CN104245736A - 抗人死亡受体5胞外区的人源化单克隆抗体 - Google Patents
抗人死亡受体5胞外区的人源化单克隆抗体 Download PDFInfo
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Classifications
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Abstract
本发明提供了抗人死亡受体5(DR5)胞外区的人源化单克隆抗体，其包括与SEQ ID NO：1所示的氨基酸序列同一性至少为90％的轻链可变区氨基酸序列，与SEQ ID NO：2所示的氨基酸序列同一性至少为90％的重链可变区氨基酸序列，以及人抗体功能IgG1的恒定区。本发明还提供了所属人源化单克隆抗体的编码核苷酸序列，重组真核表达载体，以及所述抗体的生产方法，其组合物以及用途。本发明所述的人源化单克隆抗体在体内外对多种肿瘤细胞具有特异性的凋亡诱导活性，可单独或与DR5的天然配体肿瘤坏死因子相关凋亡诱导配体或其它药物联合使用，用于多种肿瘤和与DR5高表达相关的疾病的治疗。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/083627 WO2014063368A1 (zh) | 2012-10-26 | 2012-10-26 | 抗人死亡受体5胞外区的人源化单克隆抗体 |
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| Publication Number | Publication Date |
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| CN104245736A true CN104245736A (zh) | 2014-12-24 |
| CN104245736B CN104245736B (zh) | 2016-12-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201280072668.6A Active CN104245736B (zh) | 2012-10-26 | 2012-10-26 | 抗人死亡受体5胞外区的人源化单克隆抗体 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US9725517B2 (zh) |
| CN (1) | CN104245736B (zh) |
| WO (1) | WO2014063368A1 (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110637032A (zh) * | 2017-03-21 | 2019-12-31 | 东亚St株式会社 | 抗dr5抗体及其用途 |
| CN115819587A (zh) * | 2022-10-14 | 2023-03-21 | 北京东方百泰生物科技股份有限公司 | 一种抗nkg2a单克隆抗体及其应用 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201705116SA (en) | 2015-01-20 | 2017-08-30 | Igm Biosciences Inc | Tumor necrosis factor (tnf) superfamily receptor binding molecules and uses thereof |
| KR20180069066A (ko) * | 2015-10-30 | 2018-06-22 | 갤럭시 바이오테크, 엘엘씨 | 사멸 수용체 4 및 사멸 수용체 5에 결합하는 매우 강력한 항체 |
| CN109414492A (zh) * | 2016-06-16 | 2019-03-01 | 小利兰斯坦福大学理事会 | 针对cd81的人源化和嵌合单克隆抗体 |
| US11230592B2 (en) | 2017-09-27 | 2022-01-25 | The Wistar Institute Of Anatomy And Biology | DNA antibody constructs for use against middle east respiratory syndrome coronavirus |
| CN109957024A (zh) * | 2017-12-25 | 2019-07-02 | 深圳宾德生物技术有限公司 | 一种靶向dr5的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN108452320B (zh) * | 2018-02-13 | 2020-04-10 | 烟台市和元艾迪斯生物医药科技有限公司 | 抗trailr2抗体-毒素-偶联物及其在抗肿瘤治疗中的药物用途 |
| CN110141666B (zh) * | 2018-02-13 | 2022-09-27 | 烟台市和元艾迪斯生物医药科技有限公司 | 抗trailr2抗体-毒素-偶联物及其在抗肿瘤治疗中的药物用途 |
| CN110152014B (zh) * | 2018-02-13 | 2022-09-27 | 烟台市和元艾迪斯生物医药科技有限公司 | 抗trailr2抗体-毒素-偶联物及其在抗肿瘤治疗中的药物用途 |
| WO2019157772A1 (zh) * | 2018-02-13 | 2019-08-22 | 和元生物技术（上海）股份有限公司 | 抗trailr2抗体-毒素-偶联物及其在抗肿瘤治疗中的药物用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673232A (zh) * | 2004-08-19 | 2005-09-28 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体（ad5－10）及其制法与用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
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2012
- 2012-10-26 US US14/435,684 patent/US9725517B2/en active Active
- 2012-10-26 WO PCT/CN2012/083627 patent/WO2014063368A1/zh active Application Filing
- 2012-10-26 CN CN201280072668.6A patent/CN104245736B/zh active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1673232A (zh) * | 2004-08-19 | 2005-09-28 | 中国医学科学院基础医学研究所 | 抗人肿瘤坏死因子相关凋亡诱导配体的受体dr5单克隆抗体（ad5－10）及其制法与用途 |
Non-Patent Citations (1)
| Title |
|---|
| WILLIAM YING KHEE HWANG ET AL.: "Use of human germline genes in a CDR homology-based approach to antibody humanization", 《METHODS》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110637032A (zh) * | 2017-03-21 | 2019-12-31 | 东亚St株式会社 | 抗dr5抗体及其用途 |
| CN110637032B (zh) * | 2017-03-21 | 2023-05-12 | 东亚St株式会社 | 抗dr5抗体及其用途 |
| US11840574B2 (en) | 2017-03-21 | 2023-12-12 | Dong-A St Co., Ltd. | Anti-DR5 antibody and use thereof |
| CN115819587A (zh) * | 2022-10-14 | 2023-03-21 | 北京东方百泰生物科技股份有限公司 | 一种抗nkg2a单克隆抗体及其应用 |
| CN115819587B (zh) * | 2022-10-14 | 2023-06-09 | 北京东方百泰生物科技股份有限公司 | 一种抗nkg2a单克隆抗体及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014063368A1 (zh) | 2014-05-01 |
| CN104245736B (zh) | 2016-12-21 |
| US9725517B2 (en) | 2017-08-08 |
| US20150353638A1 (en) | 2015-12-10 |
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