JP2006345867A5 - - Google Patents

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Publication number
JP2006345867A5
JP2006345867A5 JP2006203335A JP2006203335A JP2006345867A5 JP 2006345867 A5 JP2006345867 A5 JP 2006345867A5 JP 2006203335 A JP2006203335 A JP 2006203335A JP 2006203335 A JP2006203335 A JP 2006203335A JP 2006345867 A5 JP2006345867 A5 JP 2006345867A5
Authority
JP
Japan
Prior art keywords
dna
nuclear
localization signal
transport agent
nuclear localization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2006203335A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006345867A (ja
Filing date
Publication date
Priority claimed from DE19933939A external-priority patent/DE19933939A1/de
Application filed filed Critical
Publication of JP2006345867A publication Critical patent/JP2006345867A/ja
Publication of JP2006345867A5 publication Critical patent/JP2006345867A5/ja
Pending legal-status Critical Current

Links

JP2006203335A 1999-01-08 2006-07-26 核膜を通した核酸の移動のための細胞輸送システムの使用 Pending JP2006345867A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19900513 1999-01-08
DE19933939A DE19933939A1 (de) 1999-01-08 1999-07-20 Ausnutzung zelleigener Transportsysteme zum Transfer von Nukleinsäuren durch die Kernhülle

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2000592436A Division JP3997056B2 (ja) 1999-01-08 2000-01-03 核膜を通した核酸の移動のための細胞輸送システムの使用

Publications (2)

Publication Number Publication Date
JP2006345867A JP2006345867A (ja) 2006-12-28
JP2006345867A5 true JP2006345867A5 (enExample) 2007-10-18

Family

ID=26051245

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000592436A Expired - Fee Related JP3997056B2 (ja) 1999-01-08 2000-01-03 核膜を通した核酸の移動のための細胞輸送システムの使用
JP2006203335A Pending JP2006345867A (ja) 1999-01-08 2006-07-26 核膜を通した核酸の移動のための細胞輸送システムの使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2000592436A Expired - Fee Related JP3997056B2 (ja) 1999-01-08 2000-01-03 核膜を通した核酸の移動のための細胞輸送システムの使用

Country Status (8)

Country Link
US (1) US6521456B1 (enExample)
EP (1) EP1141364A1 (enExample)
JP (2) JP3997056B2 (enExample)
CN (1) CN1262668C (enExample)
AU (1) AU764660B2 (enExample)
CA (1) CA2358040C (enExample)
IL (1) IL143983A0 (enExample)
WO (1) WO2000040742A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069173A1 (en) * 1998-03-16 2003-04-10 Life Technologies, Inc. Peptide-enhanced transfections
AU764660B2 (en) * 1999-01-08 2003-08-28 Lonza Cologne Ag Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane
JP2003514564A (ja) * 1999-11-24 2003-04-22 エムシーエス マイクロ キャリア システムズ ゲーエムベーハー 核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法
EP1335933A2 (en) * 2000-11-24 2003-08-20 Pantheco A/S Pna analogues
AU2002216946A1 (en) * 2001-01-05 2002-07-16 Pantheco A/S Modified pna molecules
KR100912741B1 (ko) 2001-01-10 2009-08-18 아막사 아게 모듈식 트랜스펙션 시스템
WO2003092735A2 (en) * 2002-05-01 2003-11-13 Pantheco A/S Peptide nucleic acid conjugates with beta-amino acid polymers or reptoids
AU2003219576A1 (en) * 2003-04-03 2004-10-25 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
US8969543B2 (en) * 2003-04-03 2015-03-03 Bioneer Corporation SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
CN101287835A (zh) * 2005-08-17 2008-10-15 株式会社百奥尼 用于siRNA细胞内输送的siRNA-亲水性聚合物结合物及其方法
EP1900820A1 (en) * 2006-09-13 2008-03-19 Amaxa AG Nuclear transport agent and method for producing said agent
WO2019219721A1 (en) 2018-05-18 2019-11-21 F. Hoffmann-La Roche Ag Targeted intracellular delivery of large nucleic acids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
AU682308C (en) 1992-04-03 2006-08-17 Regents Of The University Of California, The Self-assembling polynucleotide delivery system
US5574142A (en) 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
US5631237A (en) 1992-12-22 1997-05-20 Dzau; Victor J. Method for producing in vivo delivery of therapeutic agents via liposomes
JPH10501681A (ja) * 1994-02-22 1998-02-17 ダナ−ファーバー キャンサー インスティチュート 核酸送達システムならびにその合成および使用方法
JPH10501963A (ja) * 1994-04-15 1998-02-24 ターゲテッド ジェネティクス コーポレイション 遺伝子送達融合タンパク質
US5670347A (en) * 1994-05-11 1997-09-23 Amba Biosciences Llc Peptide-mediated gene transfer
WO1996040961A1 (en) * 1995-06-07 1996-12-19 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
DE19541679A1 (de) 1995-11-08 1997-05-15 Gerhard Dr Friedrich Nicht virale Gentransfersysteme mit NLS (nuclear localization sequences) und/oder magnetisierbaren Mikropartikeln und das damit verbundene Herstellungsverfahren
AUPN741696A0 (en) * 1996-01-05 1996-01-25 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids ii
WO1998028417A1 (en) * 1996-12-23 1998-07-02 Gene-Cell Nucleic acid constructs and uses thereof for direct nucleic acid incorporation into cells
AU7127598A (en) * 1997-04-18 1998-11-13 Millennium Pharmaceuticals, Inc. Novel molecules of the fthma-070-related protein family and the t85-related pro tein family and uses thereof
AU764660B2 (en) * 1999-01-08 2003-08-28 Lonza Cologne Ag Use of the cell's own transport system for transferring nucleic acids across the nuclear membrane
US6312956B1 (en) * 1999-10-01 2001-11-06 Vanderbilt University Nuclear targeted peptide nucleic acid oligomer

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