|
US20060106020A1
(en)
*
|
2004-04-28 |
2006-05-18 |
Rodgers James D |
Tetracyclic inhibitors of Janus kinases
|
|
PT1966202E
(pt)
|
2005-12-13 |
2012-01-03 |
Incyte Corp |
Pirrolo[2,3-b] pirimidinas e pirrolo[2,3-b]piridinas substituídas com heteroarilo como inibidores de janus quinase
|
|
EP2121692B1
(en)
*
|
2006-12-22 |
2013-04-10 |
Incyte Corporation |
Substituted heterocycles as janus kinase inhibitors
|
|
RS53245B2
(sr)
|
2007-06-13 |
2022-10-31 |
Incyte Holdings Corp |
Soli inhibitora janus kinaze (r)-3-(4-(7h-pirolo(2,3-d) pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropan-nitrila
|
|
CL2008001709A1
(es)
|
2007-06-13 |
2008-11-03 |
Incyte Corp |
Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras.
|
|
FR2938537B1
(fr)
|
2008-11-14 |
2012-10-26 |
Sanofi Aventis |
Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
|
|
JOP20190231A1
(ar)
|
2009-01-15 |
2017-06-16 |
Incyte Corp |
طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به
|
|
TW201100429A
(en)
|
2009-05-22 |
2011-01-01 |
Incyte Corp |
N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
PL2432472T3
(pl)
|
2009-05-22 |
2020-03-31 |
Incyte Holdings Corporation |
3-[4-(7H-Pirolo[2,3-d]pirymidyn-4-ylo)-1H-pirazol-1-ilo]oktano- lub heptano-nitryle jako inhibitory JAK
|
|
TW201113285A
(en)
|
2009-09-01 |
2011-04-16 |
Incyte Corp |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
US20110207736A1
(en)
*
|
2009-12-23 |
2011-08-25 |
Gatekeeper Pharmaceuticals, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
CA2789186A1
(en)
*
|
2010-02-10 |
2011-08-18 |
Genon Biotechnologies Oy |
Dual activity kinase domains and uses thereof
|
|
CN102844317B
(zh)
*
|
2010-02-18 |
2015-06-03 |
因西特公司 |
作为Janus激酶抑制剂的环丁烷和甲基环丁烷衍生物
|
|
MX354212B
(es)
|
2010-03-10 |
2018-02-19 |
Incyte Corp |
Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
|
|
GB201007286D0
(en)
|
2010-04-30 |
2010-06-16 |
Astex Therapeutics Ltd |
New compounds
|
|
EA202091303A3
(ru)
|
2010-05-21 |
2021-05-31 |
Инсайт Холдингс Корпорейшн |
Композиция ингибитора jak для местного применения
|
|
EP3075730B1
(en)
|
2010-06-04 |
2018-10-24 |
Genentech, Inc. |
Aminopyrimidine derivatives as lrrk2 modulators
|
|
EP2638018A1
(en)
*
|
2010-11-09 |
2013-09-18 |
Cellzome Limited |
Pyridine compounds and aza analogues thereof as tyk2 inhibitors
|
|
ES2746134T3
(es)
|
2010-11-10 |
2020-03-04 |
Genentech Inc |
Derivados de pirazol aminopirimidina como moduladores de LRRK2
|
|
WO2012068440A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
CA2818542A1
(en)
|
2010-11-19 |
2012-05-24 |
Incyte Corporation |
Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
GB201020179D0
(en)
|
2010-11-29 |
2011-01-12 |
Astex Therapeutics Ltd |
New compounds
|
|
EP2675451B9
(en)
|
2011-02-18 |
2017-07-26 |
Novartis Pharma AG |
mTOR/JAK INHIBITOR COMBINATION THERAPY
|
|
JP5976778B2
(ja)
*
|
2011-04-11 |
2016-08-24 |
ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ |
キナーゼ阻害剤としてのピラゾリル−ピリミジン誘導体
|
|
CN103797010B
(zh)
|
2011-06-20 |
2016-02-24 |
因塞特控股公司 |
作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
|
|
HK1198579A1
(en)
|
2011-08-10 |
2015-04-30 |
Novartis Pharma Ag |
Jak p13k/mtor combination therapy
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
UA111854C2
(uk)
|
2011-09-07 |
2016-06-24 |
Інсайт Холдінгс Корпорейшн |
Способи і проміжні сполуки для отримання інгібіторів jak
|
|
US9394282B2
(en)
*
|
2011-09-22 |
2016-07-19 |
Merck Sharp & Dohme Corp. |
Pyrazole carboxamides as Janus kinase inhibitors
|
|
GB201118652D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118675D0
(en)
|
2011-10-28 |
2011-12-14 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118654D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201118656D0
(en)
|
2011-10-28 |
2011-12-07 |
Astex Therapeutics Ltd |
New compounds
|
|
CN103102359B
(zh)
*
|
2011-11-15 |
2016-11-09 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
CA2856722C
(en)
|
2011-11-30 |
2022-11-22 |
Emory University |
Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
|
|
US9193733B2
(en)
|
2012-05-18 |
2015-11-24 |
Incyte Holdings Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
|
|
GB201209609D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
GB201209613D0
(en)
|
2012-05-30 |
2012-07-11 |
Astex Therapeutics Ltd |
New compounds
|
|
EP2872161B1
(en)
|
2012-06-26 |
2020-12-16 |
Del Mar Pharmaceuticals |
Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations
|
|
US8809359B2
(en)
*
|
2012-06-29 |
2014-08-19 |
Ym Biosciences Australia Pty Ltd |
Phenyl amino pyrimidine bicyclic compounds and uses thereof
|
|
EP2911675A4
(en)
*
|
2012-10-23 |
2016-06-01 |
Merck Sharp & Dohme |
2-PYRIDYLOXY-3-SUBSTITUTED 4-NITRIL-OREXINE RECEPTOR ANTAGONISTS
|
|
BR112015009942A2
(pt)
|
2012-11-01 |
2017-07-11 |
Incyte Corp |
derivados de tiofeno fundidos tricíclicos como inibidores de jak
|
|
US9499539B2
(en)
|
2012-11-05 |
2016-11-22 |
Nantbioscience, Inc. |
Cyclic sulfonamide containing derivatives as inhibitors of hedgehog signaling pathway
|
|
NZ708157A
(en)
|
2012-11-15 |
2019-07-26 |
Incyte Holdings Corp |
Sustained-release dosage forms of ruxolitinib
|
|
WO2014075318A1
(zh)
*
|
2012-11-19 |
2014-05-22 |
江苏先声药业有限公司 |
嘧啶类化合物及其应用
|
|
TWI623531B
(zh)
|
2012-11-21 |
2018-05-11 |
Ｐｔｃ治療公司 |
經取代反向嘧啶ｂｍｉ－１抑制劑
|
|
TWI634121B
(zh)
*
|
2013-03-06 |
2018-09-01 |
英塞特控股公司 |
用於製備ｊａｋ抑制劑之方法及中間物
|
|
WO2014146249A1
(en)
*
|
2013-03-19 |
2014-09-25 |
Merck Sharp & Dohme Corp. |
Geminally substituted cyanoethylpyrazolo pyridones as janus kinase inhibitors
|
|
GB201307577D0
(en)
|
2013-04-26 |
2013-06-12 |
Astex Therapeutics Ltd |
New compounds
|
|
WO2014186706A1
(en)
*
|
2013-05-17 |
2014-11-20 |
Incyte Corporation |
Bipyrazole derivatives as jak inhibitors
|
|
CN105283443B
(zh)
*
|
2013-06-05 |
2018-08-17 |
株式会社C&C新药研究所 |
杂环衍生物及其用途
|
|
MX394928B
(es)
|
2013-08-07 |
2025-03-24 |
Incyte Holdings Corp |
Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
|
|
JP6524094B2
(ja)
*
|
2013-08-30 |
2019-06-05 |
ピーティーシー セラピューティクス， インコーポレイテッド |
置換ピリミジンＢｍｉ−１阻害剤
|
|
CA2929753A1
(en)
|
2013-11-08 |
2015-05-14 |
Bayer Pharma Aktiengesellschaft |
Substituted uracils and use thereof
|
|
US10584115B2
(en)
|
2013-11-21 |
2020-03-10 |
Ptc Therapeutics, Inc. |
Substituted pyridine and pyrazine BMI-1 inhibitors
|
|
CN104860941B
(zh)
*
|
2014-02-25 |
2017-03-22 |
上海海雁医药科技有限公司 |
2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物
|
|
HUE053653T2
(hu)
|
2014-03-26 |
2021-07-28 |
Astex Therapeutics Ltd |
FGFR inhibitor és IGF1R inhibitor kombinációi
|
|
MX370099B
(es)
|
2014-03-26 |
2019-12-02 |
Astex Therapeutics Ltd |
Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer.
|
|
JO3512B1
(ar)
|
2014-03-26 |
2020-07-05 |
Astex Therapeutics Ltd |
مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
|
|
SG11201609016VA
(en)
|
2014-04-30 |
2016-11-29 |
Incyte Corp |
Processes of preparing a jak1 inhibitor and new forms thereto
|
|
US9498467B2
(en)
|
2014-05-30 |
2016-11-22 |
Incyte Corporation |
Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
|
|
WO2016105525A2
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Novel pyrimidines as egfr inhibitors and methods of treating disorders
|
|
JOP20200201A1
(ar)
|
2015-02-10 |
2017-06-16 |
Astex Therapeutics Ltd |
تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
|
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
|
EP3327014A4
(en)
*
|
2015-07-24 |
2019-01-02 |
Shanghai Haiyan Pharmaceutical Technology Co., Ltd. |
Egfr inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof
|
|
JP6898919B2
(ja)
|
2015-09-23 |
2021-07-07 |
ヤンセン ファーマシューティカ エヌ．ベー． |
新規化合物
|
|
WO2017050865A1
(en)
|
2015-09-23 |
2017-03-30 |
Janssen Pharmaceutica Nv |
Bi-heteroaryl substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
|
|
CN110139692B
(zh)
*
|
2016-11-22 |
2023-08-25 |
财团法人生物技术开发中心 |
用于调节刺猬途径的杂芳基胺化合物和其制法和用途
|
|
MX2020003862A
(es)
|
2017-10-18 |
2020-08-13 |
Incyte Corp |
Derivados condensados de imidazol sustituidos por grupos hidroxi terciarios como inhibidores de fosfoinositido 3-cinasas gamma (pi3k-gamma).
|
|
AR113922A1
(es)
|
2017-12-08 |
2020-07-01 |
Incyte Corp |
Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
|
|
WO2019152374A1
(en)
|
2018-01-30 |
2019-08-08 |
Incyte Corporation |
Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one)
|
|
WO2019161098A1
(en)
|
2018-02-16 |
2019-08-22 |
Incyte Corporation |
Jak1 pathway inhibitors for the treatment of cytokine-related disorders
|
|
HUE067471T2
(hu)
|
2018-03-30 |
2024-10-28 |
Incyte Corp |
Gennyes verejtékmirigy-gyulladás kezelése jak inhibitorok alkalmazásával
|
|
US11584961B2
(en)
|
2018-03-30 |
2023-02-21 |
Incyte Corporation |
Biomarkers for inflammatory skin disease
|
|
US11372003B2
(en)
|
2018-04-13 |
2022-06-28 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
US12023335B2
(en)
|
2018-08-17 |
2024-07-02 |
Ptc Therapeutics, Inc. |
Method for treating pancreatic cancer
|
|
CR20250050A
(es)
|
2018-09-05 |
2025-03-19 |
Incyte Corp |
Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
JP7186874B2
(ja)
*
|
2018-10-26 |
2022-12-09 |
アーリーン ファーマシューティカルズ エルエルシー |
ピラゾリル化合物およびその使用方法
|
|
KR20210109522A
(ko)
|
2018-10-31 |
2021-09-06 |
인사이트 코포레이션 |
혈액 질환의 치료를 위한 병용 요법
|
|
WO2020118683A1
(en)
*
|
2018-12-14 |
2020-06-18 |
Lynk Pharmaceuticals Co. Ltd. |
Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
US11919904B2
(en)
|
2019-03-29 |
2024-03-05 |
Incyte Corporation |
Sulfonylamide compounds as CDK2 inhibitors
|
|
EP3956330A4
(en)
|
2019-04-18 |
2023-01-18 |
The Johns Hopkins University |
SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A]PYRIDINE DERIVATIVES AND THEIR USE
|
|
US11447494B2
(en)
|
2019-05-01 |
2022-09-20 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
RS66292B1
(sr)
*
|
2019-06-28 |
2025-01-31 |
Chengdu Zenitar Biomedical Technology Co Ltd |
2,4-disupstituisani derivat pirimidina, način pripreme istog i njegova upotreba
|
|
CN112142731B
(zh)
*
|
2019-06-28 |
2022-07-22 |
成都赜灵生物医药科技有限公司 |
一种2，4-二取代嘧啶衍生物及其制备方法和用途
|
|
PH12022550361A1
(en)
|
2019-08-14 |
2023-02-27 |
Incyte Corp |
Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
|
|
KR20220088699A
(ko)
|
2019-09-27 |
2022-06-28 |
디스크 메디슨, 인크. |
골수섬유증 및 관련 상태의 치료 방법
|
|
US12360120B2
(en)
|
2019-10-10 |
2025-07-15 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
EP4041204A1
(en)
|
2019-10-10 |
2022-08-17 |
Incyte Corporation |
Biomarkers for graft-versus-host disease
|
|
JP7693656B2
(ja)
|
2019-10-11 |
2025-06-17 |
インサイト・コーポレイション |
Ｃｄｋ２阻害剤としての二環式アミン
|
|
CA3160312A1
(en)
|
2019-11-22 |
2021-05-27 |
Incyte Corporation |
Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor
|
|
CA3172750A1
(en)
*
|
2020-03-23 |
2021-09-30 |
Ge Hyeong Lee |
Novel pyrimidine derivative, and composition for preventing or treating neurodegenerative diseases and cancer, comprising same
|
|
JP2023528223A
(ja)
|
2020-05-13 |
2023-07-04 |
ディスク・メディシン・インコーポレイテッド |
骨髄線維症を処置するための抗ヘモジュベリン（ｈｊｖ）抗体
|
|
JP2023528868A
(ja)
|
2020-06-02 |
2023-07-06 |
インサイト・コーポレイション |
Ｊａｋ１阻害剤の調製プロセス
|
|
US11833155B2
(en)
|
2020-06-03 |
2023-12-05 |
Incyte Corporation |
Combination therapy for treatment of myeloproliferative neoplasms
|
|
WO2022040180A1
(en)
|
2020-08-18 |
2022-02-24 |
Incyte Corporation |
Process and intermediates for preparing a jak inhibitor
|
|
BR112023002939A2
(pt)
|
2020-08-18 |
2023-04-25 |
Incyte Corp |
Processo e intermediários para preparar um inibidor de jak1
|
|
CN114181199B
(zh)
*
|
2020-09-15 |
2023-09-26 |
成都赜灵生物医药科技有限公司 |
2，4-二取代嘧啶衍生物及其制备方法和用途
|
|
CN112159394B
(zh)
*
|
2020-10-09 |
2021-10-22 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
CN112142675B
(zh)
*
|
2020-10-09 |
2021-11-30 |
嘉兴特科罗生物科技有限公司 |
一种作为jak激酶抑制剂的小分子化合物及其用途
|
|
JP2023552452A
(ja)
|
2020-12-08 |
2023-12-15 |
インサイト・コーポレイション |
白斑治療用のｊａｋ１経路阻害薬
|
|
WO2022166916A1
(zh)
*
|
2021-02-05 |
2022-08-11 |
深圳市塔吉瑞生物医药有限公司 |
取代的杂芳基衍生物及其组合物及用途
|
|
US12268667B2
(en)
|
2021-05-03 |
2025-04-08 |
Incyte Corporation |
JAK1 pathway inhibitors for the treatment of prurigo nodularis
|
|
US11981671B2
(en)
|
2021-06-21 |
2024-05-14 |
Incyte Corporation |
Bicyclic pyrazolyl amines as CDK2 inhibitors
|
|
JP2024526762A
(ja)
|
2021-07-12 |
2024-07-19 |
インサイト・コーポレイション |
Ｊａｋ阻害剤を調製するためのプロセス及び中間体
|
|
AU2022361055A1
(en)
*
|
2021-10-06 |
2024-04-04 |
Alcon Inc. |
Janus kinase inhibiting pyrazole compounds and uses thereof
|
|
US11976073B2
(en)
|
2021-12-10 |
2024-05-07 |
Incyte Corporation |
Bicyclic amines as CDK2 inhibitors
|
|
JP2025529836A
(ja)
*
|
2022-08-22 |
2025-09-09 |
ハンチョウ ハイライトゥル ファーマシューティカル カンパニー リミテッド |
皮膚疾患の局所的処置のためのｊａｋ１／ｊａｋ２／ｔｙｋ２阻害剤
|
|
CN115594664B
(zh)
*
|
2022-11-25 |
2023-02-24 |
英矽智能科技(上海)有限公司 |
一类螺环衍生物作为kif18a抑制剂
|