JP2010536767A5 - - Google Patents
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- Publication number
- JP2010536767A5 JP2010536767A5 JP2010521081A JP2010521081A JP2010536767A5 JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5 JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- ring
- independently
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96511507P | 2007-08-17 | 2007-08-17 | |
| US60/965,115 | 2007-08-17 | ||
| US4345908P | 2008-04-09 | 2008-04-09 | |
| US61/043,459 | 2008-04-09 | ||
| US8045408P | 2008-07-14 | 2008-07-14 | |
| US61/080,454 | 2008-07-14 | ||
| PCT/US2008/072074 WO2009025983A2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Division JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536767A JP2010536767A (ja) | 2010-12-02 |
| JP2010536767A5 true JP2010536767A5 (show.php) | 2011-09-15 |
| JP5965102B2 JP5965102B2 (ja) | 2016-08-03 |
Family
ID=40350174
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521081A Active JP5965102B2 (ja) | 2007-08-17 | 2008-08-04 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8217180B2 (show.php) |
| EP (1) | EP2176244B1 (show.php) |
| JP (2) | JP5965102B2 (show.php) |
| KR (2) | KR20150082693A (show.php) |
| CN (2) | CN101855215A (show.php) |
| AR (1) | AR067948A1 (show.php) |
| AU (1) | AU2008289321B2 (show.php) |
| BR (1) | BRPI0814153B8 (show.php) |
| CA (1) | CA2693067C (show.php) |
| CO (1) | CO6260136A2 (show.php) |
| ES (1) | ES2587386T3 (show.php) |
| IL (1) | IL203174A (show.php) |
| MX (2) | MX2010001773A (show.php) |
| MY (2) | MY176115A (show.php) |
| PT (1) | PT2176244T (show.php) |
| RU (1) | RU2536039C2 (show.php) |
| TW (3) | TWI600639B (show.php) |
| WO (1) | WO2009025983A2 (show.php) |
| ZA (1) | ZA201000214B (show.php) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| MX2009013469A (es) * | 2007-06-13 | 2010-01-20 | Du Pont | Insecticidas de isoxazolina. |
| TWI430995B (zh) * | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| US8952175B2 (en) | 2007-06-27 | 2015-02-10 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound |
| WO2009003075A1 (en) | 2007-06-27 | 2008-12-31 | E.I. Du Pont De Nemours And Company | Animal pest control method |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備5-鹵烷基-4,5-二氫異唑衍生物之化合物 |
| KR20100075996A (ko) * | 2007-10-03 | 2010-07-05 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물 |
| TWI518076B (zh) | 2008-04-09 | 2016-01-21 | 杜邦股份有限公司 | 製備雜環化合物之方法 |
| EP2306837B2 (en) | 2008-07-09 | 2023-10-25 | Basf Se | Pesticidal active mixtures comprising isoxazoline compounds i |
| BRPI0915818A2 (pt) | 2008-07-09 | 2015-08-04 | Basf Se | Mistura pesticida, composição pesticida, método para controlar fungos nocivos fitopatogênicos, para proteger plantas de fungos nocivos fitopatogênicos, para controlar insetos, aracnídeos ou nematódeos, para proteger plantas do ataque ou infestação por insetos, acarídeos ou nematódeos, e para a proteção de semente, semente, e, uso de uma mistura. |
| CN102131804B (zh) | 2008-08-22 | 2014-12-03 | 先正达参股股份有限公司 | 杀虫化合物 |
| KR20110044873A (ko) | 2008-08-22 | 2011-05-02 | 신젠타 파티서페이션즈 아게 | 살충성 화합물 |
| WO2010025998A1 (en) | 2008-09-04 | 2010-03-11 | Syngenta Participations Ag | Insecticidal compounds |
| US8633134B2 (en) | 2008-12-23 | 2014-01-21 | Basf Se | Substituted amidine compounds for combating animal pests |
| TW201029997A (en) | 2008-12-23 | 2010-08-16 | Basf Se | Imine compounds for combating invertebrate pests |
| EP2414353A1 (en) * | 2009-04-01 | 2012-02-08 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
| NZ600922A (en) | 2009-12-17 | 2013-10-25 | Merial Ltd | Anti parasitic dihydroazole compounds and compositions comprising same |
| BR112012019103A2 (pt) | 2010-02-01 | 2015-10-20 | Basf Se | compostos de isoxazolina cetônica, composto cetônico, composição agrícola, composição veterinária, uso de um composto, método e material de propagação de planta |
| BR112012030151B8 (pt) | 2010-05-27 | 2019-12-10 | Du Pont | polimorfo cristalino, composição, método para controlar uma praga invertebrada e uso do polimorfo |
| UY33403A (es) | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| WO2012038851A1 (en) | 2010-09-24 | 2012-03-29 | Pfizer Inc. | Isoxazoline oximes as antiparasitic agents |
| UA113615C2 (xx) | 2010-09-27 | 2017-02-27 | Спосіб отримання 2-аміно-n-(2,2,2-трифторетил)ацетаміду | |
| AR085354A1 (es) | 2011-02-10 | 2013-09-25 | Novartis Ag | Derivados de isoxazol para control de pestes invertebrados |
| AU2012224521B2 (en) | 2011-03-10 | 2015-10-29 | Novartis Tiergesundheit Ag | Isoxazole derivatives |
| US9126995B2 (en) | 2011-11-08 | 2015-09-08 | Nissan Chemical Industries, Ltd. | Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound |
| US9732051B2 (en) | 2011-12-23 | 2017-08-15 | Basf Se | Isothiazoline compounds for combating invertebrate pests |
| PT2922845T (pt) | 2012-11-20 | 2018-10-23 | Merial Inc | Compostos e composições anti-helmínticos e métodos de utilização dos mesmos |
| US9447084B2 (en) | 2013-11-01 | 2016-09-20 | Merial, Inc. | Antiparisitic and pesticidal isoxazoline compounds |
| JP6616786B2 (ja) | 2014-05-19 | 2019-12-04 | メリアル インコーポレイテッド | 駆虫性化合物 |
| NZ731446A (en) | 2014-10-31 | 2018-09-28 | Boehringer Ingelheim Animal Health Usa Inc | Parasiticidal composition comprising fipronil |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| CN114805234A (zh) | 2016-04-06 | 2022-07-29 | 勃林格殷格翰动物保健美国公司 | 用于制备对映异构地富集的异噁唑啉化合物-(S)-afoxolaner的结晶甲苯溶剂化物的方法 |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| WO2018187623A1 (en) * | 2017-04-05 | 2018-10-11 | Merial, Inc. | Crystalline forms of (s)-afoxolaner |
| AU2018318945A1 (en) | 2017-08-14 | 2020-03-05 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal pyrazole-isoxazoline compounds |
| KR102586510B1 (ko) | 2018-02-13 | 2023-10-12 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| AU2019255750B2 (en) | 2018-04-19 | 2021-10-21 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| IL278229B2 (en) | 2018-04-27 | 2023-11-01 | Kumiai Chemical Industry Co | A method for the production of 5,5-di-converted-5,4- dihydroisoxazole |
| AU2019301811B2 (en) | 2018-07-13 | 2022-05-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP7158577B2 (ja) | 2018-10-24 | 2022-10-21 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
| CA3151645A1 (en) | 2019-10-08 | 2021-04-15 | Donaldson Company, Inc. | Filter medium comprising a fine fiber layer |
| CN115210221B (zh) | 2019-12-18 | 2025-03-18 | 礼蓝动物保健有限公司 | 作为农药的异噁唑啉衍生物 |
| CN116234620A (zh) | 2020-04-03 | 2023-06-06 | 唐纳森公司 | 过滤介质 |
| AU2021280287A1 (en) | 2020-05-27 | 2023-01-05 | Axial Therapeutics, Inc. | TLR2 modulator compounds, pharmaceutical compositions and uses thereof |
| AU2021385572A1 (en) | 2020-11-25 | 2023-06-22 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
| WO2023012821A1 (en) * | 2021-08-01 | 2023-02-09 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates |
| CN115710185B (zh) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | 利用金属碳化物催化剂生产甲胺的方法 |
| US12064479B2 (en) | 2022-05-25 | 2024-08-20 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| CN116903488B (zh) * | 2022-11-25 | 2023-12-15 | 济南久隆医药科技有限公司 | 一种阿福拉纳的合成方法 |
| CN115772091B (zh) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法 |
| CN119899156A (zh) * | 2023-10-27 | 2025-04-29 | 华北制药集团动物保健品有限责任公司 | 一种阿福拉纳的制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879532A (en) | 1974-01-18 | 1975-04-22 | Shell Oil Co | Control by isoxazoles of endoparasitic nematodes |
| US4129568A (en) | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| WO1997041118A1 (en) | 1996-04-26 | 1997-11-06 | Nippon Soda Co., Ltd. | Benzene derivatives substituted by heterocycles and herbicides |
| CA2206151A1 (en) | 1996-06-06 | 1997-12-06 | Rohm And Haas Company | Benzyloxy substituted aromatics and their use as fungicides and insecticides |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10114597A1 (de) | 2001-03-23 | 2002-10-02 | Bayer Cropscience Gmbh | Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| WO2004018410A1 (ja) | 2002-08-26 | 2004-03-04 | Nissan Chemical Industries, Ltd. | 置換ベンズアニリド化合物及び有害生物防除剤 |
| DE10320782A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Cropscience Ag | Substituierte Oxyarene |
| JP2005272452A (ja) | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | 置換ベンズアニリド化合物及び有害生物防除剤 |
| CN102558082B (zh) | 2004-03-05 | 2015-09-30 | 日产化学工业株式会社 | 异噁唑啉取代苯甲酰胺化合物的制备中间体 |
| AU2005228417A1 (en) | 2004-03-26 | 2005-10-13 | Cytokine Pharmasciences, Inc. | Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| JP5051340B2 (ja) * | 2005-06-06 | 2012-10-17 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MY146795A (en) | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| KR100546831B1 (ko) | 2005-08-31 | 2006-01-25 | (주) 마이크로프랜드 | 프로브 카드의 탐침팁 공정 방법 |
| CA2621228C (en) * | 2005-09-02 | 2014-05-27 | Nissan Chemical Industries, Ltd. | Isoxazoline-substituted benzamide compound and pesticide |
| JP2007106756A (ja) | 2005-09-14 | 2007-04-26 | Nissan Chem Ind Ltd | 置換イソキサゾリン化合物及び有害生物防除剤 |
| TWI266597B (en) * | 2005-09-27 | 2006-11-11 | Delta Electronics Inc | Electronic apparatus capable of dissipating heat uniformly |
| JP2009519937A (ja) | 2005-12-14 | 2009-05-21 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除用イソオキサゾリン |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| JP5304981B2 (ja) * | 2005-12-26 | 2013-10-02 | 日産化学工業株式会社 | 1,3−ビス(置換フェニル)−3−ヒドロキシプロパン−1−オンおよび2−プロペン−1−オン化合物およびその塩 |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| EP1997813B1 (en) | 2006-03-10 | 2010-05-05 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline compound and pest control agent |
| BRPI0710403A2 (pt) | 2006-04-20 | 2011-08-09 | Du Pont | composto composição, composição de controle, de pulverização, de isca, dispositivo de armadilha, métodos de controle, métodos de proteção, semente tratada, composição de proteção |
| JPWO2007125984A1 (ja) | 2006-04-28 | 2009-09-10 | 日本農薬株式会社 | イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法 |
| JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| EP2151437A4 (en) | 2007-03-07 | 2012-05-02 | Nissan Chemical Ind Ltd | ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT |
| CA2683180A1 (en) | 2007-04-10 | 2008-10-16 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| MX2009013469A (es) | 2007-06-13 | 2010-01-20 | Du Pont | Insecticidas de isoxazolina. |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| WO2009003075A1 (en) | 2007-06-27 | 2008-12-31 | E.I. Du Pont De Nemours And Company | Animal pest control method |
| US8952175B2 (en) | 2007-06-27 | 2015-02-10 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備5-鹵烷基-4,5-二氫異唑衍生物之化合物 |
| JP5365806B2 (ja) | 2007-09-10 | 2013-12-11 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| KR20100075996A (ko) | 2007-10-03 | 2010-07-05 | 이 아이 듀폰 디 네모아 앤드 캄파니 | 무척추 해충의 방제를 위한 나프탈렌 이속사졸린 화합물 |
-
2008
- 2008-07-31 TW TW103118216A patent/TWI600639B/zh active
- 2008-07-31 TW TW106102361A patent/TWI649303B/zh active
- 2008-07-31 TW TW97129034A patent/TWI461411B/zh active
- 2008-08-04 ES ES08797091.9T patent/ES2587386T3/es active Active
- 2008-08-04 KR KR1020157017534A patent/KR20150082693A/ko not_active Ceased
- 2008-08-04 WO PCT/US2008/072074 patent/WO2009025983A2/en not_active Ceased
- 2008-08-04 US US12/679,382 patent/US8217180B2/en active Active
- 2008-08-04 MX MX2010001773A patent/MX2010001773A/es active IP Right Grant
- 2008-08-04 CN CN200880103362A patent/CN101855215A/zh active Pending
- 2008-08-04 PT PT87970919T patent/PT2176244T/pt unknown
- 2008-08-04 JP JP2010521081A patent/JP5965102B2/ja active Active
- 2008-08-04 AU AU2008289321A patent/AU2008289321B2/en active Active
- 2008-08-04 EP EP08797091.9A patent/EP2176244B1/en active Active
- 2008-08-04 RU RU2010109881/04A patent/RU2536039C2/ru active
- 2008-08-04 KR KR1020107005776A patent/KR101597839B1/ko active Active
- 2008-08-04 CN CN201610091532.XA patent/CN105693646A/zh active Pending
- 2008-08-04 MY MYPI2014000219A patent/MY176115A/en unknown
- 2008-08-04 BR BRPI0814153A patent/BRPI0814153B8/pt active IP Right Grant
- 2008-08-04 MY MYPI20100137 patent/MY150980A/en unknown
- 2008-08-04 MX MX2013011829A patent/MX337588B/es unknown
- 2008-08-04 CA CA2693067A patent/CA2693067C/en active Active
- 2008-08-15 AR ARP080103565 patent/AR067948A1/es active IP Right Grant
-
2010
- 2010-01-06 IL IL203174A patent/IL203174A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00214A patent/ZA201000214B/en unknown
- 2010-02-17 CO CO10018337A patent/CO6260136A2/es active IP Right Grant
-
2012
- 2012-07-09 US US13/544,113 patent/US8513431B2/en active Active
-
2014
- 2014-06-18 JP JP2014125041A patent/JP2014221775A/ja active Pending
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