JP2012017341A5 - - Google Patents
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- JP2012017341A5 JP2012017341A5 JP2011224347A JP2011224347A JP2012017341A5 JP 2012017341 A5 JP2012017341 A5 JP 2012017341A5 JP 2011224347 A JP2011224347 A JP 2011224347A JP 2011224347 A JP2011224347 A JP 2011224347A JP 2012017341 A5 JP2012017341 A5 JP 2012017341A5
- Authority
- JP
- Japan
- Prior art keywords
- egfr
- use according
- heterodimer
- tumor
- irradiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 17
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 17
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 16
- 239000000833 heterodimer Substances 0.000 claims 5
- 239000000178 monomer Substances 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 230000015572 biosynthetic process Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 claims 1
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 230000001093 anti-cancer Effects 0.000 claims 1
- 201000008275 breast carcinoma Diseases 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7678898P | 1998-03-04 | 1998-03-04 | |
| US60/076,788 | 1998-03-04 | ||
| US09/111,681 US6417168B1 (en) | 1998-03-04 | 1998-07-08 | Compositions and methods of treating tumors |
| US09/111,681 | 1998-07-08 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534245A Division JP2002505309A (ja) | 1998-03-04 | 1999-03-04 | 腫瘍治療のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012017341A JP2012017341A (ja) | 2012-01-26 |
| JP2012017341A5 true JP2012017341A5 (enExample) | 2013-01-10 |
| JP5719270B2 JP5719270B2 (ja) | 2015-05-13 |
Family
ID=26758479
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534245A Pending JP2002505309A (ja) | 1998-03-04 | 1999-03-04 | 腫瘍治療のための組成物および方法 |
| JP2011224347A Expired - Lifetime JP5719270B2 (ja) | 1998-03-04 | 2011-10-11 | 腫瘍治療のための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000534245A Pending JP2002505309A (ja) | 1998-03-04 | 1999-03-04 | 腫瘍治療のための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (8) | US6417168B1 (enExample) |
| EP (2) | EP3034093B1 (enExample) |
| JP (2) | JP2002505309A (enExample) |
| AT (1) | ATE334702T1 (enExample) |
| AU (1) | AU757237C (enExample) |
| CA (1) | CA2322592A1 (enExample) |
| CY (1) | CY1105475T1 (enExample) |
| DE (1) | DE69932600T2 (enExample) |
| DK (1) | DK1058562T3 (enExample) |
| ES (2) | ES2551932T3 (enExample) |
| HK (1) | HK1225997A1 (enExample) |
| PT (1) | PT1058562E (enExample) |
| WO (1) | WO1999044645A1 (enExample) |
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1998
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1999
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- 1999-03-04 CA CA002322592A patent/CA2322592A1/en not_active Expired - Lifetime
- 1999-03-04 DE DE69932600T patent/DE69932600T2/de not_active Expired - Lifetime
- 1999-03-04 ES ES06076149.1T patent/ES2551932T3/es not_active Expired - Lifetime
- 1999-03-04 ES ES99908641T patent/ES2270586T3/es not_active Expired - Lifetime
- 1999-03-04 EP EP15183218.5A patent/EP3034093B1/en not_active Revoked
- 1999-03-04 AU AU28021/99A patent/AU757237C/en not_active Expired
- 1999-03-04 PT PT99908641T patent/PT1058562E/pt unknown
- 1999-03-04 AT AT99908641T patent/ATE334702T1/de active
- 1999-03-04 WO PCT/US1999/004777 patent/WO1999044645A1/en not_active Ceased
- 1999-03-04 EP EP99908641A patent/EP1058562B1/en not_active Revoked
- 1999-03-04 JP JP2000534245A patent/JP2002505309A/ja active Pending
-
2002
- 2002-03-19 US US10/100,952 patent/US7625558B2/en not_active Expired - Lifetime
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2006
- 2006-09-14 CY CY20061101312T patent/CY1105475T1/el unknown
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2008
- 2008-05-02 US US12/114,475 patent/US20090010935A1/en not_active Abandoned
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2011
- 2011-04-05 US US13/080,313 patent/US20120014965A1/en not_active Abandoned
- 2011-10-11 JP JP2011224347A patent/JP5719270B2/ja not_active Expired - Lifetime
-
2013
- 2013-03-12 US US13/796,468 patent/US20130204069A1/en not_active Abandoned
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2014
- 2014-09-12 US US14/485,525 patent/US20150010551A1/en not_active Abandoned
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2015
- 2015-06-03 US US14/729,798 patent/US20160289334A2/en not_active Abandoned
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2016
- 2016-12-21 HK HK16114528.4A patent/HK1225997A1/en unknown
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2017
- 2017-02-01 US US15/422,046 patent/US20170355778A1/en not_active Abandoned
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