AU2009208947B2 - Oxim derivatives as HSP90 inhibitors - Google Patents

Oxim derivatives as HSP90 inhibitors Download PDF

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Publication number
AU2009208947B2
AU2009208947B2 AU2009208947A AU2009208947A AU2009208947B2 AU 2009208947 B2 AU2009208947 B2 AU 2009208947B2 AU 2009208947 A AU2009208947 A AU 2009208947A AU 2009208947 A AU2009208947 A AU 2009208947A AU 2009208947 B2 AU2009208947 B2 AU 2009208947B2
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AU
Australia
Prior art keywords
alkyl
methyl
hetero
amino
dihydropyrido
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Expired - Fee Related
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AU2009208947A
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AU2009208947A1 (en
Inventor
Young K. Chen
Erick Wang Co
Prasuna Guntupalli
John David Lawson
Wolfgang Reinhard Ludwig Notz
Jeffrey A. Stafford
Huong-Thu Ton-Nu
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
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    • C—CHEMISTRY; METALLURGY
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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AU2009208947A 2008-02-01 2009-01-30 Oxim derivatives as HSP90 inhibitors Expired - Fee Related AU2009208947B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2572508P 2008-02-01 2008-02-01
US61/025,725 2008-02-01
US10159508P 2008-09-30 2008-09-30
US61/101,595 2008-09-30
PCT/US2009/032728 WO2009097578A1 (en) 2008-02-01 2009-01-30 Oxim derivatives as hsp90 inhibitors

Publications (2)

Publication Number Publication Date
AU2009208947A1 AU2009208947A1 (en) 2009-08-06
AU2009208947B2 true AU2009208947B2 (en) 2014-02-06

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AU2009208947A Expired - Fee Related AU2009208947B2 (en) 2008-02-01 2009-01-30 Oxim derivatives as HSP90 inhibitors

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US (4) US20110053873A1 (https=)
EP (1) EP2252595B1 (https=)
JP (1) JP5524084B2 (https=)
KR (1) KR20100116206A (https=)
CN (1) CN101983191B (https=)
AR (1) AR071452A1 (https=)
AU (1) AU2009208947B2 (https=)
BR (1) BRPI0906598A2 (https=)
CA (1) CA2713658C (https=)
CL (1) CL2009000228A1 (https=)
CR (1) CR11659A (https=)
DO (1) DOP2010000236A (https=)
EA (1) EA019156B1 (https=)
EC (1) ECSP10010434A (https=)
ES (1) ES2475206T3 (https=)
GE (1) GEP20125718B (https=)
IL (1) IL207227A0 (https=)
MA (1) MA32104B1 (https=)
MX (1) MX2010008269A (https=)
MY (1) MY150596A (https=)
NZ (1) NZ587207A (https=)
PE (1) PE20091371A1 (https=)
SG (1) SG187502A1 (https=)
TW (1) TW200946531A (https=)
WO (1) WO2009097578A1 (https=)
ZA (1) ZA201005435B (https=)

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