CN101790522B - 取代的哌嗪基吡嗪和吡啶作为5-ht7受体拮抗剂 - Google Patents
取代的哌嗪基吡嗪和吡啶作为5-ht7受体拮抗剂 Download PDFInfo
- Publication number
- CN101790522B CN101790522B CN2008801048354A CN200880104835A CN101790522B CN 101790522 B CN101790522 B CN 101790522B CN 2008801048354 A CN2008801048354 A CN 2008801048354A CN 200880104835 A CN200880104835 A CN 200880104835A CN 101790522 B CN101790522 B CN 101790522B
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- China
- Prior art keywords
- compound
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- ethyl
- pharmacology
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 CC(N1CCN(CCN(C)S(c(c(F)cc(F)c2)c2F)(=O)=O)CC1)=NC=* Chemical compound CC(N1CCN(CCN(C)S(c(c(F)cc(F)c2)c2F)(=O)=O)CC1)=NC=* 0.000 description 4
- MXVRVQOHSGENHC-IHYYBNPGSA-N C/C=C\C=C(/C(CC=C)=C)\N1CCN(CCN(C)S(c2c[n](C)nc2)(=O)=O)CC1 Chemical compound C/C=C\C=C(/C(CC=C)=C)\N1CCN(CCN(C)S(c2c[n](C)nc2)(=O)=O)CC1 MXVRVQOHSGENHC-IHYYBNPGSA-N 0.000 description 1
- RTPSWIBYZQVMFZ-UHFFFAOYSA-N C[n]1ncc(S(NCCN(CC2)CCN2c2nccnc2-c2ccc(COC)cc2)(=C)=O)c1 Chemical compound C[n]1ncc(S(NCCN(CC2)CCN2c2nccnc2-c2ccc(COC)cc2)(=C)=O)c1 RTPSWIBYZQVMFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96834407P | 2007-08-28 | 2007-08-28 | |
| US60/968344 | 2007-08-28 | ||
| US4875208P | 2008-04-29 | 2008-04-29 | |
| US61/048752 | 2008-04-29 | ||
| PCT/US2008/073543 WO2009029439A1 (en) | 2007-08-28 | 2008-08-19 | Substituted piperazinyl pyrazines and pyridines as 5-ht7 receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101790522A CN101790522A (zh) | 2010-07-28 |
| CN101790522B true CN101790522B (zh) | 2012-06-27 |
Family
ID=39873874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801048354A Expired - Fee Related CN101790522B (zh) | 2007-08-28 | 2008-08-19 | 取代的哌嗪基吡嗪和吡啶作为5-ht7受体拮抗剂 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8048884B2 (enExample) |
| EP (1) | EP2188268B1 (enExample) |
| JP (1) | JP5290293B2 (enExample) |
| KR (1) | KR101148616B1 (enExample) |
| CN (1) | CN101790522B (enExample) |
| AR (1) | AR068111A1 (enExample) |
| AT (1) | ATE520673T1 (enExample) |
| AU (1) | AU2008293715B2 (enExample) |
| BR (1) | BRPI0816468A2 (enExample) |
| CA (1) | CA2694911C (enExample) |
| CY (1) | CY1111848T1 (enExample) |
| DK (1) | DK2188268T3 (enExample) |
| EA (1) | EA017809B1 (enExample) |
| HR (1) | HRP20110624T1 (enExample) |
| MX (1) | MX2010002352A (enExample) |
| PE (1) | PE20090629A1 (enExample) |
| PL (1) | PL2188268T3 (enExample) |
| PT (1) | PT2188268E (enExample) |
| SI (1) | SI2188268T1 (enExample) |
| TW (1) | TW200914020A (enExample) |
| WO (1) | WO2009029439A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI118473B (fi) | 2006-02-17 | 2007-11-30 | Outotec Oyj | Menetelmä kuparin talteenottamiseksi kuparisulfidimalmista |
| PL2201002T3 (pl) * | 2007-10-12 | 2012-07-31 | Lilly Co Eli | Antagoniści receptora 5-HT7 |
| ES2651002T3 (es) | 2010-04-16 | 2018-01-23 | Bayer Intellectual Property Gmbh | Nuevos compuestos heterocíclicos como pesticidas |
| ES2546317T3 (es) | 2011-10-11 | 2015-09-22 | Ucb Biopharma Sprl | Derivados de 2-oxo-piperidinilo |
| FR2995605B1 (fr) | 2012-09-18 | 2014-09-19 | Sanofi Sa | Derives de macrolides, leur preparation et leur application therapeutique. |
| MA39145B1 (fr) * | 2013-12-20 | 2018-05-31 | Esteve Labor Dr | Dérivés de pipérazine ayant une activité multimode contre la douleur |
| JP6920759B2 (ja) | 2017-03-03 | 2021-08-18 | 國立臺灣大學 | 化合物および化合物の使用 |
| KR102014335B1 (ko) * | 2017-12-01 | 2019-08-26 | 한국과학기술연구원 | 5-ht7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340045A (zh) * | 1999-02-10 | 2002-03-13 | 伊莱利利公司 | 5－ht1f激动剂 |
| EP1254905A1 (en) * | 2001-05-02 | 2002-11-06 | Pfizer Products Inc. | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1592772A2 (en) * | 2003-01-31 | 2005-11-09 | Pfizer Products Incorporated | 5ht7 antagonists and inverse agonists |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
-
2008
- 2008-08-01 TW TW097129418A patent/TW200914020A/zh unknown
- 2008-08-19 CA CA2694911A patent/CA2694911C/en not_active Expired - Fee Related
- 2008-08-19 US US12/447,546 patent/US8048884B2/en not_active Expired - Fee Related
- 2008-08-19 SI SI200830392T patent/SI2188268T1/sl unknown
- 2008-08-19 AT AT08798144T patent/ATE520673T1/de active
- 2008-08-19 JP JP2010523034A patent/JP5290293B2/ja not_active Expired - Fee Related
- 2008-08-19 KR KR1020107004378A patent/KR101148616B1/ko not_active Expired - Fee Related
- 2008-08-19 AU AU2008293715A patent/AU2008293715B2/en not_active Ceased
- 2008-08-19 EP EP08798144A patent/EP2188268B1/en not_active Not-in-force
- 2008-08-19 BR BRPI0816468 patent/BRPI0816468A2/pt not_active Application Discontinuation
- 2008-08-19 HR HR20110624T patent/HRP20110624T1/hr unknown
- 2008-08-19 CN CN2008801048354A patent/CN101790522B/zh not_active Expired - Fee Related
- 2008-08-19 EA EA201070321A patent/EA017809B1/ru not_active IP Right Cessation
- 2008-08-19 PT PT08798144T patent/PT2188268E/pt unknown
- 2008-08-19 MX MX2010002352A patent/MX2010002352A/es active IP Right Grant
- 2008-08-19 DK DK08798144.5T patent/DK2188268T3/da active
- 2008-08-19 WO PCT/US2008/073543 patent/WO2009029439A1/en not_active Ceased
- 2008-08-19 PL PL08798144T patent/PL2188268T3/pl unknown
- 2008-08-27 PE PE2008001449A patent/PE20090629A1/es not_active Application Discontinuation
- 2008-08-27 AR ARP080103721A patent/AR068111A1/es unknown
-
2011
- 2011-09-20 CY CY20111100910T patent/CY1111848T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1340045A (zh) * | 1999-02-10 | 2002-03-13 | 伊莱利利公司 | 5－ht1f激动剂 |
| EP1254905A1 (en) * | 2001-05-02 | 2002-11-06 | Pfizer Products Inc. | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity |
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20110624T1 (hr) | 2011-09-30 |
| CY1111848T1 (el) | 2015-10-07 |
| SI2188268T1 (sl) | 2011-11-30 |
| EP2188268B1 (en) | 2011-08-17 |
| AU2008293715A1 (en) | 2009-03-05 |
| WO2009029439A1 (en) | 2009-03-05 |
| AR068111A1 (es) | 2009-11-04 |
| US20100075976A1 (en) | 2010-03-25 |
| PT2188268E (pt) | 2011-10-03 |
| MX2010002352A (es) | 2010-08-04 |
| EP2188268A1 (en) | 2010-05-26 |
| AU2008293715B2 (en) | 2013-09-19 |
| KR20100038117A (ko) | 2010-04-12 |
| CA2694911A1 (en) | 2009-03-05 |
| CN101790522A (zh) | 2010-07-28 |
| PL2188268T3 (pl) | 2011-12-30 |
| PE20090629A1 (es) | 2009-05-16 |
| EA017809B1 (ru) | 2013-03-29 |
| JP5290293B2 (ja) | 2013-09-18 |
| JP2010537994A (ja) | 2010-12-09 |
| US8048884B2 (en) | 2011-11-01 |
| EA201070321A1 (ru) | 2010-08-30 |
| CA2694911C (en) | 2013-05-07 |
| KR101148616B1 (ko) | 2012-05-21 |
| TW200914020A (en) | 2009-04-01 |
| ATE520673T1 (de) | 2011-09-15 |
| BRPI0816468A2 (pt) | 2015-03-24 |
| DK2188268T3 (da) | 2011-10-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120627 Termination date: 20180819 |