CN101679323A - 用于治疗杜兴氏肌营养不良症的化合物的多晶型体 - Google Patents

用于治疗杜兴氏肌营养不良症的化合物的多晶型体 Download PDF

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Publication number
CN101679323A
CN101679323A CN200880015864A CN200880015864A CN101679323A CN 101679323 A CN101679323 A CN 101679323A CN 200880015864 A CN200880015864 A CN 200880015864A CN 200880015864 A CN200880015864 A CN 200880015864A CN 101679323 A CN101679323 A CN 101679323A
Authority
CN
China
Prior art keywords
polymorphic forms
ethylsulfonyl
oxazole
benzo
naphthalene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880015864A
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English (en)
Chinese (zh)
Inventor
亚历山大·查尔斯·韦茅斯-威尔逊
莎芭娜·艾哈迈德
马克·威廉·霍珀
凯伦·琼·埃瑟林顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Summit Therapeutics Ltd
Original Assignee
Summit Corp PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Summit Corp PLC filed Critical Summit Corp PLC
Publication of CN101679323A publication Critical patent/CN101679323A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN200880015864A 2007-08-15 2008-08-14 用于治疗杜兴氏肌营养不良症的化合物的多晶型体 Pending CN101679323A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0715937.9 2007-08-15
GBGB0715937.9A GB0715937D0 (en) 2007-08-15 2007-08-15 Method of treatment og duchenne muscular dystrophy
PCT/EP2008/006718 WO2009021748A2 (en) 2007-08-15 2008-08-14 Polymorphs of a compound for the treatment of duchenne muscular dystrophy

Publications (1)

Publication Number Publication Date
CN101679323A true CN101679323A (zh) 2010-03-24

Family

ID=38566447

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2008800158003A Pending CN101896475A (zh) 2007-08-15 2008-08-14 用于治疗杜兴氏肌营养不良的化合物的制备
CN200880015864A Pending CN101679323A (zh) 2007-08-15 2008-08-14 用于治疗杜兴氏肌营养不良症的化合物的多晶型体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN2008800158003A Pending CN101896475A (zh) 2007-08-15 2008-08-14 用于治疗杜兴氏肌营养不良的化合物的制备

Country Status (17)

Country Link
US (2) US8138351B2 (enExample)
EP (2) EP2188270A2 (enExample)
JP (2) JP2010535830A (enExample)
KR (1) KR20100075777A (enExample)
CN (2) CN101896475A (enExample)
AR (1) AR068810A1 (enExample)
AU (2) AU2008286324A1 (enExample)
BR (2) BRPI0811315A2 (enExample)
CA (2) CA2685590A1 (enExample)
CL (1) CL2008002391A1 (enExample)
GB (1) GB0715937D0 (enExample)
IL (1) IL201908A0 (enExample)
MX (2) MX2009011916A (enExample)
PE (1) PE20090604A1 (enExample)
RU (1) RU2009141831A (enExample)
TW (1) TW200911767A (enExample)
WO (2) WO2009021749A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803641A (zh) * 2016-03-30 2019-05-24 萨米特(牛津)有限公司 用于治疗杜兴氏肌肉营养不良症的组合物

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101426093B1 (ko) * 2006-02-10 2014-08-01 서미트 코포레이션 피엘씨 뒤시엔느 근이영양증의 치료
GB201208178D0 (en) 2012-05-10 2012-06-20 Summit Corp Plc Pharmaceutical composition for the treatment of duchenne muscular dystrophy
GB201412010D0 (en) 2014-07-04 2014-08-20 Summit Corp Plc Treatment of hypertransaminasemia
WO2017175842A1 (ja) * 2016-04-07 2017-10-12 国立大学法人京都大学 スプライシングの改変に関する化合物及び医薬組成物
KR102019048B1 (ko) 2017-02-06 2019-09-09 가톨릭대학교 산학협력단 MG53과 Orai1의 결합을 이용한 근육긴장저하 치료제 스크리닝 방법
KR101886788B1 (ko) 2017-02-07 2018-08-09 가톨릭대학교 산학협력단 MG53과 Orai1의 결합을 이용한 뒤시엔느 골격근 위축증 치료제 스크리닝 방법
WO2018236879A1 (en) 2017-06-19 2018-12-27 University Of Maryland, Baltimore Microtubule polymerization inhibitor prodrugs and methods of using the same

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803641A (zh) * 2016-03-30 2019-05-24 萨米特(牛津)有限公司 用于治疗杜兴氏肌肉营养不良症的组合物

Also Published As

Publication number Publication date
WO2009021749A8 (en) 2009-09-11
MX2009011967A (es) 2009-11-19
WO2009021748A3 (en) 2009-04-02
BRPI0811548A2 (pt) 2014-11-18
PE20090604A1 (es) 2009-05-16
IL201908A0 (en) 2010-06-16
GB0715937D0 (en) 2007-09-26
CA2685939A1 (en) 2009-02-19
US20090048314A1 (en) 2009-02-19
EP2176246A2 (en) 2010-04-21
CN101896475A (zh) 2010-11-24
CL2008002391A1 (es) 2009-05-22
US8138351B2 (en) 2012-03-20
AU2008286325A1 (en) 2009-02-19
AU2008286324A1 (en) 2009-02-19
CA2685590A1 (en) 2009-02-19
TW200911767A (en) 2009-03-16
RU2009141831A (ru) 2011-05-20
KR20100075777A (ko) 2010-07-05
EP2188270A2 (en) 2010-05-26
WO2009021749A3 (en) 2009-04-02
MX2009011916A (es) 2009-11-18
AR068810A1 (es) 2009-12-09
JP2010535829A (ja) 2010-11-25
WO2009021749A2 (en) 2009-02-19
US20100267961A1 (en) 2010-10-21
WO2009021748A2 (en) 2009-02-19
BRPI0811315A2 (pt) 2015-01-27
JP2010535830A (ja) 2010-11-25

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Application publication date: 20100324