JP2010526107A5 - - Google Patents
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- JP2010526107A5 JP2010526107A5 JP2010506714A JP2010506714A JP2010526107A5 JP 2010526107 A5 JP2010526107 A5 JP 2010526107A5 JP 2010506714 A JP2010506714 A JP 2010506714A JP 2010506714 A JP2010506714 A JP 2010506714A JP 2010526107 A5 JP2010526107 A5 JP 2010526107A5
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- 239000003795 chemical substances by application Substances 0.000 claims 16
- 208000023275 Autoimmune disease Diseases 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 claims 4
- 101000583692 Homo sapiens Pleckstrin homology-like domain family A member 1 Proteins 0.000 claims 4
- 102100030887 Pleckstrin homology-like domain family A member 1 Human genes 0.000 claims 4
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 108010036781 Fumarate Hydratase Proteins 0.000 claims 3
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 claims 3
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 108091008726 retinoic acid receptors α Proteins 0.000 claims 3
- 102100033756 39S ribosomal protein L45, mitochondrial Human genes 0.000 claims 2
- 102100033416 60S acidic ribosomal protein P1 Human genes 0.000 claims 2
- 241000351920 Aspergillus nidulans Species 0.000 claims 2
- 208000031713 Autosomal recessive spastic paraplegia type 20 Diseases 0.000 claims 2
- 108010059013 Chaperonin 10 Proteins 0.000 claims 2
- 102100028843 DNA mismatch repair protein Mlh1 Human genes 0.000 claims 2
- 102000008013 Electron Transport Complex I Human genes 0.000 claims 2
- 108010089760 Electron Transport Complex I Proteins 0.000 claims 2
- 101000980303 Homo sapiens 10 kDa heat shock protein, mitochondrial Proteins 0.000 claims 2
- 101000733888 Homo sapiens 39S ribosomal protein L45, mitochondrial Proteins 0.000 claims 2
- 101000712357 Homo sapiens 60S acidic ribosomal protein P1 Proteins 0.000 claims 2
- 101000577853 Homo sapiens DNA mismatch repair protein Mlh1 Proteins 0.000 claims 2
- 101001068011 Homo sapiens Hydroxyacylglutathione hydrolase-like protein Proteins 0.000 claims 2
- 101000582846 Homo sapiens Mediator of RNA polymerase II transcription subunit 22 Proteins 0.000 claims 2
- 101000992387 Homo sapiens Oxysterol-binding protein-related protein 9 Proteins 0.000 claims 2
- 101000705766 Homo sapiens Proteasome activator complex subunit 3 Proteins 0.000 claims 2
- 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 claims 2
- 102100034468 Hydroxyacylglutathione hydrolase-like protein Human genes 0.000 claims 2
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 2
- 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 claims 2
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 claims 2
- 102100030223 Mediator of RNA polymerase II transcription subunit 22 Human genes 0.000 claims 2
- 102100027869 Moesin Human genes 0.000 claims 2
- 201000002481 Myositis Diseases 0.000 claims 2
- 102100032162 Oxysterol-binding protein-related protein 9 Human genes 0.000 claims 2
- 206010033892 Paraplegia Diseases 0.000 claims 2
- 102100031298 Proteasome activator complex subunit 3 Human genes 0.000 claims 2
- 102100040923 Protein flightless-1 homolog Human genes 0.000 claims 2
- 102100039407 Pyrroline-5-carboxylate reductase 1, mitochondrial Human genes 0.000 claims 2
- 102100022122 Ras-related C3 botulinum toxin substrate 1 Human genes 0.000 claims 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims 2
- 102100030537 Spartin Human genes 0.000 claims 2
- 101710015530 Spartin Proteins 0.000 claims 2
- 208000032930 Spastic paraplegia Diseases 0.000 claims 2
- 102100033632 Tropomyosin alpha-1 chain Human genes 0.000 claims 2
- 101710128188 Tropomyosin alpha-1 chain Proteins 0.000 claims 2
- 102100033080 Tropomyosin alpha-3 chain Human genes 0.000 claims 2
- 101710091952 Tropomyosin alpha-3 chain Proteins 0.000 claims 2
- 201000003397 Troyer syndrome Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 208000033017 acquired idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 210000004292 cytoskeleton Anatomy 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 108010087599 lactate dehydrogenase 1 Proteins 0.000 claims 2
- 210000004901 leucine-rich repeat Anatomy 0.000 claims 2
- 108010071525 moesin Proteins 0.000 claims 2
- 108010062302 rac1 GTP Binding Protein Proteins 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 238000000638 solvent extraction Methods 0.000 claims 2
- FCEHFCFHANDXMB-UMEYXWOPSA-N tocosimplex Chemical compound OS(O)(=O)=O.C1N2CCCC[C@@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 FCEHFCFHANDXMB-UMEYXWOPSA-N 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 1
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 claims 1
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 1
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 1
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 claims 1
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 1
- 101001078626 Homo sapiens Heat shock protein HSP 90-alpha A2 Proteins 0.000 claims 1
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 1
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 1
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 1
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 1
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 1
- 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 claims 1
- 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 1
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 1
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 1
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 1
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 1
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 1
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 1
- 102100032131 Lymphocyte antigen 6E Human genes 0.000 claims 1
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
- 101710142338 Pyrroline-5-carboxylate reductase 1 Proteins 0.000 claims 1
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 1
- 102000034527 Retinoid X Receptors Human genes 0.000 claims 1
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
- 102000042463 Rho family Human genes 0.000 claims 1
- 108091078243 Rho family Proteins 0.000 claims 1
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92421907P | 2007-05-03 | 2007-05-03 | |
| US92422007P | 2007-05-03 | 2007-05-03 | |
| US92458407P | 2007-05-21 | 2007-05-21 | |
| US96018707P | 2007-09-19 | 2007-09-19 | |
| US99617407P | 2007-11-05 | 2007-11-05 | |
| US99617607P | 2007-11-05 | 2007-11-05 | |
| US99621907P | 2007-11-06 | 2007-11-06 | |
| US99682007P | 2007-12-06 | 2007-12-06 | |
| PCT/US2007/024941 WO2008070135A2 (en) | 2006-12-06 | 2007-12-06 | Methods of treating systemic lupus erythematosus |
| PCT/US2007/024947 WO2008070137A2 (en) | 2006-12-06 | 2007-12-06 | Interferon alpha-induced pharmacodynamic markers |
| US696308P | 2008-02-08 | 2008-02-08 | |
| PCT/US2008/062639 WO2008137835A2 (en) | 2007-05-03 | 2008-05-05 | Auto-antibody markers of autoimmune disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010526107A JP2010526107A (ja) | 2010-07-29 |
| JP2010526107A5 true JP2010526107A5 (enExample) | 2011-06-16 |
Family
ID=39944226
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506715A Expired - Fee Related JP5411129B2 (ja) | 2007-05-03 | 2008-05-05 | インターフェロンα誘導性薬力学的マーカー |
| JP2010506714A Withdrawn JP2010526107A (ja) | 2007-05-03 | 2008-05-05 | 自己免疫疾患の自己抗体マーカー |
| JP2013230753A Pending JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506715A Expired - Fee Related JP5411129B2 (ja) | 2007-05-03 | 2008-05-05 | インターフェロンα誘導性薬力学的マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230753A Pending JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9181345B2 (enExample) |
| EP (2) | EP2076590A4 (enExample) |
| JP (3) | JP5411129B2 (enExample) |
| AU (2) | AU2008247395A1 (enExample) |
| CA (2) | CA2686861A1 (enExample) |
| WO (2) | WO2008137838A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201704689XA (en) | 2008-01-18 | 2017-07-28 | Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| SMT201700063T1 (it) * | 2009-09-03 | 2017-03-08 | Medimmune Llc | Diagnosi di interferoni di tipo 1 |
| AU2011223789A1 (en) | 2010-03-01 | 2012-09-20 | Caris Life Sciences Switzerland Holdings Gmbh | Biomarkers for theranostics |
| KR20130043104A (ko) | 2010-04-06 | 2013-04-29 | 카리스 라이프 사이언스 룩셈부르크 홀딩스 | 질병용 순환 생물학적 지표들 |
| MX2013000917A (es) | 2010-07-23 | 2013-07-05 | Harvard College | Metodos para detectar las enfermedades o condiciones usando celulas fagociticas. |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| SG10201505723UA (en) | 2010-07-23 | 2015-09-29 | Harvard College | Methods for detecting signatures of disease or conditions in bodily fluids |
| CA2806304A1 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting prenatal or pregnancy-related diseases or conditions |
| US9244079B2 (en) | 2010-09-22 | 2016-01-26 | National University Corporation Chiba University | Testing method and testing reagent for angiitis |
| GB201017520D0 (en) * | 2010-10-15 | 2010-12-01 | Sense Proteomic Ltd | Biomarkers |
| WO2012149228A1 (en) * | 2011-04-26 | 2012-11-01 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| AU2013204880B2 (en) * | 2011-04-26 | 2016-11-24 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| EP2923205B1 (en) * | 2012-11-23 | 2019-05-15 | Baerlecken, Niklas | Analysis for adult-onset still's disease |
| EP2931356B1 (en) * | 2012-12-14 | 2019-03-06 | Mindera Corporation | Methods and devices for detection and acquisition of biomarkers |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| WO2015085172A2 (en) * | 2013-12-06 | 2015-06-11 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers |
| EP4428251A3 (en) | 2014-09-11 | 2024-12-18 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| MA45554A (fr) | 2016-07-01 | 2019-05-08 | Resolve Therapeutics Llc | Fusions de binucléase optimisées. |
| CN111315767B (zh) | 2017-08-22 | 2025-03-18 | 萨纳生物有限责任公司 | 可溶性干扰素受体及其用途 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CA3117102A1 (en) | 2018-10-26 | 2020-04-30 | Janssen Biotech, Inc. | Type i interferon signatures and methods of use |
| CN110747190B (zh) * | 2019-11-27 | 2021-03-09 | 浙江华睿生物技术有限公司 | 一种马来酸水合酶突变体及其应用 |
| CN122122462A (zh) * | 2023-09-22 | 2026-05-29 | 默克专利有限公司 | Tlr抑制剂治疗的生物标志物 |
| WO2026004792A1 (ja) * | 2024-06-24 | 2026-01-02 | キヤノンメディカルダイアグノスティックス株式会社 | 細胞性免疫応答活性を測定する方法及びそのためのキット |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60500864A (ja) | 1983-02-04 | 1985-06-06 | ワドリ、テクナラジズ、インコーパレイティド | 近縁関係にあるが別個のタンパク質間に存在する共通決定基に対して特異的なハイブリド−マ抗体の製造および特性づけ |
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| ATE78262T1 (de) | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| FR2692168B1 (fr) | 1992-06-16 | 1995-03-24 | Centre Nat Rech Scient | Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères. |
| US5888511A (en) * | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| US5972901A (en) | 1994-03-23 | 1999-10-26 | Case Western Reserve University | Serpin enzyme complex receptor--mediated gene transfer |
| CA2186118C (en) | 1994-03-23 | 2010-10-19 | Richard W. Hanson | Compacted nucleic acids and their delivery to cells |
| JP2002506436A (ja) | 1997-06-13 | 2002-02-26 | ザ ジョンズ ホプキンス ユニバーシティー | 治療用ナノスフェア |
| US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
| US20040265874A1 (en) * | 2000-10-17 | 2004-12-30 | Bio-Rad Laboratories, Inc. | Pattern recognition method for diagnosis of systemic autoimmune diseases |
| JP4394350B2 (ja) * | 2001-01-09 | 2010-01-06 | ベイラー リサーチ インスティテュート | 対象における自己免疫疾患の治療法及びｉｎｖｉｔｒｏ診断アッセイ |
| US7087726B2 (en) * | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| AU2002365514A1 (en) * | 2001-11-30 | 2003-06-10 | Innogenetics N.V. | Therapeutic use of antibodies and fragments thereof binding primate ifn-gamma |
| DK1569696T3 (da) * | 2002-11-21 | 2010-11-15 | Bayhill Therapeutics Inc | Fremgangsmåder og immunmodulatoriske nukleinsyrepræparater til forebyggelse og behandling af sygdomme |
| AU2004271200A1 (en) * | 2003-09-05 | 2005-03-17 | Gtc Biotherapeutics, Inc. | Method for the production of fusion proteins in transgenic mammal milk |
| PT2418220T (pt) * | 2003-12-10 | 2017-10-04 | Squibb & Sons Llc | Anticorpos contra interferão alfa e suas utilizações |
| EP1851248B1 (en) * | 2005-02-10 | 2016-08-10 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| US20070117105A1 (en) * | 2005-05-12 | 2007-05-24 | Crow Mary K | Interferon assay |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| ES2432026T3 (es) * | 2005-08-05 | 2013-11-29 | Genentech, Inc. | Métodos y composiciones para detectar trastornos autoinmunes |
| US7608395B2 (en) * | 2005-09-15 | 2009-10-27 | Baylor Research Institute | Systemic lupus erythematosus diagnostic assay |
| KR20080074120A (ko) * | 2005-10-13 | 2008-08-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 자가항체 양성 질환 환자의 치료에 유용한 방법 및 조성물 |
| WO2008070135A2 (en) * | 2006-12-06 | 2008-06-12 | Medimmune, Llc. | Methods of treating systemic lupus erythematosus |
| US20110287022A1 (en) * | 2008-06-20 | 2011-11-24 | Medlmmune, Llc | Interferon alpha-induced pharmacodynamic markers |
| SMT201700063T1 (it) * | 2009-09-03 | 2017-03-08 | Medimmune Llc | Diagnosi di interferoni di tipo 1 |
-
2008
- 2008-05-05 WO PCT/US2008/062646 patent/WO2008137838A2/en not_active Ceased
- 2008-05-05 EP EP08769294A patent/EP2076590A4/en not_active Withdrawn
- 2008-05-05 CA CA002686861A patent/CA2686861A1/en not_active Abandoned
- 2008-05-05 CA CA002685147A patent/CA2685147A1/en not_active Abandoned
- 2008-05-05 WO PCT/US2008/062639 patent/WO2008137835A2/en not_active Ceased
- 2008-05-05 AU AU2008247395A patent/AU2008247395A1/en not_active Abandoned
- 2008-05-05 EP EP08747639A patent/EP2068924A4/en not_active Withdrawn
- 2008-05-05 JP JP2010506715A patent/JP5411129B2/ja not_active Expired - Fee Related
- 2008-05-05 JP JP2010506714A patent/JP2010526107A/ja not_active Withdrawn
- 2008-05-05 AU AU2008247398A patent/AU2008247398B2/en not_active Ceased
-
2011
- 2011-11-07 US US13/290,850 patent/US9181345B2/en active Active
-
2013
- 2013-11-07 JP JP2013230753A patent/JP2014064577A/ja active Pending
-
2014
- 2014-09-23 US US14/494,439 patent/US20150132313A1/en not_active Abandoned
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