JP2011503150A5 - - Google Patents
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- JP2011503150A5 JP2011503150A5 JP2010533594A JP2010533594A JP2011503150A5 JP 2011503150 A5 JP2011503150 A5 JP 2011503150A5 JP 2010533594 A JP2010533594 A JP 2010533594A JP 2010533594 A JP2010533594 A JP 2010533594A JP 2011503150 A5 JP2011503150 A5 JP 2011503150A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkyloxy
- oxo
- piperazin
- carbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(N(CC1)C2CC(*)=C(*)C1C2)=O Chemical compound *C(N(CC1)C2CC(*)=C(*)C1C2)=O 0.000 description 3
- BJXTXJPIWACIGE-UHFFFAOYSA-N CC(CC1)(C2)c3n[nH]c(O)c3CC2N1C(c1ccccc1)=O Chemical compound CC(CC1)(C2)c3n[nH]c(O)c3CC2N1C(c1ccccc1)=O BJXTXJPIWACIGE-UHFFFAOYSA-N 0.000 description 1
- OWLQOGDUQQKVJE-UHFFFAOYSA-N CC(CC1)(C2)c3ncccc3CC2N1C(c1ccccc1)=O Chemical compound CC(CC1)(C2)c3ncccc3CC2N1C(c1ccccc1)=O OWLQOGDUQQKVJE-UHFFFAOYSA-N 0.000 description 1
- XIGIWJPCMRDPCW-UHFFFAOYSA-N CC(CC1)(CC(C2)N1C(c1ccccc1)=O)c1c2c(cccc2)c2[nH]1 Chemical compound CC(CC1)(CC(C2)N1C(c1ccccc1)=O)c1c2c(cccc2)c2[nH]1 XIGIWJPCMRDPCW-UHFFFAOYSA-N 0.000 description 1
- WWZVFPCAATXZIJ-OXJNMPFZSA-N C[C@@](C1)(C2)c3cc(OC)ccc3C[C@@H]1N2C(c1ccccc1)=O Chemical compound C[C@@](C1)(C2)c3cc(OC)ccc3C[C@@H]1N2C(c1ccccc1)=O WWZVFPCAATXZIJ-OXJNMPFZSA-N 0.000 description 1
- WWZVFPCAATXZIJ-UZLBHIALSA-N C[C@](C1)(C2)c3cc(OC)ccc3C[C@H]1N2C(c1ccccc1)=O Chemical compound C[C@](C1)(C2)c3cc(OC)ccc3C[C@H]1N2C(c1ccccc1)=O WWZVFPCAATXZIJ-UZLBHIALSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07120914.2 | 2007-11-16 | ||
| EP07120914 | 2007-11-16 | ||
| EP07123942 | 2007-12-21 | ||
| EP07123942.0 | 2007-12-21 | ||
| EP08155137.6 | 2008-04-24 | ||
| EP08155137 | 2008-04-24 | ||
| PCT/EP2008/065577 WO2009063061A2 (en) | 2007-11-16 | 2008-11-14 | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126666A Division JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011503150A JP2011503150A (ja) | 2011-01-27 |
| JP2011503150A5 true JP2011503150A5 (cg-RX-API-DMAC7.html) | 2012-01-19 |
| JP5769970B2 JP5769970B2 (ja) | 2015-08-26 |
Family
ID=40560240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533594A Active JP5769970B2 (ja) | 2007-11-16 | 2008-11-14 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
| JP2015126666A Active JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015126666A Active JP6134754B2 (ja) | 2007-11-16 | 2015-06-24 | ベンゾモルファン及び関連骨格のアリール−及びヘテロアリールカルボニル誘導体、かかる化合物を含有する医薬及びこれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8859580B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2220048B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5769970B2 (cg-RX-API-DMAC7.html) |
| AR (1) | AR069545A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2704628C (cg-RX-API-DMAC7.html) |
| CL (1) | CL2008003407A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200927115A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009063061A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| ES2395081T3 (es) | 2007-07-26 | 2013-02-08 | Vitae Pharmaceuticals, Inc. | Síntesis de inhibidores de la 11beta-hidroxiesteroide deshidrogenasa de tipo 1 |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| US8859580B2 (en) | 2007-11-16 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| EP2229368A1 (en) | 2007-12-11 | 2010-09-22 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| TW200934490A (en) | 2008-01-07 | 2009-08-16 | Vitae Pharmaceuticals Inc | Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1 |
| JP5490020B2 (ja) | 2008-01-24 | 2014-05-14 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター |
| CA2714532A1 (en) * | 2008-02-11 | 2009-08-20 | Vitae Pharmaceuticals, Inc. | 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| US20110028445A1 (en) * | 2008-02-12 | 2011-02-03 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| JP5730021B2 (ja) | 2008-02-15 | 2015-06-03 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体 |
| EP2274287B1 (en) * | 2008-03-18 | 2016-03-09 | Vitae Pharmaceuticals, Inc. | Inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| TW200946520A (en) * | 2008-05-01 | 2009-11-16 | Vitae Pharmaceuticals Inc | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CL2009001058A1 (es) | 2008-05-01 | 2010-09-10 | Vitae Pharmaceuticals Inc | Compuestos derivados de oxazinas sustituidas, inhibidores de la 11b-hidroxiesteroide deshidrogenasa de tipo-1; composicion farmaceutica; y uso del compuesto para inhibir la actividad de 11b-hsd1, como en el tratamiento de la diabetes, dislipidemia, hipertension, obesidad, cancer, glaucoma, entre otras. |
| CA2723034A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2723032A1 (en) * | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2724214A1 (en) * | 2008-05-13 | 2009-11-19 | Boehringer Ingelheim International Gmbh | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| JP5390610B2 (ja) | 2008-07-25 | 2014-01-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成 |
| CA2729998A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| EP2324018B1 (en) | 2008-07-25 | 2013-09-04 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| CA2738453C (en) | 2008-10-23 | 2017-07-04 | Boehringer Ingelheim International Gmbh | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| EA019320B1 (ru) | 2008-12-22 | 2014-02-28 | Мерк Патент Гмбх | Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения |
| JP5679997B2 (ja) | 2009-02-04 | 2015-03-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤 |
| UA109255C2 (ru) | 2009-04-30 | 2015-08-10 | Берінгер Інгельхайм Інтернешнл Гмбх | Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1 |
| US8703765B2 (en) | 2009-06-02 | 2014-04-22 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2440537A1 (en) | 2009-06-11 | 2012-04-18 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| WO2011002910A1 (en) | 2009-07-01 | 2011-01-06 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011056737A1 (en) | 2009-11-05 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Novel chiral phosphorus ligands |
| UY33001A (es) * | 2009-11-06 | 2011-05-31 | Boehringer Ingelheim Int | Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| JP2013531636A (ja) | 2010-05-26 | 2013-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−オキソ−１，２−ジヒドロピリジン−４−イルボロン酸誘導体 |
| WO2011159760A1 (en) | 2010-06-16 | 2011-12-22 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| EA201300522A1 (ru) | 2010-11-02 | 2013-11-29 | Бёрингер Ингельхайм Интернациональ Гмбх | Фармацевтические комбинации для лечения метаболических нарушений |
| TWI537258B (zh) | 2010-11-05 | 2016-06-11 | 百靈佳殷格翰國際股份有限公司 | 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物 |
| US8735585B2 (en) | 2011-08-17 | 2014-05-27 | Boehringer Ingelheim International Gmbh | Indenopyridine derivatives |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8962660B2 (en) | 2013-03-14 | 2015-02-24 | Bristol-Myers Squibb Company | Oxabicyclo [2.2.2] acid GPR120 modulators |
| WO2015009742A2 (en) | 2013-07-15 | 2015-01-22 | Board Of Regents, The University Of Texas System | Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain |
| CN107922341A (zh) * | 2015-08-28 | 2018-04-17 | 日本脏器制药株式会社 | 新型的4‑苯并偶氮宁衍生物的制造方法 |
| CA3001484A1 (en) | 2015-10-19 | 2017-04-27 | Board Of Regents, The University Of Texas System | Piperazinyl norbenzomorphan compounds and methods for using the same |
| WO2017190109A1 (en) | 2016-04-29 | 2017-11-02 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
| WO2019121143A1 (en) | 2017-12-20 | 2019-06-27 | Basf Se | Substituted cyclopropyl derivatives |
| CN115160341B (zh) * | 2022-07-18 | 2023-07-18 | 中国医学科学院医学实验动物研究所 | 苯并噁嗪类化合物及其药物用途 |
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-
2008
- 2008-11-14 US US12/742,680 patent/US8859580B2/en active Active
- 2008-11-14 JP JP2010533594A patent/JP5769970B2/ja active Active
- 2008-11-14 EP EP08850194.5A patent/EP2220048B1/en active Active
- 2008-11-14 AR ARP080104991A patent/AR069545A1/es unknown
- 2008-11-14 CA CA2704628A patent/CA2704628C/en active Active
- 2008-11-14 TW TW097144255A patent/TW200927115A/zh unknown
- 2008-11-14 CL CL2008003407A patent/CL2008003407A1/es unknown
- 2008-11-14 WO PCT/EP2008/065577 patent/WO2009063061A2/en not_active Ceased
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2015
- 2015-06-24 JP JP2015126666A patent/JP6134754B2/ja active Active
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