JP2011511003A5 - - Google Patents
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- Publication number
- JP2011511003A5 JP2011511003A5 JP2010545233A JP2010545233A JP2011511003A5 JP 2011511003 A5 JP2011511003 A5 JP 2011511003A5 JP 2010545233 A JP2010545233 A JP 2010545233A JP 2010545233 A JP2010545233 A JP 2010545233A JP 2011511003 A5 JP2011511003 A5 JP 2011511003A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- amino
- dihydropyrido
- fluoro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 amino, carbonylamino, aminocarbonyl Chemical group 0.000 claims 90
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000005842 heteroatom Chemical group 0.000 claims 16
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- BDTRIDKONHOQQN-UHFFFAOYSA-N 4h-pyrimidin-5-one Chemical compound O=C1CN=CN=C1 BDTRIDKONHOQQN-UHFFFAOYSA-N 0.000 claims 6
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 125000005843 halogen group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 150000001602 bicycloalkyls Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 150000002923 oximes Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000004104 aryloxy group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- DRQRNJQGXVDZBU-TZIWHRDSSA-N (2r)-2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-4-hydroxy-n,n-dimethylbutanamide Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\O[C@H](CCO)C(=O)N(C)C)=N1 DRQRNJQGXVDZBU-TZIWHRDSSA-N 0.000 claims 1
- DRQRNJQGXVDZBU-CTNGQTDRSA-N (2s)-2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-4-hydroxy-n,n-dimethylbutanamide Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\O[C@@H](CCO)C(=O)N(C)C)=N1 DRQRNJQGXVDZBU-CTNGQTDRSA-N 0.000 claims 1
- VWBPRIBQAARILO-MJGOQNOKSA-N (2s)-4-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-2-hydroxybutanamide Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC[C@H](O)C(N)=O)=N1 VWBPRIBQAARILO-MJGOQNOKSA-N 0.000 claims 1
- NELKHPYWKAUWEN-MJGOQNOKSA-N (2s)-4-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-2-hydroxybutanoic acid Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC[C@H](O)C(O)=O)=N1 NELKHPYWKAUWEN-MJGOQNOKSA-N 0.000 claims 1
- WZUYUECAUGEKFC-SQJMNOBHSA-N (4s)-4-[[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxymethyl]-3-benzyl-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OC[C@H]2N(C(=O)OC2)CC=2C=CC=CC=2)=N1 WZUYUECAUGEKFC-SQJMNOBHSA-N 0.000 claims 1
- NOELJGWWOVBLOL-KBXCAEBGSA-N (5s)-5-[[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxymethyl]-1,3-oxazolidin-2-one Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OC[C@H]2OC(=O)NC2)=N1 NOELJGWWOVBLOL-KBXCAEBGSA-N 0.000 claims 1
- LVDVFHGRIJTUMH-OAQYLSRUSA-N (7r)-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-5-n-(2-morpholin-4-ylethoxy)-7,8-dihydropyrido[4,3-d]pyrimidine-2,5-diamine Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCCN2CCOCC2)=N1 LVDVFHGRIJTUMH-OAQYLSRUSA-N 0.000 claims 1
- VPUBOTVYSMAHIN-OTOKDRCRSA-N (7r)-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-5-n-(morpholin-2-ylmethoxy)-7,8-dihydropyrido[4,3-d]pyrimidine-2,5-diamine Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC2OCCNC2)=N1 VPUBOTVYSMAHIN-OTOKDRCRSA-N 0.000 claims 1
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 claims 1
- HDFHEIOIKDQXSX-LMNIDFBRSA-N 2-[2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxyacetyl]-1,3,4,7,8,8a-hexahydropyrrolo[1,2-a]pyrazin-6-one Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC(=O)N2CC3N(C(CC3)=O)CC2)=N1 HDFHEIOIKDQXSX-LMNIDFBRSA-N 0.000 claims 1
- YJOHWPAQHRFQFA-GOSISDBHSA-N 2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-1-(3,3-difluoroazetidin-1-yl)ethanone Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC(=O)N2CC(F)(F)C2)=N1 YJOHWPAQHRFQFA-GOSISDBHSA-N 0.000 claims 1
- NQHCNSDEHKYAOC-OAQYLSRUSA-N 2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-1-(4-hydroxypiperidin-1-yl)ethanone Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC(=O)N2CCC(O)CC2)=N1 NQHCNSDEHKYAOC-OAQYLSRUSA-N 0.000 claims 1
- NXWODOMWROKIKJ-DUSLRRAJSA-N 2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-4-hydroxybutanamide Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OC(CCO)C(N)=O)=N1 NXWODOMWROKIKJ-DUSLRRAJSA-N 0.000 claims 1
- VCEAAVLZGHPLBA-HXUWFJFHSA-N 2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxy-n-(2-methoxyethyl)-n-methylacetamide Chemical compound C1([C@@H]2N\C(C3=C(C)N=C(N)N=C3C2)=N/OCC(=O)N(C)CCOC)=CC=C(F)C=C1C1=CC=CC(OC)=N1 VCEAAVLZGHPLBA-HXUWFJFHSA-N 0.000 claims 1
- VXBCMBJFQXGFJD-GOSISDBHSA-N 2-[[2-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxyacetyl]-methylamino]acetamide Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC(=O)N(C)CC(N)=O)=N1 VXBCMBJFQXGFJD-GOSISDBHSA-N 0.000 claims 1
- ZPNUCOCBFHMOMV-GOSISDBHSA-N 3-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxypropan-1-ol Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCCCO)=N1 ZPNUCOCBFHMOMV-GOSISDBHSA-N 0.000 claims 1
- YJQOTPHRPJQSLQ-FQNRMIAFSA-N 4-[[(7r)-2-amino-7-[2-(5-amino-6-methoxypyrazin-2-yl)-4-fluorophenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxybutane-1,2-diol Chemical compound N1=C(N)C(OC)=NC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCCC(O)CO)=C1 YJQOTPHRPJQSLQ-FQNRMIAFSA-N 0.000 claims 1
- QGNOTWMPRVBVFZ-FBMWCMRBSA-N 4-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyrazin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxybutane-1,2-diol Chemical compound COC1=CN=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCCC(O)CO)=N1 QGNOTWMPRVBVFZ-FBMWCMRBSA-N 0.000 claims 1
- RTIMCVAWDIGQHH-LJQANCHMSA-N 4-[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxybutan-1-ol Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCCCCO)=N1 RTIMCVAWDIGQHH-LJQANCHMSA-N 0.000 claims 1
- AEOIOPGFKIUHME-TYJDENFWSA-N 4-[[(7s)-2-amino-7-[2-(5-amino-6-methoxypyrazin-2-yl)-4-fluorophenyl]-8,8-difluoro-4-methyl-7h-pyrido[4,3-d]pyrimidin-5-yl]amino]oxybutane-1,2-diol Chemical compound N1=C(N)C(OC)=NC(C=2C(=CC=C(F)C=2)[C@H]2C(C3=NC(N)=NC(C)=C3C(=N/OCCC(O)CO)/N2)(F)F)=C1 AEOIOPGFKIUHME-TYJDENFWSA-N 0.000 claims 1
- ZWSDBPUELLQSJZ-WQHGFJKVSA-N 4-[[(7s)-2-amino-7-[2-(5-amino-6-methoxypyrazin-2-yl)-4-fluorophenyl]-8-fluoro-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxybutane-1,2-diol Chemical compound N1=C(N)C(OC)=NC(C=2C(=CC=C(F)C=2)[C@H]2C(C3=NC(N)=NC(C)=C3C(=N/OCCC(O)CO)/N2)F)=C1 ZWSDBPUELLQSJZ-WQHGFJKVSA-N 0.000 claims 1
- UUMCAVHRUOVLEN-QPDBELLOSA-N 4-[[(7s)-2-amino-8-fluoro-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxybutane-1,2-diol Chemical compound COC1=CC=CC(C=2C(=CC=C(F)C=2)[C@H]2C(C3=NC(N)=NC(C)=C3C(=N/OCCC(O)CO)/N2)F)=N1 UUMCAVHRUOVLEN-QPDBELLOSA-N 0.000 claims 1
- MGITXHIKJISZGA-IHTASXDUSA-N 5-[[[(7r)-2-amino-7-[2-(5-amino-6-methoxypyrazin-2-yl)-4-fluorophenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxymethyl]-3,4-dihydroxyoxolan-2-one Chemical compound N1=C(N)C(OC)=NC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC2C(C(O)C(=O)O2)O)=C1 MGITXHIKJISZGA-IHTASXDUSA-N 0.000 claims 1
- IUJOVWRTZOKKAK-JLGDOQARSA-N 5-[[[(7r)-2-amino-7-[4-fluoro-2-(6-methoxypyrazin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5-yl]amino]oxymethyl]-3,4-dihydroxyoxolan-2-one Chemical compound COC1=CN=CC(C=2C(=CC=C(F)C=2)[C@@H]2NC(/C3=C(C)N=C(N)N=C3C2)=N\OCC2C(C(O)C(=O)O2)O)=N1 IUJOVWRTZOKKAK-JLGDOQARSA-N 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- XLXNSEBFJITLOU-UHFFFAOYSA-N OCC(CCON=C1C=NC=NC1)O Chemical compound OCC(CCON=C1C=NC=NC1)O XLXNSEBFJITLOU-UHFFFAOYSA-N 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000002723 alicyclic group Chemical group 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000006588 heterocycloalkylene group Chemical group 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- VGPBPWRBXBKGRE-UHFFFAOYSA-N n-(oxomethylidene)hydroxylamine Chemical compound ON=C=O VGPBPWRBXBKGRE-UHFFFAOYSA-N 0.000 claims 1
- 125000005188 oxoalkyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- AKCMCFPQVUTWFW-UHFFFAOYSA-N pyrrolidin-3-yl acetate Chemical compound CC(=O)OC1CCNC1 AKCMCFPQVUTWFW-UHFFFAOYSA-N 0.000 claims 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2572508P | 2008-02-01 | 2008-02-01 | |
| US61/025,725 | 2008-02-01 | ||
| US10159508P | 2008-09-30 | 2008-09-30 | |
| US61/101,595 | 2008-09-30 | ||
| PCT/US2009/032728 WO2009097578A1 (en) | 2008-02-01 | 2009-01-30 | Oxim derivatives as hsp90 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011511003A JP2011511003A (ja) | 2011-04-07 |
| JP2011511003A5 true JP2011511003A5 (https=) | 2012-03-15 |
| JP5524084B2 JP5524084B2 (ja) | 2014-06-18 |
Family
ID=40436400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545233A Expired - Fee Related JP5524084B2 (ja) | 2008-02-01 | 2009-01-30 | Ｈｓｐ９０阻害剤としてのオキシム誘導体 |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20110053873A1 (https=) |
| EP (1) | EP2252595B1 (https=) |
| JP (1) | JP5524084B2 (https=) |
| KR (1) | KR20100116206A (https=) |
| CN (1) | CN101983191B (https=) |
| AR (1) | AR071452A1 (https=) |
| AU (1) | AU2009208947B2 (https=) |
| BR (1) | BRPI0906598A2 (https=) |
| CA (1) | CA2713658C (https=) |
| CL (1) | CL2009000228A1 (https=) |
| CR (1) | CR11659A (https=) |
| DO (1) | DOP2010000236A (https=) |
| EA (1) | EA019156B1 (https=) |
| EC (1) | ECSP10010434A (https=) |
| ES (1) | ES2475206T3 (https=) |
| GE (1) | GEP20125718B (https=) |
| IL (1) | IL207227A0 (https=) |
| MA (1) | MA32104B1 (https=) |
| MX (1) | MX2010008269A (https=) |
| MY (1) | MY150596A (https=) |
| NZ (1) | NZ587207A (https=) |
| PE (1) | PE20091371A1 (https=) |
| SG (1) | SG187502A1 (https=) |
| TW (1) | TW200946531A (https=) |
| WO (1) | WO2009097578A1 (https=) |
| ZA (1) | ZA201005435B (https=) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2416603C9 (ru) | 2005-10-25 | 2012-06-20 | Сионоги Энд Ко., Лтд. | Производные аминодигидротиазина |
| AR061185A1 (es) | 2006-05-26 | 2008-08-13 | Chugai Pharmaceutical Co Ltd | Compuestos heterociclicos como inhibidores de hsp90. composiciones farmaceuticas. |
| CA2679126A1 (en) | 2007-03-01 | 2008-09-04 | Chugai Seiyaku Kabushiki Kaisha | Macrocyclic compound |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| EP2147914B1 (en) | 2007-04-24 | 2014-06-04 | Shionogi&Co., Ltd. | Aminodihydrothiazine derivatives substituted with cyclic groups |
| GB2449293A (en) * | 2007-05-17 | 2008-11-19 | Evotec | Compounds having Hsp90 inhibitory activity |
| ES2475206T3 (es) * | 2008-02-01 | 2014-07-10 | Takeda Pharmaceutical Company Limited | Derivados de oxima como inhibidores de HSP90 |
| WO2009151098A1 (ja) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | βセクレターゼ阻害作用を有する含硫黄複素環誘導体 |
| CN102186841A (zh) | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物 |
| TWI488852B (zh) | 2009-12-11 | 2015-06-21 | Shionogi & Co | 衍生物 |
| JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
| JP5766198B2 (ja) | 2010-10-29 | 2015-08-19 | 塩野義製薬株式会社 | 縮合アミノジヒドロピリミジン誘導体 |
| TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
| ITTO20111013A1 (it) | 2011-11-03 | 2013-05-04 | Dac Srl | Composti farmaceutici |
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