JP2010526107A5 - - Google Patents

Info

Publication number

JP2010526107A5

JP2010526107A5 JP2010506714A JP2010506714A JP2010526107A5 JP 2010526107 A5 JP2010526107 A5 JP 2010526107A5 JP 2010506714 A JP2010506714 A JP 2010506714A JP 2010506714 A JP2010506714 A JP 2010506714A JP 2010526107 A5 JP2010526107 A5 JP 2010526107A5

Authority

JP

Japan

Prior art keywords

protein

agent

ifn

type

kda

Prior art date

2008-05-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 239000003795 chemical substances by application Substances 0.000 claims 16
• 208000023275 Autoimmune disease Diseases 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 9
• 102000004169 proteins and genes Human genes 0.000 claims 7
• 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 claims 4
• 101000583692 Homo sapiens Pleckstrin homology-like domain family A member 1 Proteins 0.000 claims 4
• 102100030887 Pleckstrin homology-like domain family A member 1 Human genes 0.000 claims 4
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 4
• 230000000694 effects Effects 0.000 claims 4
• 108010036781 Fumarate Hydratase Proteins 0.000 claims 3
• 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 claims 3
• 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 3
• 201000004681 Psoriasis Diseases 0.000 claims 3
• 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 3
• 206010025135 lupus erythematosus Diseases 0.000 claims 3
• 108091008726 retinoic acid receptors α Proteins 0.000 claims 3
• 102100033756 39S ribosomal protein L45, mitochondrial Human genes 0.000 claims 2
• 102100033416 60S acidic ribosomal protein P1 Human genes 0.000 claims 2
• 241000351920 Aspergillus nidulans Species 0.000 claims 2
• 208000031713 Autosomal recessive spastic paraplegia type 20 Diseases 0.000 claims 2
• 108010059013 Chaperonin 10 Proteins 0.000 claims 2
• 102100028843 DNA mismatch repair protein Mlh1 Human genes 0.000 claims 2
• 102000008013 Electron Transport Complex I Human genes 0.000 claims 2
• 108010089760 Electron Transport Complex I Proteins 0.000 claims 2
• 101000980303 Homo sapiens 10 kDa heat shock protein, mitochondrial Proteins 0.000 claims 2
• 101000733888 Homo sapiens 39S ribosomal protein L45, mitochondrial Proteins 0.000 claims 2
• 101000712357 Homo sapiens 60S acidic ribosomal protein P1 Proteins 0.000 claims 2
• 101000577853 Homo sapiens DNA mismatch repair protein Mlh1 Proteins 0.000 claims 2
• 101001068011 Homo sapiens Hydroxyacylglutathione hydrolase-like protein Proteins 0.000 claims 2
• 101000582846 Homo sapiens Mediator of RNA polymerase II transcription subunit 22 Proteins 0.000 claims 2
• 101000992387 Homo sapiens Oxysterol-binding protein-related protein 9 Proteins 0.000 claims 2
• 101000705766 Homo sapiens Proteasome activator complex subunit 3 Proteins 0.000 claims 2
• 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 claims 2
• 102100034468 Hydroxyacylglutathione hydrolase-like protein Human genes 0.000 claims 2
• 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 2
• 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 claims 2
• 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 claims 2
• 102100030223 Mediator of RNA polymerase II transcription subunit 22 Human genes 0.000 claims 2
• 102100027869 Moesin Human genes 0.000 claims 2
• 201000002481 Myositis Diseases 0.000 claims 2
• 102100032162 Oxysterol-binding protein-related protein 9 Human genes 0.000 claims 2
• 206010033892 Paraplegia Diseases 0.000 claims 2
• 102100031298 Proteasome activator complex subunit 3 Human genes 0.000 claims 2
• 102100040923 Protein flightless-1 homolog Human genes 0.000 claims 2
• 102100039407 Pyrroline-5-carboxylate reductase 1, mitochondrial Human genes 0.000 claims 2
• 102100022122 Ras-related C3 botulinum toxin substrate 1 Human genes 0.000 claims 2
• 102000004389 Ribonucleoproteins Human genes 0.000 claims 2
• 108010081734 Ribonucleoproteins Proteins 0.000 claims 2
• 102100030537 Spartin Human genes 0.000 claims 2
• 101710015530 Spartin Proteins 0.000 claims 2
• 208000032930 Spastic paraplegia Diseases 0.000 claims 2
• 102100033632 Tropomyosin alpha-1 chain Human genes 0.000 claims 2
• 101710128188 Tropomyosin alpha-1 chain Proteins 0.000 claims 2
• 102100033080 Tropomyosin alpha-3 chain Human genes 0.000 claims 2
• 101710091952 Tropomyosin alpha-3 chain Proteins 0.000 claims 2
• 201000003397 Troyer syndrome Diseases 0.000 claims 2
• 206010047115 Vasculitis Diseases 0.000 claims 2
• 208000033017 acquired idiopathic inflammatory myopathy Diseases 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 210000004292 cytoskeleton Anatomy 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 2
• 108010087599 lactate dehydrogenase 1 Proteins 0.000 claims 2
• 210000004901 leucine-rich repeat Anatomy 0.000 claims 2
• 108010071525 moesin Proteins 0.000 claims 2
• 108010062302 rac1 GTP Binding Protein Proteins 0.000 claims 2
• 201000000306 sarcoidosis Diseases 0.000 claims 2
• 238000000638 solvent extraction Methods 0.000 claims 2
• FCEHFCFHANDXMB-UMEYXWOPSA-N tocosimplex Chemical compound OS(O)(=O)=O.C1N2CCCC[C@@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 FCEHFCFHANDXMB-UMEYXWOPSA-N 0.000 claims 2
• 241000712461 unidentified influenza virus Species 0.000 claims 2
• 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 1
• 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 claims 1
• GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 1
• 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 1
• 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 1
• 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 claims 1
• 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 1
• 101001078626 Homo sapiens Heat shock protein HSP 90-alpha A2 Proteins 0.000 claims 1
• 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 1
• 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 1
• 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 1
• 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 1
• 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 1
• 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 claims 1
• 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
• 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 1
• 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 1
• 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 1
• 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 1
• 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 1
• 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 1
• 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 1
• 102100032131 Lymphocyte antigen 6E Human genes 0.000 claims 1
• 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
• 101710142338 Pyrroline-5-carboxylate reductase 1 Proteins 0.000 claims 1
• 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 1
• 102000034527 Retinoid X Receptors Human genes 0.000 claims 1
• 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
• 102000042463 Rho family Human genes 0.000 claims 1
• 108091078243 Rho family Proteins 0.000 claims 1
• 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 1
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 229930002330 retinoic acid Natural products 0.000 claims 1
• 230000035939 shock Effects 0.000 claims 1
• 229960001727 tretinoin Drugs 0.000 claims 1