JP2011182797A5 - - Google Patents

Download PDF

Info

Publication number
JP2011182797A5
JP2011182797A5 JP2011095240A JP2011095240A JP2011182797A5 JP 2011182797 A5 JP2011182797 A5 JP 2011182797A5 JP 2011095240 A JP2011095240 A JP 2011095240A JP 2011095240 A JP2011095240 A JP 2011095240A JP 2011182797 A5 JP2011182797 A5 JP 2011182797A5
Authority
JP
Japan
Prior art keywords
linked
vector
termination sequence
transcription termination
influenza virus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011095240A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011182797A (ja
JP5775351B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011182797A publication Critical patent/JP2011182797A/ja
Publication of JP2011182797A5 publication Critical patent/JP2011182797A5/ja
Application granted granted Critical
Publication of JP5775351B2 publication Critical patent/JP5775351B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2011095240A 1999-04-06 2011-04-21 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス Expired - Lifetime JP5775351B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12791299P 1999-04-06 1999-04-06
US60/127,912 1999-04-06
US13283999P 1999-05-06 1999-05-06
US60/132,839 1999-05-06

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000609542A Division JP5543048B2 (ja) 1999-04-06 2000-04-05 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015071406A Division JP6224645B2 (ja) 1999-04-06 2015-03-31 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス

Publications (3)

Publication Number Publication Date
JP2011182797A JP2011182797A (ja) 2011-09-22
JP2011182797A5 true JP2011182797A5 (https=) 2013-04-04
JP5775351B2 JP5775351B2 (ja) 2015-09-09

Family

ID=26826080

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000609542A Expired - Lifetime JP5543048B2 (ja) 1999-04-06 2000-04-05 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス
JP2011095240A Expired - Lifetime JP5775351B2 (ja) 1999-04-06 2011-04-21 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス
JP2015071406A Expired - Lifetime JP6224645B2 (ja) 1999-04-06 2015-03-31 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000609542A Expired - Lifetime JP5543048B2 (ja) 1999-04-06 2000-04-05 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015071406A Expired - Lifetime JP6224645B2 (ja) 1999-04-06 2015-03-31 ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス

Country Status (19)

Country Link
EP (4) EP1820853B1 (https=)
JP (3) JP5543048B2 (https=)
KR (1) KR100702275B1 (https=)
CN (2) CN101851636B (https=)
AT (2) ATE368729T1 (https=)
AU (1) AU4073300A (https=)
BR (1) BRPI0009580B8 (https=)
CA (2) CA2365526C (https=)
CY (2) CY1108520T1 (https=)
DE (6) DE122008000035I1 (https=)
DK (3) DK2345716T3 (https=)
ES (3) ES2290024T3 (https=)
FR (1) FR11C0027I2 (https=)
HK (1) HK1214298A1 (https=)
IL (2) IL145702A0 (https=)
MX (1) MXPA01010082A (https=)
NL (2) NL300364I2 (https=)
PT (2) PT1820853E (https=)
WO (1) WO2000060050A2 (https=)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
EP1820853B1 (en) * 1999-04-06 2011-09-21 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
GB9916794D0 (en) * 1999-07-16 1999-09-22 Isis Innovation In vitro virus reconstitution
ES2278621T5 (es) * 1999-07-14 2011-02-02 Mount Sinai School Of Medicine Of New York University Reconstrucción in vitro de virus arn segmentados de polaridad negativa.
MXPA02010642A (es) 2000-04-28 2004-05-17 St Jude Children S Res Hospital Sistema de transfeccion de adn para la generacion de virus de influenza infeccioso.
EP1862550A1 (en) * 2000-06-23 2007-12-05 Wyeth Holdings Corporation Assembly of wild-type and chimeric influenza virus-like particles (VLPs)
JP5008244B2 (ja) 2000-06-23 2012-08-22 ワイス・ホールディングズ・コーポレイション 野性型およびキメラのインフルエンザウイルス様粒子（ｖｌｐ）のアセンブリー
US7211378B2 (en) 2002-01-31 2007-05-01 Wisconsin Alumni Research Foundation Filovirus vectors and noninfectious filovirus-based particles
AU2003219745B8 (en) 2002-02-13 2008-10-09 Wisconsin Alumni Research Foundation Signal for packaging of influenza virus vectors
ES2526191T3 (es) 2002-04-26 2015-01-08 Medimmune, Llc Método para producir virus influenza B infeccioso en cultivo celular
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
AU2004249133B2 (en) * 2003-05-28 2009-05-28 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines and gene therapy
US7566458B2 (en) 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
ATE469972T1 (de) 2003-12-23 2010-06-15 Medimmune Llc Multiplasmid-system zur erzeugung des grippevirus
FR2866031B1 (fr) * 2004-02-11 2012-10-19 David Francois Joseph Millet Chimere de virus pathogene emergent, medicament la contenant et utilisation en therapie antivirale
WO2005107797A1 (en) 2004-03-09 2005-11-17 Chiron Corporation Influenza virus vaccines
CA2879182C (en) 2004-05-25 2017-02-14 Medimmune, Inc. Influenza hemagglutinin and neuraminidase variants
CN101103103A (zh) 2004-11-19 2008-01-09 威斯康星旧生研究基金会 具有串联转录单位的重组流感病毒载体
ES2536745T3 (es) 2004-12-08 2015-05-28 Medimmune, Llc Métodos de producción de composiciones de vacuna contra la gripe
EP2295542B1 (en) 2004-12-24 2013-01-30 Abbott Biologicals B.V. Rescue of influenza virus
EP2441471B1 (en) 2005-03-08 2014-10-08 MedImmune, LLC Reassortant influenza viruses
US11707520B2 (en) 2005-11-03 2023-07-25 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
NZ568211A (en) 2005-11-04 2011-11-25 Novartis Vaccines & Diagnostic Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
ES2420829T3 (es) * 2005-11-04 2013-08-27 Novartis Vaccines And Diagnostics S.R.L. Vacunas adyuvantadas con antígeno de no virión preparadas a partir de virus de la gripe cultivados en cultivo celular
EP1951298A1 (en) 2005-11-04 2008-08-06 Novartis Vaccines and Diagnostics S.r.l. Adjuvanted influenza vaccines including cytokine-inducing agents
WO2007052061A2 (en) 2005-11-04 2007-05-10 Novartis Vaccines And Diagnostics Srl Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines
KR101492643B1 (ko) 2005-12-02 2015-02-12 이칸 스쿨 오브 메디슨 엣 마운트 시나이 비-천연 표면 단백질을 제시하는 키메라 바이러스 및 그의용도
EP3753574A1 (en) 2006-01-27 2020-12-23 Seqirus UK Limited Influenza vaccines containing hemagglutinin and matrix proteins
EP2004226A1 (en) 2006-03-24 2008-12-24 Novartis Vaccines and Diagnostics GmbH & Co. KG Storage of influenza vaccines without refrigeration
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
US20090017444A1 (en) * 2006-06-09 2009-01-15 Wisconsin Alumni Research Foundation Screening method for modulators of viral transcription or replication
GB0614460D0 (en) 2006-07-20 2006-08-30 Novartis Ag Vaccines
WO2008133701A1 (en) 2006-07-21 2008-11-06 Medimmune, Llc. Methods and compositions for increasing replication capacity of an influenza virus
EP2056872A4 (en) 2006-08-09 2016-12-21 Medimmune Llc INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS
ES2536401T3 (es) 2006-09-11 2015-05-25 Novartis Ag Fabricación de vacunas contra virus de la gripe sin usar huevos
SG177141A1 (en) 2006-12-06 2012-01-30 Novartis Ag Vaccines including antigen from four strains of influenza virus
US8597661B2 (en) 2007-05-04 2013-12-03 Wisconsin Alumni Research Foundation Neuraminidase-deficient live influenza vaccines
CA2690196A1 (en) 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
EA201070066A1 (ru) 2007-06-27 2010-06-30 Новартис Аг Вакцины против гриппа с низким содержанием добавок
EP2045323A1 (en) * 2007-10-05 2009-04-08 Avir Green Hills Biotechnology Research Development Trade Ag Linear expression constructs for production of influenza virus particles
CN101497877B (zh) * 2008-01-28 2012-09-05 河北摩百生物科技有限公司 流感全病毒减活疫苗重组体、其构建方法及应用
WO2009115917A2 (en) 2008-03-18 2009-09-24 Novartis Ag Improvements in preparation of influenza virus vaccine antigens
WO2010006144A2 (en) 2008-07-11 2010-01-14 Medlmmune, Llc. Influenza hemagglutinin and neuraminidase variants
US20110195091A1 (en) 2008-08-18 2011-08-11 The Kitasato Institute Avian Influenza Virus Antigen, and Booster Immunization Method for Avian Influenza Vaccine in Combination with Mucosal Adjuvant Which is Effective Through Oral Administration
EP2233568A1 (en) 2009-03-19 2010-09-29 Avir Green Hills Biotechnology Research Development Trade AG Novel method for generation of RNA virus
SI2396030T1 (sl) 2009-02-10 2015-12-31 Novartis Ag Sheme dajanja cepiva proti gripi za seve, povezane s pandemijo
AU2010212548A1 (en) 2009-02-10 2011-09-15 Novartis Ag Influenza vaccines with increased amounts of H3 antigen
WO2010092479A2 (en) 2009-02-10 2010-08-19 Novartis Ag Influenza vaccines with reduced amounts of squalene
CN102361649A (zh) 2009-02-12 2012-02-22 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
FR2949344A1 (fr) 2009-04-27 2011-03-04 Novartis Ag Vaccins de protection contre la grippe
CN102695523A (zh) 2009-09-10 2012-09-26 诺华有限公司 针对呼吸道疾病的组合疫苗
EP2493912B1 (en) 2009-10-26 2020-07-29 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2013529913A (ja) 2010-06-02 2013-07-25 アヴィール グリーン ヒルズ バイオテクノロジー リサーチ ディベロプメント トレード アクチエンゲゼルシャフト Ｒｎａウィルスの作製のための方法及びヘルパーウィルス
CN102220293B (zh) * 2011-05-26 2012-12-19 中国农业科学院上海兽医研究所 犬流感重组病毒及其制备方法和应用
ES2655051T3 (es) 2011-08-26 2018-02-16 Wisconsin Alumni Research Foundation Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas
US20140302077A1 (en) 2011-09-02 2014-10-09 Westfaelische Wilhelms-Universitaet Munester Live attenuated influenza virus
CA2852857A1 (en) 2011-10-20 2013-04-25 Novartis Ag Adjuvanted influenza b virus vaccines for pediatric priming
GB201218195D0 (en) 2012-10-10 2012-11-21 Istituto Zooprofilattico Sperimentale Delle Venezie Composition
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CN104450695B (zh) * 2014-11-26 2017-08-25 扬州大学 A型流感病毒基因pcr扩增引物及其快速克隆方法
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
EP3307308A2 (en) * 2015-06-10 2018-04-18 Hookipa Biotech AG Hpv vaccines
HK1254344A1 (zh) 2015-06-26 2019-07-19 Seqirus UK Limited 抗原匹配的流感疫苗
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
HUE051783T2 (hu) 2015-07-07 2021-03-29 Seqirus Uk Ltd Eljárás immunogén hemagglutinin mennyiségi meghatározására
WO2017040203A1 (en) * 2015-08-28 2017-03-09 Yoshihiro Kawaoka Generation of infectious influenza viruses from virus-like particles
CA3014435C (en) 2016-02-19 2023-04-18 Wisconsin Alumni Research Foundation (Warf) Improved influenza b virus replication for vaccine development
US11013695B2 (en) * 2017-08-28 2021-05-25 Wisconsin Alumni Research Foundation Nanocapsule delivery system for ribonucleoproteins
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION
CN107964035B (zh) * 2017-12-06 2020-07-24 中国科学院微生物研究所 一种用于流感病毒的有限复制型黏膜免疫疫苗
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
CN109097341B (zh) * 2018-08-28 2021-09-24 青岛农业大学 一种同时表达ha和hef的复制缺陷型重组流感病毒
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
WO2021150874A1 (en) 2020-01-24 2021-07-29 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized na
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840520A (en) * 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
US5658772A (en) 1989-12-22 1997-08-19 E. I. Du Pont De Nemours And Company Site-specific recombination of DNA in plant cells
US5919676A (en) * 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
EP0704533A1 (en) * 1994-09-30 1996-04-03 Bayer Ag An attenuated vaccination virus, a method to make the virus and a pharmaceutical compositions comprising the virus
WO1996010633A1 (en) * 1994-09-30 1996-04-11 Aviron Chimeric influenza virus and electroporation method
CN1200675A (zh) * 1995-10-20 1998-12-02 耶路撒冷希伯来语大学依苏姆研究开发公司 流感疫苗
US5994526A (en) * 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
EP1035209A1 (en) * 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
EP1820853B1 (en) * 1999-04-06 2011-09-21 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy

Similar Documents

Publication Publication Date Title
JP2011182797A5 (https=)
EP1631663B1 (en) High titer recombinant influenza viruses for vaccines and gene therapy
US7723094B2 (en) Recombinant influenza vectors with a polII promoter and ribozymes for vaccines and gene therapy
JP2015119730A5 (https=)
JP5438065B2 (ja) 突然変異した膜タンパク質をコードするウイルス
EP2010557B1 (en) High titer recombinant influenza viruses for vaccines
JP2010042030A5 (https=)
JP2022172369A (ja) 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス
JP2020010711A (ja) Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
US20060134138A1 (en) Recombinant influenza viruses for vaccines and gene therapy
RU2008101367A (ru) Способы и композиции для экспрессии отрицательной смысловой вирусной рнк в собачьих клетках
JP2012511579A5 (https=)
CA2406100A1 (en) Dna transfection system for the generation of infectious influenza virus
CN114929269A (zh) 用于疫苗开发的改进的流感病毒复制
JP2016521553A5 (https=)
CN1350578A (zh) 用于疫苗和基因治疗的重组流感病毒
WO2008156681A2 (en) Adenoviral vectors for influenza virus production
JP2016501020A5 (https=)
CN104195154B (zh) 新城疫病毒Mukteswar中等毒力疫苗株反向遗传操作系统及其应用
CN111363728A (zh) 携带乙型肝炎病毒基因的重组甲型流感病毒、宿主细胞及其制备方法与应用
CN116144612A (zh) 重组乙型流感病毒及其制备方法与应用
Elderfield et al. Using reverse genetics to improve influenza vaccines
HK1082769B (en) High titer recombinant influenza viruses for vaccines and gene therapy
Kawaoka et al. Recombinant influenza vectors with a polII promoter and ribozymes for vaccines and gene therapy
MXPA05012700A (en) Recombinant influenza vectors with a polii promoter and ribozymes