JP2010537994A5 - - Google Patents
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- Publication number
- JP2010537994A5 JP2010537994A5 JP2010523034A JP2010523034A JP2010537994A5 JP 2010537994 A5 JP2010537994 A5 JP 2010537994A5 JP 2010523034 A JP2010523034 A JP 2010523034A JP 2010523034 A JP2010523034 A JP 2010523034A JP 2010537994 A5 JP2010537994 A5 JP 2010537994A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pharmaceutically acceptable
- compound according
- acceptable salt
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 pyrazol-4-yl Chemical group 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- WHYASBKVZHKQTN-UHFFFAOYSA-N 1-methylpyrazole-4-sulfonic acid Chemical compound CN1C=C(S(O)(=O)=O)C=N1 WHYASBKVZHKQTN-UHFFFAOYSA-N 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96834407P | 2007-08-28 | 2007-08-28 | |
| US60/968,344 | 2007-08-28 | ||
| US4875208P | 2008-04-29 | 2008-04-29 | |
| US61/048,752 | 2008-04-29 | ||
| PCT/US2008/073543 WO2009029439A1 (en) | 2007-08-28 | 2008-08-19 | Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010537994A JP2010537994A (ja) | 2010-12-09 |
| JP2010537994A5 true JP2010537994A5 (enExample) | 2011-10-06 |
| JP5290293B2 JP5290293B2 (ja) | 2013-09-18 |
Family
ID=39873874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523034A Expired - Fee Related JP5290293B2 (ja) | 2007-08-28 | 2008-08-19 | ５−ｈｔ７受容体拮抗薬としての置換ピペラジニルピラジンおよびピリジン |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8048884B2 (enExample) |
| EP (1) | EP2188268B1 (enExample) |
| JP (1) | JP5290293B2 (enExample) |
| KR (1) | KR101148616B1 (enExample) |
| CN (1) | CN101790522B (enExample) |
| AR (1) | AR068111A1 (enExample) |
| AT (1) | ATE520673T1 (enExample) |
| AU (1) | AU2008293715B2 (enExample) |
| BR (1) | BRPI0816468A2 (enExample) |
| CA (1) | CA2694911C (enExample) |
| CY (1) | CY1111848T1 (enExample) |
| DK (1) | DK2188268T3 (enExample) |
| EA (1) | EA017809B1 (enExample) |
| HR (1) | HRP20110624T1 (enExample) |
| MX (1) | MX2010002352A (enExample) |
| PE (1) | PE20090629A1 (enExample) |
| PL (1) | PL2188268T3 (enExample) |
| PT (1) | PT2188268E (enExample) |
| SI (1) | SI2188268T1 (enExample) |
| TW (1) | TW200914020A (enExample) |
| WO (1) | WO2009029439A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI118473B (fi) | 2006-02-17 | 2007-11-30 | Outotec Oyj | Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista |
| EA016787B1 (ru) * | 2007-10-12 | 2012-07-30 | Эли Лилли Энд Компани | Антагонисты рецептора 5-нт |
| CN103119034B (zh) | 2010-04-16 | 2016-08-03 | 拜耳知识产权有限责任公司 | 作为害虫防治剂的杂环化合物 |
| CN103857670B (zh) | 2011-10-11 | 2016-03-23 | Ucb医药有限公司 | 2-氧代-哌啶基衍生物 |
| FR2995605B1 (fr) | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
| MA39145B1 (fr) | 2013-12-20 | 2018-05-31 | Esteve Labor Dr | Dérivés de pipérazine ayant une activité multimode contre la douleur |
| TWI648265B (zh) | 2017-03-03 | 2019-01-21 | 國立臺灣大學 | ８－苯基異喹啉及其醫藥組合物用於治療腸躁症候群 |
| KR102014335B1 (ko) * | 2017-12-01 | 2019-08-26 | 한국과학기술연구원 | 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1153013B1 (en) * | 1999-02-10 | 2007-10-31 | Eli Lilly And Company | 5-ht1f agonists |
| US20030008880A1 (en) * | 2001-05-02 | 2003-01-09 | Pfizer Inc. | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity |
| CA2514656A1 (en) * | 2003-01-31 | 2004-08-12 | Pfizer Products Inc. | 5ht7 antagonists and inverse agonists |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
-
2008
- 2008-08-01 TW TW097129418A patent/TW200914020A/zh unknown
- 2008-08-19 AT AT08798144T patent/ATE520673T1/de active
- 2008-08-19 KR KR1020107004378A patent/KR101148616B1/ko not_active Expired - Fee Related
- 2008-08-19 SI SI200830392T patent/SI2188268T1/sl unknown
- 2008-08-19 HR HR20110624T patent/HRP20110624T1/hr unknown
- 2008-08-19 CN CN2008801048354A patent/CN101790522B/zh not_active Expired - Fee Related
- 2008-08-19 AU AU2008293715A patent/AU2008293715B2/en not_active Ceased
- 2008-08-19 PL PL08798144T patent/PL2188268T3/pl unknown
- 2008-08-19 CA CA2694911A patent/CA2694911C/en not_active Expired - Fee Related
- 2008-08-19 JP JP2010523034A patent/JP5290293B2/ja not_active Expired - Fee Related
- 2008-08-19 MX MX2010002352A patent/MX2010002352A/es active IP Right Grant
- 2008-08-19 EA EA201070321A patent/EA017809B1/ru not_active IP Right Cessation
- 2008-08-19 BR BRPI0816468 patent/BRPI0816468A2/pt not_active Application Discontinuation
- 2008-08-19 EP EP08798144A patent/EP2188268B1/en not_active Not-in-force
- 2008-08-19 WO PCT/US2008/073543 patent/WO2009029439A1/en not_active Ceased
- 2008-08-19 DK DK08798144.5T patent/DK2188268T3/da active
- 2008-08-19 US US12/447,546 patent/US8048884B2/en not_active Expired - Fee Related
- 2008-08-19 PT PT08798144T patent/PT2188268E/pt unknown
- 2008-08-27 PE PE2008001449A patent/PE20090629A1/es not_active Application Discontinuation
- 2008-08-27 AR ARP080103721A patent/AR068111A1/es unknown
-
2011
- 2011-09-20 CY CY20111100910T patent/CY1111848T1/el unknown