JP2011088902A5 - - Google Patents

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JP2011088902A5
JP2011088902A5 JP2010265830A JP2010265830A JP2011088902A5 JP 2011088902 A5 JP2011088902 A5 JP 2011088902A5 JP 2010265830 A JP2010265830 A JP 2010265830A JP 2010265830 A JP2010265830 A JP 2010265830A JP 2011088902 A5 JP2011088902 A5 JP 2011088902A5
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alkyl
hydrogen
composition
hormone
stereoisomer
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JP2010265830A
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JP5226760B2 (ja
JP2011088902A (ja
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JP2010265830A 2003-07-07 2010-11-29 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体 Expired - Lifetime JP5226760B2 (ja)

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US48543403P 2003-07-07 2003-07-07
US60/485,434 2003-07-07

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JP2006518842A Division JP4722844B2 (ja) 2003-07-07 2004-07-06 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体

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JP2011088902A JP2011088902A (ja) 2011-05-06
JP2011088902A5 true JP2011088902A5 (US20080242721A1-20081002-C00053.png) 2012-01-19
JP5226760B2 JP5226760B2 (ja) 2013-07-03

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JP2006518842A Expired - Lifetime JP4722844B2 (ja) 2003-07-07 2004-07-06 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体
JP2010265830A Expired - Lifetime JP5226760B2 (ja) 2003-07-07 2010-11-29 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体

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JP2006518842A Expired - Lifetime JP4722844B2 (ja) 2003-07-07 2004-07-06 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体

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US (3) US7056927B2 (US20080242721A1-20081002-C00053.png)
EP (1) EP1646389B1 (US20080242721A1-20081002-C00053.png)
JP (2) JP4722844B2 (US20080242721A1-20081002-C00053.png)
KR (1) KR101139148B1 (US20080242721A1-20081002-C00053.png)
CN (1) CN100424078C (US20080242721A1-20081002-C00053.png)
AT (1) ATE407679T1 (US20080242721A1-20081002-C00053.png)
AU (1) AU2004257639B2 (US20080242721A1-20081002-C00053.png)
BR (1) BRPI0412314B8 (US20080242721A1-20081002-C00053.png)
CA (1) CA2531508C (US20080242721A1-20081002-C00053.png)
CY (1) CY1108656T1 (US20080242721A1-20081002-C00053.png)
DE (1) DE602004016516D1 (US20080242721A1-20081002-C00053.png)
DK (1) DK1646389T3 (US20080242721A1-20081002-C00053.png)
EA (1) EA010370B1 (US20080242721A1-20081002-C00053.png)
ES (1) ES2314448T3 (US20080242721A1-20081002-C00053.png)
HR (1) HRP20080646T3 (US20080242721A1-20081002-C00053.png)
IL (1) IL172833A (US20080242721A1-20081002-C00053.png)
MX (1) MXPA06000297A (US20080242721A1-20081002-C00053.png)
NO (1) NO334897B1 (US20080242721A1-20081002-C00053.png)
NZ (1) NZ544747A (US20080242721A1-20081002-C00053.png)
PL (1) PL1646389T3 (US20080242721A1-20081002-C00053.png)
PT (1) PT1646389E (US20080242721A1-20081002-C00053.png)
SI (1) SI1646389T1 (US20080242721A1-20081002-C00053.png)
WO (1) WO2005007165A1 (US20080242721A1-20081002-C00053.png)
ZA (1) ZA200600475B (US20080242721A1-20081002-C00053.png)

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CN110938037A (zh) * 2018-09-21 2020-03-31 苏州鹏旭医药科技有限公司 一种依拉戈利钠盐药物中间体的制备方法
JP7200261B2 (ja) * 2017-12-05 2023-01-06 スージョウ ポンシュー ファーマテック カンパニー リミテッド エラゴリクスを作製するプロセス
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CN109970663B (zh) 2017-12-27 2023-04-11 上海科胜药物研发有限公司 一种制备噁拉戈利中间体的方法
CN108129400B (zh) * 2017-12-29 2021-10-15 安帝康(无锡)生物科技有限公司 氘代噁拉戈利衍生物及其用途
CN112261942A (zh) 2018-04-19 2021-01-22 艾伯维公司 治疗重度月经出血的方法
CN110669013A (zh) * 2018-07-03 2020-01-10 江苏海悦康医药科技有限公司 一种噁拉戈利中间体的制备方法
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CN109293634A (zh) * 2018-12-04 2019-02-01 中国药科大学 恶拉戈利杂质的制备方法
CN109651171A (zh) * 2019-01-13 2019-04-19 苏州鹏旭医药科技有限公司 依拉戈利及其钠盐的中间体及其盐的制备方法和应用
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CN109651265A (zh) * 2019-02-16 2019-04-19 安徽诺全药业有限公司 一种Elagolix的制备方法
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CN110372608A (zh) * 2019-07-09 2019-10-25 丽珠集团新北江制药股份有限公司 一种促性腺激素释放激素拮抗剂的制备方法
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CN110372609B (zh) * 2019-07-25 2021-04-09 奥锐特药业股份有限公司 一种噁拉戈利钠盐的纯化方法
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TWI755055B (zh) * 2019-09-18 2022-02-11 台灣神隆股份有限公司 用於製備惡拉戈利鈉及其中間體的方法
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CN112694445B (zh) * 2019-10-22 2023-07-28 成都倍特药业股份有限公司 一种噁拉戈利钠中间体的纯化方法
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CN113125575B (zh) * 2019-12-31 2023-04-18 济南尚博生物科技有限公司 一种1-(2-氟-6-(三氟甲基)苄基)-6-甲基嘧啶-二酮的定量分析方法
CN111116490A (zh) * 2020-01-15 2020-05-08 奥锐特药业股份有限公司 一种噁拉戈利中间体水杨酸盐的制备与纯化方法
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JP2023516404A (ja) * 2020-03-05 2023-04-19 アッヴィ・インコーポレイテッド エラゴリクスの投与方法
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