JP2010527917A5 - - Google Patents
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- Publication number
- JP2010527917A5 JP2010527917A5 JP2010506715A JP2010506715A JP2010527917A5 JP 2010527917 A5 JP2010527917 A5 JP 2010527917A5 JP 2010506715 A JP2010506715 A JP 2010506715A JP 2010506715 A JP2010506715 A JP 2010506715A JP 2010527917 A5 JP2010527917 A5 JP 2010527917A5
- Authority
- JP
- Japan
- Prior art keywords
- ifnα
- expression profile
- inducible
- patient
- marker expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 21
- 239000003550 marker Substances 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 8
- 230000003827 upregulation Effects 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 206010025135 lupus erythematosus Diseases 0.000 claims 4
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 3
- 102100035688 Guanylate-binding protein 1 Human genes 0.000 claims 3
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 3
- 101001001336 Homo sapiens Guanylate-binding protein 1 Proteins 0.000 claims 3
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 3
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 3
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 3
- 101000880044 Homo sapiens SLIT-ROBO Rho GTPase-activating protein 3 Proteins 0.000 claims 3
- 101000822540 Homo sapiens Sterile alpha motif domain-containing protein 9-like Proteins 0.000 claims 3
- 101000814514 Homo sapiens XIAP-associated factor 1 Proteins 0.000 claims 3
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 3
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 3
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 3
- 102100037372 SLIT-ROBO Rho GTPase-activating protein 2 Human genes 0.000 claims 3
- 102100022459 Sterile alpha motif domain-containing protein 9-like Human genes 0.000 claims 3
- 102100039488 XIAP-associated factor 1 Human genes 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 201000002481 Myositis Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 208000033017 acquired idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 239000003124 biologic agent Substances 0.000 claims 2
- 201000001981 dermatomyositis Diseases 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 201000008319 inclusion body myositis Diseases 0.000 claims 2
- 208000005987 polymyositis Diseases 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92422007P | 2007-05-03 | 2007-05-03 | |
| US92421907P | 2007-05-03 | 2007-05-03 | |
| US60/924,219 | 2007-05-03 | ||
| US60/924,220 | 2007-05-03 | ||
| US92458407P | 2007-05-21 | 2007-05-21 | |
| US60/924,584 | 2007-05-21 | ||
| US96018707P | 2007-09-19 | 2007-09-19 | |
| US60/960,187 | 2007-09-19 | ||
| US99617407P | 2007-11-05 | 2007-11-05 | |
| US99617607P | 2007-11-05 | 2007-11-05 | |
| US60/996,176 | 2007-11-05 | ||
| US60/996,174 | 2007-11-05 | ||
| US99621907P | 2007-11-06 | 2007-11-06 | |
| US60/996,219 | 2007-11-06 | ||
| US99682007P | 2007-12-06 | 2007-12-06 | |
| USPCT/US2007/024941 | 2007-12-06 | ||
| USPCT/US2007/024947 | 2007-12-06 | ||
| PCT/US2007/024941 WO2008070135A2 (en) | 2006-12-06 | 2007-12-06 | Methods of treating systemic lupus erythematosus |
| US60/996,820 | 2007-12-06 | ||
| PCT/US2007/024947 WO2008070137A2 (en) | 2006-12-06 | 2007-12-06 | Interferon alpha-induced pharmacodynamic markers |
| US696308P | 2008-02-08 | 2008-02-08 | |
| US61/006,963 | 2008-02-08 | ||
| PCT/US2008/062646 WO2008137838A2 (en) | 2007-05-03 | 2008-05-05 | Interferon alpha-induced pharmacodynamic markers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230753A Division JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010527917A JP2010527917A (ja) | 2010-08-19 |
| JP2010527917A5 true JP2010527917A5 (enExample) | 2011-06-16 |
| JP5411129B2 JP5411129B2 (ja) | 2014-02-12 |
Family
ID=39944226
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506715A Expired - Fee Related JP5411129B2 (ja) | 2007-05-03 | 2008-05-05 | インターフェロンα誘導性薬力学的マーカー |
| JP2010506714A Withdrawn JP2010526107A (ja) | 2007-05-03 | 2008-05-05 | 自己免疫疾患の自己抗体マーカー |
| JP2013230753A Pending JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506714A Withdrawn JP2010526107A (ja) | 2007-05-03 | 2008-05-05 | 自己免疫疾患の自己抗体マーカー |
| JP2013230753A Pending JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9181345B2 (enExample) |
| EP (2) | EP2076590A4 (enExample) |
| JP (3) | JP5411129B2 (enExample) |
| AU (2) | AU2008247395A1 (enExample) |
| CA (2) | CA2685147A1 (enExample) |
| WO (2) | WO2008137838A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2878025C (en) | 2008-01-18 | 2018-12-11 | President And Fellows Of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| ES2613055T3 (es) * | 2009-09-03 | 2017-05-22 | Medimmune, Llc | Diagnóstico de interferón de tipo 1 |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| WO2012012717A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| KR20130041961A (ko) | 2010-07-23 | 2013-04-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 체액에서 질환 또는 상태의 특징을 검출하는 방법 |
| MX2013000917A (es) | 2010-07-23 | 2013-07-05 | Harvard College | Metodos para detectar las enfermedades o condiciones usando celulas fagociticas. |
| JP5998318B2 (ja) * | 2010-09-22 | 2016-09-28 | 国立大学法人 千葉大学 | 新規血管炎の検査方法および検査用試薬 |
| GB201017520D0 (en) * | 2010-10-15 | 2010-12-01 | Sense Proteomic Ltd | Biomarkers |
| CA2834203A1 (en) * | 2011-04-26 | 2012-11-01 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| AU2013204880B2 (en) * | 2011-04-26 | 2016-11-24 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| EP2923205B1 (en) * | 2012-11-23 | 2019-05-15 | Baerlecken, Niklas | Analysis for adult-onset still's disease |
| KR102216949B1 (ko) * | 2012-12-14 | 2021-02-22 | 민데라 코포레이션 | 바이오마커의 검출 및 취득을 위한 방법 및 디바이스 |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| EP2965077B1 (en) | 2013-03-09 | 2022-07-13 | Harry Stylli | Methods of detecting cancer |
| EP4428251A3 (en) | 2014-09-11 | 2024-12-18 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| DK3478830T3 (da) | 2016-07-01 | 2024-05-21 | Resolve Therapeutics Llc | Optimerede binucleasefusioner og metoder |
| JP7374091B2 (ja) | 2017-08-22 | 2023-11-06 | サナバイオ， エルエルシー | 可溶性インターフェロン受容体およびその使用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| EA202191133A1 (ru) * | 2018-10-26 | 2021-07-12 | Янссен Байотек, Инк. | Сигнатуры интерферона типа i и способы их применения |
| CN110747190B (zh) * | 2019-11-27 | 2021-03-09 | 浙江华睿生物技术有限公司 | 一种马来酸水合酶突变体及其应用 |
| WO2025062016A2 (en) * | 2023-09-22 | 2025-03-27 | Merck Patent Gmbh | Biomarkers for tlr inhibitor treatment |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| EP0139676B1 (en) | 1983-02-04 | 1992-11-25 | Cytoclonal Pharmaceutics Inc. | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| EP0205404B1 (en) | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| FR2692168B1 (fr) | 1992-06-16 | 1995-03-24 | Centre Nat Rech Scient | Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères. |
| US5888511A (en) * | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| AU696455C (en) | 1994-03-23 | 2006-03-02 | Case Western Reserve University | Compacted nucleic acids and their delivery to cells |
| US5972901A (en) | 1994-03-23 | 1999-10-26 | Case Western Reserve University | Serpin enzyme complex receptor--mediated gene transfer |
| EP0989849A2 (en) | 1997-06-13 | 2000-04-05 | The Johns Hopkins University School Of Medicine | Therapeutic nanospheres |
| US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
| US20040265874A1 (en) * | 2000-10-17 | 2004-12-30 | Bio-Rad Laboratories, Inc. | Pattern recognition method for diagnosis of systemic autoimmune diseases |
| EP2236156A3 (en) * | 2001-01-09 | 2011-01-05 | Baylor Research Institute | Methods for treating and diagnosing Psoriasis |
| US7087726B2 (en) * | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| WO2003046008A1 (en) * | 2001-11-30 | 2003-06-05 | Innogenetics N.V. | Therapeutic use of antibodies and fragments thereof binding primate ifn-gamma |
| PT1569696E (pt) * | 2002-11-21 | 2010-11-11 | Bayhill Therapeutics Inc | Composições para prevenção e tratamento de esclerose múltipla e diabetes de tipo 1 |
| JP2007503838A (ja) * | 2003-09-05 | 2007-03-01 | ジーティーシー バイオセラピューティクス， インコーポレイティド | トランスジェニック動物の乳汁中での融合タンパク質の産生方法 |
| DK1711207T3 (da) * | 2003-12-10 | 2013-03-11 | Medarex Inc | Interferon-alpha-antistoffer og anvendelse heraf |
| CA2597265C (en) * | 2005-02-10 | 2015-03-24 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| US20070117105A1 (en) * | 2005-05-12 | 2007-05-24 | Crow Mary K | Interferon assay |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| EP1945800B1 (en) * | 2005-08-05 | 2012-03-14 | Genentech, Inc. | Methods and compositions for detecting autoimmune disorders |
| US7608395B2 (en) * | 2005-09-15 | 2009-10-27 | Baylor Research Institute | Systemic lupus erythematosus diagnostic assay |
| EA015860B1 (ru) * | 2005-10-13 | 2011-12-30 | Хьюман Дженом Сайенсиз, Инк. | Способы лечения аутоиммунных заболеваний при использовании антагониста нейтрокина-альфа |
| WO2008070135A2 (en) * | 2006-12-06 | 2008-06-12 | Medimmune, Llc. | Methods of treating systemic lupus erythematosus |
| US20110287022A1 (en) * | 2008-06-20 | 2011-11-24 | Medlmmune, Llc | Interferon alpha-induced pharmacodynamic markers |
| ES2613055T3 (es) * | 2009-09-03 | 2017-05-22 | Medimmune, Llc | Diagnóstico de interferón de tipo 1 |
-
2008
- 2008-05-05 CA CA002685147A patent/CA2685147A1/en not_active Abandoned
- 2008-05-05 EP EP08769294A patent/EP2076590A4/en not_active Withdrawn
- 2008-05-05 EP EP08747639A patent/EP2068924A4/en not_active Withdrawn
- 2008-05-05 CA CA002686861A patent/CA2686861A1/en not_active Abandoned
- 2008-05-05 WO PCT/US2008/062646 patent/WO2008137838A2/en not_active Ceased
- 2008-05-05 WO PCT/US2008/062639 patent/WO2008137835A2/en not_active Ceased
- 2008-05-05 AU AU2008247395A patent/AU2008247395A1/en not_active Abandoned
- 2008-05-05 JP JP2010506715A patent/JP5411129B2/ja not_active Expired - Fee Related
- 2008-05-05 JP JP2010506714A patent/JP2010526107A/ja not_active Withdrawn
- 2008-05-05 AU AU2008247398A patent/AU2008247398B2/en not_active Ceased
-
2011
- 2011-11-07 US US13/290,850 patent/US9181345B2/en active Active
-
2013
- 2013-11-07 JP JP2013230753A patent/JP2014064577A/ja active Pending
-
2014
- 2014-09-23 US US14/494,439 patent/US20150132313A1/en not_active Abandoned
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