CN110799501A - 一种食欲素受体拮抗剂的晶型及其制备方法和用途 - Google Patents
一种食欲素受体拮抗剂的晶型及其制备方法和用途 Download PDFInfo
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- CN110799501A CN110799501A CN201880040538.1A CN201880040538A CN110799501A CN 110799501 A CN110799501 A CN 110799501A CN 201880040538 A CN201880040538 A CN 201880040538A CN 110799501 A CN110799501 A CN 110799501A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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Abstract
一种化合物Lemborexant的晶型及其制备方法,含有该晶型的药物组合物,以及该晶型在制备食欲素受体拮抗剂、治疗失眠症和不规则睡眠‑觉醒节律障碍药物制剂中的用途。提供的化合物Lemborexant的晶型比现有技术具有一种或多种改进的特性,对未来该药物的优化和开发具有重要价值。
Description
PCT国内申请,说明书已公开。
Claims (9)
- PCT国内申请,权利要求书已公开。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202211397034.XA CN115710250A (zh) | 2017-08-01 | 2018-07-31 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN201710648135 | 2017-08-01 | ||
CN2017106481352 | 2017-08-01 | ||
PCT/CN2018/097797 WO2019024845A1 (zh) | 2017-08-01 | 2018-07-31 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202211397034.XA Division CN115710250A (zh) | 2017-08-01 | 2018-07-31 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN110799501A true CN110799501A (zh) | 2020-02-14 |
CN110799501B CN110799501B (zh) | 2022-11-22 |
Family
ID=65233118
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201880040538.1A Active CN110799501B (zh) | 2017-08-01 | 2018-07-31 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
CN202211397034.XA Pending CN115710250A (zh) | 2017-08-01 | 2018-07-31 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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CN202211397034.XA Pending CN115710250A (zh) | 2017-08-01 | 2018-07-31 | 一种食欲素受体拮抗剂的晶型及其制备方法和用途 |
Country Status (4)
Country | Link |
---|---|
US (1) | US10759779B2 (zh) |
JP (2) | JP7179049B2 (zh) |
CN (2) | CN110799501B (zh) |
WO (1) | WO2019024845A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220008804A (ko) * | 2019-05-15 | 2022-01-21 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 오렉신-2 수용체 길항제의 제조에 유용한 방법 및 화합물, 및 약간의 불순물을 갖는 렘보렉산트 |
WO2020263253A1 (en) * | 2019-06-26 | 2020-12-30 | Moline Margaret | Lemborexant for treating sleep issues |
MX2022002038A (es) * | 2019-09-13 | 2022-03-11 | Eisai R&D Man Co Ltd | Composicion farmaceutica para el tratamiento del insomnio. |
US20240010629A1 (en) | 2019-12-11 | 2024-01-11 | Teva Czech Industries S.R.O | Solid state form of lemborexant |
IL294033A (en) * | 2020-01-16 | 2022-08-01 | Eisai R&D Man Co Ltd | Medicinal substance of lamborexant and medical preparation containing it |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104114524A (zh) * | 2012-02-17 | 2014-10-22 | 卫材R&D管理有限公司 | 用于食欲肽-2受体拮抗剂的合成的方法和化合物 |
CN104592184A (zh) * | 2014-12-15 | 2015-05-06 | 云南省药物研究所 | 灯盏乙素苷元晶型及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020157A (en) * | 1997-04-30 | 2000-02-01 | Smithkline Beecham Corporation | Polynucleotides encoding HFGAN72X receptor |
US6166193A (en) * | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
PE20081229A1 (es) | 2006-12-01 | 2008-08-28 | Merck & Co Inc | Antagonistas de receptor de orexina de diazepam sustituido |
PE20091010A1 (es) | 2007-10-10 | 2009-08-08 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroquinolina |
TWI516484B (zh) * | 2010-09-22 | 2016-01-11 | 衛材R&D企管股份有限公司 | 環丙烷化合物 |
JP6659681B2 (ja) * | 2014-10-23 | 2020-03-04 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 不眠症を治療するための組成物および方法 |
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2018
- 2018-07-31 JP JP2020504160A patent/JP7179049B2/ja active Active
- 2018-07-31 CN CN201880040538.1A patent/CN110799501B/zh active Active
- 2018-07-31 WO PCT/CN2018/097797 patent/WO2019024845A1/zh active Application Filing
- 2018-07-31 CN CN202211397034.XA patent/CN115710250A/zh active Pending
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2020
- 2020-01-30 US US16/777,121 patent/US10759779B2/en active Active
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2022
- 2022-11-15 JP JP2022182194A patent/JP2023027066A/ja active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104114524A (zh) * | 2012-02-17 | 2014-10-22 | 卫材R&D管理有限公司 | 用于食欲肽-2受体拮抗剂的合成的方法和化合物 |
CN104592184A (zh) * | 2014-12-15 | 2015-05-06 | 云南省药物研究所 | 灯盏乙素苷元晶型及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2020528913A (ja) | 2020-10-01 |
US10759779B2 (en) | 2020-09-01 |
CN115710250A (zh) | 2023-02-24 |
US20200190060A1 (en) | 2020-06-18 |
CN110799501B (zh) | 2022-11-22 |
JP7179049B2 (ja) | 2022-11-28 |
WO2019024845A1 (zh) | 2019-02-07 |
JP2023027066A (ja) | 2023-03-01 |
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Effective date of registration: 20210513 Address after: Delaware, USA Applicant after: Bojian Pharmaceutical Co.,Ltd. Address before: 215123 Bio-nano Park B4301, No. 218 Xinghu Street, Suzhou Industrial Park, Jiangsu Province Applicant before: CRYSTAL PHARMACEUTICAL (SUZHOU) Co.,Ltd. |
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