JP2010536767A5 - - Google Patents
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- JP2010536767A5 JP2010536767A5 JP2010521081A JP2010521081A JP2010536767A5 JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5 JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010521081 A JP2010521081 A JP 2010521081A JP 2010536767 A5 JP2010536767 A5 JP 2010536767A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- ring
- independently
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96511507P | 2007-08-17 | 2007-08-17 | |
| US60/965,115 | 2007-08-17 | ||
| US4345908P | 2008-04-09 | 2008-04-09 | |
| US61/043,459 | 2008-04-09 | ||
| US8045408P | 2008-07-14 | 2008-07-14 | |
| US61/080,454 | 2008-07-14 | ||
| PCT/US2008/072074 WO2009025983A2 (en) | 2007-08-17 | 2008-08-04 | Method for preparing 5-haloalkyl-4,5-dihydroisoxazole derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Division JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536767A JP2010536767A (ja) | 2010-12-02 |
| JP2010536767A5 true JP2010536767A5 (Direct) | 2011-09-15 |
| JP5965102B2 JP5965102B2 (ja) | 2016-08-03 |
Family
ID=40350174
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521081A Active JP5965102B2 (ja) | 2007-08-17 | 2008-08-04 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014125041A Pending JP2014221775A (ja) | 2007-08-17 | 2014-06-18 | 5−ハロアルキル−4,5−ジヒドロイソキサゾール誘導体を調製する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8217180B2 (Direct) |
| EP (1) | EP2176244B1 (Direct) |
| JP (2) | JP5965102B2 (Direct) |
| KR (2) | KR20150082693A (Direct) |
| CN (2) | CN105693646A (Direct) |
| AR (1) | AR067948A1 (Direct) |
| AU (1) | AU2008289321B2 (Direct) |
| BR (1) | BRPI0814153B8 (Direct) |
| CA (1) | CA2693067C (Direct) |
| CO (1) | CO6260136A2 (Direct) |
| ES (1) | ES2587386T3 (Direct) |
| IL (1) | IL203174A (Direct) |
| MX (2) | MX337588B (Direct) |
| MY (2) | MY150980A (Direct) |
| PT (1) | PT2176244T (Direct) |
| RU (1) | RU2536039C2 (Direct) |
| TW (3) | TWI600639B (Direct) |
| WO (1) | WO2009025983A2 (Direct) |
| ZA (1) | ZA201000214B (Direct) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005085216A1 (ja) | 2004-03-05 | 2005-09-15 | Nissan Chemical Industries, Ltd. | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| US8623875B2 (en) * | 2007-06-13 | 2014-01-07 | E.I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| TWI430995B (zh) * | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| EP2957284B1 (en) | 2007-06-27 | 2018-01-17 | E. I. du Pont de Nemours and Company | Animal pest control method |
| EP2172462A4 (en) * | 2007-06-27 | 2010-12-15 | Nissan Chemical Ind Ltd | METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備5-鹵烷基-4,5-二氫異唑衍生物之化合物 |
| EP2193124B1 (en) | 2007-10-03 | 2012-12-19 | E. I. du Pont de Nemours and Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
| TWI583664B (zh) * | 2008-04-09 | 2017-05-21 | 杜邦股份有限公司 | 羰基化合物及其製備方法 |
| CN102088857A (zh) | 2008-07-09 | 2011-06-08 | 巴斯夫欧洲公司 | 包含异噁唑啉化合物的杀虫活性混合物ⅱ |
| ES2635120T5 (es) | 2008-07-09 | 2024-06-03 | Basf Se | Mezclas activas de pesticidas que comprenden compuestos I de isoxazolina |
| BRPI0917188A2 (pt) | 2008-08-22 | 2015-08-18 | Syngenta Participations Ag | Compostos inseticidas |
| ES2434734T3 (es) | 2008-08-22 | 2013-12-17 | Syngenta Participations Ag | Compuestos insecticidas |
| KR20110050659A (ko) | 2008-09-04 | 2011-05-16 | 신젠타 파티서페이션즈 아게 | 살충성 화합물 |
| MX2011006736A (es) | 2008-12-23 | 2011-11-18 | Basf Se | Compuestos de amidina sustituida para combatir plagas de animales. |
| KR20110098848A (ko) | 2008-12-23 | 2011-09-01 | 바스프 에스이 | 무척추동물 해충을 퇴치하기 위한 이민 화합물 |
| WO2010112545A1 (en) * | 2009-04-01 | 2010-10-07 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
| DK3078664T3 (da) | 2009-12-17 | 2019-05-13 | Merial Inc | Antiparasitiske dihydroazol-sammensætninger |
| WO2011092287A1 (en) | 2010-02-01 | 2011-08-04 | Basf Se | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests |
| MA34247B1 (fr) | 2010-05-27 | 2013-05-02 | Du Pont | Forme cristalline du 4-[5-[3-chloro-5-(trifluorométhyl) phényl] -4,5-dihydro-5-(trifluorométhyl)-3-isoxazolyl]-n-[2-oxo-2-[(2, 2,2-trifluoroéthyl) amino] éthyl]-1-naphtalènecarboxamide |
| UY33403A (es) | 2010-06-17 | 2011-12-30 | Novartis Ag | Compuestos orgánicos con novedosas isoxazolinas, sus n-óxidos, s-óxidos y sales |
| BR112013006686A2 (pt) | 2010-09-24 | 2017-11-14 | Zoetis Llc | isoxazolina oximas como agentes antiparasitários |
| CA3197676A1 (en) * | 2010-09-27 | 2012-04-12 | E.I. Du Pont De Nemours And Company | Method for preparing 2-amino-n-(2,2,2-trifluoroethyl)acetamide |
| AU2012215440B2 (en) | 2011-02-10 | 2015-08-27 | Novartis Tiergesundheit Ag | Isoxazoline derivatives for controlling invertebrate pests |
| AU2012224521B2 (en) | 2011-03-10 | 2015-10-29 | Novartis Tiergesundheit Ag | Isoxazole derivatives |
| JP6075563B2 (ja) | 2011-11-08 | 2017-02-08 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法及び光学活性イソキサゾリン化合物 |
| WO2013092943A1 (en) | 2011-12-23 | 2013-06-27 | Basf Se | Isothiazoline compounds for combating invertebrate pests |
| BR112015011441A2 (pt) | 2012-11-20 | 2017-07-11 | Merial Inc | composições e compostos antihelmínticos e métodos de usos dos mesmos |
| NZ719916A (en) | 2013-11-01 | 2017-09-29 | Merial Inc | Antiparasitic and pesticidal isoxazoline compounds |
| CN106536518B (zh) | 2014-05-19 | 2020-05-12 | 勃林格殷格翰动物保健美国公司 | 驱蠕虫化合物 |
| ES2887302T3 (es) | 2014-10-31 | 2021-12-22 | Boehringer Ingelheim Animal Health Usa Inc | Composiciones parasiticidas que comprenden fipronil |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| MD20220052A2 (ro) | 2016-04-06 | 2023-05-31 | Boehringer Ingelheim Animal Health USA Inc. | Procedeu de preparare a compuşilor izoxazolinici enantiomeric îmbogăţiţi şi a solvatului de toluen cristalin al (S)-afoxolanerului |
| CN110381738B (zh) | 2016-10-14 | 2021-07-16 | 勃林格殷格翰动物保健美国公司 | 农药的和杀寄生物的乙烯基异噁唑啉化合物 |
| AU2018250304B2 (en) * | 2017-04-05 | 2022-03-03 | Boehringer lngelheim Vetmedica GMBH | Crystalline forms of (S)-afoxolaner |
| ES2944616T3 (es) | 2017-08-14 | 2023-06-22 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos de pirazol-isoxazolina plaguicidas y parasiticidas |
| UA126458C2 (uk) | 2018-02-13 | 2022-10-05 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| US11753384B2 (en) | 2018-04-27 | 2023-09-12 | Kumiai Chemical Industry Co., Ltd. | Production method for 5,5-di-substituted-4,5-dihydroisoxazole |
| EP3820572B1 (en) | 2018-07-13 | 2023-08-16 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| JP2022551565A (ja) | 2019-10-08 | 2022-12-12 | ドナルドソン カンパニー,インコーポレイティド | 細繊維層を含む濾材 |
| WO2021127188A1 (en) | 2019-12-18 | 2021-06-24 | Elanco Tiergesundheit Ag | Isoxazoline derivatives as pesticides |
| EP4171547A4 (en) | 2020-05-27 | 2024-07-17 | Axial Therapeutics, Inc. | TLR2 MODULATING COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES |
| CN117098541A (zh) | 2020-11-25 | 2023-11-21 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及相关使用方法 |
| WO2023012821A1 (en) * | 2021-08-01 | 2023-02-09 | Zenfold Sustainable Technologies Private Limited | A process for the preparation of carbamoyl benzamide phenyl isoxazoline class drug/s and its intermediates |
| CN115710185B (zh) * | 2021-08-23 | 2024-05-03 | 中国石油化工股份有限公司 | 利用金属碳化物催化剂生产甲胺的方法 |
| AU2023275780A1 (en) | 2022-05-25 | 2024-12-05 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| CN116903488B (zh) * | 2022-11-25 | 2023-12-15 | 济南久隆医药科技有限公司 | 一种阿福拉纳的合成方法 |
| CN115772091B (zh) * | 2023-01-05 | 2023-06-23 | 济南久隆医药科技有限公司 | 一种2-氨基-n-(2,2,2-三氟乙基)乙酰胺的合成方法 |
| CN119899156A (zh) * | 2023-10-27 | 2025-04-29 | 华北制药集团动物保健品有限责任公司 | 一种阿福拉纳的制备方法 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3879532A (en) | 1974-01-18 | 1975-04-22 | Shell Oil Co | Control by isoxazoles of endoparasitic nematodes |
| US4129568A (en) | 1977-05-12 | 1978-12-12 | Monsanto Company | 2-[3-Aryl-2-isoxazolin-5-yl]benzoates |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| GB9505651D0 (en) | 1995-03-21 | 1995-05-10 | Agrevo Uk Ltd | AgrEvo UK Limited |
| EP0900795B1 (en) | 1996-04-26 | 2004-04-21 | Nippon Soda Co., Ltd. | Benzene derivatives substituted by heterocycles and herbicides |
| CA2206151A1 (en) | 1996-06-06 | 1997-12-06 | Rohm And Haas Company | Benzyloxy substituted aromatics and their use as fungicides and insecticides |
| GB2351081A (en) | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| DE10114597A1 (de) | 2001-03-23 | 2002-10-02 | Bayer Cropscience Gmbh | Arylisoxazolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel |
| AU2003261713A1 (en) * | 2002-08-26 | 2004-03-11 | Nissan Chemical Industries, Ltd. | Substituted benzanilide compound and pest control agent |
| DE10320782A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Cropscience Ag | Substituierte Oxyarene |
| JP2005272452A (ja) | 2004-02-23 | 2005-10-06 | Nissan Chem Ind Ltd | 置換ベンズアニリド化合物及び有害生物防除剤 |
| WO2005085216A1 (ja) * | 2004-03-05 | 2005-09-15 | Nissan Chemical Industries, Ltd. | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| AU2005228417A1 (en) | 2004-03-26 | 2005-10-13 | Cytokine Pharmasciences, Inc. | Compouns, compositions, processes of making, and methods of use related to inhibiting macrophage migration inhibitory factor |
| JP5051340B2 (ja) * | 2005-06-06 | 2012-10-17 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| MY146795A (en) | 2005-06-09 | 2012-09-28 | Novartis Ag | Process for the synthesis of organic compounds |
| GB0514071D0 (en) | 2005-07-07 | 2005-08-17 | Zealand Pharma As | N- or C- terminally modified small peptides |
| KR100546831B1 (ko) | 2005-08-31 | 2006-01-25 | (주) 마이크로프랜드 | 프로브 카드의 탐침팁 공정 방법 |
| JP5293921B2 (ja) * | 2005-09-02 | 2013-09-18 | 日産化学工業株式会社 | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| JP2007106756A (ja) | 2005-09-14 | 2007-04-26 | Nissan Chem Ind Ltd | 置換イソキサゾリン化合物及び有害生物防除剤 |
| TWI266597B (en) * | 2005-09-27 | 2006-11-11 | Delta Electronics Inc | Electronic apparatus capable of dissipating heat uniformly |
| WO2007070606A2 (en) * | 2005-12-14 | 2007-06-21 | E. I. Du Pont De Nemours And Company | Isoxazolines for controlling invertebrate pests |
| TW200803740A (en) * | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| WO2007074789A1 (ja) * | 2005-12-26 | 2007-07-05 | Nissan Chemical Industries, Ltd. | 1,3-ビス(置換フェニル)-3-ヒドロキシプロパン-1-オンおよび2-プロペン-1-オン化合物およびその塩 |
| TWI412322B (zh) | 2005-12-30 | 2013-10-21 | Du Pont | 控制無脊椎害蟲之異唑啉 |
| ATE466846T1 (de) | 2006-03-10 | 2010-05-15 | Nissan Chemical Ind Ltd | Substituierte isoxazolin-verbindung und schädlingsbekämpfungsmittel |
| MX2008013307A (es) | 2006-04-20 | 2008-10-27 | Du Pont | Pirazolinas para controlar plagas de invertebrados. |
| JPWO2007125984A1 (ja) | 2006-04-28 | 2009-09-10 | 日本農薬株式会社 | イソキサゾリン誘導体及び有害生物防除剤並びにその使用方法 |
| JP2008044880A (ja) | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| WO2008108448A1 (ja) | 2007-03-07 | 2008-09-12 | Nissan Chemical Industries, Ltd. | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
| NZ580241A (en) * | 2007-04-10 | 2011-02-25 | Bayer Cropscience Ag | Insecticidal aryl isoxazoline derivatives |
| US8623875B2 (en) | 2007-06-13 | 2014-01-07 | E.I. Du Pont De Nemours And Company | Isoxazoline insecticides |
| TWI430995B (zh) | 2007-06-26 | 2014-03-21 | Du Pont | 萘異唑啉無脊椎有害動物控制劑 |
| EP2957284B1 (en) | 2007-06-27 | 2018-01-17 | E. I. du Pont de Nemours and Company | Animal pest control method |
| EP2172462A4 (en) * | 2007-06-27 | 2010-12-15 | Nissan Chemical Ind Ltd | METHOD FOR PRODUCING A 3-HYDROXYPROPAN-1-ON COMPOUND, METHOD FOR PRODUCING A 2-PROPENE-1-ON COMPOUND, AND METHOD FOR PRODUCING AN ISOXAZOLINE COMPOUND |
| TWI600639B (zh) | 2007-08-17 | 2017-10-01 | 杜邦股份有限公司 | 製備5-鹵烷基-4,5-二氫異唑衍生物之化合物 |
| TWI556741B (zh) | 2007-08-17 | 2016-11-11 | 英特威特國際股份有限公司 | 異唑啉組成物及其作為抗寄生蟲藥上的應用 |
| US8318757B2 (en) | 2007-09-10 | 2012-11-27 | Nissan Chemical Industries, Ltd. | Substituted isoxazoline compound and pest control agent |
| EP2193124B1 (en) | 2007-10-03 | 2012-12-19 | E. I. du Pont de Nemours and Company | Naphthalene isoxazoline compounds for control of invertebrate pests |
-
2008
- 2008-07-31 TW TW103118216A patent/TWI600639B/zh active
- 2008-07-31 TW TW106102361A patent/TWI649303B/zh active
- 2008-07-31 TW TW97129034A patent/TWI461411B/zh active
- 2008-08-04 MY MYPI20100137 patent/MY150980A/en unknown
- 2008-08-04 PT PT87970919T patent/PT2176244T/pt unknown
- 2008-08-04 RU RU2010109881/04A patent/RU2536039C2/ru active
- 2008-08-04 US US12/679,382 patent/US8217180B2/en active Active
- 2008-08-04 MY MYPI2014000219A patent/MY176115A/en unknown
- 2008-08-04 EP EP08797091.9A patent/EP2176244B1/en active Active
- 2008-08-04 CN CN201610091532.XA patent/CN105693646A/zh active Pending
- 2008-08-04 BR BRPI0814153A patent/BRPI0814153B8/pt active IP Right Grant
- 2008-08-04 WO PCT/US2008/072074 patent/WO2009025983A2/en not_active Ceased
- 2008-08-04 CA CA2693067A patent/CA2693067C/en active Active
- 2008-08-04 MX MX2013011829A patent/MX337588B/es unknown
- 2008-08-04 ES ES08797091.9T patent/ES2587386T3/es active Active
- 2008-08-04 KR KR1020157017534A patent/KR20150082693A/ko not_active Ceased
- 2008-08-04 KR KR1020107005776A patent/KR101597839B1/ko active Active
- 2008-08-04 AU AU2008289321A patent/AU2008289321B2/en active Active
- 2008-08-04 CN CN200880103362A patent/CN101855215A/zh active Pending
- 2008-08-04 MX MX2010001773A patent/MX2010001773A/es active IP Right Grant
- 2008-08-04 JP JP2010521081A patent/JP5965102B2/ja active Active
- 2008-08-15 AR ARP080103565 patent/AR067948A1/es active IP Right Grant
-
2010
- 2010-01-06 IL IL203174A patent/IL203174A/en active IP Right Grant
- 2010-01-12 ZA ZA2010/00214A patent/ZA201000214B/en unknown
- 2010-02-17 CO CO10018337A patent/CO6260136A2/es active IP Right Grant
-
2012
- 2012-07-09 US US13/544,113 patent/US8513431B2/en active Active
-
2014
- 2014-06-18 JP JP2014125041A patent/JP2014221775A/ja active Pending
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