|
EP2016953A3
(en)
|
1998-12-22 |
2009-04-15 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists and uses thereof
|
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
|
IL145941A
(en)
|
1999-04-28 |
2007-08-19 |
Univ Texas |
Compositions and methods for cancer treatment by selectively inhibiting vegf
|
|
LT2762140T
(lt)
|
2001-02-19 |
2017-06-26 |
Novartis Ag |
Solidinių smegenų navikų gydymas rapamicino dariniu
|
|
BR0209647A
(pt)
|
2001-05-16 |
2004-07-27 |
Novartis Ag |
Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico
|
|
EE200300559A
(et)
*
|
2001-05-17 |
2004-02-16 |
Applied Research Systems Ars Holding N.V. |
Osteopontiini kasutamine neuroloogiliste haigusteraviks ja/või vältimiseks
|
|
AU2002319402B2
(en)
*
|
2001-06-28 |
2008-09-11 |
Domantis Limited |
Dual-specific ligand and its use
|
|
US20050271663A1
(en)
*
|
2001-06-28 |
2005-12-08 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
|
TWI315982B
(en)
|
2001-07-19 |
2009-10-21 |
Novartis Ag |
Combinations comprising epothilones and pharmaceutical uses thereof
|
|
GB0206215D0
(en)
|
2002-03-15 |
2002-05-01 |
Novartis Ag |
Organic compounds
|
|
CA2483594C
(en)
|
2002-05-16 |
2011-02-15 |
Novartis Ag |
Use of edg receptor binding agents in cancer
|
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
|
US9321832B2
(en)
*
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
|
EP1600459A3
(en)
*
|
2002-06-28 |
2005-12-07 |
Domantis Limited |
Ligand
|
|
JP2006523090A
(ja)
*
|
2002-12-27 |
2006-10-12 |
ドマンティス リミテッド |
リガンドに、そしてリガンド受容体に特異的な二重特異性単一ドメイン抗体
|
|
CA2513113A1
(en)
|
2003-01-23 |
2004-08-05 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
|
MY150088A
(en)
|
2003-05-19 |
2013-11-29 |
Irm Llc |
Immunosuppressant compounds and compositions
|
|
AU2004251146A1
(en)
|
2003-05-19 |
2005-01-06 |
Irm, Llc |
Immunosuppressant compounds and compositions
|
|
NZ621449A
(en)
*
|
2003-05-30 |
2015-07-31 |
Genentech Inc |
Treatment with anti-vegf antibodies
|
|
US7582726B2
(en)
|
2003-11-10 |
2009-09-01 |
Ghc Research Development Corporation |
VEGF receptor antagonists
|
|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
CA2623034A1
(en)
|
2005-09-27 |
2007-04-05 |
Novartis Ag |
Carboxyamine compounds and their use in the treatment of hdac dependent diseases
|
|
EP2275103B1
(en)
|
2005-11-21 |
2014-04-23 |
Novartis AG |
mTOR inhibitors in the treatment of endocrine tumors
|
|
CN101454344A
(zh)
*
|
2005-12-01 |
2009-06-10 |
杜门蒂斯有限公司 |
与白细胞介素-1受体1型结合的非竞争性域抗体形式
|
|
EP2596807B1
(en)
*
|
2006-03-08 |
2015-12-16 |
Archemix LLC |
Complement binding aptamers and anti-C5 agents useful in the treatment of ocular disorders
|
|
TW200812615A
(en)
*
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
|
CN101405030B
(zh)
*
|
2006-03-22 |
2013-03-13 |
霍夫曼-拉罗奇有限公司 |
针对血管内皮生长因子的抗体和针对人表皮生长因子2型受体的抗体在制备治疗肿瘤的试剂盒中的应用
|
|
JP2009532503A
(ja)
|
2006-04-05 |
2009-09-10 |
ノバルティス アクチエンゲゼルシャフト |
癌を処置するための治療剤の組合せ
|
|
US20090317489A1
(en)
|
2006-05-09 |
2009-12-24 |
Hanspeter Nick |
Combination Comprising an Iron Chelator and an Anti-Neoplastic Agent and Use Thereof
|
|
GB0612721D0
(en)
|
2006-06-27 |
2006-08-09 |
Novartis Ag |
Organic compounds
|
|
JP5959795B2
(ja)
|
2006-08-18 |
2016-08-02 |
アーメイゲン・テクノロジーズ・インコーポレイテッドArmagen Technologies, Inc. |
血液脳関門送達のための物質
|
|
KR20090073121A
(ko)
|
2006-09-29 |
2009-07-02 |
노파르티스 아게 |
Pi3k 지질 키나제 억제제로서의 피라졸로피리미딘
|
|
EP2491923A3
(en)
|
2007-02-15 |
2012-12-26 |
Novartis AG |
Combinations of therapeutic agents for treating cancer
|
|
WO2008103301A2
(en)
*
|
2007-02-16 |
2008-08-28 |
President And Fellows Of Harvard College |
Treatment of the eye using macrophages and/or agents able to affect blood vessel morphology
|
|
NZ580530A
(en)
|
2007-06-06 |
2012-04-27 |
Domantis Ltd |
Anti vegf polypeptides, antibody variable domains and antagonists
|
|
EP2997976A1
(en)
|
2007-07-27 |
2016-03-23 |
Armagen Technologies, Inc. |
Methods and compositions for increasing alpha-l-iduronidase activity in the cns
|
|
PT2260020E
(pt)
|
2008-03-26 |
2014-10-28 |
Novartis Ag |
Inibidores das desacetilases b baseados no hidroxamato
|
|
ES2704986T3
(es)
|
2008-10-16 |
2019-03-21 |
Celator Pharmaceuticals Inc |
Combinaciones de una camptotecina liposomal soluble en agua con cetuximab o bevacizumab
|
|
EP2379499B1
(en)
|
2008-12-18 |
2014-04-09 |
Novartis AG |
Hydrochloride salt of 1-(4-(1-((E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl)-2-ethyl-benzyl)-azetidine-3-carboxylic acid
|
|
RS53041B
(sr)
|
2008-12-18 |
2014-04-30 |
Novartis Ag |
Hemifumaratna so 1-[4-[1-(4-cikloheksil-3-trifluorometil-benziloksiimino)-etil]-2-etil-benzil]-azetidin-3-karboksilne kiseline
|
|
AU2009327405A1
(en)
|
2008-12-18 |
2011-06-30 |
Novartis Ag |
New polymorphic form of 1- (4- { l- [ (E) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
|
|
PL2391366T3
(pl)
|
2009-01-29 |
2013-04-30 |
Novartis Ag |
Podstawione benzimidazole do leczenia gwiaździaków
|
|
US9533055B2
(en)
|
2009-03-18 |
2017-01-03 |
Armagen Technologies, Inc. |
Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins
|
|
WO2010108503A1
(en)
*
|
2009-03-24 |
2010-09-30 |
Life & Brain Gmbh |
Promotion of neuronal integration in neural stem cell grafts
|
|
BRPI1012321A8
(pt)
*
|
2009-06-17 |
2016-09-27 |
Abbott Biotherapeutics Corp |
Anticorpos anti-vegf e seus usos
|
|
MA33451B1
(fr)
|
2009-06-26 |
2012-07-03 |
Novartis Ag |
Dérivés d'imidazolidin-2-one 1,3-disubstitués en tant qu'inhibiteurs de cyp 17
|
|
WO2011013668A1
(ja)
*
|
2009-07-27 |
2011-02-03 |
国立大学法人新潟大学 |
虚血性イベントの治療用医薬品組成物
|
|
US8652476B2
(en)
|
2009-07-27 |
2014-02-18 |
Niigata University |
Pharmaceutical composition for treating ischemic events
|
|
JP5823672B2
(ja)
*
|
2009-07-27 |
2015-11-25 |
国立大学法人 新潟大学 |
受容体シグナル伝達阻害剤を含む脳梗塞治療用医薬品組成物
|
|
JP5823671B2
(ja)
*
|
2009-07-27 |
2015-11-25 |
国立大学法人 新潟大学 |
免疫製剤を含む脳梗塞治療用医薬品組成物
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
EA201200260A1
(ru)
|
2009-08-12 |
2012-09-28 |
Новартис Аг |
Гетероциклические гидразоны и их применение для лечения рака и воспаления
|
|
MY162604A
(en)
|
2009-08-17 |
2017-06-30 |
Intellikine Llc |
Heterocyclic compounds and uses thereof
|
|
MX2012002179A
(es)
|
2009-08-20 |
2012-03-16 |
Novartis Ag |
Compuestos heterociclicos de oxima.
|
|
AU2010288534A1
(en)
|
2009-08-26 |
2012-03-15 |
Novartis Ag |
Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators
|
|
AU2010294209A1
(en)
|
2009-09-10 |
2012-03-29 |
Irm Llc |
Ether derivatives of bicyclic heteroaryls
|
|
SI2485761T1
(sl)
|
2009-10-09 |
2019-05-31 |
Armagen, Inc. |
Postopki in sestavki za povečanje aktivnosti iduronat-2-sulfataze v CŽS
|
|
MY156209A
(en)
|
2009-11-04 |
2016-01-29 |
Novartis Ag |
Heterocyclic sulfonamide derivatives useful mek inhibitors
|
|
WO2011064211A1
(en)
|
2009-11-25 |
2011-06-03 |
Novartis Ag |
Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls
|
|
AU2012265844A1
(en)
|
2009-12-08 |
2013-05-02 |
Novartis Ag |
Heterocyclic sulfonamide derivatives
|
|
JP5456908B2
(ja)
|
2009-12-08 |
2014-04-02 |
ノバルティス アーゲー |
ヘテロ環式スルホンアミド誘導体
|
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
|
CU24130B1
(es)
|
2009-12-22 |
2015-09-29 |
Novartis Ag |
Isoquinolinonas y quinazolinonas sustituidas
|
|
EP2582681A1
(en)
|
2010-06-17 |
2013-04-24 |
Novartis AG |
Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
|
|
CN102947274A
(zh)
|
2010-06-17 |
2013-02-27 |
诺瓦提斯公司 |
联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
|
|
JP2013537210A
(ja)
|
2010-09-16 |
2013-09-30 |
ノバルティス アーゲー |
17α−ヒドロキシラーゼ/C17,20−リアーゼ阻害剤
|
|
JP2014505088A
(ja)
|
2011-02-10 |
2014-02-27 |
ノバルティス アーゲー |
C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
CN103492390A
(zh)
|
2011-03-08 |
2014-01-01 |
诺瓦提斯公司 |
氟苯基双环杂芳基化合物
|
|
EA023064B1
(ru)
|
2011-04-28 |
2016-04-29 |
Новартис Аг |
ИНГИБИТОРЫ 17α-ГИДРОКСИЛАЗЫ/C-ЛИАЗЫ
|
|
US8859535B2
(en)
|
2011-06-20 |
2014-10-14 |
Novartis Ag |
Hydroxy substituted isoquinolinone derivatives
|
|
EP2721007B1
(en)
|
2011-06-20 |
2015-04-29 |
Novartis AG |
Cyclohexyl isoquinolinone compounds
|
|
UY34329A
(es)
|
2011-09-15 |
2013-04-30 |
Novartis Ag |
Compuestos de triazolopiridina
|
|
US8969341B2
(en)
|
2011-11-29 |
2015-03-03 |
Novartis Ag |
Pyrazolopyrrolidine compounds
|
|
US8486399B2
(en)
|
2011-12-02 |
2013-07-16 |
Armagen Technologies, Inc. |
Methods and compositions for increasing arylsulfatase A activity in the CNS
|
|
CN104136429A
(zh)
|
2011-12-23 |
2014-11-05 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
CN104125955A
(zh)
|
2011-12-23 |
2014-10-29 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
AU2012355615A1
(en)
|
2011-12-23 |
2014-07-10 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
|
CN104125953A
(zh)
|
2011-12-23 |
2014-10-29 |
诺华股份有限公司 |
用于抑制bcl2与结合配偶体相互作用的化合物
|
|
US9126979B2
(en)
|
2011-12-23 |
2015-09-08 |
Novartis Ag |
Compounds for inhibiting the interaction of BCL2 with binding partners
|
|
JO3357B1
(ar)
|
2012-01-26 |
2019-03-13 |
Novartis Ag |
مركبات إيميدازوبيروليدينون
|
|
SI2825558T1
(sl)
|
2012-03-13 |
2019-08-30 |
F. Hoffmann-La Roche Ag |
Kombinirana terapija za zdravljenje raka jajčnikov
|
|
CN110507654A
(zh)
|
2012-04-03 |
2019-11-29 |
诺华有限公司 |
有酪氨酸激酶抑制剂的组合产品和其应用
|
|
JP6171003B2
(ja)
|
2012-05-24 |
2017-07-26 |
ノバルティス アーゲー |
ピロロピロリジノン化合物
|
|
US20140154255A1
(en)
|
2012-11-30 |
2014-06-05 |
Abbvie Biotherapeutics Inc. |
Anti-vegf antibodies and their uses
|
|
US9403827B2
(en)
|
2013-01-22 |
2016-08-02 |
Novartis Ag |
Substituted purinone compounds
|
|
US9556180B2
(en)
|
2013-01-22 |
2017-01-31 |
Novartis Ag |
Pyrazolo[3,4-d]pyrimidinone compounds as inhibitors of the P53/MDM2 interaction
|
|
EP2968340A4
(en)
|
2013-03-15 |
2016-08-10 |
Intellikine Llc |
COMBINING KINASE INHIBITORS AND USES THEREOF
|
|
WO2014155268A2
(en)
|
2013-03-25 |
2014-10-02 |
Novartis Ag |
Fgf-r tyrosine kinase activity inhibitors - use in diseases associated with lack of or reduced snf5 activity
|
|
KR102049990B1
(ko)
|
2013-03-28 |
2019-12-03 |
삼성전자주식회사 |
c-Met 항체 및 VEGF 결합 단편이 연결된 융합 단백질
|
|
WO2015022664A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
|
US9227969B2
(en)
|
2013-08-14 |
2016-01-05 |
Novartis Ag |
Compounds and compositions as inhibitors of MEK
|
|
WO2015022663A1
(en)
|
2013-08-14 |
2015-02-19 |
Novartis Ag |
Compounds and compositions as inhibitors of mek
|
|
WO2015084804A1
(en)
|
2013-12-03 |
2015-06-11 |
Novartis Ag |
Combination of mdm2 inhibitor and braf inhibitor and their use
|
|
MX379491B
(es)
*
|
2014-06-28 |
2025-03-10 |
Kodiak Sciences Inc |
Antagonistas duales de factor de crecimiento derivado de plaquetas (pdgf)/factor de crecimiento endotelial vascular (vegf)
|
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
|
KR20170036037A
(ko)
|
2014-07-31 |
2017-03-31 |
노파르티스 아게 |
조합 요법
|
|
US10538589B2
(en)
|
2015-01-14 |
2020-01-21 |
Armagen Inc. |
Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
|
|
KR20250057128A
(ko)
|
2015-12-30 |
2025-04-28 |
코디악 사이언시스 인코포레이티드 |
항체 및 이의 접합체
|
|
US10617756B2
(en)
|
2017-01-05 |
2020-04-14 |
Shimojani, LLC |
Drug regimen for treatment of cerebral ischemia
|
|
AU2017444054B2
(en)
|
2017-12-21 |
2021-10-07 |
Hefei Institutes Of Physical Science, Chinese Academy Of Sciences |
Class of pyrimidine derivative kinase inhibitors
|
|
US12071476B2
(en)
|
2018-03-02 |
2024-08-27 |
Kodiak Sciences Inc. |
IL-6 antibodies and fusion constructs and conjugates thereof
|
|
AU2020364071A1
(en)
|
2019-10-10 |
2022-05-26 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
|
US20220395553A1
(en)
|
2019-11-14 |
2022-12-15 |
Cohbar, Inc. |
Cxcr4 antagonist peptides
|