JP2010535829A - デュシェンヌ型筋ジストロフィーの治療用の化合物の多形体 - Google Patents
デュシェンヌ型筋ジストロフィーの治療用の化合物の多形体 Download PDFInfo
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- JP2010535829A JP2010535829A JP2010520498A JP2010520498A JP2010535829A JP 2010535829 A JP2010535829 A JP 2010535829A JP 2010520498 A JP2010520498 A JP 2010520498A JP 2010520498 A JP2010520498 A JP 2010520498A JP 2010535829 A JP2010535829 A JP 2010535829A
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- oxazole
- ethylsulfonyl
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- naphthalen
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- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0715937.9A GB0715937D0 (en) | 2007-08-15 | 2007-08-15 | Method of treatment og duchenne muscular dystrophy |
| PCT/EP2008/006718 WO2009021748A2 (en) | 2007-08-15 | 2008-08-14 | Polymorphs of a compound for the treatment of duchenne muscular dystrophy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010535829A true JP2010535829A (ja) | 2010-11-25 |
| JP2010535829A5 JP2010535829A5 (enExample) | 2011-09-29 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520498A Pending JP2010535829A (ja) | 2007-08-15 | 2008-08-14 | デュシェンヌ型筋ジストロフィーの治療用の化合物の多形体 |
| JP2010520499A Pending JP2010535830A (ja) | 2007-08-15 | 2008-08-14 | デュシェンヌ型筋ジストロフィーの治療用化合物の製造 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520499A Pending JP2010535830A (ja) | 2007-08-15 | 2008-08-14 | デュシェンヌ型筋ジストロフィーの治療用化合物の製造 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20090048314A1 (enExample) |
| EP (2) | EP2176246A2 (enExample) |
| JP (2) | JP2010535829A (enExample) |
| KR (1) | KR20100075777A (enExample) |
| CN (2) | CN101896475A (enExample) |
| AR (1) | AR068810A1 (enExample) |
| AU (2) | AU2008286324A1 (enExample) |
| BR (2) | BRPI0811548A2 (enExample) |
| CA (2) | CA2685939A1 (enExample) |
| CL (1) | CL2008002391A1 (enExample) |
| GB (1) | GB0715937D0 (enExample) |
| IL (1) | IL201908A0 (enExample) |
| MX (2) | MX2009011916A (enExample) |
| PE (1) | PE20090604A1 (enExample) |
| RU (1) | RU2009141831A (enExample) |
| TW (1) | TW200911767A (enExample) |
| WO (2) | WO2009021748A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1986633B1 (en) * | 2006-02-10 | 2014-07-30 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| GB201208178D0 (en) | 2012-05-10 | 2012-06-20 | Summit Corp Plc | Pharmaceutical composition for the treatment of duchenne muscular dystrophy |
| GB201412010D0 (en) | 2014-07-04 | 2014-08-20 | Summit Corp Plc | Treatment of hypertransaminasemia |
| KR20190026647A (ko) | 2016-03-30 | 2019-03-13 | 서밋 (옥스포드) 리미티드 | 뒤쉔 근육 영양장애의 치료용 조성물 |
| WO2017175842A1 (ja) * | 2016-04-07 | 2017-10-12 | 国立大学法人京都大学 | スプライシングの改変に関する化合物及び医薬組成物 |
| KR102019048B1 (ko) | 2017-02-06 | 2019-09-09 | 가톨릭대학교 산학협력단 | MG53과 Orai1의 결합을 이용한 근육긴장저하 치료제 스크리닝 방법 |
| KR101886788B1 (ko) | 2017-02-07 | 2018-08-09 | 가톨릭대학교 산학협력단 | MG53과 Orai1의 결합을 이용한 뒤시엔느 골격근 위축증 치료제 스크리닝 방법 |
| EP4403171A3 (en) | 2017-06-19 | 2024-09-11 | University of Maryland, Baltimore | Microtubule polymerization inhibitor prodrugs and methods of using the same |
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| US3993659A (en) * | 1971-08-10 | 1976-11-23 | Ciba-Geigy Corporation | Bis-benzoxazolyl-naphthalenes as optical brighteners |
| CH617809GA3 (enExample) * | 1975-10-10 | 1980-06-30 | ||
| US4110246A (en) * | 1976-05-13 | 1978-08-29 | Hoechst Aktiengesellschaft | Mixture of benzoxazole derivatives |
| DE3027479A1 (de) * | 1980-07-19 | 1982-03-04 | Hoechst Ag, 6000 Frankfurt | Mischungen von optischen aufhellern und deren verwendung |
| JPS615071A (ja) * | 1984-06-15 | 1986-01-10 | Fuji Photo Film Co Ltd | ベンゾオキサゾ−ル誘導体 |
| DE3617451A1 (de) * | 1986-05-23 | 1987-11-26 | Hoechst Ag | Sulfonat- oder sulfonamidgruppen-haltige bis-benzoxazolylnaphthaline, verfahren zu deren herstellung und deren verwendung |
| DE3819051A1 (de) * | 1988-06-04 | 1989-12-07 | Agfa Gevaert Ag | Farbfotografisches aufzeichnungsmaterial |
| DE59206989D1 (de) * | 1991-08-08 | 1996-10-02 | Ciba Geigy Ag | Farbstoffe, Verfahren zu deren Herstellung und deren Verwendung |
| ES2157268T5 (es) * | 1994-02-24 | 2004-12-01 | SYMRISE GMBH & CO KG | Preparados cosmeticos y dermatologicos que contienen acidos fenilen-1,4-bisbencimidazolsulfonicos. |
| US6004719A (en) * | 1994-04-25 | 1999-12-21 | Polaroid Corporation | Imaging medium and process for producing an image |
| WO1996000560A2 (en) * | 1994-06-30 | 1996-01-11 | Minnesota Mining And Manufacturing Company | Dental impression material with cure-indicating dye |
| AU3002495A (en) * | 1994-06-30 | 1996-01-25 | Minnesota Mining And Manufacturing Company | Cure-indicating molding and coating composition |
| US6222044B1 (en) * | 1995-03-20 | 2001-04-24 | The Dow Chemical Company | Process for making 2-aryl benz (ox, thi, imid) azoles and 2-aminoaryl aminobenz (ox, thi, imid) azoles |
| US5567843A (en) * | 1995-03-20 | 1996-10-22 | The Dow Chemical Company | Process for making 2-aryl benz (ox, thi, imid)azoles and 2-aminoaryl aminobenz(ox, thi, imid)azoles |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| US5645948A (en) * | 1996-08-20 | 1997-07-08 | Eastman Kodak Company | Blue organic electroluminescent devices |
| US5914213A (en) * | 1996-11-27 | 1999-06-22 | Polaroid Corporation | Process and composition for generation of acid |
| US6110638A (en) * | 1996-11-27 | 2000-08-29 | Polaroid Corporation | Process and composition for generation of acid |
| US6177572B1 (en) * | 1997-08-20 | 2001-01-23 | Sepracor, Inc. | Solid and liquid-phase synthesis of benzoxazoles and benzothiazoles and their use |
| US6312822B1 (en) * | 1998-05-28 | 2001-11-06 | Eastman Chem Co | Dispersion aids for optical brighteners in polyolefins |
| GB9815880D0 (en) * | 1998-07-21 | 1998-09-16 | Pfizer Ltd | Heterocycles |
| US6436558B1 (en) * | 1998-08-07 | 2002-08-20 | Fuji Photo Film Co., Ltd. | Organic electroluminescence element |
| FR2789582B1 (fr) * | 1999-02-12 | 2001-05-04 | Oreal | Compositions photoprotectrices contenant un derive de bis-resorcinyl triazine et un compose a groupements benzoazolyle ou benzodiazolyle |
| FR2789581B1 (fr) * | 1999-02-12 | 2001-05-04 | Oreal | Compositions photoprotectrices contenant un derive de benzotriazole, un derive de bis-resorcinyl triazine et un compose a groupements benzoazolyle ou benzodiazolyle |
| EP1177179A1 (de) * | 1999-05-07 | 2002-02-06 | Basf Aktiengesellschaft | Benzoheterocyclylcyclohexenone und ihre verwendung als herbizide |
| CA2373293A1 (en) * | 1999-05-07 | 2000-11-16 | Basf Aktiengesellschaft | 4-(3',4'-heterocyclyl benzoyl) pyrazoles as herbicidal agents |
| FR2794645B1 (fr) * | 1999-06-08 | 2001-08-10 | Oreal | Compositions photoprotectrices contenant un compose hydrocarbone bis-hydroxyphenylbenzotriazole et un compose a groupements benzoazolyle ou benzodiazolyle |
| AU7320100A (en) * | 1999-09-24 | 2001-04-24 | Ono Pharmaceutical Co. Ltd. | Hydroxamic acid derivatives, process for the production thereof and drugs containing the same as the active ingredient |
| US6565987B2 (en) * | 1999-11-12 | 2003-05-20 | Eastman Chemical Company | Non-exuding optically brightened polyolefin blends |
| US7361678B2 (en) * | 2002-03-05 | 2008-04-22 | Transtech Pharma, Inc. | Azole derivatives and fused bicyclic azole derivatives as therapeutic agents |
| US6716413B1 (en) * | 2000-10-16 | 2004-04-06 | Mallinckrodt, Inc. | Indole compounds as tissue-specific exogenous optical agents |
| CN1285601C (zh) * | 2000-11-30 | 2006-11-22 | 佳能株式会社 | 发光器件和显示器 |
| US20050261298A1 (en) * | 2002-01-18 | 2005-11-24 | David Solow-Cordero | Methods of treating conditions associated with an Edg-7 receptor |
| US20050113283A1 (en) * | 2002-01-18 | 2005-05-26 | David Solow-Cordero | Methods of treating conditions associated with an EDG-4 receptor |
| CA2496633A1 (en) * | 2002-08-30 | 2004-04-29 | Bf Research Institute, Inc. | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein |
| US20040242673A1 (en) * | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| AU2004251599A1 (en) * | 2003-05-20 | 2005-01-06 | Transtech Pharma, Inc. | Rage antagonists as agents to reverse amyloidosis and diseases associated therewith |
| WO2005023761A2 (en) * | 2003-09-11 | 2005-03-17 | Kemia, Inc. | Cytokine inhibitors |
| CN1882879B (zh) * | 2003-09-22 | 2010-08-11 | 爱克发印艺公司 | 可光聚合的组合物 |
| US7097888B2 (en) * | 2003-12-15 | 2006-08-29 | Eastman Kodak Company | Aligned liquid crystal layer containing azolium salts and process for increasing the tilt |
| US7592373B2 (en) * | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| AU2005211255A1 (en) * | 2004-02-06 | 2005-08-18 | Insight Biopharmaceuticals Ltd | Heparanase inhibitors and uses thereof |
| MY144903A (en) * | 2004-06-17 | 2011-11-30 | Novartis Ag | Pyrrolopyridine derivatives and their use as crth2 antagonists |
| KR100718765B1 (ko) * | 2004-08-19 | 2007-05-15 | 주식회사 엘지화학 | 버퍼층을 포함하는 유기 발광 소자 및 이의 제작 방법 |
| US7723340B2 (en) * | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| US7893267B2 (en) * | 2005-03-14 | 2011-02-22 | High Point Pharmaceuticals, Llc | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors |
| JP2007086165A (ja) * | 2005-09-20 | 2007-04-05 | Fujifilm Corp | 感光性組成物、これを用いた平版印刷版原版及び画像記録方法 |
| JP5001949B2 (ja) * | 2005-12-02 | 2012-08-15 | サッチェム，インコーポレイテッド | 陰イオン交換置換クロマトグラフィー方法および陰イオン交換置換クロマトグラフィー方法における置換剤化合物として用いられる陰イオン性有機化合物 |
| KR101213485B1 (ko) * | 2006-01-27 | 2012-12-18 | 삼성디스플레이 주식회사 | 유기 금속 착물 및 이를 이용한 유기 전계 발광 소자 |
| KR101213486B1 (ko) * | 2006-02-02 | 2012-12-20 | 삼성디스플레이 주식회사 | 유기 금속 착물 및 이를 이용한 유기 전계 발광 소자 |
| EP1986633B1 (en) * | 2006-02-10 | 2014-07-30 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| KR101325062B1 (ko) * | 2006-05-19 | 2013-11-05 | 삼성디스플레이 주식회사 | 발광 이종 핵 구리-이리듐 착체 및 이를 이용한 유기 전계발광 소자 |
-
2007
- 2007-08-15 GB GBGB0715937.9A patent/GB0715937D0/en not_active Ceased
-
2008
- 2008-08-14 KR KR1020097023605A patent/KR20100075777A/ko not_active Withdrawn
- 2008-08-14 US US12/192,053 patent/US20090048314A1/en not_active Abandoned
- 2008-08-14 BR BRPI0811548-6A2A patent/BRPI0811548A2/pt not_active Application Discontinuation
- 2008-08-14 TW TW097131010A patent/TW200911767A/zh unknown
- 2008-08-14 AU AU2008286324A patent/AU2008286324A1/en not_active Abandoned
- 2008-08-14 CL CL2008002391A patent/CL2008002391A1/es unknown
- 2008-08-14 AU AU2008286325A patent/AU2008286325A1/en not_active Abandoned
- 2008-08-14 US US12/599,970 patent/US8138351B2/en not_active Expired - Fee Related
- 2008-08-14 MX MX2009011916A patent/MX2009011916A/es not_active Application Discontinuation
- 2008-08-14 WO PCT/EP2008/006718 patent/WO2009021748A2/en not_active Ceased
- 2008-08-14 EP EP08785565A patent/EP2176246A2/en not_active Withdrawn
- 2008-08-14 CA CA002685939A patent/CA2685939A1/en not_active Abandoned
- 2008-08-14 BR BRPI0811315-7A2A patent/BRPI0811315A2/pt not_active Application Discontinuation
- 2008-08-14 MX MX2009011967A patent/MX2009011967A/es not_active Application Discontinuation
- 2008-08-14 CN CN2008800158003A patent/CN101896475A/zh active Pending
- 2008-08-14 RU RU2009141831/04A patent/RU2009141831A/ru not_active Application Discontinuation
- 2008-08-14 AR ARP080103560A patent/AR068810A1/es not_active Application Discontinuation
- 2008-08-14 WO PCT/EP2008/006719 patent/WO2009021749A2/en not_active Ceased
- 2008-08-14 JP JP2010520498A patent/JP2010535829A/ja active Pending
- 2008-08-14 PE PE2008001385A patent/PE20090604A1/es not_active Application Discontinuation
- 2008-08-14 EP EP08785566A patent/EP2188270A2/en not_active Withdrawn
- 2008-08-14 CN CN200880015864A patent/CN101679323A/zh active Pending
- 2008-08-14 JP JP2010520499A patent/JP2010535830A/ja active Pending
- 2008-08-14 CA CA002685590A patent/CA2685590A1/en not_active Abandoned
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2009
- 2009-11-03 IL IL201908A patent/IL201908A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090048314A1 (en) | 2009-02-19 |
| AU2008286324A1 (en) | 2009-02-19 |
| GB0715937D0 (en) | 2007-09-26 |
| AR068810A1 (es) | 2009-12-09 |
| CL2008002391A1 (es) | 2009-05-22 |
| CN101896475A (zh) | 2010-11-24 |
| AU2008286325A1 (en) | 2009-02-19 |
| EP2188270A2 (en) | 2010-05-26 |
| PE20090604A1 (es) | 2009-05-16 |
| RU2009141831A (ru) | 2011-05-20 |
| BRPI0811315A2 (pt) | 2015-01-27 |
| WO2009021748A2 (en) | 2009-02-19 |
| MX2009011967A (es) | 2009-11-19 |
| WO2009021749A8 (en) | 2009-09-11 |
| WO2009021749A3 (en) | 2009-04-02 |
| EP2176246A2 (en) | 2010-04-21 |
| JP2010535830A (ja) | 2010-11-25 |
| KR20100075777A (ko) | 2010-07-05 |
| US20100267961A1 (en) | 2010-10-21 |
| WO2009021748A3 (en) | 2009-04-02 |
| CA2685590A1 (en) | 2009-02-19 |
| CA2685939A1 (en) | 2009-02-19 |
| CN101679323A (zh) | 2010-03-24 |
| US8138351B2 (en) | 2012-03-20 |
| WO2009021749A2 (en) | 2009-02-19 |
| BRPI0811548A2 (pt) | 2014-11-18 |
| TW200911767A (en) | 2009-03-16 |
| MX2009011916A (es) | 2009-11-18 |
| IL201908A0 (en) | 2010-06-16 |
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