JP2011509289A - 新規なアシルシアノピロリジン誘導体 - Google Patents

新規なアシルシアノピロリジン誘導体 Download PDF

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Publication number
JP2011509289A
JP2011509289A JP2010541890A JP2010541890A JP2011509289A JP 2011509289 A JP2011509289 A JP 2011509289A JP 2010541890 A JP2010541890 A JP 2010541890A JP 2010541890 A JP2010541890 A JP 2010541890A JP 2011509289 A JP2011509289 A JP 2011509289A
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Prior art keywords
isopropylidene
piperidine
deoxy
carbonitrile
methyl
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JP2011509289A5 (cg-RX-API-DMAC10.html
Inventor
アコルカール・ナクル・プラモッド
アドヒャパック・ジェイ・プラカシュチャンドラ
アラディ・ジェイラ・ディリブハイ
クムバニ・アニル・サヴァジバイ
パンチャル・バヴェッシュ・モハンバイ
ジヴァニ・ジグネッシュ・カンティラル
サマンタ・ビスワジット
パル・ランジャン・クマール
ゼンナティ・ラジャマンナール
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サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド
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Publication of JP2011509289A publication Critical patent/JP2011509289A/ja
Publication of JP2011509289A5 publication Critical patent/JP2011509289A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
JP2010541890A 2008-01-10 2009-01-09 新規なアシルシアノピロリジン誘導体 Pending JP2011509289A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN79MU2008 2008-01-10
PCT/IN2009/000029 WO2009116067A2 (en) 2008-01-10 2009-01-09 Novel derivatives of acyl cyanopyrrolidines

Publications (2)

Publication Number Publication Date
JP2011509289A true JP2011509289A (ja) 2011-03-24
JP2011509289A5 JP2011509289A5 (cg-RX-API-DMAC10.html) 2012-01-26

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JP2010541890A Pending JP2011509289A (ja) 2008-01-10 2009-01-09 新規なアシルシアノピロリジン誘導体

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Country Link
US (1) US20120040897A1 (cg-RX-API-DMAC10.html)
EP (1) EP2231687A4 (cg-RX-API-DMAC10.html)
JP (1) JP2011509289A (cg-RX-API-DMAC10.html)
BR (1) BRPI0906448A2 (cg-RX-API-DMAC10.html)
EA (1) EA201070839A1 (cg-RX-API-DMAC10.html)
MX (1) MX2010007593A (cg-RX-API-DMAC10.html)
WO (1) WO2009116067A2 (cg-RX-API-DMAC10.html)

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EP2365753B1 (en) * 2008-11-17 2013-07-17 Anadys Pharmaceuticals, Inc. Method of preparing deoxyribofuranose compounds
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN105142621A (zh) 2012-10-24 2015-12-09 国家健康科学研究所 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂
EP3273981B1 (en) 2015-03-24 2020-04-29 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of diabetes
AU2018386298B2 (en) 2017-12-15 2023-09-07 Praxis Biotech LLC Inhibitors of fibroblast activation protein
CN113811529A (zh) 2018-12-21 2021-12-17 普拉西斯生物技术有限责任公司 成纤维细胞激活蛋白抑制剂

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JP2002356471A (ja) * 2000-10-06 2002-12-13 Tanabe Seiyaku Co Ltd 脂肪族含窒素五員環化合物
JP2004002368A (ja) * 2002-04-04 2004-01-08 Tanabe Seiyaku Co Ltd 医薬組成物
WO2004007446A1 (ja) * 2002-07-10 2004-01-22 Yamanouchi Pharmaceutical Co., Ltd. 新規なアゼチジン誘導体又はその塩
WO2004009544A1 (ja) * 2002-07-23 2004-01-29 Yamanouchi Pharmaceutical Co., Ltd. 2-シアノ−４−フルオロピロリジン誘導体又はその塩
WO2006040625A1 (en) * 2004-10-12 2006-04-20 Glenmark Pharmaceuticals S.A. Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation

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AU2002344820B2 (en) * 2001-06-20 2006-12-14 Merck & Co., Inc. Dipeptidyl peptidase inhibitors for the treatment of diabetes
WO2005075426A1 (en) * 2004-02-03 2005-08-18 Glenmark Pharmaceuticals Ltd. Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof

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JP2002356471A (ja) * 2000-10-06 2002-12-13 Tanabe Seiyaku Co Ltd 脂肪族含窒素五員環化合物
JP2004002368A (ja) * 2002-04-04 2004-01-08 Tanabe Seiyaku Co Ltd 医薬組成物
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WO2006040625A1 (en) * 2004-10-12 2006-04-20 Glenmark Pharmaceuticals S.A. Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation

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BRPI0906448A2 (pt) 2015-07-14
US20120040897A1 (en) 2012-02-16
MX2010007593A (es) 2010-10-13
EP2231687A2 (en) 2010-09-29

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