513307A5 true JP2011513307A5 (OSRAM) | 2013-04-25 |
| JP5292413B2 JP5292413B2 (ja) | 2013-09-18 |
Family
ID=40600003
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548747A Expired - Fee Related JP5567503B2 (ja) | 2008-02-29 | 2009-02-27 | 置換キサンチン誘導体 |
| JP2010548745A Active JP5292413B2 (ja) | 2008-02-29 | 2009-02-27 | 置換キサンチン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548747A Expired - Fee Related JP5567503B2 (ja) | 2008-02-29 | 2009-02-27 | 置換キサンチン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20090239886A1 (OSRAM) |
| EP (3) | EP3199203B1 (OSRAM) |
| JP (2) | JP5567503B2 (OSRAM) |
| KR (1) | KR20100121527A (OSRAM) |
| CN (1) | CN101998957B (OSRAM) |
| AU (1) | AU2009217680B2 (OSRAM) |
| BR (1) | BRPI0908107A2 (OSRAM) |
| CA (1) | CA2716788C (OSRAM) |
| EA (1) | EA019088B1 (OSRAM) |
| MX (1) | MX2010009300A (OSRAM) |
| WO (2) | WO2009108375A1 (OSRAM) |
| ZA (1) | ZA201006104B (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010009300A (es) | 2008-02-29 | 2010-11-05 | Concert Pharmaceuticals Inc | Derivados de xantina substituidos. |
| KR101671537B1 (ko) | 2008-08-11 | 2016-11-01 | 넥타르 테라퓨틱스 | 다분지형 중합체 알카노에이트 컨쥬게이트 |
| US20100087455A1 (en) * | 2008-10-06 | 2010-04-08 | Auspex Pharmaceuticals, Inc. | Substituted xanthine compounds |
| WO2010075086A2 (en) * | 2008-12-15 | 2010-07-01 | Auspex Pharmaceuticals, Inc. | Pyrrolidinone inhibitors of pde-4 |
| US20110053961A1 (en) * | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| JP2013503883A (ja) * | 2009-09-02 | 2013-02-04 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換キサンチン誘導体 |
| US9260432B2 (en) | 2009-09-02 | 2016-02-16 | Concert Pharmaceuticals, Inc. | Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds |
| US9074233B2 (en) | 2010-09-01 | 2015-07-07 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| US20130324564A1 (en) * | 2010-09-01 | 2013-12-05 | Concert Pharmaceuticals, Inc. | Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)-dione |
| WO2012031068A1 (en) * | 2010-09-01 | 2012-03-08 | Concert Pharmaceuticals, Inc. | Method of utilizing recycled deuterium oxide in the synthesis of deuterated compounds |
| US9085788B2 (en) | 2010-09-01 | 2015-07-21 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| WO2012088422A1 (en) | 2010-12-22 | 2012-06-28 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of taxane-based compounds |
| US10894087B2 (en) | 2010-12-22 | 2021-01-19 | Nektar Therapeutics | Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds |
| WO2012166459A1 (en) * | 2011-05-27 | 2012-12-06 | Bristol-Myers Squibb Company | Tripeptides incorporating deuterium as inhibitors of hepatitis c virus |
| US20140296263A1 (en) * | 2011-07-19 | 2014-10-02 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| IN2014DN08443A (OSRAM) | 2012-04-13 | 2015-05-08 | Concert Pharmaceuticals Inc | |
| US20150087660A1 (en) * | 2012-05-10 | 2015-03-26 | Mahesh Kandula | Compositions and methods for the treatment of chronic diseases and inflammatory disorders |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| CA2981791A1 (en) * | 2014-04-18 | 2015-10-22 | Concert Pharmaceuticals, Inc. | Methods of treating hyperglycemia |
| WO2015175008A1 (en) * | 2014-05-14 | 2015-11-19 | Concert Pharmaceuticals, Inc. | Methods of treating chronic kidney disease characterized by macroalbuminuria |
| US10954300B2 (en) | 2015-09-28 | 2021-03-23 | The Trustees Of Columbia University In The City Of New York | Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma |
| WO2017071606A1 (zh) * | 2015-10-29 | 2017-05-04 | 南京明德新药研发股份有限公司 | 羟基嘌呤类化合物的医药用途 |
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| CA2581169A1 (en) | 2004-09-29 | 2006-04-13 | Cordis Corporation | Pharmaceutical dosage forms of stable amorphous rapamycin like compounds |
| CN101309917B (zh) * | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+，k+-atp酶氘代抑制剂 |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| CA2661404A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| MX2010009300A (es) | 2008-02-29 | 2010-11-05 | Concert Pharmaceuticals Inc | Derivados de xantina substituidos. |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| US20110053961A1 (en) * | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US8485557B2 (en) | 2009-08-27 | 2013-07-16 | Kermit Zarley Enterprises | Self-supporting book |
| JP2013503883A (ja) * | 2009-09-02 | 2013-02-04 | コンサート ファーマシューティカルズ インコーポレイテッド | 置換キサンチン誘導体 |
-
2009
- 2009-02-27 MX MX2010009300A patent/MX2010009300A/es active IP Right Grant
- 2009-02-27 JP JP2010548747A patent/JP5567503B2/ja not_active Expired - Fee Related
- 2009-02-27 CA CA2716788A patent/CA2716788C/en active Active
- 2009-02-27 CN CN2009801114859A patent/CN101998957B/zh active Active
- 2009-02-27 WO PCT/US2009/001294 patent/WO2009108375A1/en not_active Ceased
- 2009-02-27 EA EA201001391A patent/EA019088B1/ru not_active IP Right Cessation
- 2009-02-27 EP EP17160882.1A patent/EP3199203B1/en active Active
- 2009-02-27 KR KR1020107021407A patent/KR20100121527A/ko not_active Abandoned
- 2009-02-27 US US12/380,579 patent/US20090239886A1/en not_active Abandoned
- 2009-02-27 EP EP09715566.7A patent/EP2265612B1/en active Active
- 2009-02-27 EP EP09714926A patent/EP2265334A2/en not_active Withdrawn
- 2009-02-27 BR BRPI0908107A patent/BRPI0908107A2/pt not_active IP Right Cessation
- 2009-02-27 WO PCT/US2009/001305 patent/WO2009108383A2/en not_active Ceased
- 2009-02-27 AU AU2009217680A patent/AU2009217680B2/en active Active
- 2009-02-27 JP JP2010548745A patent/JP5292413B2/ja active Active
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2010
- 2010-08-26 ZA ZA2010/06104A patent/ZA201006104B/en unknown
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2013
- 2013-07-24 US US13/949,888 patent/US9035050B2/en active Active
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2015
- 2015-05-15 US US14/713,423 patent/US9493463B2/en active Active
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