JP2011501661A5 - - Google Patents
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- JP2011501661A5 JP2011501661A5 JP2010528141A JP2010528141A JP2011501661A5 JP 2011501661 A5 JP2011501661 A5 JP 2011501661A5 JP 2010528141 A JP2010528141 A JP 2010528141A JP 2010528141 A JP2010528141 A JP 2010528141A JP 2011501661 A5 JP2011501661 A5 JP 2011501661A5
- Authority
- JP
- Japan
- Prior art keywords
- acid
- oil
- weight percent
- eicosapentaenoic
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 9
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 9
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 9
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 9
- 230000000813 microbial effect Effects 0.000 claims 8
- 241001465754 Metazoa Species 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims 5
- 229930195729 fatty acid Natural products 0.000 claims 5
- 239000000194 fatty acid Substances 0.000 claims 5
- 150000004665 fatty acids Chemical class 0.000 claims 5
- 235000013305 food Nutrition 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 241000235013 Yarrowia Species 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 2
- 239000002028 Biomass Substances 0.000 claims 2
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 2
- 241000282412 Homo Species 0.000 claims 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 2
- 244000144974 aquaculture Species 0.000 claims 2
- 238000009360 aquaculture Methods 0.000 claims 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 108010022240 delta-8 fatty acid desaturase Proteins 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 235000020778 linoleic acid Nutrition 0.000 claims 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims 1
- BBWMTEYXFFWPIF-CJBMEHDJSA-N (2e,4e,6e)-icosa-2,4,6-trienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C=C\C(O)=O BBWMTEYXFFWPIF-CJBMEHDJSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- 235000021297 Eicosadienoic acid Nutrition 0.000 claims 1
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 241000490645 Yarrowia sp. Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 1
- 235000021342 arachidonic acid Nutrition 0.000 claims 1
- 229940114079 arachidonic acid Drugs 0.000 claims 1
- BIRYUMUXPVBNBH-UHFFFAOYSA-N docosa-1,3,5,7-tetraene Chemical compound CCCCCCCCCCCCCCC=CC=CC=CC=C BIRYUMUXPVBNBH-UHFFFAOYSA-N 0.000 claims 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 1
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 1
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 1
- 235000013376 functional food Nutrition 0.000 claims 1
- 229940098330 gamma linoleic acid Drugs 0.000 claims 1
- VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 1
- VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 1
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims 1
- 229960002733 gamolenic acid Drugs 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 229960004488 linolenic acid Drugs 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97717707P | 2007-10-03 | 2007-10-03 | |
| US97717407P | 2007-10-03 | 2007-10-03 | |
| US60/977,177 | 2007-10-03 | ||
| US60/977,174 | 2007-10-03 | ||
| PCT/US2008/078642 WO2009046231A1 (en) | 2007-10-03 | 2008-10-03 | Optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501661A JP2011501661A (ja) | 2011-01-13 |
| JP2011501661A5 true JP2011501661A5 (cg-RX-API-DMAC7.html) | 2011-11-17 |
| JP5711968B2 JP5711968B2 (ja) | 2015-05-07 |
Family
ID=40084411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528141A Expired - Fee Related JP5711968B2 (ja) | 2007-10-03 | 2008-10-03 | 高エイコサペンタエン酸を生成するためのヤロウィア・リポリティカ（ＹａｒｒｏｗｉａＬｉｐｏｌｙｔｉｃａ）の最適化株 |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US20090117253A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2195415A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5711968B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101970638B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2701094A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009046231A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7794701B2 (en) * | 2007-04-16 | 2010-09-14 | E.I. Du Pont De Nemours And Company | Δ-9 elongases and their use in making polyunsaturated fatty acids |
| US7943365B2 (en) * | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| US8476059B2 (en) | 2007-06-01 | 2013-07-02 | Solazyme, Inc. | Sucrose feedstock utilization for oil-based fuel manufacturing |
| DK2324120T3 (en) | 2008-08-29 | 2016-05-02 | Du Pont | Manipulating SNF1 protein kinase OF REVISION OF OIL CONTENT IN OLEAGINOUS ORGANISMS |
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| US9175318B2 (en) | 2008-12-18 | 2015-11-03 | E. I. Dupont De Nemours And Company | Reducing byproduction of malonates by yeast in a fermentation process |
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| EP2475679B1 (en) * | 2009-06-16 | 2016-02-10 | E. I. du Pont de Nemours and Company | Improved optimized strains of yarrowia lipolytica for high eicosapentaenoic acid production |
| CA2763424C (en) * | 2009-06-16 | 2018-06-12 | E.I. Du Pont De Nemours And Company | Improvement of long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-coa lysophospholipid acyltransferases |
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| JP5920890B2 (ja) * | 2010-01-19 | 2016-05-18 | ディーエスエム アイピー アセッツ ビー．ブイ． | エイコサペンタエン酸生成微生物、脂肪酸組成物、ならびにそれらを作る方法およびそれらの使用 |
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| AU2011293180B2 (en) * | 2010-08-26 | 2017-03-02 | E. I. Du Pont De Nemours And Company | Recombinant microbial host cells for high eicosapentaenoic acid production |
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| KR20140008295A (ko) * | 2010-08-26 | 2014-01-21 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 돌연변이 델타-9 연장효소 및 다중불포화 지방산의 제조에서의 그들의 용도 |
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| CN116121093B (zh) * | 2022-12-12 | 2025-11-07 | 浙江大学杭州国际科创中心 | 一种用于表达细胞色素p450的工程酵母菌株及其应用 |
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| CN118703533B (zh) * | 2024-08-01 | 2025-11-21 | 湖南农业大学 | OsGAT3基因在调控水稻Cd、Cu或Mn含量及株高中的应用 |
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| DE3783396T2 (de) | 1986-07-08 | 1993-07-29 | Suntory Ltd | Verfahren zur herstellung von bishomo-gamma-linolensaeure und eicosapentaensaeure. |
| US5246841A (en) | 1986-12-26 | 1993-09-21 | Sagami Chemical Research Center | Microbial process for production of eicosapentaenoic acid |
| US5244921A (en) | 1990-03-21 | 1993-09-14 | Martek Corporation | Eicosapentaenoic acids and methods for their production |
| US5246842A (en) | 1991-10-30 | 1993-09-21 | The United States Of America As Represented By The Secretary Of Agriculture | Production of eicosapentaenoic acid from filamentous fungi utilizing lactose as a primary carbon source |
| IL129367A0 (en) | 1996-10-11 | 2000-02-17 | Scotia Holdings Plc | Pharmaceutical preparation comprising eicosapentaenoic acid and/or stearidonic acid |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6825017B1 (en) | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| DK1088552T3 (da) * | 1999-09-30 | 2006-05-29 | Loders Croklaan Bv | Sammensætninger, der indeholder pinolensyre, samt deres anvendelse som en sund bestanddel |
| EP1279400A1 (en) | 2001-07-25 | 2003-01-29 | Target Hit sa | Modifying the fatty acid composition of cell membranes of organs and tissues |
| CN1309813C (zh) | 2002-08-07 | 2007-04-11 | 花王株式会社 | 油脂组合物 |
| US7410663B2 (en) | 2002-08-07 | 2008-08-12 | Kao Corporation | Oil or fat composition |
| BR0317609B1 (pt) | 2002-12-20 | 2013-10-08 | Textura laminada com tufos | |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US8313911B2 (en) * | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7214491B2 (en) | 2003-05-07 | 2007-05-08 | E. I. Du Pont De Nemours And Company | Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts |
| US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| US7504259B2 (en) * | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| EP1758991B1 (en) | 2004-06-25 | 2013-01-16 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7465564B2 (en) | 2004-08-10 | 2008-12-16 | E.I. Du Pont De Nemours And Company | Production of γ-linolenic acid in oleaginous yeast |
| US7588931B2 (en) * | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
| AU2006247618A1 (en) * | 2005-05-12 | 2006-11-23 | Martek Biosciences Corporation | Biomass hydrolysate and uses and production thereof |
| FR2888976B1 (fr) | 2005-07-25 | 2007-10-12 | Oberthur Card Syst Sa | Entite electronique avec moyens de communication par contact et a distance |
| AU2006316610B2 (en) | 2005-11-23 | 2012-06-14 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US20070225370A1 (en) | 2006-03-21 | 2007-09-27 | Joar Opheim | Nutritional Compositions and Methods |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| US7709239B2 (en) * | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| UA103595C2 (uk) | 2007-04-03 | 2013-11-11 | Е. І. Дю Пон Де Немур Енд Компані | Мультизими і їх застосування в отриманні поліненасичених жирних кислот |
| US7790156B2 (en) * | 2007-04-10 | 2010-09-07 | E. I. Du Pont De Nemours And Company | Δ-8 desaturases and their use in making polyunsaturated fatty acids |
-
2008
- 2008-10-03 CN CN200880118875.4A patent/CN101970638B/zh not_active Expired - Fee Related
- 2008-10-03 CA CA2701094A patent/CA2701094A1/en not_active Abandoned
- 2008-10-03 JP JP2010528141A patent/JP5711968B2/ja not_active Expired - Fee Related
- 2008-10-03 US US12/244,950 patent/US20090117253A1/en not_active Abandoned
- 2008-10-03 US US12/244,822 patent/US8323935B2/en active Active
- 2008-10-03 EP EP08835977A patent/EP2195415A1/en not_active Withdrawn
- 2008-10-03 WO PCT/US2008/078642 patent/WO2009046231A1/en not_active Ceased
-
2012
- 2012-07-20 US US13/554,429 patent/US8735108B2/en active Active
-
2013
- 2013-02-28 US US13/780,532 patent/US8822185B2/en active Active
-
2014
- 2014-07-22 US US14/337,593 patent/US9617571B2/en active Active
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