ATE420109T1 - Konstitutiv translozierende zelllinie - Google Patents

Konstitutiv translozierende zelllinie

Info

Publication number
ATE420109T1
ATE420109T1 AT03726733T AT03726733T ATE420109T1 AT E420109 T1 ATE420109 T1 AT E420109T1 AT 03726733 T AT03726733 T AT 03726733T AT 03726733 T AT03726733 T AT 03726733T AT E420109 T1 ATE420109 T1 AT E420109T1
Authority
AT
Austria
Prior art keywords
agonist
present
methods
translocing
constitutive
Prior art date
Application number
AT03726733T
Other languages
English (en)
Inventor
Robert Oakley
Christine Hudson
Original Assignee
Molecular Devices Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Devices Corp filed Critical Molecular Devices Corp
Application granted granted Critical
Publication of ATE420109T1 publication Critical patent/ATE420109T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells
AT03726733T 2002-05-13 2003-05-12 Konstitutiv translozierende zelllinie ATE420109T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37998602P 2002-05-13 2002-05-13
US40169802P 2002-08-07 2002-08-07

Publications (1)

Publication Number Publication Date
ATE420109T1 true ATE420109T1 (de) 2009-01-15

Family

ID=29553491

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03726733T ATE420109T1 (de) 2002-05-13 2003-05-12 Konstitutiv translozierende zelllinie

Country Status (8)

Country Link
US (3) US7332292B2 (de)
EP (1) EP1504030B1 (de)
JP (1) JP2005525814A (de)
AT (1) ATE420109T1 (de)
AU (1) AU2003228956B2 (de)
CA (1) CA2483692A1 (de)
DE (1) DE60325719D1 (de)
WO (1) WO2003097795A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003228956B2 (en) * 2002-05-13 2009-10-01 Mds Analytical Technologies (Us) Inc. Constitutively translocating cell line
AU2003256789A1 (en) * 2002-08-13 2004-02-25 U.S. Department Of Veterans Affairs Method of detecting and preventing alzheimer's disease, particularly at prodromal and early stages
US20060099646A1 (en) * 2002-10-11 2006-05-11 Anders Heding Bret assay
DE60325640D1 (de) 2002-10-25 2009-02-12 Mds Analytical Technologies Us Verfahren zur identifizierung von transmembranrezeptoragonisten mit reduzierter internalisierung
WO2005047905A1 (en) * 2003-10-28 2005-05-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 22 (gpr22)
ATE483981T1 (de) * 2004-04-20 2010-10-15 Galapagos Nv Verfahren, zusammensetzungen und verbindungstests zur hemmung der amyloid-beta-proteinproduktion
EP1910297B1 (de) * 2005-07-11 2016-05-25 Aerie Pharmaceuticals, Inc. Isochinolinverbindungen
US20070135499A1 (en) * 2005-07-11 2007-06-14 Aerie Pharmaceuticals, Inc. Hydrazide compounds
US7763437B1 (en) * 2005-07-15 2010-07-27 Duke University Methods for identifying compounds that regulate β-Arrestin signaling complexes
CA2630461A1 (en) * 2005-11-30 2007-06-07 Axitare, Inc. Compositions and methods of modulating the taste and smell receptors and screening methods therefore
WO2008036540A2 (en) 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) * 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3828172A1 (de) 2009-05-01 2021-06-02 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
CA2853722A1 (en) 2011-10-27 2013-05-02 Mayo Foundation For Medical Education And Research Inhibiting g protein coupled receptor 6 kinase polypeptides
ITMI20112038A1 (it) * 2011-11-10 2013-05-11 Arterra Bioscience S R L "nuovi recettori gpcr chimerici, loro usi per lo screening di fitofarmaci, e metodi di screening relativi"
EP3811943B1 (de) 2013-03-15 2023-02-22 Aerie Pharmaceuticals, Inc. Verbindung zur verwendung in der behandlung von augenkrankheiten
WO2015164411A2 (en) 2014-04-21 2015-10-29 Mayo Foundation For Medical Education And Research Small molecule inhibitors of g protein coupled receptor 6 kinases polypeptides
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6832946B2 (ja) 2015-11-17 2021-02-24 アエリエ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤およびその中間体の調製方法
US11389441B2 (en) 2016-08-31 2022-07-19 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
MX2019011784A (es) 2017-03-31 2019-11-18 Aerie Pharmaceuticals Inc Compuestos de aril ciclopropil-amino-isoquinolinil amida.
EP3849555A4 (de) 2018-09-14 2022-05-04 Aerie Pharmaceuticals, Inc. Aryl-cyclopropyl-amino-isochinolinyl-amidverbindungen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427912A (en) * 1993-08-27 1995-06-27 Boehringer Mannheim Corporation Electrochemical enzymatic complementation immunoassay
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US6528271B1 (en) 1997-06-05 2003-03-04 Duke University Inhibition of βarrestin mediated effects prolongs and potentiates opioid receptor-mediated analgesia
US5891646A (en) * 1997-06-05 1999-04-06 Duke University Methods of assaying receptor activity and constructs useful in such methods
US6893827B1 (en) * 2000-02-07 2005-05-17 Applera Corporation Receptor function assay for G-protein coupled receptors and orphan receptors by reporter enzyme mutant complementation
US7279324B2 (en) 2001-01-23 2007-10-09 Duke University Nucleic acid encoding G-protein coupled receptor with modified DRY motif
US20030013137A1 (en) 2001-03-13 2003-01-16 Barak Larry S. Automated methods of detecting receptor activity
US20030182669A1 (en) 2002-03-19 2003-09-25 Rockman Howard A. Phosphoinositide 3-kinase mediated inhibition of GPCRs
AU2003228956B2 (en) * 2002-05-13 2009-10-01 Mds Analytical Technologies (Us) Inc. Constitutively translocating cell line

Also Published As

Publication number Publication date
US20090081652A1 (en) 2009-03-26
WO2003097795A2 (en) 2003-11-27
US20060029983A1 (en) 2006-02-09
US7332292B2 (en) 2008-02-19
EP1504030A2 (de) 2005-02-09
DE60325719D1 (de) 2009-02-26
EP1504030B1 (de) 2009-01-07
AU2003228956A1 (en) 2003-12-02
WO2003097795A3 (en) 2004-06-24
JP2005525814A (ja) 2005-09-02
CA2483692A1 (en) 2003-11-27
EP1504030A4 (de) 2006-10-25
AU2003228956B2 (en) 2009-10-01
US20050032125A1 (en) 2005-02-10

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