JP2011136981A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011136981A5 JP2011136981A5 JP2010264759A JP2010264759A JP2011136981A5 JP 2011136981 A5 JP2011136981 A5 JP 2011136981A5 JP 2010264759 A JP2010264759 A JP 2010264759A JP 2010264759 A JP2010264759 A JP 2010264759A JP 2011136981 A5 JP2011136981 A5 JP 2011136981A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- set forth
- ttr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/117,109 US20030191056A1 (en) | 2002-04-04 | 2002-04-04 | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| US10/117,109 | 2002-04-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583462A Division JP4738743B2 (ja) | 2002-04-04 | 2003-04-03 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011136981A JP2011136981A (ja) | 2011-07-14 |
| JP2011136981A5 true JP2011136981A5 (https=) | 2012-03-08 |
Family
ID=28674128
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583462A Expired - Fee Related JP4738743B2 (ja) | 2002-04-04 | 2003-04-03 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
| JP2010264759A Withdrawn JP2011136981A (ja) | 2002-04-04 | 2010-11-29 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583462A Expired - Fee Related JP4738743B2 (ja) | 2002-04-04 | 2003-04-03 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20030191056A1 (https=) |
| EP (2) | EP2298331A3 (https=) |
| JP (2) | JP4738743B2 (https=) |
| AU (1) | AU2003224844B2 (https=) |
| CA (1) | CA2480883A1 (https=) |
| ES (1) | ES2400341T3 (https=) |
| MX (1) | MXPA04009680A (https=) |
| PL (1) | PL372849A1 (https=) |
| WO (1) | WO2003086444A1 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE459647T1 (de) | 2003-04-15 | 2010-03-15 | Glaxosmithkline Llc | Humane il-18 substitutionsmutanten und deren konjugate |
| US8263084B2 (en) * | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
| ATE555133T1 (de) * | 2003-11-13 | 2012-05-15 | Hanmi Holdings Co Ltd | Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung |
| US20090238838A1 (en) * | 2003-11-13 | 2009-09-24 | Hanmi Pharm. Ind. Co. Ltd. | Insulinotropic peptide conjugate using an immunoglobulin fc |
| WO2005074460A2 (en) * | 2003-12-05 | 2005-08-18 | Becton Dickinson And Company | Methods of enhancing immune response in the intradermal compartment and compounds useful in the methods |
| MXPA06006745A (es) * | 2003-12-18 | 2006-08-18 | Novo Nordisk As | Compuestos glp-1 novedosos. |
| WO2005077976A2 (en) * | 2004-02-13 | 2005-08-25 | Avidis Sa | Coiled-coil domains from c4b-binding protein |
| WO2006010057A2 (en) * | 2004-07-08 | 2006-01-26 | Amgen Inc. | Therapeutic peptides |
| CN100344323C (zh) * | 2004-09-30 | 2007-10-24 | 华东师范大学 | 一种人胰高血糖素样肽－1的复合物及其制备方法 |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| EA011166B1 (ru) * | 2004-12-22 | 2009-02-27 | Эли Лилли Энд Компани | Композиции слитых белков-аналогов glp-1 |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| PL1767545T3 (pl) | 2005-09-22 | 2010-04-30 | Biocompatibles Uk Ltd | Polipeptydy fuzyjne GLP-1 (glukagonopodobny peptyd-1) o zwiększonej odporności na peptydazy |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Ｇｌｐ−１のポリマ複合体 |
| ATE444741T1 (de) | 2006-05-10 | 2009-10-15 | Biocompatibles Uk Ltd | Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung |
| PE20081140A1 (es) * | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| EP1972349A1 (en) * | 2007-03-21 | 2008-09-24 | Biocompatibles UK Limited | GLP-1 fusion peptides conjugated to polymer(s), their production and use |
| EP1975176A1 (en) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Novel glp-1 fusion peptides, their production and use |
| EP2162540A2 (en) | 2007-05-22 | 2010-03-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| US20090054332A1 (en) * | 2007-06-21 | 2009-02-26 | Conjuchem Biotechnologies, Inc. | Thombopoietin peptide conjugates |
| CL2008001887A1 (es) | 2007-06-29 | 2008-10-03 | Amgen Inc | Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende. |
| EP2163243A1 (en) * | 2008-09-12 | 2010-03-17 | Biocompatibles UK Limited | Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof |
| EA036772B1 (ru) | 2008-10-20 | 2020-12-18 | Элнилэм Фармасьютикалз, Инк. | Композиции и способы для ингибирования экспрессии транстиретина |
| MX2011007647A (es) | 2009-01-21 | 2011-09-01 | Amgen Inc | Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. |
| US20120101021A1 (en) | 2009-02-06 | 2012-04-26 | Surendra Sharma | Compositions, formulations and methods of treating preeclampsia-type disorders of pregnancy |
| CN103382222B (zh) | 2009-03-20 | 2016-12-28 | 安姆根有限公司 | α-4-β-7异二聚体特异性拮抗剂抗体 |
| EP2408814B1 (en) | 2009-03-20 | 2018-11-21 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| US20120231013A1 (en) | 2009-07-31 | 2012-09-13 | Black Roy A | Polypeptides that bind tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| US8999343B2 (en) | 2010-08-16 | 2015-04-07 | Amgen Inc. | Antibodies that bind myostatin, compositions and methods |
| WO2012040518A2 (en) | 2010-09-22 | 2012-03-29 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| CA2825894C (en) | 2011-02-02 | 2021-11-30 | Amgen Inc. | Prognosis of cancer using a circulating biomarker |
| US20140105898A1 (en) | 2011-02-28 | 2014-04-17 | Istituto Di Ricovero E Cura A Carattere Scientific Materno-Infantile Burlo Garo | Apoptosis-inducing molecules and uses therefor |
| CA2830065A1 (en) | 2011-03-16 | 2012-09-20 | Amgen Inc. | Potent and selective inhibitors of nav1.3 and nav1.7 |
| JP2014132832A (ja) * | 2011-05-10 | 2014-07-24 | Sekisui Chem Co Ltd | 医薬、機能性食品、目的蛋白質の安定化方法、融合蛋白質、核酸、並びに、組換え体 |
| EP2780690A4 (en) * | 2011-11-18 | 2015-12-09 | Alnylam Pharmaceuticals Inc | QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS |
| HUE048622T2 (hu) | 2011-11-18 | 2020-08-28 | Alnylam Pharmaceuticals Inc | RNSi szerek, készítmények és alkalmazási eljárások transztiretin (TTR) asszociált betegségek kezelésére |
| US9309318B2 (en) | 2012-10-17 | 2016-04-12 | Amgen, Inc. | Compositions relating to anti-IL-21 receptor antibodies |
| ES2875957T3 (es) | 2012-12-20 | 2021-11-11 | Amgen Inc | Agonistas del receptor APJ y usos de los mismos |
| US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
| EP2970483A2 (en) | 2013-03-15 | 2016-01-20 | Amgen Inc. | Methods and compositions relating to anti-ccr7 antigen binding proteins |
| CA2935903A1 (en) | 2014-01-09 | 2015-07-16 | Hadasit Medical Research Services And Development Ltd. | Improved cell compositions and methods for cancer therapy |
| JP6803236B2 (ja) | 2014-06-10 | 2020-12-23 | アムジェン インコーポレイテッド | アペリンポリペプチド |
| US20160045609A1 (en) | 2014-08-14 | 2016-02-18 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
| EP3186276B1 (en) | 2014-08-27 | 2019-07-10 | Amgen Inc. | Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods |
| MY188430A (en) | 2015-04-10 | 2021-12-08 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| CN108138182B (zh) | 2015-07-31 | 2022-08-19 | 阿尔尼拉姆医药品有限公司 | 甲状腺素运载蛋白(TTR)iRNA组合物及其治疗或预防TTR相关疾病的使用方法 |
| WO2017155981A1 (en) * | 2016-03-07 | 2017-09-14 | Massachusetts Institute Of Technology | Protein-chaperoned t-cell vaccines |
| WO2018132768A1 (en) | 2017-01-13 | 2018-07-19 | Sanna Pietro P | Methods and compositions for treating hpa hyperactivity |
| CN108623690A (zh) * | 2017-03-16 | 2018-10-09 | 兰州大学 | 一种促血小板生成素的融合蛋白及其制备方法和应用 |
| CN106977609B (zh) * | 2017-04-19 | 2020-07-28 | 刘崇东 | 一种融合蛋白、制备方法及其应用 |
| FI3661562T3 (fi) | 2017-08-04 | 2024-12-09 | Amgen Inc | Cys-mab:ien konjugointimenetelmä |
| KR20250046363A (ko) | 2017-09-19 | 2025-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법 |
| US12269898B2 (en) | 2017-10-04 | 2025-04-08 | Amgen Inc. | Transthyretin immunoglobulin fusions |
| CN114174334A (zh) | 2019-03-22 | 2022-03-11 | 反射制药有限公司 | 针对vegf的d-肽化合物 |
| CN114144433A (zh) | 2019-03-22 | 2022-03-04 | 反射制药有限公司 | 用于目标蛋白的多价d-肽化合物 |
| JP7360142B2 (ja) * | 2019-05-21 | 2023-10-12 | 国立大学法人 熊本大学 | アミロイドーシス治療薬の新規スクリーニング方法 |
| IL267614A (en) | 2019-06-24 | 2019-09-26 | Lotem Michal | Nucleic acids to modulate SLAMF6 isoforms |
| EP3997112A1 (en) | 2019-07-08 | 2022-05-18 | Amgen, Inc | Multispecific transthyretin immunoglobulin fusions |
| CA3147757A1 (en) | 2019-07-26 | 2021-02-04 | Visterra, Inc. | Interleukin-2 agents and uses thereof |
| AU2020328038B2 (en) | 2019-08-13 | 2025-10-09 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| CN110960687A (zh) * | 2019-12-17 | 2020-04-07 | 上海卡序生物医药科技有限公司 | 转甲状腺素蛋白转运融合蛋白进入眼内的应用 |
| EP3988122A4 (en) * | 2019-12-17 | 2023-01-18 | Yizhou (Shanghai) Biological Medicine Co, Ltd. | USE OF TRANSTHYRETIN FOR INTRODUCTION TO THE EYE AND MAKING DROPS |
| EP4208474A2 (en) | 2020-09-01 | 2023-07-12 | Takeda Pharmaceutical Company Limited | Interleukin-2 muteins and uses thereof |
| CN114558112B (zh) * | 2020-09-16 | 2024-07-26 | 易舟(上海)生物医药有限公司 | 一种眼用制剂及其制备方法和应用 |
| EP4255466A1 (en) | 2020-12-04 | 2023-10-11 | Visterra, Inc. | Methods of using interleukin-2 agents |
| CA3227852A1 (en) | 2021-08-03 | 2023-02-09 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| JPS5923252A (ja) * | 1982-07-30 | 1984-02-06 | Fuji Photo Film Co Ltd | チロキシンの蛍光測定もしくは比色による定量分析法 |
| KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| JPS63500636A (ja) | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ |
| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| US4902502A (en) * | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| RU2212411C2 (ru) | 1989-10-16 | 2003-09-20 | Эмджен Инк. | Полипептид, обладающий гемопоэтической биологической активностью фактора стволовых клеток (варианты), днк (варианты), экспрессирующий вектор (варианты), фармацевтическая композиция для гемопоэтической терапии, способ получения полипептида и способ его использования (варианты) |
| BR9007883A (pt) | 1989-11-29 | 1992-09-29 | Synergen Inc | Producao de inibidor de interleucina-1 humana recombinante |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| US5372808A (en) | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| DK0575545T3 (da) | 1991-03-15 | 2003-09-15 | Amgen Inc | Pegylering af polypeptider |
| AU643141B2 (en) | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| DK0578774T3 (da) | 1991-04-05 | 1999-04-26 | Univ Washington | Monoklonale antistoffer mod stamcellefaktor-receptorer |
| US5716805A (en) * | 1991-10-25 | 1998-02-10 | Immunex Corporation | Methods of preparing soluble, oligomeric proteins |
| US5962406A (en) * | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| IT1255439B (it) | 1992-07-17 | 1995-10-31 | Getters Spa | Pompa getter non evaporabile |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| NZ250844A (en) | 1993-04-07 | 1996-03-26 | Pfizer | Treatment of non-insulin dependant diabetes with peptides; composition |
| CN1057534C (zh) | 1993-08-17 | 2000-10-18 | 柯瑞英-艾格公司 | 促红细胞生成素类似物 |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US6288030B1 (en) | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| SG47030A1 (en) | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
| US5786331A (en) | 1994-02-02 | 1998-07-28 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5880096A (en) | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5608035A (en) | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| SK100896A3 (en) | 1994-02-14 | 1997-10-08 | Zymogenetics Inc | Hematopoietic protein and materials and methods for making it |
| WO1995021919A2 (en) | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| JPH09509428A (ja) * | 1994-02-23 | 1997-09-22 | カイロン コーポレイション | 薬理学的に活性な薬剤の血清半減期を増加させるための方法および組成物 |
| CN1229385C (zh) | 1994-03-31 | 2005-11-30 | 安姆根有限公司 | 刺激巨核细胞生长和分化的组合物及方法 |
| US5532166A (en) * | 1994-04-18 | 1996-07-02 | Ma; Yinfa | Quantitative retinol assay for serum and dried blood spots |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| AU6028396A (en) | 1995-06-07 | 1996-12-30 | Amgen, Inc. | Ob protein compositions and method |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5581005A (en) | 1995-06-16 | 1996-12-03 | The Procter & Gamble Company | Method for manufacturing cobalt catalysts |
| GB2302559B (en) | 1995-06-23 | 1998-06-03 | Draftex Ind Ltd | Opening arrangements and methods for closure members |
| US5746516A (en) | 1995-08-11 | 1998-05-05 | Hitachi Powdered Metals Co., Ltd. | Porous bearing system having internal grooves and electric motor provided with the same |
| AU6688896A (en) | 1995-08-17 | 1997-03-12 | Amgen, Inc. | Methods of reducing or maintaining reduced levels of blood lipids using ob protein compositions |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
| WO1998028427A1 (en) | 1996-12-20 | 1998-07-02 | Amgen Inc. | Ob fusion protein compositions and methods |
| PT1783222E (pt) | 1998-10-23 | 2012-07-26 | Kirin Amgen Inc | Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| KR100345214B1 (ko) | 1999-08-17 | 2002-07-25 | 이강춘 | 생체적합성 고분자가 수식된 펩타이드의 비점막 전달 |
| EP2206720A1 (en) * | 2000-04-12 | 2010-07-14 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2399940A1 (en) * | 2000-04-13 | 2001-10-25 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
| BR0116024A (pt) * | 2000-12-07 | 2005-12-13 | Lilly Co Eli | Proteìna de fusão heteróloga e uso da mesma |
| WO2002059621A2 (en) * | 2001-01-24 | 2002-08-01 | Bayer Corporation | Regulation of transthyretin to treat obesity |
| EP1567178A4 (en) * | 2002-11-01 | 2009-07-15 | Amgen Inc | MODULATORS OF RECEPTORS FOR NEUTRAL THERAPY HORMONE AND SIDE-HORSE HORMONE-RELATED PROTEINS |
-
2002
- 2002-04-04 US US10/117,109 patent/US20030191056A1/en not_active Abandoned
-
2003
- 2003-04-03 JP JP2003583462A patent/JP4738743B2/ja not_active Expired - Fee Related
- 2003-04-03 EP EP10178081A patent/EP2298331A3/en not_active Withdrawn
- 2003-04-03 EP EP03721538A patent/EP1496926B1/en not_active Expired - Lifetime
- 2003-04-03 WO PCT/US2003/010443 patent/WO2003086444A1/en not_active Ceased
- 2003-04-03 ES ES03721538T patent/ES2400341T3/es not_active Expired - Lifetime
- 2003-04-03 AU AU2003224844A patent/AU2003224844B2/en not_active Ceased
- 2003-04-03 US US10/407,078 patent/US20030195154A1/en not_active Abandoned
- 2003-04-03 CA CA002480883A patent/CA2480883A1/en not_active Abandoned
- 2003-04-03 PL PL03372849A patent/PL372849A1/xx unknown
- 2003-04-03 MX MXPA04009680A patent/MXPA04009680A/es active IP Right Grant
-
2009
- 2009-02-26 US US12/380,451 patent/US8633153B2/en not_active Expired - Fee Related
-
2010
- 2010-11-29 JP JP2010264759A patent/JP2011136981A/ja not_active Withdrawn
-
2014
- 2014-01-16 US US14/157,325 patent/US20140234945A1/en not_active Abandoned