JP2017514813A5 - - Google Patents
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- JP2017514813A5 JP2017514813A5 JP2016563822A JP2016563822A JP2017514813A5 JP 2017514813 A5 JP2017514813 A5 JP 2017514813A5 JP 2016563822 A JP2016563822 A JP 2016563822A JP 2016563822 A JP2016563822 A JP 2016563822A JP 2017514813 A5 JP2017514813 A5 JP 2017514813A5
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- JP
- Japan
- Prior art keywords
- seq
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- compound
- lncrna
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108091046869 Telomeric non-coding RNA Proteins 0.000 claims description 32
- 230000014509 gene expression Effects 0.000 claims description 28
- 150000001875 compounds Chemical class 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 23
- 150000007523 nucleic acids Chemical group 0.000 claims description 16
- 108020005198 Long Noncoding RNA Proteins 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 14
- 206010007572 Cardiac hypertrophy Diseases 0.000 claims description 12
- 208000006029 Cardiomegaly Diseases 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 8
- 239000013604 expression vector Substances 0.000 claims description 8
- 239000002773 nucleotide Substances 0.000 claims description 8
- 125000003729 nucleotide group Chemical group 0.000 claims description 8
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 230000000295 complement effect Effects 0.000 claims description 4
- 150000003384 small molecules Chemical class 0.000 claims description 4
- 230000003321 amplification Effects 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 3
- 108091023037 Aptamer Proteins 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- 238000011529 RT qPCR Methods 0.000 claims description 2
- 108091023040 Transcription factor Proteins 0.000 claims description 2
- 102000040945 Transcription factor Human genes 0.000 claims description 2
- 206010047295 Ventricular hypertrophy Diseases 0.000 claims description 2
- -1 antibody Proteins 0.000 claims description 2
- 230000003828 downregulation Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims description 2
- 210000005003 heart tissue Anatomy 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 238000004020 luminiscence type Methods 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000011002 quantification Methods 0.000 claims description 2
- 238000003753 real-time PCR Methods 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 238000011895 specific detection Methods 0.000 claims description 2
- 230000003827 upregulation Effects 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002018 overexpression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14165504.3 | 2014-04-22 | ||
| EP14165504 | 2014-04-22 | ||
| PCT/EP2015/058684 WO2015162161A1 (en) | 2014-04-22 | 2015-04-22 | Lncrnas for therapy and diagnosis of cardiac hypertrophy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019152429A Division JP6805304B2 (ja) | 2014-04-22 | 2019-08-23 | 心肥大の治療および診断のためのｌｎｃＲＮＡ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017514813A JP2017514813A (ja) | 2017-06-08 |
| JP2017514813A5 true JP2017514813A5 (enExample) | 2018-03-29 |
| JP6577960B2 JP6577960B2 (ja) | 2019-09-18 |
Family
ID=50630577
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016563822A Active JP6577960B2 (ja) | 2014-04-22 | 2015-04-22 | 心肥大の治療および診断のためのｌｎｃＲＮＡ |
| JP2019152429A Active JP6805304B2 (ja) | 2014-04-22 | 2019-08-23 | 心肥大の治療および診断のためのｌｎｃＲＮＡ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019152429A Active JP6805304B2 (ja) | 2014-04-22 | 2019-08-23 | 心肥大の治療および診断のためのｌｎｃＲＮＡ |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20170183652A1 (enExample) |
| EP (2) | EP3134526B1 (enExample) |
| JP (2) | JP6577960B2 (enExample) |
| CN (2) | CN117224687A (enExample) |
| DK (2) | DK3467111T3 (enExample) |
| ES (2) | ES2706878T3 (enExample) |
| HU (2) | HUE057484T2 (enExample) |
| PL (2) | PL3467111T3 (enExample) |
| TR (1) | TR201818825T4 (enExample) |
| WO (1) | WO2015162161A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201608907D0 (en) * | 2016-05-20 | 2016-07-06 | Ucl Business Plc | Means for modulating gene expression |
| WO2018229046A1 (en) * | 2017-06-12 | 2018-12-20 | Firalis Sa | DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC USES OF LONG NONCODING RNAs FOR PATHOLOGIES AND TOXICITIES INDUCING HEART DISORDERS |
| EP3641833B1 (en) * | 2017-06-19 | 2025-07-23 | Université de Lausanne | Compositions for controlling cardiac fibrosis and remodeling |
| CN107326072A (zh) * | 2017-06-23 | 2017-11-07 | 陈梦麟 | Linc00702及其在调控心血管系统中的应用 |
| WO2019014656A1 (en) | 2017-07-14 | 2019-01-17 | Han Si Ping | METALLIC OLIGONUCLEOTIDE JONCTIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS |
| CN111630166B (zh) * | 2017-08-10 | 2024-04-19 | 希望之城 | 条件性-siRNA及其在治疗心肌肥大中的用途 |
| CN113166750B (zh) | 2018-08-10 | 2025-02-18 | 希望之城 | 可编程的条件性sirna及其用途 |
| SG11202110607WA (en) | 2019-04-01 | 2021-10-28 | Tenaya Therapeutics Inc | Adeno-associated virus with engineered capsid |
| CN110229879B (zh) * | 2019-07-01 | 2022-11-18 | 青岛大学 | 一种piRNA-500核苷酸类似物及其反义核苷酸的应用和应用其的产品 |
| CN110878348B (zh) * | 2019-11-19 | 2023-03-28 | 南京启医科技有限公司 | 一种具有较高特异性的心衰lnc RNA生物标志物及其检测方法和应用 |
| CN111690673A (zh) * | 2020-06-22 | 2020-09-22 | 扬州大学 | 一种lncRNA通过编码小肽促进PGCs形成的验证方法 |
| CN112494651A (zh) * | 2020-09-30 | 2021-03-16 | 吉林大学 | lncRNA H19作为分子靶点在动脉粥样硬化治疗中的应用 |
| US11781156B2 (en) | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
| CN115698304A (zh) * | 2020-10-09 | 2023-02-03 | 特纳亚治疗股份有限公司 | 亲斑蛋白-2基因疗法的方法和组合物 |
| CN114959008B (zh) * | 2022-04-20 | 2024-11-26 | 华中科技大学同济医学院附属协和医院 | 长链非编码RNA-lnc-TSI的用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US6080560A (en) | 1994-07-25 | 2000-06-27 | Monsanto Company | Method for producing antibodies in plant cells |
| CA2342283C (en) | 1998-09-11 | 2004-05-25 | The Regents Of The University Of California | Recombinant adenovirus for tissue specific expression in heart |
| WO2002092124A1 (en) * | 2001-05-11 | 2002-11-21 | Wyeth | Methods for diagnosing and treating ischemia and reperfusion injury and compositions thereof |
| GB0112343D0 (en) | 2001-05-21 | 2001-07-11 | Norske Stats Oljeselskap | Well treatment |
| AU2003291631A1 (en) * | 2002-10-03 | 2004-04-23 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method for regulating expression genes |
| WO2008104290A1 (en) * | 2007-02-27 | 2008-09-04 | Bayer Schering Pharma Aktiengesellschaft | H19 as a biomarker for ppara modulators |
| US8383346B2 (en) | 2008-06-13 | 2013-02-26 | Codexis, Inc. | Combined automated parallel synthesis of polynucleotide variants |
-
2015
- 2015-04-22 PL PL18201238T patent/PL3467111T3/pl unknown
- 2015-04-22 CN CN202310780826.3A patent/CN117224687A/zh active Pending
- 2015-04-22 TR TR2018/18825T patent/TR201818825T4/tr unknown
- 2015-04-22 ES ES15717502T patent/ES2706878T3/es active Active
- 2015-04-22 CN CN201580033597.2A patent/CN106488777A/zh active Pending
- 2015-04-22 WO PCT/EP2015/058684 patent/WO2015162161A1/en not_active Ceased
- 2015-04-22 HU HUE18201238A patent/HUE057484T2/hu unknown
- 2015-04-22 US US15/305,976 patent/US20170183652A1/en not_active Abandoned
- 2015-04-22 PL PL15717502T patent/PL3134526T3/pl unknown
- 2015-04-22 JP JP2016563822A patent/JP6577960B2/ja active Active
- 2015-04-22 HU HUE15717502A patent/HUE041700T2/hu unknown
- 2015-04-22 EP EP15717502.7A patent/EP3134526B1/en active Active
- 2015-04-22 EP EP18201238.5A patent/EP3467111B1/en active Active
- 2015-04-22 DK DK18201238.5T patent/DK3467111T3/da active
- 2015-04-22 ES ES18201238T patent/ES2906995T3/es active Active
- 2015-04-22 DK DK15717502.7T patent/DK3134526T3/en active
-
2018
- 2018-06-25 US US16/017,375 patent/US11371043B2/en active Active
-
2019
- 2019-08-23 JP JP2019152429A patent/JP6805304B2/ja active Active
-
2022
- 2022-04-12 US US17/658,957 patent/US20220315924A1/en active Pending
- 2022-07-12 US US17/811,995 patent/US20220348920A1/en active Pending
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