JP2010539186A5 - - Google Patents

Download PDF

Info

Publication number
JP2010539186A5
JP2010539186A5 JP2010525102A JP2010525102A JP2010539186A5 JP 2010539186 A5 JP2010539186 A5 JP 2010539186A5 JP 2010525102 A JP2010525102 A JP 2010525102A JP 2010525102 A JP2010525102 A JP 2010525102A JP 2010539186 A5 JP2010539186 A5 JP 2010539186A5
Authority
JP
Japan
Prior art keywords
group
independently
alkyl
alkenyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010525102A
Other languages
English (en)
Japanese (ja)
Other versions
JP5734654B2 (ja
JP2010539186A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/076576 external-priority patent/WO2009039127A1/en
Publication of JP2010539186A publication Critical patent/JP2010539186A/ja
Publication of JP2010539186A5 publication Critical patent/JP2010539186A5/ja
Application granted granted Critical
Publication of JP5734654B2 publication Critical patent/JP5734654B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010525102A 2007-09-17 2008-09-17 Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体 Expired - Fee Related JP5734654B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97287707P 2007-09-17 2007-09-17
US60/972,877 2007-09-17
US9679108P 2008-09-13 2008-09-13
US61/096,791 2008-09-13
PCT/US2008/076576 WO2009039127A1 (en) 2007-09-17 2008-09-17 Uracil or thymine derivative for treating hepatitis c

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012225875A Division JP2013049681A (ja) 2007-09-17 2012-10-11 Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体

Publications (3)

Publication Number Publication Date
JP2010539186A JP2010539186A (ja) 2010-12-16
JP2010539186A5 true JP2010539186A5 (https=) 2012-11-15
JP5734654B2 JP5734654B2 (ja) 2015-06-17

Family

ID=39948002

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010525102A Expired - Fee Related JP5734654B2 (ja) 2007-09-17 2008-09-17 Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体
JP2012225875A Pending JP2013049681A (ja) 2007-09-17 2012-10-11 Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012225875A Pending JP2013049681A (ja) 2007-09-17 2012-10-11 Ｃ型肝炎を治療するためのウラシルまたはチミン誘導体

Country Status (30)

Country Link
US (3) US8415351B2 (https=)
EP (2) EP2222646B1 (https=)
JP (2) JP5734654B2 (https=)
KR (2) KR101660360B1 (https=)
CN (2) CN101801935B (https=)
AR (2) AR070027A1 (https=)
AU (1) AU2008302448B2 (https=)
BR (1) BRPI0816994B8 (https=)
CA (2) CA2699981C (https=)
CL (2) CL2008002794A1 (https=)
CO (1) CO6260076A2 (https=)
CR (2) CR11316A (https=)
DO (2) DOP2010000084A (https=)
ES (1) ES2453591T3 (https=)
GT (1) GT201000061A (https=)
IL (1) IL204547A (https=)
IN (1) IN2012DN05113A (https=)
MX (2) MX2010002905A (https=)
MY (1) MY162760A (https=)
NZ (3) NZ584720A (https=)
PA (1) PA8796201A1 (https=)
PE (2) PE20090705A1 (https=)
PH (1) PH12013500365A1 (https=)
RU (2) RU2543620C2 (https=)
SG (1) SG183733A1 (https=)
TW (2) TWI437994B (https=)
UA (1) UA117800C2 (https=)
UY (1) UY31344A1 (https=)
WO (1) WO2009039127A1 (https=)
ZA (2) ZA201204223B (https=)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2368882T1 (sl) 2007-09-17 2015-02-27 Abbvie Bahamas Ltd. Antiinfekcijski pirimidini in njihove uporabe
DK2203430T3 (da) 2007-09-17 2011-09-26 Abbott Lab N-phenyl-dioxo-hydropyrimidiner anvendelige som inhibitorer for hepatitis C virus (HCV)
MY162760A (en) 2007-09-17 2017-07-14 Abbvie Bahamas Ltd Anti-infective agents and uses thereof
MX2010005356A (es) * 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
PE20110409A1 (es) 2008-07-23 2011-06-22 Hoffmann La Roche Compuestos heterociclicos antiviricos
CN102164909A (zh) 2008-09-26 2011-08-24 弗·哈夫曼-拉罗切有限公司 用于治疗hcv的吡啶或吡嗪衍生物
BRPI1009854A2 (pt) * 2009-03-24 2015-08-25 Abbott Lab Processo para preparar composto antiviral
CA2755023C (en) * 2009-03-25 2016-12-13 Abbott Laboratories Antiviral compounds and uses thereof
US20120065247A1 (en) * 2009-03-27 2012-03-15 Discoverybiomed, Inc. Modulating ires-mediated translation
KR20120011880A (ko) 2009-04-25 2012-02-08 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스성 화합물
TWI428332B (zh) 2009-06-09 2014-03-01 Hoffmann La Roche 雜環抗病毒化合物
BRPI1011744A2 (pt) * 2009-06-24 2016-03-22 Hoffmann La Roche composto antiviral heterocíclico.
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
AU2010297290A1 (en) 2009-09-21 2012-03-15 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
WO2011061243A1 (en) * 2009-11-21 2011-05-26 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
WO2011073114A1 (en) 2009-12-14 2011-06-23 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
JP5651239B2 (ja) 2010-07-07 2015-01-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 複素環式抗ウイルス化合物
BR112013001138A2 (pt) 2010-07-16 2016-07-05 Abbvie Inc ligantes de fosfina para reações catalíticas
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
AU2015201698B2 (en) * 2010-07-16 2017-02-02 Abbvie Ireland Unlimited Company Process for preparing antiviral compounds
US8895737B2 (en) 2010-07-16 2014-11-25 Shashank Shekhar Process for preparing antiviral compounds
RU2436786C1 (ru) * 2010-07-23 2011-12-20 Александр Васильевич Иващенко Замещенные индолы, противовирусный активный компонент, способ получения и применения
WO2012020725A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体
MX2013001273A (es) 2010-08-13 2013-04-10 Hoffmann La Roche Compuestos heterociclicos antivirales.
CN102675092B (zh) * 2011-03-14 2014-11-05 江苏中丹药物研究有限公司 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法
CA2829768A1 (en) 2011-03-18 2012-09-27 Abbvie Inc. Formulations of phenyl uracil compounds
US20140065223A1 (en) * 2011-03-31 2014-03-06 Jeanette Libera-Koerner Perfluorinated compounds for the non-viral transfer of nucleic acids
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
JP5734124B2 (ja) * 2011-07-21 2015-06-10 株式会社 東邦アーステック １，３−ジヨードヒダントイン類の製造方法
CN104024241B (zh) 2011-08-01 2016-01-20 大日本住友制药株式会社 尿嘧啶衍生物和其用于医学目的的用途
DE112012002748T5 (de) 2011-10-21 2014-07-31 Abbvie Inc. Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon
AU2015200715A1 (en) * 2011-10-21 2015-03-05 Abbvie Ireland Unlimited Company Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
SE1450131A1 (sv) 2011-10-21 2014-05-07 Abbvie Inc DAA-kombinationsbehandling (t.ex. med ABT-072 eller ABT-333)för användning vid behandling av HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
WO2013171641A1 (en) 2012-05-15 2013-11-21 Novartis Ag Compounds and compositions for inhibiting the activity of abl1, abl2 and bcr-abl1
ES2670667T3 (es) 2012-05-15 2018-05-31 Novartis Ag Derivados de benzamida para inhibir la actividad de ABL1, ABL2 y BCR-ABL1
PT2861579T (pt) 2012-05-15 2018-04-27 Novartis Ag Derivados de benzamida para inibir a atividade de abl1, abl2 e bcr-abl
KR20150008406A (ko) 2012-05-15 2015-01-22 노파르티스 아게 Abl1, abl2 및 bcr-abl1의 활성을 억제하기 위한 벤즈아미드 유도체
JP2015522022A (ja) 2012-06-27 2015-08-03 アッヴィ・インコーポレイテッド Ｈｃｖの処置に使用するためのａｂｔ−４５０およびリトナビルおよび例えばａｂｔ−０７２および／またはａｂｔ−３３３の併用処置
MX360161B (es) * 2012-08-21 2018-10-09 Abbvie Inc Proceso para preparar compuestos antiviricos.
EA032913B1 (ru) * 2012-10-18 2019-08-30 Эббви Инк. Препараты производных пиримидиндиона
JP2014101316A (ja) * 2012-11-20 2014-06-05 Toyobo Co Ltd ベンゾ［１，２−ｄ；４，５−ｄ’］ビスチアゾール化合物の製造方法
EP3016651A1 (en) 2013-07-02 2016-05-11 AbbVie Inc. Methods for treating hcv
ES2728531T3 (es) 2013-07-08 2019-10-25 Bayer Cropscience Ag Derivados de arilsulfuro y arilsulfóxido de seis miembros enlazados con C-N como agentes para combatir parásitos
SI3043803T1 (sl) 2013-09-11 2022-09-30 Emory University Nukleotidne in nukleozidne sestave in njihova uporaba
EP3089757A1 (en) 2014-01-03 2016-11-09 AbbVie Inc. Solid antiviral dosage forms
EP3099295A1 (en) 2014-01-28 2016-12-07 Abbvie Inc. Dose adjustment in combination therapy of hepatitis c
EP3102576B8 (en) 2014-02-03 2019-06-19 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma
WO2015197028A1 (en) * 2014-06-28 2015-12-30 Sunshine Lake Pharma Co., Ltd. Compounds as hepatitis c virus (hcv) inhibitors and uses thereof in medicine
US20170216252A1 (en) * 2014-07-11 2017-08-03 Simon Fraser University Anti-bacterial pyruvate kinase modulator compounds, compositions, uses and methods
RU2743074C2 (ru) 2014-08-01 2021-02-15 Нуэволюшон А/С Соединения, активные по отношению к бромодоменам
WO2016040588A1 (en) 2014-09-11 2016-03-17 Abbvie Inc. Treatment of hcv by administering four different anti-hcv compounds with food
PT3207043T (pt) 2014-10-14 2019-03-25 Vitae Pharmaceuticals Llc Inibidores de di-hidropirrolopiridina de ror-gama
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
WO2016105547A1 (en) 2014-12-24 2016-06-30 Concert Pharmaceuticals, Inc. Deuterated dasabuvir
RU2590952C1 (ru) * 2015-05-26 2016-07-10 Вячеслав Энгельсович Семёнов Средство гепатопротекторного действия
WO2016196280A1 (en) 2015-06-02 2016-12-08 E I Du Pont De Nemours And Company Heterocycle-substituted bicyclic pesticides
JP2018525371A (ja) * 2015-07-30 2018-09-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ アリール置換された二環式ヘテロアリール化合物
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
US11008340B2 (en) 2015-11-20 2021-05-18 Vitae Pharmaceuticals, Llc Modulators of ROR-gamma
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
JP2020528904A (ja) 2017-07-24 2020-10-01 ヴァイティー ファーマシューティカルズ，エルエルシー ＲＯＲγの阻害剤
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN107266373A (zh) * 2017-08-01 2017-10-20 安徽拜善晟制药有限公司 一种原料药达沙布韦的制备方法
EP3774804A1 (en) 2018-03-26 2021-02-17 Novartis AG N-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)benzamide derivatives
CN110483496B (zh) * 2019-07-17 2021-05-04 杭州市西溪医院 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用
JP7785663B2 (ja) * 2019-09-16 2025-12-15 ノバルティス アーゲー 二機能性分解誘導薬及びそれらの使用方法
EP3819006A1 (en) 2019-11-05 2021-05-12 Technische Universität Dresden Compounds with thymine skeleton for use in medicine
CN111518036A (zh) * 2020-04-29 2020-08-11 杭州勇诚睿生物科技有限公司 一种达沙布韦关键中间体的制备方法
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4239888A (en) * 1974-11-04 1980-12-16 Pfizer Inc. 1-Phenyluracils
JPS60243017A (ja) * 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
US5084084A (en) * 1989-07-14 1992-01-28 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
AU627906B2 (en) * 1989-07-14 1992-09-03 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
US5162326A (en) 1990-02-15 1992-11-10 Takeda Chemical Industries, Ltd. Pyrimidinedione derivatives, their production and use
NL9001075A (https=) * 1990-05-04 1991-12-02 Duphar Int Res
EP0489480A1 (en) * 1990-12-05 1992-06-10 Nissan Chemical Industries Ltd. Uracil derivatives and herbicides containing the same as active ingredient
JPH05213755A (ja) 1992-02-07 1993-08-24 Nikko Kyodo Co Ltd 肝臓障害治療薬
DE19528305A1 (de) 1995-08-02 1997-02-06 Bayer Ag Substituierte Phenyluracile
US6380387B1 (en) * 1999-12-06 2002-04-30 Hoffmann-La Roche Inc. 4-Pyrimidinyl-n-acyl-l phenylalanines
PL207160B1 (pl) * 1999-12-06 2010-11-30 Hoffmann La Roche Pochodne 4-pirymidynylo-N-acylo-L-fenyloalaniny, związki pośrednie, środek farmaceutyczny i ich zastosowanie
IL167954A (en) * 2000-02-04 2007-10-31 Sumitomo Chemical Co History of pyrimidine
RU2264395C2 (ru) * 2000-02-04 2005-11-20 Сумитомо Кемикал Компани, Лимитед Производные урацила, гербицидная композиция, способ борьбы с сорняками и промежуточные продукты (варианты)
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
KR100589964B1 (ko) * 2003-06-13 2006-06-19 주식회사 엘지생명과학 Ｃ형 간염 바이러스의 억제제
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
JO2934B1 (en) * 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
SI2368882T1 (sl) * 2007-09-17 2015-02-27 Abbvie Bahamas Ltd. Antiinfekcijski pirimidini in njihove uporabe
DK2203430T3 (da) * 2007-09-17 2011-09-26 Abbott Lab N-phenyl-dioxo-hydropyrimidiner anvendelige som inhibitorer for hepatitis C virus (HCV)
MY162760A (en) * 2007-09-17 2017-07-14 Abbvie Bahamas Ltd Anti-infective agents and uses thereof
PE20110409A1 (es) 2008-07-23 2011-06-22 Hoffmann La Roche Compuestos heterociclicos antiviricos

Similar Documents

Publication Publication Date Title
JP2010539186A5 (https=)
JP2010539188A5 (https=)
RU2013104270A (ru) Производные урацила или тимина для лечения гепатита с
JP2010539187A5 (https=)
HRP20110632T1 (hr) N-fenil-diokso-hidropirimidini korisni kao inhibitori virusa hepatitisa c (hcv)
JP2011520906A5 (https=)
JP2014530900A5 (https=)
RU2010114827A (ru) Пиримидины, которые могут быть использованы в качестве противоинфекционных средств, и их применения
JP2010510233A5 (https=)
JP2021534124A5 (https=)
JP2009523760A5 (https=)
JP2011521911A5 (https=)
JP5571167B2 (ja) 抗ウイルス組成物およびこの使用
JP2019509276A5 (https=)
JP2013531031A5 (https=)
RU2011142978A (ru) Противовирусные соединения и их применения
RU2003137561A (ru) 4-замещенные нуклеозиды
JP2012507566A5 (https=)
JP2019522055A5 (https=)
RU2015151204A (ru) Композиции и способы
JP2009514823A5 (https=)
JP2009506039A5 (https=)
JP2011507878A5 (https=)
JP2017533968A5 (https=)
JP2010534654A5 (https=)