JP2010534627A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010534627A5 JP2010534627A5 JP2010517324A JP2010517324A JP2010534627A5 JP 2010534627 A5 JP2010534627 A5 JP 2010534627A5 JP 2010517324 A JP2010517324 A JP 2010517324A JP 2010517324 A JP2010517324 A JP 2010517324A JP 2010534627 A5 JP2010534627 A5 JP 2010534627A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- seq
- peptide
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 6
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 241000272478 Aquila Species 0.000 claims 1
- 102000009016 Cholera Toxin Human genes 0.000 claims 1
- 108010049048 Cholera Toxin Proteins 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 claims 1
- GUVMFDICMFQHSZ-UHFFFAOYSA-N N-(1-aminoethenyl)-1-[4-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[hydroxy-[[3-[hydroxy-[[3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl]oxy-5-[[[2-[[[2-[[[5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[5-(4-amino-2-oxopyrimidin-1-yl)-2-[[hydroxy-[2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphinothioyl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphinothioyl]oxymethyl]oxolan-2-yl]-5-methylimidazole-4-carboxamide Chemical compound CC1=C(C(=O)NC(N)=C)N=CN1C1OC(COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=S)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=S)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)CO)C(OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(N=C(N)C=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C3=C(C(NC(N)=N3)=O)N=C2)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)OP(O)(=S)OCC2C(CC(O2)N2C(NC(=O)C(C)=C2)=O)O)C1 GUVMFDICMFQHSZ-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229940047120 colony stimulating factors Drugs 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 108010017271 denileukin diftitox Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940056913 eftilagimod alfa Drugs 0.000 claims 1
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 claims 1
- 229960002751 imiquimod Drugs 0.000 claims 1
- 239000000568 immunological adjuvant Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 229940100027 ontak Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 239000000277 virosome Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07014796.2 | 2007-07-27 | ||
| EP07014796 | 2007-07-27 | ||
| US95310907P | 2007-07-31 | 2007-07-31 | |
| US60/953,109 | 2007-07-31 | ||
| US98124107P | 2007-10-19 | 2007-10-19 | |
| US60/981,241 | 2007-10-19 | ||
| PCT/EP2008/006152 WO2009015841A1 (en) | 2007-07-27 | 2008-07-25 | Composition of tumour-associated peptides and related anti-cancer vaccine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013061688A Division JP5746251B2 (ja) | 2007-07-27 | 2013-03-25 | 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010534627A JP2010534627A (ja) | 2010-11-11 |
| JP2010534627A5 true JP2010534627A5 (enExample) | 2011-11-17 |
| JP5352586B2 JP5352586B2 (ja) | 2013-11-27 |
Family
ID=39926464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517324A Expired - Fee Related JP5352586B2 (ja) | 2007-07-27 | 2008-07-25 | 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物 |
| JP2013061688A Expired - Fee Related JP5746251B2 (ja) | 2007-07-27 | 2013-03-25 | 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013061688A Expired - Fee Related JP5746251B2 (ja) | 2007-07-27 | 2013-03-25 | 腫瘍関連ペプチドおよび関連抗癌ワクチンの組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7994276B2 (enExample) |
| EP (2) | EP2178557B1 (enExample) |
| JP (2) | JP5352586B2 (enExample) |
| KR (1) | KR101167392B1 (enExample) |
| CN (2) | CN101765434B (enExample) |
| AU (1) | AU2008281013B2 (enExample) |
| BR (1) | BRPI0814140A2 (enExample) |
| CA (2) | CA2817054C (enExample) |
| DK (1) | DK2567707T3 (enExample) |
| EA (2) | EA023928B1 (enExample) |
| ES (1) | ES2608583T3 (enExample) |
| HU (1) | HUE032379T2 (enExample) |
| LT (1) | LT2567707T (enExample) |
| MX (1) | MX2010001088A (enExample) |
| NZ (1) | NZ582823A (enExample) |
| PL (1) | PL2567707T3 (enExample) |
| PT (1) | PT2567707T (enExample) |
| SI (1) | SI2567707T1 (enExample) |
| UA (2) | UA103882C2 (enExample) |
| WO (1) | WO2009015841A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090004213A1 (en) | 2007-03-26 | 2009-01-01 | Immatics Biotechnologies Gmbh | Combination therapy using active immunotherapy |
| EP2178557B1 (en) * | 2007-07-27 | 2017-03-01 | Immatics Biotechnologies GmbH | Composition of tumour-associated peptides and related anti-cancer vaccine |
| SI2119726T2 (en) * | 2008-05-14 | 2018-03-30 | Immatics Biotechnologies Gmbh | New and powerful Class II MHC peptides derived from survivin and neurocane |
| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| GB201004575D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
| GB201019331D0 (en) * | 2010-03-19 | 2010-12-29 | Immatics Biotechnologies Gmbh | Methods for the diagnosis and treatment of cancer based on AVL9 |
| GB201009222D0 (en) | 2010-06-02 | 2010-07-21 | Immatics Biotechnologies Gmbh | Improved cancer therapy based on tumour associated antigens derived from cyclin D1 |
| GB201021289D0 (en) * | 2010-12-15 | 2011-01-26 | Immatics Biotechnologies Gmbh | Novel biomarkers for a prediction of the outcome of an immunotherapy against cancer |
| DK3296317T3 (da) * | 2011-10-28 | 2020-02-24 | Oncotherapy Science Inc | Topk-peptider og vacciner, der indbefatter disse |
| AU2013259598B2 (en) * | 2012-05-08 | 2018-10-04 | Western University Of Health Sciences | Standardized ex vivo platforms for the antigen-specific expansion of CD4+ T cell populations |
| GB201214007D0 (en) * | 2012-08-07 | 2012-09-19 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
| TWI775117B (zh) * | 2013-08-05 | 2022-08-21 | 德商伊瑪提克斯生物科技有限公司 | 新穎肽類，細胞及其用於治療多種腫瘤的用途，其製造方法及包含其等之醫藥組成物（二） |
| WO2015075939A1 (ja) | 2013-11-21 | 2015-05-28 | Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 | Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用 |
| GB201501017D0 (en) * | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| CN113456812B (zh) | 2015-01-09 | 2024-08-20 | 埃图比克斯公司 | 用于联合免疫治疗的方法和组合物 |
| CN104630145A (zh) * | 2015-01-12 | 2015-05-20 | 杨世成 | 一种抗肿瘤t细胞、其制备方法和抗肿瘤药物 |
| GB201505585D0 (en) * | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| TWI772927B (zh) * | 2015-03-31 | 2022-08-01 | 德商英麥提克生物技術股份有限公司 | 用於腎細胞癌(rcc)免疫治療的新型肽和肽組合物和支架 |
| US11149087B2 (en) * | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| CN104926944B (zh) * | 2015-05-22 | 2018-04-13 | 北京康爱瑞浩生物科技股份有限公司空港分公司 | 多靶点复合抗原负载cd8+细胞毒性t淋巴细胞的制备方法及其用途 |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| GB201511191D0 (en) * | 2015-06-25 | 2015-08-12 | Immatics Biotechnologies Gmbh | T-cell epitopes for the immunotherapy of myeloma |
| GB201511546D0 (en) | 2015-07-01 | 2015-08-12 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers |
| PE20230321A1 (es) | 2015-07-01 | 2023-02-22 | Immatics Biotechnologies Gmbh | Nuevos peptidos y nuevas combinaciones de peptidos para el uso en la inmunoterapia contra el cancer de ovario y otros tipos de cancer |
| GB201512703D0 (en) | 2015-07-20 | 2015-08-26 | Scancell Ltd | Anti-tumour immune responses to modified self-epitopes |
| TWI765875B (zh) | 2015-12-16 | 2022-06-01 | 美商磨石生物公司 | 新抗原辨識、製造及用途 |
| CN105586312A (zh) * | 2016-02-29 | 2016-05-18 | 时宏珍 | Hla-a0201限制性抗muc-1抗原特异性ctl的制备方法 |
| US20180085319A1 (en) * | 2016-09-27 | 2018-03-29 | Takashi Kei Kishimoto | Methods and compositions for treating cancer |
| KR102379955B1 (ko) | 2016-12-08 | 2022-03-29 | 이매틱스 바이오테크놀로지스 게엠베하 | 짝짓기가 향상된 t 세포 수용체 |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| JP7346302B2 (ja) * | 2017-03-28 | 2023-09-19 | オハイオ・ステイト・イノベーション・ファウンデーション | ヒトｐｄ－１ペプチドワクチン及びその使用法 |
| CR20210160A (es) * | 2017-04-10 | 2021-04-26 | Immatics Biotechnologies Gmbh | Péptidos y combinaciones de los mismos para el uso en la inmunoterapia contra diversos tipos de cáncer (divisional de solicitud 2019-0508) |
| SG10202100326SA (en) * | 2017-04-10 | 2021-02-25 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against leukemias and other cancers |
| WO2019075112A1 (en) | 2017-10-10 | 2019-04-18 | Gritstone Oncology, Inc. | IDENTIFICATION OF NEO-ANTIGENS USING HOT POINTS |
| AU2018373154B2 (en) | 2017-11-22 | 2025-08-07 | Seattle Project Corp. | Reducing junction epitope presentation for neoantigens |
| GB201810358D0 (en) * | 2018-06-25 | 2018-08-08 | Univ College Cardiff Consultants Ltd | Cancer-specific t-cell receptors |
| GB201815041D0 (en) | 2018-09-14 | 2018-10-31 | Scancell Ltd | Epitopes |
| US20220281942A1 (en) * | 2019-07-30 | 2022-09-08 | University Health Network | T cell receptors and methods of use thereof |
| EP4076507A1 (en) * | 2019-12-18 | 2022-10-26 | Evaxion Biotech A/S | Nucleic acid vaccination using neo-epitope encoding constructs |
| CN111363009B (zh) * | 2020-03-18 | 2020-10-30 | 北京鼎成肽源生物技术有限公司 | 一种直肠癌靶标抗原及其刺激培养的ctl细胞及其应用 |
| CN111617238B (zh) * | 2020-06-02 | 2022-12-13 | 苏州药明康德新药开发有限公司 | 小鼠ct26结直肠癌治疗性肿瘤多肽疫苗制剂及其制备方法 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA725596A (en) | 1960-08-26 | 1966-01-11 | J. Wretlind Arvid | Method of preparing intravenously injectable fat emulsions free from side reactions or complications |
| US4897445A (en) | 1986-06-27 | 1990-01-30 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide bond |
| US4803261A (en) * | 1986-06-27 | 1989-02-07 | The Administrators Of The Tulane Educational Fund | Method for synthesizing a peptide containing a non-peptide |
| JPH02107189A (ja) * | 1988-05-25 | 1990-04-19 | City Of Hope | 癌胎児抗原フラグメント |
| AUPM322393A0 (en) | 1993-12-24 | 1994-01-27 | Austin Research Institute, The | Mucin carbohydrate compounds and their use in immunotherapy |
| US6096313A (en) * | 1996-02-09 | 2000-08-01 | Ludwig Institute For Cancer Research | Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant |
| US5849589A (en) | 1996-03-11 | 1998-12-15 | Duke University | Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US6756038B1 (en) * | 1997-10-10 | 2004-06-29 | The United States Of America As Represented By The Department Of Health And Human Services | Agonist and antagonist peptides of carcinoembryonic antigen (CEA) |
| WO1999019478A1 (en) | 1997-10-10 | 1999-04-22 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Agonist and antagonist peptides of carcinoembryonic antigen (cea) |
| US6623923B1 (en) * | 1998-12-23 | 2003-09-23 | Corixa Corporation | Compounds for immunotherapy and diagnosis of colon cancer and methods for their use |
| IL125608A0 (en) | 1998-07-30 | 1999-03-12 | Yeda Res & Dev | Tumor associated antigen peptides and use of same as anti-tumor vaccines |
| CA2384713A1 (en) * | 1999-09-29 | 2001-04-05 | Human Genome Sciences, Inc. | Colon and colon cancer associated polynucleotides and polypeptides |
| CA2411278A1 (en) * | 2000-06-09 | 2001-12-20 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| US20030017167A1 (en) * | 2000-06-09 | 2003-01-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| US20020102544A1 (en) * | 2000-09-15 | 2002-08-01 | David Mack | Novel methods of diagnosing colorectal cancer, compositions, and methods of screening for colorectal cancer modulators |
| US7229960B2 (en) * | 2000-11-03 | 2007-06-12 | University Of Vermont And State Agricultural College | Methods and compositions for inhibiting GRB7 |
| CA2431313A1 (en) * | 2000-12-08 | 2002-08-01 | Eos Biotechnology, Inc. | Methods of diagnosing colorectal cancer and/or breast cancer, compositions, and methods of screening for colorectal cancer and/or breast cancer modulators |
| CA2459219A1 (en) * | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
| WO2003084467A2 (en) * | 2002-04-01 | 2003-10-16 | Euro-Celtique S.A. | Epitope constructs comprising antigen presenting cell targeting mechanisms |
| US20030211477A1 (en) * | 2002-04-05 | 2003-11-13 | Holmes Kathryn V. | Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) structure and uses thereof in drug identification and screening |
| AU2002368151A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Matrix metalloproteinase inhibitors and methods for identification of lead compounds |
| AU2004203749A1 (en) * | 2003-01-06 | 2004-07-22 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
| KR20060003903A (ko) * | 2003-05-05 | 2006-01-11 | 이스티투토 디 리세르쉐 디 비올로지아 몰레콜라레 피. 안젤레티에스.피.에이. | 사람 암배아 항원을 암호화하는 합성 유전자 및 이의 용도 |
| CN1727362B (zh) * | 2004-07-30 | 2010-12-01 | 中国人民解放军第二军医大学 | 癌胚抗原阳性肿瘤治疗性疫苗的制备及应用 |
| EP1786906A2 (en) | 2004-09-09 | 2007-05-23 | Exonhit Therapeutics SA | Tumor specific genes and variant rnas and uses thereof as targets for cancer therapy and diagnosis |
| ES2319286T3 (es) | 2004-10-02 | 2009-05-06 | Immatics Biotechnologies Gmbh | Epitopos inmunogenos de linfocitos t colaboradores de antigenos de tumor humanos y utilizacion de dichos epitopos en metodos inmunoterapeuticos. |
| ITRM20050064A1 (it) * | 2005-02-16 | 2006-08-17 | Univ Siena | Peptide poliepitopico derivato dalla timidilato sintetasi avente attivita' immunologica e antitumorale e composizioni farmaceutiche relative. |
| ES2367643T3 (es) * | 2005-04-26 | 2011-11-07 | Immatics Biotechnologies Gmbh | Identificador de un epítopo de linfocitos t presentado por el antígeno hla-a2 y derivado de la proteína del receptor de laminina inmadura del antígeno oncofetal y usos de este. |
| DK1760088T3 (da) | 2005-09-05 | 2008-06-09 | Immatics Biotechnologies Gmbh | Tumor associerede peptider, der bindes promiskuöst til human leuko-cyt-antigen (HLA) klasse II-molekyler |
| EP1760089B1 (en) * | 2005-09-05 | 2009-08-19 | Immatics Biotechnologies GmbH | Tumor-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules and related anti-cancer vaccine |
| US8298544B2 (en) * | 2006-02-27 | 2012-10-30 | Gal Markel | CEACAM based antibacterial agents |
| EP2178557B1 (en) * | 2007-07-27 | 2017-03-01 | Immatics Biotechnologies GmbH | Composition of tumour-associated peptides and related anti-cancer vaccine |
| WO2009117656A2 (en) * | 2008-03-21 | 2009-09-24 | Vectorlogics,Inc. | Capsid-incorporated antigen for novel adenovirus vaccine |
| SI2119726T2 (en) * | 2008-05-14 | 2018-03-30 | Immatics Biotechnologies Gmbh | New and powerful Class II MHC peptides derived from survivin and neurocane |
-
2008
- 2008-07-25 EP EP08785105.1A patent/EP2178557B1/en active Active
- 2008-07-25 CA CA2817054A patent/CA2817054C/en not_active Expired - Fee Related
- 2008-07-25 CN CN200880100807.5A patent/CN101765434B/zh not_active Expired - Fee Related
- 2008-07-25 UA UAA201001960A patent/UA103882C2/uk unknown
- 2008-07-25 KR KR1020107001771A patent/KR101167392B1/ko not_active Expired - Fee Related
- 2008-07-25 NZ NZ582823A patent/NZ582823A/en not_active IP Right Cessation
- 2008-07-25 LT LTEP12187307.9T patent/LT2567707T/lt unknown
- 2008-07-25 BR BRPI0814140A patent/BRPI0814140A2/pt not_active IP Right Cessation
- 2008-07-25 WO PCT/EP2008/006152 patent/WO2009015841A1/en not_active Ceased
- 2008-07-25 EA EA201300322A patent/EA023928B1/ru not_active IP Right Cessation
- 2008-07-25 DK DK12187307.9T patent/DK2567707T3/da active
- 2008-07-25 EP EP12187307.9A patent/EP2567707B1/en active Active
- 2008-07-25 EA EA201000208A patent/EA018457B1/ru not_active IP Right Cessation
- 2008-07-25 JP JP2010517324A patent/JP5352586B2/ja not_active Expired - Fee Related
- 2008-07-25 UA UAA201302331A patent/UA117216C2/uk unknown
- 2008-07-25 HU HUE12187307A patent/HUE032379T2/en unknown
- 2008-07-25 MX MX2010001088A patent/MX2010001088A/es active IP Right Grant
- 2008-07-25 AU AU2008281013A patent/AU2008281013B2/en not_active Ceased
- 2008-07-25 ES ES12187307.9T patent/ES2608583T3/es active Active
- 2008-07-25 CN CN201310109229.4A patent/CN103360466B/zh not_active Expired - Fee Related
- 2008-07-25 CA CA2694771A patent/CA2694771A1/en not_active Abandoned
- 2008-07-25 SI SI200831735A patent/SI2567707T1/sl unknown
- 2008-07-25 US US12/180,113 patent/US7994276B2/en active Active
- 2008-07-25 PL PL12187307T patent/PL2567707T3/pl unknown
- 2008-07-25 PT PT121873079T patent/PT2567707T/pt unknown
-
2013
- 2013-03-25 JP JP2013061688A patent/JP5746251B2/ja not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010534627A5 (enExample) | ||
| JP2013522276A5 (enExample) | ||
| JP2018521028A5 (enExample) | ||
| Weinberger et al. | Vaccines for the elderly | |
| JP2013530157A5 (enExample) | ||
| RU2021122284A (ru) | Составы вакцин против неоплазии и способы их получения | |
| US20170143820A1 (en) | Immunogenic combinations | |
| JP2014534202A5 (enExample) | ||
| JP2014521687A5 (enExample) | ||
| JP2013507907A5 (enExample) | ||
| JP2016518355A5 (enExample) | ||
| JP2007508272A5 (enExample) | ||
| EA202091233A2 (ru) | Новые способы иммунотерапии нескольких видов опухолей, в том числе рака желудочно-кишечного тракта и рака желудка | |
| HRP20110965T1 (hr) | Nove formulacije peptida povezanih s tumorima koji se vežu za molekule ljudskog leukocitnog antigena (hla) klase i ili ii za cjepiva | |
| AU2011344652B2 (en) | HLA-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof | |
| BRPI0713711A2 (pt) | vacina viral recombinante, kit para vacinação, e, método para usar pelo menos um composto | |
| JP2015533376A5 (enExample) | ||
| ES2993567T3 (en) | Peptides and combinations of peptides for use in immunotherapy against an infection by sars-cov-2 (covid-19) | |
| JP2018532782A5 (enExample) | ||
| RU2018120009A (ru) | Способ вакцинации против аутоантигена у пациента-человека | |
| JP2014508734A5 (enExample) | ||
| JP2014521605A5 (enExample) | ||
| JP2014139185A5 (enExample) | ||
| AR099960A1 (es) | Procedimientos y composición farmaceutica para inducir una respuesta inmunitaria | |
| RU2015115785A (ru) | Мсн-специфичные пептиды со смещенной рамкой считывания (псрс) для предотвращения и лечения рака |