|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
|
US4323546A
(en)
|
1978-05-22 |
1982-04-06 |
Nuc Med Inc. |
Method and composition for cancer detection in humans
|
|
US4411990A
(en)
|
1979-06-13 |
1983-10-25 |
University Patents, Inc. |
Primary bioassay of human tumor stem cells
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4612282A
(en)
|
1981-12-15 |
1986-09-16 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Monoclonal antibodies reactive with human breast cancer
|
|
US4670393A
(en)
|
1982-03-22 |
1987-06-02 |
Genentech, Inc. |
DNA vectors encoding a novel human growth hormone-variant protein
|
|
US4588585A
(en)
|
1982-10-19 |
1986-05-13 |
Cetus Corporation |
Human recombinant cysteine depleted interferon-β muteins
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US5019497A
(en)
|
1984-11-09 |
1991-05-28 |
Lennart Olsson |
Human squamous lung carcinoma cell specific antigens and antibodies
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5087570A
(en)
|
1988-05-10 |
1992-02-11 |
Weissman Irving L |
Homogeneous mammalian hematopoietic stem cell composition
|
|
US4981785A
(en)
|
1988-06-06 |
1991-01-01 |
Ventrex Laboratories, Inc. |
Apparatus and method for performing immunoassays
|
|
US4968103A
(en)
|
1988-07-22 |
1990-11-06 |
Photofinish Cosmetics Inc. |
Method of making a brush
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5994617A
(en)
|
1988-09-19 |
1999-11-30 |
Hsc Research Development Corporation |
Engraftment of immune-deficient mice with human cells
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
US5534617A
(en)
|
1988-10-28 |
1996-07-09 |
Genentech, Inc. |
Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
|
|
US5688666A
(en)
|
1988-10-28 |
1997-11-18 |
Genentech, Inc. |
Growth hormone variants with altered binding properties
|
|
JP2989002B2
(ja)
|
1988-12-22 |
1999-12-13 |
キリン―アムジエン・インコーポレーテツド |
化学修飾顆粒球コロニー刺激因子
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB8901778D0
(en)
|
1989-01-27 |
1989-03-15 |
Univ Court Of The University O |
Manipulatory technique
|
|
US6583115B1
(en)
|
1989-10-12 |
2003-06-24 |
Ohio University/Edison Biotechnology Institute |
Methods for treating acromegaly and giantism with growth hormone antagonists
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
US5614396A
(en)
|
1990-06-14 |
1997-03-25 |
Baylor College Of Medicine |
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
AU8507191A
(en)
|
1990-08-29 |
1992-03-30 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
IL101728A
(en)
|
1991-05-03 |
2007-08-19 |
Univ Yale |
Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
|
|
US5856441A
(en)
|
1991-05-03 |
1999-01-05 |
Yale University |
Serrate fragments and derivatives
|
|
IE20030749A1
(en)
|
1991-05-03 |
2003-11-12 |
Indiana University Foundation |
Human notch and delta binding domains in torporythmic proteins, and methods based thereon
|
|
US6429186B1
(en)
|
1991-05-10 |
2002-08-06 |
Genentech, Inc. |
Ligand antagonists for treatment of breast cancer
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
US5750376A
(en)
|
1991-07-08 |
1998-05-12 |
Neurospheres Holdings Ltd. |
In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US5753229A
(en)
|
1991-09-25 |
1998-05-19 |
Mordoh; Jose |
Monoclonal antibodies reactive with tumor proliferating cells
|
|
US6353150B1
(en)
|
1991-11-22 |
2002-03-05 |
Hsc Research And Development Limited Partnership |
Chimeric mammals with human hematopoietic cells
|
|
US5869282A
(en)
|
1991-12-11 |
1999-02-09 |
Imperial Cancer Research Technology, Ltd. |
Nucleotide and protein sequences of the serrate gene and methods based thereon
|
|
US6004924A
(en)
|
1991-12-11 |
1999-12-21 |
Imperial Cancer Research Technology, Ltd. |
Protein sequences of serrate gene products
|
|
DE69326967T2
(de)
|
1992-01-17 |
2000-06-15 |
Lakowicz, Joseph R. |
Phasenmodulationsenergieübertragungsfluoroimmunassay
|
|
US5376313A
(en)
|
1992-03-27 |
1994-12-27 |
Abbott Laboratories |
Injection molding a plastic assay cuvette having low birefringence
|
|
US5786158A
(en)
|
1992-04-30 |
1998-07-28 |
Yale University |
Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
|
|
US5693482A
(en)
|
1992-07-27 |
1997-12-02 |
California Institute Of Technology |
Neural chest stem cell assay
|
|
US5589376A
(en)
|
1992-07-27 |
1996-12-31 |
California Institute Of Technology |
Mammalian neural crest stem cells
|
|
US5849553A
(en)
|
1992-07-27 |
1998-12-15 |
California Institute Of Technology |
Mammalian multipotent neural stem cells
|
|
NZ256154A
(en)
|
1992-07-27 |
1997-02-24 |
California Inst Of Techn |
Production of mammalian multipotent neural stem cells, antibodies
|
|
US5654183A
(en)
|
1992-07-27 |
1997-08-05 |
California Institute Of Technology |
Genetically engineered mammalian neural crest stem cells
|
|
EP1362913B1
(en)
|
1992-10-30 |
2006-01-25 |
The General Hospital Corporation |
Interaction trap system for isolating proteins
|
|
GB9223084D0
(en)
|
1992-11-04 |
1992-12-16 |
Imp Cancer Res Tech |
Compounds to target cells
|
|
JP3106021B2
(ja)
|
1992-11-30 |
2000-11-06 |
キヤノン株式会社 |
パターンデータの圧縮方法及び装置と出力方法及び装置
|
|
CA2156288C
(en)
|
1993-02-19 |
2005-10-18 |
Junichi Yano |
Glycerol derivative, device and pharmaceutical composition
|
|
US5876978A
(en)
|
1993-04-06 |
1999-03-02 |
Medical College Of Ohio |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5643765A
(en)
|
1993-04-06 |
1997-07-01 |
University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5639606A
(en)
|
1993-04-06 |
1997-06-17 |
The University Of Rochester |
Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
|
|
US5538848A
(en)
|
1994-11-16 |
1996-07-23 |
Applied Biosystems Division, Perkin-Elmer Corp. |
Method for detecting nucleic acid amplification using self-quenching fluorescence probe
|
|
CA2177827C
(en)
*
|
1993-11-30 |
2007-08-28 |
Michael C. Kiefer |
Novel apoptosis-modulating proteins, dna encoding the proteins and methods of use thereof
|
|
US5599677A
(en)
|
1993-12-29 |
1997-02-04 |
Abbott Laboratories |
Immunoassays for prostate specific antigen
|
|
EP0784690B1
(en)
|
1994-06-10 |
2006-08-16 |
Genvec, Inc. |
Complementary adenoviral vector systems and cell lines
|
|
US6156305A
(en)
|
1994-07-08 |
2000-12-05 |
Baxter International Inc. |
Implanted tumor cells for the prevention and treatment of cancer
|
|
US5650317A
(en)
|
1994-09-16 |
1997-07-22 |
Michigan State University |
Human breast epithelial cell type with stem cell and luminal epithelial cell characteristics
|
|
EP0787200B1
(en)
|
1994-10-28 |
2005-04-20 |
The Trustees Of The University Of Pennsylvania |
Improved adenovirus and methods of use thereof
|
|
US6218166B1
(en)
|
1994-12-09 |
2001-04-17 |
John Wayne Cancer Institute |
Adjuvant incorporation into antigen carrying cells: compositions and methods
|
|
US5736396A
(en)
|
1995-01-24 |
1998-04-07 |
Case Western Reserve University |
Lineage-directed induction of human mesenchymal stem cell differentiation
|
|
US5872154A
(en)
|
1995-02-24 |
1999-02-16 |
The Trustees Of The University Of Pennsylvania |
Method of reducing an immune response to a recombinant adenovirus
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5707618A
(en)
|
1995-03-24 |
1998-01-13 |
Genzyme Corporation |
Adenovirus vectors for gene therapy
|
|
US5633161A
(en)
|
1995-03-29 |
1997-05-27 |
Millennium Pharmaceuticals, Inc. |
Murine gene fomy030 coding for tumor progression inhibitor
|
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
|
US5821108A
(en)
|
1995-04-07 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US6019978A
(en)
|
1995-06-05 |
2000-02-01 |
The Wistar Institute Of Anatomy And Biology |
Replication-defective adenovirus human type 5 recombinant as a vaccine carrier
|
|
KR100470180B1
(ko)
|
1995-06-15 |
2005-02-04 |
크루셀 홀란드 비.브이. |
유전자 요법에 사용할 수 있는 인간의 재조합아데노바이러스 패키징 시스템
|
|
US6117985A
(en)
|
1995-06-16 |
2000-09-12 |
Stemcell Technologies Inc. |
Antibody compositions for preparing enriched cell preparations
|
|
AU723939B2
(en)
|
1995-06-28 |
2000-09-07 |
Imperial Cancer Research Technology Ltd |
Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
|
|
DK0851925T3
(da)
|
1995-09-21 |
2005-11-28 |
Genentech Inc |
Humane Væksthormonvarianter
|
|
US5780300A
(en)
|
1995-09-29 |
1998-07-14 |
Yale University |
Manipulation of non-terminally differentiated cells using the notch pathway
|
|
US5986170A
(en)
|
1995-11-13 |
1999-11-16 |
Corixa Corporation |
Murine model for human carcinoma
|
|
US6337387B1
(en)
|
1995-11-17 |
2002-01-08 |
Asahi Kasei Kabushiki Kaisha |
Differentiation-suppressive polypeptide
|
|
JP2000502450A
(ja)
|
1995-12-22 |
2000-02-29 |
アボツト・ラボラトリーズ |
蛍光偏光免疫アッセイによる診断法
|
|
US5994316A
(en)
|
1996-02-21 |
1999-11-30 |
The Immune Response Corporation |
Method of preparing polynucleotide-carrier complexes for delivery to cells
|
|
WO1997037004A1
(en)
|
1996-03-30 |
1997-10-09 |
Boehringer Mannheim Gmbh |
Method for the production of activated marked tumor-specific t cells and use thereof in treatment of tumors
|
|
US5753506A
(en)
|
1996-05-23 |
1998-05-19 |
Cns Stem Cell Technology, Inc. |
Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
|
|
EP0921818A4
(en)
|
1996-05-31 |
2002-09-25 |
Nat American Red Cross |
THERAPEUTIC AND DIAGNOSTIC METHODS AND COMPOSITIONS BASED ON JAGGED / NOTCH PROTEINS AND AMINO ACIDS
|
|
US6716974B1
(en)
|
1996-05-31 |
2004-04-06 |
Maine Medical Center Research Institute |
Therapeutic and diagnostic methods and compositions based on jagged/notch proteins and nucleic acids
|
|
US5885529A
(en)
|
1996-06-28 |
1999-03-23 |
Dpc Cirrus, Inc. |
Automated immunoassay analyzer
|
|
FR2751986B1
(fr)
|
1996-08-01 |
1998-12-31 |
Inst Nat Sante Rech Med |
Gene implique dans le cadasil, methode de diagnostic et application therapeutique
|
|
CA2263883C
(en)
|
1996-08-29 |
2003-07-08 |
The Regents Of The University Of California |
Kuz, a novel family of metalloproteases
|
|
ES2263181T5
(es)
|
1996-09-24 |
2011-04-07 |
Genentech, Inc. |
Una familia de genes que codifican péptidos relacionados con la apoptosis, péptidos codificados por ellos y los métodos de uso de los mismos.
|
|
DE69718029T2
(de)
|
1996-10-11 |
2003-10-16 |
The Regents Of The University Of California, Oakland |
Krebs immuntherapie unter verwendung von tumorzellen kombiniert mit lymphozytmischungen
|
|
US5994132A
(en)
|
1996-10-23 |
1999-11-30 |
University Of Michigan |
Adenovirus vectors
|
|
ES2335365T3
(es)
|
1996-11-27 |
2010-03-25 |
Genentech, Inc. |
Purificacion por afinidad de polipeptido en una matriz de proteina a.
|
|
US5859535A
(en)
|
1997-02-12 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
System for determining size and location of defects in material by use of microwave radiation
|
|
US6198107B1
(en)
|
1997-03-07 |
2001-03-06 |
Clare Chemical Research, Inc. |
Fluorometric detection using visible light
|
|
US6080912A
(en)
|
1997-03-20 |
2000-06-27 |
Wisconsin Alumni Research Foundation |
Methods for creating transgenic animals
|
|
US5861832A
(en)
|
1997-03-27 |
1999-01-19 |
Lucent Technologies Inc. |
Analog-to-digital converter having amplifier and comparator stages
|
|
US20020137890A1
(en)
|
1997-03-31 |
2002-09-26 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
ES2275304T3
(es)
|
1997-04-04 |
2007-06-01 |
Millennium Pharmaceuticals, Inc. |
Nuevas composiciones de delta-3 humana y usos diagnosticos y terapeuticos para las mismas.
|
|
US20030180784A1
(en)
|
1997-04-04 |
2003-09-25 |
Millennium Pharmaceuticals, Inc. |
Novel human Delta3 compositions and therapeutic and diagnostic uses therefor
|
|
US6121045A
(en)
|
1997-04-04 |
2000-09-19 |
Millennium Biotherapeutics, Inc. |
Human Delta3 nucleic acid molecules
|
|
US5830730A
(en)
|
1997-05-08 |
1998-11-03 |
The Regents Of The University Of California |
Enhanced adenovirus-assisted transfection composition and method
|
|
US6664098B1
(en)
|
1997-05-14 |
2003-12-16 |
Asahi Kasei Kabushiki Kaisha |
Differentiation inhibitory agent
|
|
WO1998057621A1
(en)
|
1997-06-18 |
1998-12-23 |
The Trustees Of Columbia University In The City Ofnew York |
Angiogenic modulation by notch signal transduction
|
|
US6379925B1
(en)
|
1997-06-18 |
2002-04-30 |
The Trustees Of Columbia University In The City Of New York |
Angiogenic modulation by notch signal transduction
|
|
US6136952A
(en)
|
1997-06-25 |
2000-10-24 |
University Of Washington |
Human jagged polypeptide, encoding nucleic acids and methods of use
|
|
EP0998565A1
(en)
|
1997-07-11 |
2000-05-10 |
Introgene B.V. |
Interleukin-3 gene therapy for cancer
|
|
US7361336B1
(en)
|
1997-09-18 |
2008-04-22 |
Ivan Bergstein |
Methods of cancer therapy targeted against a cancer stem line
|
|
US6004528A
(en)
|
1997-09-18 |
1999-12-21 |
Bergstein; Ivan |
Methods of cancer diagnosis and therapy targeted against the cancer stemline
|
|
US6197523B1
(en)
|
1997-11-24 |
2001-03-06 |
Robert A. Levine |
Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US5981225A
(en)
|
1998-04-16 |
1999-11-09 |
Baylor College Of Medicine |
Gene transfer vector, recombinant adenovirus particles containing the same, method for producing the same and method of use of the same
|
|
US6252050B1
(en)
|
1998-06-12 |
2001-06-26 |
Genentech, Inc. |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
|
|
CA2337492A1
(en)
|
1998-07-27 |
2000-02-10 |
Amgen Inc. |
Delta-related polypeptides
|
|
AU748523B2
(en)
|
1998-08-14 |
2002-06-06 |
Aventis Pharmaceuticals Inc. |
Adenovirus formulations for gene therapy
|
|
CN1257286C
(zh)
|
1998-08-27 |
2006-05-24 |
森泰莱昂公司 |
用于递送异源基因的定向腺病毒载体
|
|
GB9819681D0
(en)
|
1998-09-09 |
1998-11-04 |
Smithkline Beecham Plc |
Novel compounds
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
IL142905A0
(en)
|
1998-11-02 |
2002-04-21 |
Biogen Inc |
Functional antagonists of hedgehog activity
|
|
US6291516B1
(en)
|
1999-01-13 |
2001-09-18 |
Curis, Inc. |
Regulators of the hedgehog pathway, compositions and uses related thereto
|
|
US20030003572A1
(en)
|
1999-03-05 |
2003-01-02 |
David J. Anderson |
Isolation and enrichment of neural stem cells from uncultured tissue based on cell-surface marker expression
|
|
US20030119029A1
(en)
|
1999-04-30 |
2003-06-26 |
Regents Of The University Of Michigan |
Compositions and methods relating to novel benzodiazepine compounds and targets thereof
|
|
AU782493B2
(en)
|
1999-06-01 |
2005-08-04 |
Curis, Inc. |
Polymer conjugates of hedgehog proteins and uses
|
|
US6703221B1
(en)
|
1999-08-19 |
2004-03-09 |
Chiron Corporation |
Notch receptor ligands and uses thereof
|
|
WO2001026643A1
(en)
|
1999-10-14 |
2001-04-19 |
The Wistar Institute |
Inhibition of tumorigenic properties of melanoma cells
|
|
US6380362B1
(en)
|
1999-12-23 |
2002-04-30 |
Genesis Research & Development Corporation Ltd. |
Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
|
|
US20040048249A1
(en)
|
2000-01-21 |
2004-03-11 |
Tang Y. Tom |
Novel nucleic acids and secreted polypeptides
|
|
WO2001053255A1
(en)
|
2000-01-24 |
2001-07-26 |
Merck Sharp & Dohme Limited |
Gamma-secretase inhibitors
|
|
AU4314801A
(en)
|
2000-02-11 |
2001-08-20 |
Lexigen Pharm Corp |
Enhancing the circulating half-life of antibody-based fusion proteins
|
|
US7115653B2
(en)
|
2000-03-30 |
2006-10-03 |
Curis, Inc. |
Small organic molecule regulators of cell proliferation
|
|
US7060436B2
(en)
|
2000-06-17 |
2006-06-13 |
Third Wave Technologies, Inc. |
Nucleic acid accessible hybridization sites
|
|
CA2414015A1
(en)
|
2000-06-21 |
2001-12-27 |
Incyte Genomics, Inc. |
Human receptors
|
|
US6632620B1
(en)
|
2000-06-22 |
2003-10-14 |
Andrew N. Makarovskiy |
Compositions for identification and isolation of stem cells
|
|
DE10031380A1
(de)
|
2000-06-28 |
2002-01-10 |
Merck Patent Gmbh |
Verfahren zur Übertragung von Alkyliden-Gruppen auf organischen Verbindungen
|
|
GB0016681D0
(en)
|
2000-07-06 |
2000-08-23 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
AU2001278076A1
(en)
|
2000-07-26 |
2002-02-05 |
Applied Genomics, Inc. |
Bstp-5 proteins and related reagents and methods of use thereof
|
|
US6984522B2
(en)
|
2000-08-03 |
2006-01-10 |
Regents Of The University Of Michigan |
Isolation and use of solid tumor stem cells
|
|
US20050089518A1
(en)
|
2001-12-07 |
2005-04-28 |
Clarke Michael F. |
Prospective identification and characterization of breast cancer stem cells
|
|
WO2002018544A2
(en)
|
2000-08-31 |
2002-03-07 |
Loyola University Chicago |
Method and reagents for treatment of skin disorders by modulating the notch pathway
|
|
US6689744B2
(en)
|
2000-09-22 |
2004-02-10 |
Genentech, Inc. |
Notch receptor agonists and uses
|
|
US7413873B2
(en)
|
2001-01-30 |
2008-08-19 |
The Regents Of The University Of California |
Method of detection and treatment of colon cancer
|
|
US20020169300A1
(en)
|
2001-01-30 |
2002-11-14 |
Waterman Marian L. |
Method of detection and treatment of colon cancer by analysis of beta-catenin-sensitive isoforms of lymphoid enhancer factor-1
|
|
US20030064384A1
(en)
|
2001-04-02 |
2003-04-03 |
Mien-Chie Hung |
Beta-catenin is a strong and independent prognostic factor for cancer
|
|
EP1381631B1
(en)
|
2001-04-24 |
2010-10-13 |
Bayer Corporation |
Human anti timp-1 antibodies
|
|
US7682607B2
(en)
|
2001-05-01 |
2010-03-23 |
The Regents Of The University Of California |
Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
|
|
US20030044409A1
(en)
*
|
2001-05-01 |
2003-03-06 |
Carson Dennis A. |
Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
|
|
US7713526B2
(en)
*
|
2001-05-01 |
2010-05-11 |
The Regents Of The University Of California |
Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
|
|
US20030096852A1
(en)
|
2001-06-15 |
2003-05-22 |
Genentech, Inc. |
Human growth hormone antagonists
|
|
US7171311B2
(en)
|
2001-06-18 |
2007-01-30 |
Rosetta Inpharmatics Llc |
Methods of assigning treatment to breast cancer patients
|
|
US20040023244A1
(en)
|
2001-06-21 |
2004-02-05 |
Griffin Jennifer A |
Receptors
|
|
ES2292772T3
(es)
|
2001-06-22 |
2008-03-16 |
Stemcells, Inc. |
Celulas de injerto de higado, analisis, y sus usos.
|
|
WO2003000893A2
(en)
|
2001-06-26 |
2003-01-03 |
Decode Genetics Ehf. |
Nucleic acids encoding g protein-coupled receptors
|
|
AU2001272892B8
(en)
|
2001-07-02 |
2006-05-04 |
Sinan Tas |
Use of cyclopamine in the treatment of basal cell carcinoma and other tumors
|
|
EP1411938B1
(en)
|
2001-07-02 |
2005-07-06 |
Tas, Sinan |
Use of cyclopamine for the manufacture of a medicament for the treatemnt of psoriasis
|
|
AU2002317105A1
(en)
|
2001-07-05 |
2003-01-21 |
University Of British Columbia |
Methods for identifying therapeutic agents for treating diseases involving wnt polypeptides and wnt receptors
|
|
EP1425694A2
(en)
|
2001-08-03 |
2004-06-09 |
Medical Research Council |
Method of identifying a consensus sequence for intracellular antibodies
|
|
ATE515495T1
(de)
|
2001-08-03 |
2011-07-15 |
Schering Corp |
Gamma sekretase inhibitoren
|
|
US7138370B2
(en)
*
|
2001-10-11 |
2006-11-21 |
Amgen Inc. |
Specific binding agents of human angiopoietin-2
|
|
AU2002339157A1
(en)
|
2001-11-14 |
2003-05-26 |
Lorantis Limited |
Inhibitors of the notch signalling pathway for use in the treatment of cancer
|
|
US7053547B2
(en)
|
2001-11-29 |
2006-05-30 |
Universal Display Corporation |
Increased emission efficiency in organic light-emitting devices on high-index substrates
|
|
US20070237770A1
(en)
|
2001-11-30 |
2007-10-11 |
Albert Lai |
Novel compositions and methods in cancer
|
|
IL162732A0
(en)
|
2001-12-26 |
2005-11-20 |
Immunomedics Inc |
Methods of generating multispecific, multivalent agents from hv and vl domains
|
|
US6713206B2
(en)
|
2002-01-14 |
2004-03-30 |
Board Of Trustees Of University Of Illinois |
Electrochemical cells comprising laminar flow induced dynamic conducting interfaces, electronic devices comprising such cells, and methods employing same
|
|
GB0201674D0
(en)
|
2002-01-25 |
2002-03-13 |
Lorantis Ltd |
Medical treatment
|
|
US20030185829A1
(en)
|
2002-03-12 |
2003-10-02 |
Erich Koller |
Jagged 2 inhibitors for inducing apoptosis
|
|
WO2003092630A2
(en)
*
|
2002-05-06 |
2003-11-13 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
|
|
JP2005527215A
(ja)
|
2002-05-24 |
2005-09-15 |
ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド |
炎症性疾患の治療に有益なＩＫＫα機能遺伝子及びその他の遺伝子の同定方法
|
|
EP2365004B1
(en)
|
2002-06-21 |
2016-01-06 |
Johns Hopkins University School of Medicine |
Membrane associated tumor endothelium markers
|
|
US7803370B2
(en)
|
2002-08-30 |
2010-09-28 |
Oncotherapy Science, Inc. |
Method for treating synovial sarcoma
|
|
AU2003256079A1
(en)
|
2002-08-30 |
2004-03-19 |
Japan As Represented By President Of The University Of Tokyo |
Method for treating synovial sarcoma
|
|
GB0221952D0
(en)
|
2002-09-20 |
2002-10-30 |
Novartis Forschungsstiftung |
Wnt mediated ErbB1 signalling,compositions and uses related thereto
|
|
US20040058217A1
(en)
*
|
2002-09-20 |
2004-03-25 |
Ohlsen Leroy J. |
Fuel cell systems having internal multistream laminar flow
|
|
CA2501235A1
(en)
|
2002-10-04 |
2004-04-22 |
The Regents Of The University Of California |
Methods for treating cancer by inhibiting wnt signaling
|
|
US7803783B2
(en)
|
2002-12-06 |
2010-09-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Use of WNT inhibitors to augment therapeutic index of chemotherapy
|
|
WO2004053069A2
(en)
|
2002-12-06 |
2004-06-24 |
The Board Of Trustees Of The Leland Stanford Junior University |
PROTECTION OF STEM CELLS FROM CYTOTOXIC AGENTS BY MODULATION OF β-CATENIN SIGNALING PATHWAYS
|
|
WO2004073657A2
(en)
|
2003-02-19 |
2004-09-02 |
Protein Design Labs, Inc. |
Methods of diagnosis of cancer and other diseases, composition and methods of screening for modulators of cancer and other diseases
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
AU2004256425A1
(en)
|
2003-06-09 |
2005-01-20 |
The Regents Of The University Of Michigan |
Compositions and methods for treating and diagnosing cancer
|
|
EP1648506B1
(en)
|
2003-07-11 |
2012-02-15 |
Oncotherapy Science, Inc. |
Method for treating synovial sarcoma
|
|
US6894522B2
(en)
|
2003-10-06 |
2005-05-17 |
International Business Machines Corporation |
Specific site backside underlaying and micromasking method for electrical characterization of semiconductor devices
|
|
US20060040883A1
(en)
|
2004-05-14 |
2006-02-23 |
The Regents Of The University Of California |
Methods for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA
|
|
WO2006036179A2
(en)
|
2004-09-21 |
2006-04-06 |
Rhode Island Hospital, A Lifespan-Partner |
Frizzled proteins and detection and treatment of cancer
|
|
WO2006034328A2
(en)
|
2004-09-21 |
2006-03-30 |
Rhode Island Hospital, A Lifespan-Partner |
Wnt proteins and detection and treatment of cancer
|
|
WO2006036175A2
(en)
|
2004-09-21 |
2006-04-06 |
Rhode Island Hospital, A Lifespan-Partner |
Wnt proteins and detection and treatment of cancer
|
|
AU2005289685B2
(en)
|
2004-09-24 |
2009-07-16 |
Amgen Inc. |
Modified Fc molecules
|
|
DE102004050620A1
(de)
|
2004-10-13 |
2006-04-20 |
Eberhard-Karls-Universität Tübingen |
Monoklonaler Antikörper gegen Frizzled-Rezeptoren
|
|
JP2008520583A
(ja)
|
2004-11-15 |
2008-06-19 |
マウント シナイ スクール オブ メディスン オブ ニューヨーク ユニバーシティー |
Ｗｎｔ自己分泌シグナル伝達を改変するための組成物および方法
|
|
WO2006056340A2
(en)
|
2004-11-24 |
2006-06-01 |
F. Hoffmann-La Roche Ag |
Method for determining genotoxicity
|
|
US7635530B2
(en)
*
|
2005-03-21 |
2009-12-22 |
The Board Of Trustees Of The University Of Illinois |
Membraneless electrochemical cell and microfluidic device without pH constraint
|
|
US20090311243A1
(en)
*
|
2005-05-30 |
2009-12-17 |
Astrazeneca Ab |
Methods for Identifying FZD8 Modulators and the Use of such Modulators for Treating Osteoarthritis
|
|
US20070072238A1
(en)
|
2005-09-26 |
2007-03-29 |
Wyeth |
Wnt-frizzled chimera
|
|
DK1931697T3
(da)
|
2005-09-28 |
2010-11-08 |
Zymogenetics Inc |
IL-17A og IL-17F-antagonister og fremgangsmåder til anvendelse af disse
|
|
US7723477B2
(en)
|
2005-10-31 |
2010-05-25 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
|
|
PL2481756T3
(pl)
|
2005-10-31 |
2018-02-28 |
Oncomed Pharmaceuticals, Inc. |
Kompozycje i sposoby diagnozowania i leczenia nowotworu
|
|
GB0603683D0
(en)
|
2006-02-23 |
2006-04-05 |
Novartis Ag |
Organic compounds
|
|
CA2652886A1
(en)
|
2006-05-24 |
2007-11-29 |
Bayer Schering Pharma Aktiengesellschaft |
High affinity human and humanized anti-.alpha.5.beta.1 integrin function blocking antibodies with reduced immunogenicity
|
|
CA2655289C
(en)
|
2006-06-21 |
2016-08-23 |
Oncotherapy Science, Inc. |
Tumor-targeting monoclonal antibodies to fzd10 and uses thereof
|
|
TW200815469A
(en)
|
2006-06-23 |
2008-04-01 |
Astrazeneca Ab |
Compounds
|
|
CA2698597A1
(en)
|
2006-09-07 |
2008-03-13 |
Stemline Therapeutics, Inc. |
Monitoring cancer stem cells
|
|
EP2061495A2
(en)
|
2006-09-08 |
2009-05-27 |
Genentech, Inc. |
Wnt antagonists and their use in the diagnosis and treatment of wnt-mediated disorders
|
|
US20100041102A1
(en)
|
2006-11-07 |
2010-02-18 |
Ayesha Sitlani |
Antagonists of pcsk9
|
|
EP2084540A2
(en)
|
2006-11-14 |
2009-08-05 |
Novartis Ag |
Methods of treating, diagnosing or detecting cancer
|
|
BRPI0817231B1
(pt)
|
2007-09-26 |
2020-06-09 |
Intrexon Corp |
vetor de expressão, método para expressar uma sequência de interesse em uma célula hospedeira e kit compreendendo o dito vetor
|
|
AR068767A1
(es)
|
2007-10-12 |
2009-12-02 |
Novartis Ag |
Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
|
|
WO2009118300A1
(en)
|
2008-03-25 |
2009-10-01 |
Novartis Forschungsstiftung Zweigniederlassung Friedrich Miescher Institute For Biomedical Research |
Treating cancer by down-regulating frizzled-4 and/or frizzled-1
|
|
FR2936255B1
(fr)
|
2008-09-19 |
2010-10-15 |
Galderma Res & Dev |
Modulateurs de fzd2 dans le traitement de l'alopecie
|
|
NZ592338A
(en)
|
2008-09-26 |
2012-11-30 |
Oncomed Pharm Inc |
Frizzled-binding agents and uses thereof
|
|
US20130295106A1
(en)
|
2008-09-26 |
2013-11-07 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-Binding Agents And Uses Thereof
|
|
EP2343080B1
(en)
|
2008-09-30 |
2017-11-08 |
Kyowa Hakko Kirin Co., Ltd. |
PHARMACEUTICAL COMPOSITION FOR TREATING BONE DISEASES WHICH COMPRISES PROTEIN COMPRISING Frizzled1, Frizzled2 OR Frizzled7 EXTRACELLULAR CYSTEINE-RICH DOMAIN AND Fc PROTEIN
|
|
AU2011235904B2
(en)
|
2010-04-01 |
2015-10-08 |
Oncomed Pharmaceuticals, Inc. |
Frizzled-binding agents and uses thereof
|
|
WO2012006027A1
(en)
|
2010-06-28 |
2012-01-12 |
Five Prime Therapeutics, Inc. |
Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules and treatments using same
|