JP3997056B2 - 核膜を通した核酸の移動のための細胞輸送システムの使用 - Google Patents

核膜を通した核酸の移動のための細胞輸送システムの使用 Download PDF

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JP3997056B2
JP3997056B2 JP2000592436A JP2000592436A JP3997056B2 JP 3997056 B2 JP3997056 B2 JP 3997056B2 JP 2000592436 A JP2000592436 A JP 2000592436A JP 2000592436 A JP2000592436 A JP 2000592436A JP 3997056 B2 JP3997056 B2 JP 3997056B2
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dna
nuclear
transport agent
nuclear transport
nls
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JP2002534437A (ja
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グレゴール ジーベンコッテン，
レイナー クリスティヌ，
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アマクサ ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2000592436A 1999-01-08 2000-01-03 核膜を通した核酸の移動のための細胞輸送システムの使用 Expired - Fee Related JP3997056B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19900513 1999-01-08
DE19900513.3 1999-01-08
DE19933939.2 1999-07-20
DE19933939A DE19933939A1 (de) 1999-01-08 1999-07-20 Ausnutzung zelleigener Transportsysteme zum Transfer von Nukleinsäuren durch die Kernhülle
PCT/DE2000/000061 WO2000040742A1 (de) 1999-01-08 2000-01-03 Ausnutzung zelleigener transportsysteme zum transfer von nukleinsäuren durch die kernhülle

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006203335A Division JP2006345867A (ja) 1999-01-08 2006-07-26 核膜を通した核酸の移動のための細胞輸送システムの使用

Publications (2)

Publication Number Publication Date
JP2002534437A JP2002534437A (ja) 2002-10-15
JP3997056B2 true JP3997056B2 (ja) 2007-10-24

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000592436A Expired - Fee Related JP3997056B2 (ja) 1999-01-08 2000-01-03 核膜を通した核酸の移動のための細胞輸送システムの使用
JP2006203335A Pending JP2006345867A (ja) 1999-01-08 2006-07-26 核膜を通した核酸の移動のための細胞輸送システムの使用

Family Applications After (1)

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JP2006203335A Pending JP2006345867A (ja) 1999-01-08 2006-07-26 核膜を通した核酸の移動のための細胞輸送システムの使用

Country Status (8)

Country Link
US (1) US6521456B1 (enExample)
EP (1) EP1141364A1 (enExample)
JP (2) JP3997056B2 (enExample)
CN (1) CN1262668C (enExample)
AU (1) AU764660B2 (enExample)
CA (1) CA2358040C (enExample)
IL (1) IL143983A0 (enExample)
WO (1) WO2000040742A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006345867A (ja) * 1999-01-08 2006-12-28 Amaxa Gmbh 核膜を通した核酸の移動のための細胞輸送システムの使用

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069173A1 (en) * 1998-03-16 2003-04-10 Life Technologies, Inc. Peptide-enhanced transfections
CA2392490A1 (en) * 1999-11-24 2001-05-31 Mcs Micro Carrier Systems Gmbh Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells
EP1335933A2 (en) * 2000-11-24 2003-08-20 Pantheco A/S Pna analogues
WO2002053574A2 (en) * 2001-01-05 2002-07-11 Pantheco A/S Modified pna molecules
JP4551058B2 (ja) 2001-01-10 2010-09-22 ロンザ・ケルン・アーゲー モジュラートランスフェクション系
WO2003092735A2 (en) * 2002-05-01 2003-11-13 Pantheco A/S Peptide nucleic acid conjugates with beta-amino acid polymers or reptoids
AU2003219576A1 (en) * 2003-04-03 2004-10-25 Korea Advanced Institute Of Science And Technology Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof
US8969543B2 (en) * 2003-04-03 2015-03-03 Bioneer Corporation SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
AU2006280600B2 (en) * 2005-08-17 2012-01-19 Bioneer Corporation Sirna-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof
EP1900820A1 (en) * 2006-09-13 2008-03-19 Amaxa AG Nuclear transport agent and method for producing said agent
JP7206297B2 (ja) 2018-05-18 2023-01-17 エフ．ホフマン－ラ ロシュ アーゲー 大核酸の細胞内標的指向送達

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
AU682308C (en) * 1992-04-03 2006-08-17 Regents Of The University Of California, The Self-assembling polynucleotide delivery system
US5574142A (en) 1992-12-15 1996-11-12 Microprobe Corporation Peptide linkers for improved oligonucleotide delivery
US5631237A (en) 1992-12-22 1997-05-20 Dzau; Victor J. Method for producing in vivo delivery of therapeutic agents via liposomes
WO1995022618A1 (en) * 1994-02-22 1995-08-24 Dana-Farber Cancer Institute Nucleic acid delivery system, method of synthesis and uses thereof
EP0753069A1 (en) * 1994-04-15 1997-01-15 Targeted Genetics Corporation Gene delivery fusion proteins
US5670347A (en) * 1994-05-11 1997-09-23 Amba Biosciences Llc Peptide-mediated gene transfer
EP0874910A4 (en) 1995-06-07 1999-04-21 Life Technologies Inc ENHANCED CATIONIC LIPID TRANSFECTION BY PEPTIDES
DE19541679A1 (de) 1995-11-08 1997-05-15 Gerhard Dr Friedrich Nicht virale Gentransfersysteme mit NLS (nuclear localization sequences) und/oder magnetisierbaren Mikropartikeln und das damit verbundene Herstellungsverfahren
AUPN741696A0 (en) * 1996-01-05 1996-01-25 Commonwealth Scientific And Industrial Research Organisation Delivery of nucleic acids ii
JP2001507230A (ja) * 1996-12-23 2001-06-05 ジィーン−セル 核酸構成物及び細胞への直接核酸組み込みのためのその使用
WO1998048051A2 (en) * 1997-04-18 1998-10-29 Millennium Biotherapeutics, Inc. Novel molecules of the fthma-070-related protein family and the t85-related protein family and uses thereof
WO2000040742A1 (de) * 1999-01-08 2000-07-13 Amaxa Gmbh Ausnutzung zelleigener transportsysteme zum transfer von nukleinsäuren durch die kernhülle
US6312956B1 (en) * 1999-10-01 2001-11-06 Vanderbilt University Nuclear targeted peptide nucleic acid oligomer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006345867A (ja) * 1999-01-08 2006-12-28 Amaxa Gmbh 核膜を通した核酸の移動のための細胞輸送システムの使用

Also Published As

Publication number Publication date
CN1262668C (zh) 2006-07-05
US6521456B1 (en) 2003-02-18
IL143983A0 (en) 2002-04-21
EP1141364A1 (de) 2001-10-10
AU764660B2 (en) 2003-08-28
WO2000040742A1 (de) 2000-07-13
CA2358040C (en) 2008-06-10
JP2002534437A (ja) 2002-10-15
AU2533700A (en) 2000-07-24
CA2358040A1 (en) 2000-07-13
JP2006345867A (ja) 2006-12-28
CN1339068A (zh) 2002-03-06

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