JP2011510014A5 - - Google Patents
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- JP2011510014A5 JP2011510014A5 JP2010543237A JP2010543237A JP2011510014A5 JP 2011510014 A5 JP2011510014 A5 JP 2011510014A5 JP 2010543237 A JP2010543237 A JP 2010543237A JP 2010543237 A JP2010543237 A JP 2010543237A JP 2011510014 A5 JP2011510014 A5 JP 2011510014A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- disease
- alkyl
- carbonyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 14
- -1 C 1 -C 4 carbonyl Chemical group 0.000 claims 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims 11
- 201000010099 disease Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 208000030533 eye disease Diseases 0.000 claims 6
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 5
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 claims 4
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims 4
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 4
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000001174 sulfone group Chemical group 0.000 claims 4
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims 4
- 108091000080 Phosphotransferase Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000020233 phosphotransferase Human genes 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 208000020084 Bone disease Diseases 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 208000012895 Gastric disease Diseases 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 206010028735 Nasal congestion Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000000693 Neurogenic Urinary Bladder Diseases 0.000 claims 2
- 206010029279 Neurogenic bladder Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 239000000470 constituent Substances 0.000 claims 2
- 208000010643 digestive system disease Diseases 0.000 claims 2
- 230000035558 fertility Effects 0.000 claims 2
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000000626 neurodegenerative effect Effects 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 101100015811 Caenorhabditis elegans grk-2 gene Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000035479 physiological effects, processes and functions Effects 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 0 *C(*Nc(cc1)cc2c1ccnc2)(N(*)*)I Chemical compound *C(*Nc(cc1)cc2c1ccnc2)(N(*)*)I 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/009,326 | 2008-01-17 | ||
| US12/009,326 US8455514B2 (en) | 2008-01-17 | 2008-01-17 | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| PCT/US2009/031117 WO2009091898A2 (en) | 2008-01-17 | 2009-01-15 | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011510014A JP2011510014A (ja) | 2011-03-31 |
| JP2011510014A5 true JP2011510014A5 (OSRAM) | 2012-03-01 |
| JP5551613B2 JP5551613B2 (ja) | 2014-07-16 |
Family
ID=40433990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543237A Active JP5551613B2 (ja) | 2008-01-17 | 2009-01-15 | ６−アミノイソキノリン化合物および７−アミノイソキノリン化合物、ならびにそれらの製造方法および使用方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8455514B2 (OSRAM) |
| EP (4) | EP2546237A1 (OSRAM) |
| JP (1) | JP5551613B2 (OSRAM) |
| AU (1) | AU2009206075B2 (OSRAM) |
| CA (2) | CA2923336A1 (OSRAM) |
| ES (3) | ES2465572T3 (OSRAM) |
| WO (1) | WO2009091898A2 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2580108T3 (es) * | 2005-07-11 | 2016-08-19 | Aerie Pharmaceuticals, Inc | Compuestos de isoquinolina |
| ES2729424T3 (es) | 2006-09-20 | 2019-11-04 | Aerie Pharmaceuticals Inc | Inhibidores de Rho cinasa |
| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8455514B2 (en) * | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| CA2760562C (en) * | 2009-05-01 | 2016-07-19 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| EP2657227B1 (en) * | 2010-12-22 | 2016-04-27 | D. Western Therapeutics Institute, Inc. | Novel substituted isoquinoline derivative |
| PT3811943T (pt) | 2013-03-15 | 2023-03-15 | Aerie Pharmaceuticals Inc | Composto para uso no tratamento de distúrbios oculares |
| US10465188B2 (en) | 2014-08-22 | 2019-11-05 | Auckland Uniservices Limited | Channel modulators |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
| JP6832946B2 (ja) | 2015-11-17 | 2021-02-24 | アエリエ ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤およびその中間体の調製方法 |
| US10109932B2 (en) | 2016-04-20 | 2018-10-23 | Hubbell Incorporated | Electrical clamps |
| CN109640966A (zh) | 2016-08-31 | 2019-04-16 | 爱瑞制药公司 | 眼用组合物 |
| KR20230128395A (ko) | 2017-02-28 | 2023-09-04 | 코와 가부시키가이샤 | 의약 제제 |
| WO2018159701A1 (ja) | 2017-02-28 | 2018-09-07 | 興和株式会社 | 医薬 |
| CN110337292A (zh) | 2017-02-28 | 2019-10-15 | 兴和株式会社 | 医药品 |
| ES2972844T3 (es) | 2017-03-27 | 2024-06-17 | Alcon Inc | Preparación farmacéutica |
| SG11201908179UA (en) | 2017-03-31 | 2019-10-30 | Aerie Pharmaceuticals Inc | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US10696638B2 (en) | 2017-12-26 | 2020-06-30 | Industrial Technology Research Institute | Compounds for inhibiting AGC kinase and pharmaceutical compositions comprising the same |
| WO2020056345A1 (en) | 2018-09-14 | 2020-03-19 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| US20220119350A1 (en) * | 2019-02-22 | 2022-04-21 | Glaukos Corporation | Compounds for the treatment of ocular disease |
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| US8455513B2 (en) * | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| WO2008124665A1 (en) * | 2007-04-10 | 2008-10-16 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| US8455514B2 (en) | 2008-01-17 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-and 7-amino isoquinoline compounds and methods for making and using the same |
| US8450344B2 (en) * | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| CA2760562C (en) | 2009-05-01 | 2016-07-19 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
-
2008
- 2008-01-17 US US12/009,326 patent/US8455514B2/en active Active
-
2009
- 2009-01-15 WO PCT/US2009/031117 patent/WO2009091898A2/en not_active Ceased
- 2009-01-15 CA CA2923336A patent/CA2923336A1/en not_active Abandoned
- 2009-01-15 EP EP12007089A patent/EP2546237A1/en not_active Withdrawn
- 2009-01-15 CA CA2712443A patent/CA2712443C/en active Active
- 2009-01-15 EP EP12007092.5A patent/EP2546238B1/en active Active
- 2009-01-15 ES ES12007092.5T patent/ES2465572T3/es active Active
- 2009-01-15 EP EP12007093.3A patent/EP2546239B1/en active Active
- 2009-01-15 ES ES12007093.3T patent/ES2535716T3/es active Active
- 2009-01-15 EP EP09702189A patent/EP2252589B1/en active Active
- 2009-01-15 AU AU2009206075A patent/AU2009206075B2/en not_active Ceased
- 2009-01-15 ES ES09702189T patent/ES2397928T3/es active Active
- 2009-01-15 JP JP2010543237A patent/JP5551613B2/ja active Active
-
2010
- 2010-02-12 US US12/704,822 patent/US8871757B2/en active Active
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