JP2013178260A5 - - Google Patents

Info

Publication number

JP2013178260A5

JP2013178260A5 JP2013087048A JP2013087048A JP2013178260A5 JP 2013178260 A5 JP2013178260 A5 JP 2013178260A5 JP 2013087048 A JP2013087048 A JP 2013087048A JP 2013087048 A JP2013087048 A JP 2013087048A JP 2013178260 A5 JP2013178260 A5 JP 2013178260A5

Authority

JP

Japan

Prior art keywords

nucleic acid

treatment

acid molecule

protein

patient

Prior art date

2013-04-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000007523 nucleic acids Chemical class 0.000 claims description 35
• 102000039446 nucleic acids Human genes 0.000 claims description 34
• 108020004707 nucleic acids Proteins 0.000 claims description 34
• 108090000623 proteins and genes Proteins 0.000 claims description 26
• 102000004169 proteins and genes Human genes 0.000 claims description 22
• 238000000034 method Methods 0.000 claims description 19
• 238000003745 diagnosis Methods 0.000 claims description 9
• 230000000295 complement effect Effects 0.000 claims description 4
• 239000003276 histone deacetylase inhibitor Substances 0.000 claims 19
• 201000010099 disease Diseases 0.000 claims 17
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 17
• 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 16
• 239000000523 sample Substances 0.000 claims 13
• 230000002062 proliferating effect Effects 0.000 claims 7
• 230000000694 effects Effects 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 4
• 230000024245 cell differentiation Effects 0.000 claims 3
• 230000004663 cell proliferation Effects 0.000 claims 3
• 230000004069 differentiation Effects 0.000 claims 3
• 230000035755 proliferation Effects 0.000 claims 3
• 230000035945 sensitivity Effects 0.000 claims 3
• 238000012544 monitoring process Methods 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 230000004962 physiological condition Effects 0.000 claims 2
• 229920001184 polypeptide Polymers 0.000 claims 2
• 102000004196 processed proteins & peptides Human genes 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 108020004711 Nucleic Acid Probes Proteins 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 230000000890 antigenic effect Effects 0.000 claims 1
• 238000009739 binding Methods 0.000 claims 1
• 230000004071 biological effect Effects 0.000 claims 1
• 238000001574 biopsy Methods 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000003153 chemical reaction reagent Substances 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 239000003446 ligand Substances 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 239000002853 nucleic acid probe Substances 0.000 claims 1
• 239000013610 patient sample Substances 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 description 3
• 125000003729 nucleotide group Chemical group 0.000 description 3
• 108091034117 Oligonucleotide Proteins 0.000 description 2
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
• 238000003491 array Methods 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 238000002405 diagnostic procedure Methods 0.000 description 1
• 238000003498 protein array Methods 0.000 description 1