JP2010540453A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010540453A5 JP2010540453A5 JP2010526011A JP2010526011A JP2010540453A5 JP 2010540453 A5 JP2010540453 A5 JP 2010540453A5 JP 2010526011 A JP2010526011 A JP 2010526011A JP 2010526011 A JP2010526011 A JP 2010526011A JP 2010540453 A5 JP2010540453 A5 JP 2010540453A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- targeting moiety
- interferon
- linker comprises
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 25
- 230000008685 targeting Effects 0.000 claims 10
- 102000014150 Interferons Human genes 0.000 claims 8
- 108010050904 Interferons Proteins 0.000 claims 8
- 229940079322 interferon Drugs 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 239000000439 tumor marker Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99471707P | 2007-09-21 | 2007-09-21 | |
| US60/994,717 | 2007-09-21 | ||
| PCT/US2008/077074 WO2009039409A1 (en) | 2007-09-21 | 2008-09-19 | Targeted interferon demonstrates potent apoptotic and anti-tumor activities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014154820A Division JP6087871B2 (ja) | 2007-09-21 | 2014-07-30 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540453A JP2010540453A (ja) | 2010-12-24 |
| JP2010540453A5 true JP2010540453A5 (enExample) | 2011-11-10 |
| JP5591701B2 JP5591701B2 (ja) | 2014-09-17 |
Family
ID=40468388
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526011A Active JP5591701B2 (ja) | 2007-09-21 | 2008-09-19 | 強力なアポトーシス活性および抗腫瘍活性を示すターゲティング化インターフェロン |
| JP2014154820A Expired - Fee Related JP6087871B2 (ja) | 2007-09-21 | 2014-07-30 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
| JP2016215048A Pending JP2017031215A (ja) | 2007-09-21 | 2016-11-02 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014154820A Expired - Fee Related JP6087871B2 (ja) | 2007-09-21 | 2014-07-30 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
| JP2016215048A Pending JP2017031215A (ja) | 2007-09-21 | 2016-11-02 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9139634B2 (enExample) |
| EP (3) | EP3150218B1 (enExample) |
| JP (3) | JP5591701B2 (enExample) |
| KR (2) | KR101661770B1 (enExample) |
| CN (3) | CN108129573B (enExample) |
| AU (1) | AU2008302111B2 (enExample) |
| BR (1) | BRPI0817108B8 (enExample) |
| CA (1) | CA2699944C (enExample) |
| ES (1) | ES2536772T3 (enExample) |
| IL (2) | IL204644A (enExample) |
| MX (2) | MX2010003099A (enExample) |
| WO (1) | WO2009039409A1 (enExample) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101835802B (zh) | 2007-06-01 | 2014-04-09 | 马里兰大学巴尔的摩分校 | 免疫球蛋白恒定区Fc受体结合剂 |
| WO2009025846A2 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| CN108129573B (zh) * | 2007-09-21 | 2021-10-08 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
| RU2636046C2 (ru) | 2009-01-12 | 2017-11-17 | Сайтомкс Терапьютикс, Инк | Композиции модифицированных антител, способы их получения и применения |
| EP2398494A4 (en) | 2009-02-23 | 2015-10-28 | Cytomx Therapeutics Inc | Proproteins and their methods of use |
| BR112012013330A2 (pt) * | 2009-12-02 | 2017-03-28 | Acceleron Pharma Inc | composições e métodos para aumentar meia vida do soro de proteínas de fusão fc |
| WO2011159835A1 (en) | 2010-06-16 | 2011-12-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Antibodies to endoplasmin and their use |
| EP3543257A1 (en) | 2010-07-28 | 2019-09-25 | Gliknik Inc. | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| WO2012170072A1 (en) | 2011-06-06 | 2012-12-13 | Immungene, Inc. | Engineered antibody-tnfsf member ligand fusion molecules |
| EP2718328A4 (en) * | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM |
| EA034989B1 (ru) | 2011-10-28 | 2020-04-15 | Тева Фармасьютикал Австралия Пти Лтд | Полипептидная конструкция для применения при лечении рака, включающая аттенуированный альфа-интерферон |
| US8961971B2 (en) | 2011-12-22 | 2015-02-24 | Development Center For Biotechnology | Bispecific T-cell activator antibody |
| EP2804877B1 (en) | 2012-01-20 | 2018-08-22 | VIB vzw | Targeted mutant alpha-helical bundle cytokines |
| PL2822575T3 (pl) * | 2012-03-03 | 2020-08-10 | Immungene, Inc. | Zmodyfikowane sposobami inżynierii cząsteczki fuzyjne przeciwciało-mutant interferonu |
| NZ714549A (en) | 2012-04-30 | 2016-10-28 | Biocon Ltd | Targeted/immunomodulatory fusion proteins and methods for making same |
| WO2013180200A1 (ja) | 2012-05-30 | 2013-12-05 | 中外製薬株式会社 | 標的組織特異的抗原結合分子 |
| CN103505722B (zh) * | 2012-06-19 | 2016-04-13 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗/预防对常规抗肿瘤疗法有抗性的肿瘤中的用途及相关的产品和方法 |
| WO2014028502A1 (en) * | 2012-08-13 | 2014-02-20 | ImmunGene Inc. | Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases |
| EP2885320A4 (en) * | 2012-08-20 | 2016-04-06 | Gliknik Inc | MOLECULES WITH ANTIGEN-BINDING AND POLYVALENT FC GAMMA RECEPTOR BINDING ACTIVITY |
| WO2014089354A1 (en) | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| PL2970512T3 (pl) | 2013-03-12 | 2019-03-29 | Biocon Limited | Immunomodulujące białka fuzyjne i sposoby ich otrzymywania |
| WO2014178820A1 (en) | 2013-04-29 | 2014-11-06 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| US10093745B2 (en) | 2013-05-29 | 2018-10-09 | The Regents Of The University Of California | Anti-CSPG4 fusions with interferon for the treatment of malignancy |
| US10683353B2 (en) * | 2013-07-11 | 2020-06-16 | The Scripps Research Institute | Coiled coil immunoglobulin fusion proteins and compositions thereof |
| CA2917937C (en) | 2013-07-18 | 2022-11-01 | Vib Vzw | Fusokines involving cytokines with strongly reduced receptor binding affinities |
| US9732135B2 (en) * | 2013-07-19 | 2017-08-15 | Vib Vzw | Targeting of human interferon antagonists |
| AU2014292377B2 (en) | 2013-07-19 | 2019-08-01 | Centre Hospitalier Regional Universitaire De Montpellier | Targeted modified IL-1 family members |
| SG11201600168UA (en) | 2013-07-19 | 2016-02-26 | Vib Vzw | Targeted modified tnf family members |
| EP4137519A1 (en) * | 2013-08-09 | 2023-02-22 | The Trustees Of The University Of Pennsylvania | Fusion protein comprising ifn-gamma and anti-erbb antibody for the treatment of cancers |
| US11446516B2 (en) | 2013-08-09 | 2022-09-20 | The Trustees Of The University Of Pennsylvania | Methods of increasing response to cancer radiation therapy |
| CN104193828B (zh) * | 2013-09-12 | 2017-04-05 | 北京韩美药品有限公司 | 同时阻断her2和vegfr信号通路的重组融合蛋白 |
| AU2014337367B2 (en) * | 2013-10-15 | 2020-04-30 | The Scripps Research Institute | Peptidic chimeric antigen receptor T cell switches and uses thereof |
| CN103536917B (zh) * | 2013-10-30 | 2015-03-11 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗肿瘤中的用途及相关的产品和方法 |
| MX388731B (es) | 2013-12-04 | 2025-03-20 | Chugai Pharmaceutical Co Ltd | Moleculas de union al antigeno, cuya actividad de union al antigeno varia de acuerdo con la concentracion de los compuestos y bibliotecas de dichas moleculas. |
| US10308697B2 (en) | 2014-04-30 | 2019-06-04 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| JP6730271B2 (ja) | 2014-10-29 | 2020-07-29 | テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド | インターフェロンα２Ｂバリアント |
| EP3221351B1 (en) * | 2014-11-19 | 2024-11-13 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for cancer treating conditions relating to over expressions of epha2 |
| CN104403004B (zh) | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| US20170002057A1 (en) * | 2015-02-26 | 2017-01-05 | Nal Pharmaceutical Group Limited | Compositions containing fusion protein of albumin and analogs thereof, methods for making and using the same |
| KR101838919B1 (ko) | 2015-03-03 | 2018-03-15 | 에이비온 주식회사 | 인간 인터페론-베타 변이체가 접합된 면역사이토카인 및 이의 제조방법 |
| US20210009720A1 (en) * | 2015-03-03 | 2021-01-14 | Genopharm Inc. | Human interferon-beta variant conjugated immunocytokine and method for preparing same |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| WO2016168773A2 (en) | 2015-04-15 | 2016-10-20 | The California Institute For Biomedical Research | Optimized pne-based chimeric receptor t cell switches and uses thereof |
| US20180312561A1 (en) * | 2015-06-12 | 2018-11-01 | Immungene, Inc. | Focused interferon immunotherapy for treatment of cancer |
| SI3325011T1 (sl) | 2015-07-24 | 2021-02-26 | Gliknik Inc. | Fuzijski proteini humanih proteinskih fragmentov za tvorbo pravilnih multimeriziranih imunoglobulin FC sestavkov s povečanim vezanjem komplementa |
| JP6452577B2 (ja) * | 2015-08-27 | 2019-01-16 | 株式会社沖データ | 画像形成装置 |
| EP3371311B1 (en) | 2015-11-06 | 2021-07-21 | Orionis Biosciences BV | Bi-functional chimeric proteins and uses thereof |
| WO2017123548A1 (en) * | 2016-01-14 | 2017-07-20 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Tumor-specific ifna secretion by car t-cells to reprogram the solid tumor microenvironment |
| US11661455B2 (en) | 2016-02-05 | 2023-05-30 | Orionis Biosciences BV | Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety |
| EP4059957A1 (en) | 2016-02-05 | 2022-09-21 | Orionis Biosciences BV | Bispecific signaling agents and uses thereof |
| EP3426278B1 (en) | 2016-03-07 | 2024-01-03 | Vib Vzw | Cd20 binding single domain antibodies |
| WO2017180764A1 (en) * | 2016-04-12 | 2017-10-19 | Immungene, Inc. | Focused interferon immunotherapy |
| CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
| EP3454887B1 (en) | 2016-05-13 | 2021-01-20 | Orionis Biosciences BV | Targeted mutant interferon-beta and uses thereof |
| EP3464347B1 (en) | 2016-06-07 | 2023-05-31 | Gliknik Inc. | Cysteine-optimized stradomers |
| US11618784B2 (en) | 2016-07-19 | 2023-04-04 | Teva Pharmaceuticals Australia Pty Ltd. | Anti-CD47 combination therapy |
| KR102613430B1 (ko) | 2016-10-19 | 2023-12-18 | 더 스크립스 리서치 인스티튜트 | 인간화된 표적화 모이어티 및/또는 최적화된 키메라 항원 수용체-상호작용 도메인을 갖는 키메라 항원 수용체 효과기 세포 스위치 및 이의 용도 |
| JP7204643B2 (ja) | 2016-10-24 | 2023-01-16 | オリオニス バイオサイエンシズ ビーブイ | 標的変異インターフェロン－ガンマおよびその使用 |
| IL266988B2 (en) | 2016-12-09 | 2024-11-01 | Gliknik Inc | Methods of treating inflammatory disorders with multivalent fc compounds |
| KR102870694B1 (ko) | 2016-12-09 | 2025-10-15 | 글리크닉 인코포레이티드 | 다합체화 스트라도머인 gl-2045의 제조 최적화 |
| JP7128529B2 (ja) | 2016-12-23 | 2022-08-31 | アールイーエムディー バイオセラピューティクス，インコーポレイテッド | プログラム死リガンド－１（ｐｄ－ｌ１）に結合する抗体を使用する免疫 |
| US11384154B2 (en) | 2017-02-06 | 2022-07-12 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
| EP3576765B1 (en) | 2017-02-06 | 2025-07-16 | Orionis Biosciences, Inc. | Targeted engineered interferon and uses thereof |
| EP3580230A1 (en) | 2017-02-07 | 2019-12-18 | VIB vzw | Immune-cell targeted bispecific chimeric proteins and uses thereof |
| US11498966B2 (en) | 2017-08-09 | 2022-11-15 | Orionis Biosciences Inc. | PD-1 and PD-L1 binding agents |
| US12091463B2 (en) | 2017-08-09 | 2024-09-17 | Orionis Biosciences, Inc. | Clec9A binding agents comprising a recombinant heavy-chain only antibody (VHH) |
| WO2019032661A1 (en) | 2017-08-09 | 2019-02-14 | Orionis Biosciences Inc. | CD8 LIAISON AGENTS |
| US10849960B2 (en) | 2017-09-08 | 2020-12-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synergistic combination of IL-4, interferon gamma, and interferon alpha in treating ovarian cancer |
| WO2019182996A1 (en) * | 2018-03-19 | 2019-09-26 | The Regents Of The University Of California | Antibody-interferon fusion proteins for enhancing adoptive t cell therapies for the treatment of cancer |
| US12084497B2 (en) | 2018-08-08 | 2024-09-10 | Orionis Biosciences, Inc. | SIRP1α targeted chimeric proteins and uses thereof |
| AU2019318031B2 (en) | 2018-08-10 | 2025-06-05 | Chugai Seiyaku Kabushiki Kaisha | Anti-CD137 antigen-binding molecule and utilization thereof |
| WO2020097350A1 (en) | 2018-11-08 | 2020-05-14 | Orionis Biosciences, Inc. | Modulation of dendritic cell lineages |
| CA3132385A1 (en) * | 2019-03-06 | 2020-09-10 | Deka Biosciences, Inc. | Il-10 variant molecules and methods of treating inflammatory disease and oncology |
| CN113840833B (zh) | 2019-03-28 | 2025-06-17 | 奥里尼斯生物科学股份有限公司 | 基于clec9a的嵌合蛋白复合物 |
| JP7689079B2 (ja) * | 2019-03-28 | 2025-06-05 | オリオニス バイオサイエンシズ，インコーポレイテッド | 治療用インターフェロンアルファ１タンパク質 |
| JP2022529943A (ja) | 2019-04-15 | 2022-06-27 | クウィクセル セラピューティクス リミテッド ライアビリティ カンパニー | がんの処置における使用のための、標的指向性のマスクされたｉ型インターフェロン（ｉｆｎａおよびｉｆｎｂ）と腫瘍抗原に対する抗体とを含む融合タンパク質組成物 |
| KR20210021861A (ko) * | 2019-08-19 | 2021-03-02 | (주)제노팜 | 사람 표피성장인자수용체 2 양성 암을 치료하기 위한 인터페론-베타 변이체 면역사이토카인의 용도 및 환자 선별 방법 |
| AU2020384375A1 (en) * | 2019-11-14 | 2022-05-26 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| WO2021110562A1 (en) | 2019-12-03 | 2021-06-10 | Evotec International Gmbh | Interferon-associated antigen binding proteins and uses thereof |
| WO2021222228A1 (en) * | 2020-04-27 | 2021-11-04 | Ohio State Innovation Foundation | A live attenuated measles virus vectored vaccine for sars-cov-2 |
| MX2023000948A (es) | 2020-07-20 | 2023-04-14 | Deka Biosciences Inc | Proteínas de fusión de citocina doble que comprenden interleucina-10 (il-10). |
| US20250002553A1 (en) * | 2021-08-12 | 2025-01-02 | Shanghai Jmt-Bio Technology Co., Ltd. | A GPC3-targeting antibody-interferon a fusion protein and a use thereof |
| KR20240015038A (ko) * | 2022-07-25 | 2024-02-02 | 충남대학교산학협력단 | 인터루킨-21의 분비를 위한 재조합 발현 벡터 및 이로형질전환된 약독화 살모넬라 균주 |
| US20240067691A1 (en) | 2022-08-18 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Interferon receptor agonists and uses thereof |
| KR20250048583A (ko) | 2022-08-18 | 2025-04-09 | 리제너론 파아마슈티컬스, 인크. | 인터페론 전구단백질 및 이의 용도 |
| WO2024238415A1 (en) | 2023-05-12 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Interferon receptor antagonists and uses thereof |
| WO2025106883A1 (en) * | 2023-11-15 | 2025-05-22 | President And Fellows Of Harvard College | Engineered fc-prolactin fusions to increase lactation |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| EP0092227B1 (en) | 1982-04-19 | 1988-07-27 | Nissan Motor Co., Ltd. | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
| US4545985A (en) | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US4894443A (en) | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| DE3680924D1 (de) | 1985-01-14 | 1991-09-26 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4892827A (en) * | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| US6893625B1 (en) * | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| US5976531A (en) | 1990-04-19 | 1999-11-02 | The Dow Chemical Company | Composite antibodies of human subgroup IV light chain capable of binding to tag-72 |
| KR100240308B1 (ko) | 1991-03-06 | 2000-01-15 | 플레믹 크리스티안 | 인간화된단클론성항체및혼성단클론성항체 |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| PL181342B1 (pl) | 1994-03-17 | 2001-07-31 | Merck Patent Gmbh | Jednolancuchowe anty-EGFR Fv i przeciwciala anty-EGFR, czasteczka DNA, sposoby wytwarzania jednolancuchowego przeciwciala anty-EGFR i przeciwciala anty-EGFR oraz kompozycja farmaceutyczna PL PL PL PL PL PL PL |
| ES2167391T3 (es) * | 1994-09-16 | 2002-05-16 | Merck Patent Gmbh | Inmunoconjugados ii. |
| US6428788B1 (en) * | 1995-03-15 | 2002-08-06 | Penn State University | Compositions and methods for specifically targeting tumors |
| EP2258726A1 (en) | 1995-06-14 | 2010-12-08 | The Regents of the University of California | High affinity human antibodies to c-erbB-2 |
| JPH11513669A (ja) * | 1995-10-13 | 1999-11-24 | アメリカ合衆国 | ジスルフィド安定化抗体フラグメントを含む免疫毒素 |
| US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| PL187400B1 (pl) * | 1996-02-20 | 2004-06-30 | Applied Research Systems | Białka hybrydowe tworzące heterodimery |
| US6645490B2 (en) * | 1998-03-02 | 2003-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities |
| US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
| EA003634B1 (ru) * | 1998-10-05 | 2003-08-28 | Фармэкса А/С | Новые способы терапевтической вакцинации |
| ES2265693T3 (es) * | 1998-10-16 | 2007-02-16 | Biogen Idec Ma Inc. | Proteinas de fusion con interferon-beta y usos. |
| CA2379388C (en) * | 1999-07-13 | 2012-05-29 | George N. Cox, Iii | Immunoglobulin fusion proteins |
| EP1278767A4 (en) * | 2000-04-12 | 2003-11-12 | Principia Pharmaceutical Corp | ALBUMIN FUSED PROTEINS |
| WO2001097844A1 (en) * | 2000-06-22 | 2001-12-27 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| HU230603B1 (hu) * | 2000-12-07 | 2017-03-28 | Eli Lilly And Company | GLP1 fúziós fehérjék |
| US7183388B2 (en) * | 2001-03-30 | 2007-02-27 | The Regents Of The University Of California | Anti-MUC-1 single chain antibodies for tumor targeting |
| US20020193569A1 (en) | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| CN100522999C (zh) | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
| US7736652B2 (en) * | 2002-03-21 | 2010-06-15 | The Regents Of The University Of California | Antibody fusion proteins: effective adjuvants of protein vaccination |
| US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US20070003514A1 (en) | 2002-04-05 | 2007-01-04 | The Regents Of The University Of California | Mono-and bi-functional antibody conjugates as effective adjuvants of protein vaccination |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| JP2004093527A (ja) * | 2002-09-04 | 2004-03-25 | Center For Advanced Science & Technology Incubation Ltd | 蛍光共鳴エネルギー転移を用いた蛋白質の分析方法 |
| WO2004074486A2 (en) | 2003-02-18 | 2004-09-02 | Merck Patent Gmbh | Fusion proteins of interferon alpha muteins with improved properties |
| US20050008649A1 (en) * | 2003-06-02 | 2005-01-13 | University Of Miami | Chimeric molecules and methods of use |
| US20050232931A1 (en) * | 2003-06-13 | 2005-10-20 | Oncomax Acquisition Corp. | Preparation and application of anti-tumor bifunctional fusion proteins |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| KR100863776B1 (ko) | 2004-07-15 | 2008-10-16 | 젠코어 인코포레이티드 | 최적화된 Ｆｃ 변이체 |
| AU2005266184A1 (en) * | 2004-07-26 | 2006-02-02 | Asterion Limited | Linkers |
| AU2006203850A1 (en) * | 2005-01-10 | 2006-07-13 | Research Development Foundation | Targeted chimeric molecules for cancer therapy |
| US20120237442A1 (en) | 2005-04-06 | 2012-09-20 | Ibc Pharmaceuticals, Inc. | Design and Construction of Novel Multivalent Antibodies |
| CN101484182B (zh) * | 2005-04-06 | 2014-06-11 | Ibc药品公司 | 由同二聚体、同四聚体或二聚体的二聚体组成的稳定连接复合体的生产方法及用途 |
| US20060269516A1 (en) * | 2005-05-26 | 2006-11-30 | Schering Corporation | Interferon-IgG fusion |
| AU2006263331B2 (en) * | 2005-06-29 | 2012-02-16 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Recombinant interferon alpha2 (IFNalpha2) mutants |
| NZ542111A (en) | 2005-08-30 | 2008-04-30 | Otago Innovation Ltd | Novel assay |
| WO2007044616A2 (en) * | 2005-10-06 | 2007-04-19 | Xencor, Inc. | Optimized anti-cd30 antibodies |
| BRPI0619056A2 (pt) | 2005-11-28 | 2011-09-20 | Genmab As | anticorpo monovalente, método para preparar e produzir um antcorpo monovalente, construção de ácido nucleico, célula hospedeira, imunoconjugado, uso de um anticorpo monovalente, e, composição farmacêutica |
| CN108129573B (zh) * | 2007-09-21 | 2021-10-08 | 加利福尼亚大学董事会 | 被导靶的干扰素显示强的细胞凋亡和抗肿瘤活性 |
| US20100047164A1 (en) | 2008-04-11 | 2010-02-25 | Duke University | Anti-Tumor Antibodies |
| WO2009134870A1 (en) | 2008-04-30 | 2009-11-05 | Immunogen, Inc. | Potent cell-binding agent drug conjugates |
| US8486393B2 (en) | 2008-09-19 | 2013-07-16 | University of Pittsburgh—of the Commonwealth System of Higher Education | Monoclonal antibodies for CSPG4 for the diagnosis and treatment of basal breast carcinoma |
| AU2010244428B2 (en) | 2009-05-06 | 2015-01-29 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| US20110165122A1 (en) * | 2009-11-10 | 2011-07-07 | The Regents Of The University Of California | Method for targeted and sustained antiviral therapy |
| WO2012075327A1 (en) | 2010-12-02 | 2012-06-07 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods for treating a tumor using an antibody that specifically binds grp94 |
| EP2672999A2 (en) | 2011-02-10 | 2013-12-18 | Roche Glycart AG | Improved immunotherapy |
| CA2848842C (en) | 2011-10-04 | 2020-09-29 | King's College London | Ige anti -hmw-maa antibody |
| PL2822575T3 (pl) * | 2012-03-03 | 2020-08-10 | Immungene, Inc. | Zmodyfikowane sposobami inżynierii cząsteczki fuzyjne przeciwciało-mutant interferonu |
| WO2014089354A1 (en) | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| US10093745B2 (en) | 2013-05-29 | 2018-10-09 | The Regents Of The University Of California | Anti-CSPG4 fusions with interferon for the treatment of malignancy |
-
2008
- 2008-09-19 CN CN201810058393.XA patent/CN108129573B/zh active Active
- 2008-09-19 MX MX2010003099A patent/MX2010003099A/es active IP Right Grant
- 2008-09-19 WO PCT/US2008/077074 patent/WO2009039409A1/en not_active Ceased
- 2008-09-19 EP EP16195608.1A patent/EP3150218B1/en active Active
- 2008-09-19 BR BRPI0817108A patent/BRPI0817108B8/pt active IP Right Grant
- 2008-09-19 MX MX2014010567A patent/MX349306B/es unknown
- 2008-09-19 US US12/678,981 patent/US9139634B2/en active Active
- 2008-09-19 ES ES08831632.8T patent/ES2536772T3/es active Active
- 2008-09-19 CN CN201410160383.9A patent/CN103880965B/zh active Active
- 2008-09-19 KR KR1020107008737A patent/KR101661770B1/ko active Active
- 2008-09-19 EP EP14180412.0A patent/EP2853267B1/en active Active
- 2008-09-19 EP EP20080831632 patent/EP2200634B1/en active Active
- 2008-09-19 JP JP2010526011A patent/JP5591701B2/ja active Active
- 2008-09-19 CA CA2699944A patent/CA2699944C/en active Active
- 2008-09-19 KR KR1020167014105A patent/KR101759460B1/ko active Active
- 2008-09-19 CN CN200880117225A patent/CN101868246A/zh active Pending
- 2008-09-19 AU AU2008302111A patent/AU2008302111B2/en active Active
-
2009
- 2009-12-30 US US12/650,329 patent/US8258263B2/en active Active
-
2010
- 2010-03-21 IL IL20464410A patent/IL204644A/en active IP Right Grant
-
2011
- 2011-01-05 US US12/985,122 patent/US8563692B2/en not_active Expired - Fee Related
-
2013
- 2013-08-30 US US14/015,838 patent/US9534033B2/en active Active
-
2014
- 2014-06-22 IL IL233305A patent/IL233305B/en active IP Right Grant
- 2014-07-30 JP JP2014154820A patent/JP6087871B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-02 JP JP2016215048A patent/JP2017031215A/ja active Pending
- 2016-11-22 US US15/359,456 patent/US10182984B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010540453A5 (enExample) | ||
| WO2012094653A4 (en) | Compositions and methods for macromolecular drug delivery | |
| NZ591130A (en) | Compositions comprising a PD-1 antagonists and cyclophosphamide and methods of use thereof | |
| JP2010516290A5 (enExample) | ||
| JP2012100677A5 (enExample) | ||
| JP2010516708A5 (enExample) | ||
| CN105142663A (zh) | 用于癌症靶向治疗的含有结合白蛋白的精氨酸脱亚胺酶的药物组合物 | |
| CN110981958B (zh) | 一种pd-l1抗体 | |
| JP2013513377A5 (enExample) | ||
| JP7330517B2 (ja) | 異種タンパク質産生のための人工分泌ペプチド | |
| JP2009540852A5 (enExample) | ||
| CN110300766A (zh) | 新型重组双功能融合蛋白及其制备方法和用途 | |
| CN105111314A (zh) | 一种新型融合蛋白、药物组合物及其制备方法和用途 | |
| CN103582494A (zh) | 靶向e-钙粘着蛋白的可溶性细胞外结构域的组合物和用于癌症治疗的有关方法 | |
| CN111278847A (zh) | 分子导向系统肽及其用途 | |
| JP2021517472A (ja) | 抗ｐｄ−ｌ１ワクチン組成物 | |
| CN111218443B (zh) | 合成核酸药物偶联物的方法 | |
| CN115916839A (zh) | 抗pdl1×egfr的双特异性抗体 | |
| CN101143902B (zh) | 抗HER2单链抗体-力达霉素强化融合蛋白HER2(Fv-LDM) | |
| JP2006345867A5 (enExample) | ||
| CN115028738B (zh) | 一种Fc融合蛋白双重靶向降解剂及应用 | |
| CN108341854A (zh) | 一种肿瘤靶向的新型多肽及其用途 | |
| WO2023020537A1 (zh) | 一种双特异性抗体及其用途 | |
| JP2015533372A5 (enExample) | ||
| CN101210048A (zh) | 用于靶向结合髓系白血病细胞的抗cd33的工程抗体及其表达载体和用途 |