ATE420109T1 - Konstitutiv translozierende zelllinie - Google Patents

Konstitutiv translozierende zelllinie

Info

Publication number
ATE420109T1
ATE420109T1 AT03726733T AT03726733T ATE420109T1 AT E420109 T1 ATE420109 T1 AT E420109T1 AT 03726733 T AT03726733 T AT 03726733T AT 03726733 T AT03726733 T AT 03726733T AT E420109 T1 ATE420109 T1 AT E420109T1
Authority
AT
Austria
Prior art keywords
agonist
present
methods
translocing
constitutive
Prior art date
Application number
AT03726733T
Other languages
English (en)
Inventor
Robert Oakley
Christine Hudson
Original Assignee
Molecular Devices Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Devices Corp filed Critical Molecular Devices Corp
Application granted granted Critical
Publication of ATE420109T1 publication Critical patent/ATE420109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT03726733T 2002-05-13 2003-05-12 Konstitutiv translozierende zelllinie ATE420109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37998602P 2002-05-13 2002-05-13
US40169802P 2002-08-07 2002-08-07

Publications (1)

Publication Number Publication Date
ATE420109T1 true ATE420109T1 (de) 2009-01-15

Family

ID=29553491

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726733T ATE420109T1 (de) 2002-05-13 2003-05-12 Konstitutiv translozierende zelllinie

Country Status (8)

Country Link
US (3) US7332292B2 (de)
EP (1) EP1504030B1 (de)
JP (1) JP2005525814A (de)
AT (1) ATE420109T1 (de)
AU (1) AU2003228956B2 (de)
CA (1) CA2483692A1 (de)
DE (1) DE60325719D1 (de)
WO (1) WO2003097795A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE420109T1 (de) * 2002-05-13 2009-01-15 Molecular Devices Corp Konstitutiv translozierende zelllinie
AU2003256789A1 (en) * 2002-08-13 2004-02-25 U.S. Department Of Veterans Affairs Method of detecting and preventing alzheimer's disease, particularly at prodromal and early stages
EP1554581A2 (de) * 2002-10-11 2005-07-20 7TM Pharma A/S Verfahren zur verbesserung und zur verlängerung der biolumineszenz resonanz energie transfer (bret) signal in einer bret assay und einer substratlösung zur anwendung in einer bret assay
EP1579212B1 (de) 2002-10-25 2008-12-31 MDS Analytical Technologies (US) Inc. Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung
WO2005047905A1 (en) * 2003-10-28 2005-05-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 22 (gpr22)
JP4890442B2 (ja) * 2004-04-20 2012-03-07 ガラパゴス・ナムローゼ・フェンノートシャップ アミロイドベータタンパク質産生を阻害するための方法、組成物及び化合物アッセイ
EP1910297B1 (de) * 2005-07-11 2016-05-25 Aerie Pharmaceuticals, Inc. Isochinolinverbindungen
WO2007008942A2 (en) * 2005-07-11 2007-01-18 Aerie Pharmaceuticals, Inc. Phenylamino-acetic acid [1-(pyridin-4-yl)-methylidene]-hydrazide derivatives and related compounds as modulators of g protein-coupled receptor kinases for the treatment of eye diseases
US7763437B1 (en) * 2005-07-15 2010-07-27 Duke University Methods for identifying compounds that regulate β-Arrestin signaling complexes
EP1954716A4 (de) * 2005-11-30 2009-06-10 Axitare Inc Zusammensetzungen und verfahren zum modulieren der geschmacks- und geruchsrezeptoren, sowie kontrollverfahren dafür
EP2526948A1 (de) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO-Kinase-Hemmer
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3053913B1 (de) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
CA2853722A1 (en) 2011-10-27 2013-05-02 Mayo Foundation For Medical Education And Research Inhibiting g protein coupled receptor 6 kinase polypeptides
ITMI20112038A1 (it) * 2011-11-10 2013-05-11 Arterra Bioscience S R L "nuovi recettori gpcr chimerici, loro usi per lo screening di fitofarmaci, e metodi di screening relativi"
CN105263494A (zh) 2013-03-15 2016-01-20 爱瑞制药公司 联合治疗
US9902739B2 (en) 2014-04-21 2018-02-27 Mayo Foundation For Medical Education And Research Small molecule inhibitors of G protein coupled receptor 6 kinases polypeptides
KR102579582B1 (ko) 2015-11-17 2023-09-15 에어리 파마슈티컬즈, 인코포레이티드 키나아제 억제제 및 이의 중간체의 제조 방법
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427912A (en) * 1993-08-27 1995-06-27 Boehringer Mannheim Corporation Electrochemical enzymatic complementation immunoassay
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US6893827B1 (en) * 2000-02-07 2005-05-17 Applera Corporation Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
US7279324B2 (en) 2001-01-23 2007-10-09 Duke University Nucleic acid encoding G-protein coupled receptor with modified DRY motif
US20030013137A1 (en) 2001-03-13 2003-01-16 Barak Larry S. Automated methods of detecting receptor activity
US20030182669A1 (en) 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
ATE420109T1 (de) * 2002-05-13 2009-01-15 Molecular Devices Corp Konstitutiv translozierende zelllinie

Also Published As

Publication number Publication date
WO2003097795A2 (en) 2003-11-27
AU2003228956A1 (en) 2003-12-02
US7332292B2 (en) 2008-02-19
EP1504030A2 (de) 2005-02-09
CA2483692A1 (en) 2003-11-27
US20050032125A1 (en) 2005-02-10
US20090081652A1 (en) 2009-03-26
WO2003097795A3 (en) 2004-06-24
EP1504030A4 (de) 2006-10-25
EP1504030B1 (de) 2009-01-07
AU2003228956B2 (en) 2009-10-01
US20060029983A1 (en) 2006-02-09
JP2005525814A (ja) 2005-09-02
DE60325719D1 (de) 2009-02-26

Similar Documents

Publication Publication Date Title
ATE420109T1 (de) Konstitutiv translozierende zelllinie
CN102209987B (zh) 用于增强的主动噪声消除的系统、方法、设备
PH12016501311B1 (en) T1r hetero-oligomeric taste receptors, cell lines that express said receptors, and taste compounds
AU2013230213B2 (en) Handling speech synthesis of content for multiple languages
Scarborough Lexical and contextual predictability: Confluent effects on the production of vowels
WO2000022131A3 (en) Non-endogenous, constitutively activated human g protein-coupled receptors
ATE483229T1 (de) Verfahren und vorrichtung zur bereitstellung einer kontinuierlichen adaptiven steuerung des sprachpaketpuffers im empfängerendgerät
MX353986B (es) Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas.
RU2010132214A (ru) Способы и устройства для осуществления распределенных многомодальных приложений
WO2013078474A1 (en) Processing signals
AU2001234430A1 (en) Improved systems for sensitive detection of g-protein coupled receptor and orphan receptor function using reporter enzyme mutant complementation
NO20045628L (no) Fremgangsmate for a skille et elektromagnetisk bolgefelts komponenter fra hverandre
NO20072085L (no) Blindsignaladskillelse ved hjelp av signalveivalg
JP2008310586A (ja) 警報処理装置及び警報処理システム
CN1868236A (zh) 根据自相关系数梯度检测信号中噪音的方法和电子设备
WO2008064981A3 (en) A method, apparatus and computer program for modifying an endpoint reference representing a web service endpoint
US9396735B2 (en) System for real time audio processing driven by interrupt and timer event
Shinn-Cunningham Understanding informational masking from a neural perspective
Liu et al. The role of the C-terminus of the human hydroxycarboxylic acid receptors 2 and 3 in G protein activation using Gα-engineered yeast cells
Almqvist et al. Contributions of microstructure and crystallographic preferred orientation to seismic anisotropy in the lower continental crust
AU2002211228A1 (en) Screening methods to identify g-proteins and other compounds which modulate phosphodiesterase (pde) activity
JP2005309096A (ja) 音声復号化装置および音声復号化方法
JP2016184110A (ja) 多地点会議装置及び多地点会議制御プログラム、並びに、多地点会議制御方法
Palla et al. Wearable speech enhancement system for motor impaired people
Kawagoe Consonant Gemination in Loanword Phonology and Rhythm Clash

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties