JP2011511804A5 - - Google Patents
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- Publication number
- JP2011511804A5 JP2011511804A5 JP2010546054A JP2010546054A JP2011511804A5 JP 2011511804 A5 JP2011511804 A5 JP 2011511804A5 JP 2010546054 A JP2010546054 A JP 2010546054A JP 2010546054 A JP2010546054 A JP 2010546054A JP 2011511804 A5 JP2011511804 A5 JP 2011511804A5
- Authority
- JP
- Japan
- Prior art keywords
- ifnα
- inducible
- expression profile
- marker expression
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000014509 gene expression Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 239000003550 marker Substances 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 4
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 4
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 4
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 3
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 3
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 3
- 239000003124 biologic agent Substances 0.000 claims 3
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 2
- 102100035389 2'-5'-oligoadenylate synthase 3 Human genes 0.000 claims 2
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 claims 2
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 2
- 102100039922 E3 ISG15-protein ligase HERC5 Human genes 0.000 claims 2
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 2
- 101000597332 Homo sapiens 2'-5'-oligoadenylate synthase 3 Proteins 0.000 claims 2
- 101001035145 Homo sapiens E3 ISG15-protein ligase HERC5 Proteins 0.000 claims 2
- 101000814134 Homo sapiens Epithelial-stromal interaction protein 1 Proteins 0.000 claims 2
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 2
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 2
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 2
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims 2
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 2
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 2
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 2
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 2
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 2
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 2
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims 2
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 claims 1
- 102100039621 Epithelial-stromal interaction protein 1 Human genes 0.000 claims 1
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 claims 1
- 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 claims 1
- 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
- 101000635777 Homo sapiens Receptor-transporting protein 4 Proteins 0.000 claims 1
- 101000868472 Homo sapiens Sialoadhesin Proteins 0.000 claims 1
- 101000644847 Homo sapiens Ubl carboxyl-terminal hydrolase 18 Proteins 0.000 claims 1
- 102100032131 Lymphocyte antigen 6E Human genes 0.000 claims 1
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 102100030854 Receptor-transporting protein 4 Human genes 0.000 claims 1
- 102100032855 Sialoadhesin Human genes 0.000 claims 1
- 102100020726 Ubl carboxyl-terminal hydrolase 18 Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004547 gene signature Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US696308P | 2008-02-08 | 2008-02-08 | |
| PCT/US2009/033407 WO2009100342A2 (en) | 2008-02-08 | 2009-02-06 | Disease markers and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511804A JP2011511804A (ja) | 2011-04-14 |
| JP2011511804A5 true JP2011511804A5 (enExample) | 2012-03-15 |
Family
ID=40952717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546054A Pending JP2011511804A (ja) | 2008-02-08 | 2009-02-06 | 疾患マーカーおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110262928A1 (enExample) |
| EP (2) | EP2848702A1 (enExample) |
| JP (1) | JP2011511804A (enExample) |
| KR (1) | KR20110005783A (enExample) |
| CN (1) | CN101999001B (enExample) |
| AU (1) | AU2009212216B2 (enExample) |
| BR (1) | BRPI0908065A2 (enExample) |
| CA (1) | CA2714410A1 (enExample) |
| ES (1) | ES2529593T3 (enExample) |
| MX (1) | MX2010008698A (enExample) |
| SG (1) | SG188147A1 (enExample) |
| WO (1) | WO2009100342A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2692784C (en) * | 2007-07-12 | 2018-10-02 | The Brigham And Women's Hospital, Inc. | Compositions and methods for diagnosing and assessing inflammatory myopathies |
| SG10201704689XA (en) | 2008-01-18 | 2017-07-28 | Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| US8785414B2 (en) * | 2009-03-31 | 2014-07-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Differentially expressed microRNAs as biomarkers for the diagnosis and treatment of Sjögren's syndrome |
| SMT201700063T1 (it) * | 2009-09-03 | 2017-03-08 | Medimmune Llc | Diagnosi di interferoni di tipo 1 |
| JPWO2011126105A1 (ja) * | 2010-04-08 | 2013-07-11 | 啓之 吉富 | 免疫系の異常疾患または関節系の異常疾患への罹患またはこれらの病勢を判定するための検査方法 |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| SG10201505723UA (en) | 2010-07-23 | 2015-09-29 | Harvard College | Methods for detecting signatures of disease or conditions in bodily fluids |
| CA2806304A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| MX2013000917A (es) | 2010-07-23 | 2013-07-05 | Harvard College | Metodos para detectar las enfermedades o condiciones usando celulas fagociticas. |
| WO2013020926A1 (en) * | 2011-08-11 | 2013-02-14 | Febit Holding Gmbh | Complex sets of mirnas as non-invasive biomarkers for psoriasis |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| EP2653554A1 (en) * | 2012-04-17 | 2013-10-23 | Istituto Nazionale Di Genetica Molecolare-INGM | Immune response biomarkers |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| EP3013985A4 (en) * | 2013-06-28 | 2017-07-19 | Acumen Research Laboratories Pte. Ltd. | Sepsis biomarkers and uses thereof |
| EP4428251A3 (en) | 2014-09-11 | 2024-12-18 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| JP6531306B2 (ja) * | 2015-02-20 | 2019-06-19 | 一三 西野 | 炎症性筋疾患鑑別マーカー及びそれを用いた炎症性筋疾患と非炎症性筋疾患の鑑別方法 |
| CN108379584B (zh) * | 2018-04-12 | 2020-08-11 | 上海交复生物医药科技有限公司 | RSAD2通过wnt通路影响肿瘤细胞替莫唑胺耐药性 |
| WO2019210179A1 (en) * | 2018-04-27 | 2019-10-31 | Stemline Therapeutics, Inc. | Methods of treating an autoimmune disease with a human interleukin-3 (il-3)-diphtheria toxin conjugate (dt-il3) |
| CN110085282A (zh) * | 2019-04-23 | 2019-08-02 | 华中师范大学 | 核酸结构中核苷酸与核苷酸相互作用预测的方法 |
| CN110108880A (zh) * | 2019-05-30 | 2019-08-09 | 四川大学华西医院 | Fez1自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| CN110161235B (zh) * | 2019-06-26 | 2022-04-12 | 江苏省中医院 | 三种血清蛋白联合用于强直性脊柱炎诊断的用途 |
| KR20220084305A (ko) * | 2019-10-04 | 2022-06-21 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 건선의 치료에서 항-종양 괴사 인자 치료법에 대한 반응성을 결정하는 방법 |
| CN111378742A (zh) * | 2020-04-16 | 2020-07-07 | 嘉兴程瑞医药科技有限公司 | microRNA生物标志物及其在制备自身免疫疾病检测试剂盒中的应用 |
| CN113388677A (zh) * | 2021-06-17 | 2021-09-14 | 河北医科大学第二医院 | 包括ifi44的干燥症诊断标志物组合 |
| CN117554614A (zh) * | 2022-09-23 | 2024-02-13 | 上海市第十人民医院 | 蛋白生物标志物dpp4在克罗恩病临床诊断中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| JPS60500864A (ja) | 1983-02-04 | 1985-06-06 | ワドリ、テクナラジズ、インコーパレイティド | 近縁関係にあるが別個のタンパク質間に存在する共通決定基に対して特異的なハイブリド−マ抗体の製造および特性づけ |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| ATE78262T1 (de) | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| US20070166281A1 (en) * | 2004-08-21 | 2007-07-19 | Kosak Kenneth M | Chloroquine coupled antibodies and other proteins with methods for their synthesis |
| US7833795B2 (en) * | 2004-08-24 | 2010-11-16 | The Trustees Of The University Of Pennsylvania | Assessment of cardiovascular risk using isoprostane biomarkers and COX-2 selective inhibitors |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| ES2432026T3 (es) * | 2005-08-05 | 2013-11-29 | Genentech, Inc. | Métodos y composiciones para detectar trastornos autoinmunes |
| WO2008070135A2 (en) | 2006-12-06 | 2008-06-12 | Medimmune, Llc. | Methods of treating systemic lupus erythematosus |
-
2009
- 2009-02-06 WO PCT/US2009/033407 patent/WO2009100342A2/en not_active Ceased
- 2009-02-06 MX MX2010008698A patent/MX2010008698A/es active IP Right Grant
- 2009-02-06 CN CN2009801123932A patent/CN101999001B/zh active Active
- 2009-02-06 CA CA2714410A patent/CA2714410A1/en not_active Abandoned
- 2009-02-06 EP EP14191479.6A patent/EP2848702A1/en not_active Withdrawn
- 2009-02-06 US US12/866,586 patent/US20110262928A1/en not_active Abandoned
- 2009-02-06 SG SG2013010608A patent/SG188147A1/en unknown
- 2009-02-06 JP JP2010546054A patent/JP2011511804A/ja active Pending
- 2009-02-06 KR KR1020107019933A patent/KR20110005783A/ko not_active Ceased
- 2009-02-06 EP EP09709316.5A patent/EP2252703B1/en active Active
- 2009-02-06 ES ES09709316.5T patent/ES2529593T3/es active Active
- 2009-02-06 BR BRPI0908065-1A patent/BRPI0908065A2/pt not_active IP Right Cessation
- 2009-02-06 AU AU2009212216A patent/AU2009212216B2/en active Active
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