JP2007508272A5 - - Google Patents
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- Publication number
- JP2007508272A5 JP2007508272A5 JP2006530155A JP2006530155A JP2007508272A5 JP 2007508272 A5 JP2007508272 A5 JP 2007508272A5 JP 2006530155 A JP2006530155 A JP 2006530155A JP 2006530155 A JP2006530155 A JP 2006530155A JP 2007508272 A5 JP2007508272 A5 JP 2007508272A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- spp
- polypeptide
- combined preparation
- biologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 claims 24
- 206010028980 Neoplasm Diseases 0.000 claims 15
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 239000002671 adjuvant Substances 0.000 claims 11
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 9
- 229930182490 saponin Natural products 0.000 claims 9
- 150000007949 saponins Chemical class 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 7
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- CTMZLDSMFCVUNX-VMIOUTBZSA-N cytidylyl-(3'->5')-guanosine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=C(C(N=C(N)N3)=O)N=C2)O)[C@@H](CO)O1 CTMZLDSMFCVUNX-VMIOUTBZSA-N 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 102100022144 Achaete-scute homolog 2 Human genes 0.000 claims 3
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims 3
- 102100035526 B melanoma antigen 1 Human genes 0.000 claims 3
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 3
- -1 CASB616 Proteins 0.000 claims 3
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 3
- 101000901109 Homo sapiens Achaete-scute homolog 2 Proteins 0.000 claims 3
- 101000874316 Homo sapiens B melanoma antigen 1 Proteins 0.000 claims 3
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 claims 3
- 101000874141 Homo sapiens Probable ATP-dependent RNA helicase DDX43 Proteins 0.000 claims 3
- 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 claims 3
- 102100034872 Kallikrein-4 Human genes 0.000 claims 3
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 claims 3
- 102100034256 Mucin-1 Human genes 0.000 claims 3
- 108010008707 Mucin-1 Proteins 0.000 claims 3
- 101100369076 Mus musculus Tdgf1 gene Proteins 0.000 claims 3
- 102000036673 PRAME Human genes 0.000 claims 3
- 108060006580 PRAME Proteins 0.000 claims 3
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims 3
- 102100035724 Probable ATP-dependent RNA helicase DDX43 Human genes 0.000 claims 3
- 102100036735 Prostate stem cell antigen Human genes 0.000 claims 3
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 3
- 102100037253 Solute carrier family 45 member 3 Human genes 0.000 claims 3
- 108010002687 Survivin Proteins 0.000 claims 3
- 108010017842 Telomerase Proteins 0.000 claims 3
- 102000003425 Tyrosinase Human genes 0.000 claims 3
- 108060008724 Tyrosinase Proteins 0.000 claims 3
- 235000012000 cholesterol Nutrition 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000003308 immunostimulating effect Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 108010024383 kallikrein 4 Proteins 0.000 claims 3
- 239000007764 o/w emulsion Substances 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 108010079891 prostein Proteins 0.000 claims 3
- 235000002020 sage Nutrition 0.000 claims 3
- 241001647372 Chlamydia pneumoniae Species 0.000 claims 2
- 241000588722 Escherichia Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 108091034117 Oligonucleotide Proteins 0.000 claims 2
- 241000224016 Plasmodium Species 0.000 claims 2
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 241000894007 species Species 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 235000010384 tocopherol Nutrition 0.000 claims 2
- 229960001295 tocopherol Drugs 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 239000011732 tocopherol Substances 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 241000588807 Bordetella Species 0.000 claims 1
- 241000589968 Borrelia Species 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241000606153 Chlamydia trachomatis Species 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 241000589989 Helicobacter Species 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 241000724675 Hepatitis E virus Species 0.000 claims 1
- 241000709721 Hepatovirus A Species 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 241000186781 Listeria Species 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- 241000711386 Mumps virus Species 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 1
- 241000223960 Plasmodium falciparum Species 0.000 claims 1
- 241000725643 Respiratory syncytial virus Species 0.000 claims 1
- 241000702670 Rotavirus Species 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 241000223996 Toxoplasma Species 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 229940038705 chlamydia trachomatis Drugs 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 231100000249 enterotoxic Toxicity 0.000 claims 1
- 230000002242 enterotoxic effect Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 229940102223 injectable solution Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0323965.4A GB0323965D0 (en) | 2003-10-13 | 2003-10-13 | Immunogenic compositions |
| PCT/EP2004/011620 WO2005039634A1 (en) | 2003-10-13 | 2004-10-11 | Vaccine compositions comprising an interleukin 18 and saponin adjuvant system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007508272A JP2007508272A (ja) | 2007-04-05 |
| JP2007508272A5 true JP2007508272A5 (enExample) | 2007-07-26 |
Family
ID=29559205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006530155A Pending JP2007508272A (ja) | 2003-10-13 | 2004-10-11 | インターロイキン１８およびサポニンアジュバント系を含むワクチン組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20070212329A1 (enExample) |
| EP (1) | EP1687025A1 (enExample) |
| JP (1) | JP2007508272A (enExample) |
| KR (1) | KR20070054136A (enExample) |
| CN (1) | CN1889977A (enExample) |
| AU (1) | AU2004283457A1 (enExample) |
| BR (1) | BRPI0415304A (enExample) |
| CA (1) | CA2541695A1 (enExample) |
| CO (1) | CO5700790A2 (enExample) |
| GB (1) | GB0323965D0 (enExample) |
| IL (1) | IL174544A0 (enExample) |
| IS (1) | IS8374A (enExample) |
| MA (1) | MA28149A1 (enExample) |
| NO (1) | NO20061912L (enExample) |
| RU (1) | RU2006111847A (enExample) |
| WO (1) | WO2005039634A1 (enExample) |
| ZA (1) | ZA200602950B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI373343B (en) * | 2000-02-10 | 2012-10-01 | Abbott Gmbh & Co Kg | Antibodies that bind human interleukin-18 and methods of making and using |
| US7727561B2 (en) | 2001-08-31 | 2010-06-01 | Pacific Arrow Limited | Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof |
| US7524824B2 (en) * | 2003-09-04 | 2009-04-28 | Pacific Arrow Limited | Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof |
| SG172476A1 (en) * | 2002-08-12 | 2011-07-28 | Dynavax Tech Corp | Immunomodulatory compositions comprising a cationic condensing agent, an immunostimulatory compound comprising 5'-cg-3', an a non ionic detergent |
| US7514412B2 (en) * | 2003-10-09 | 2009-04-07 | Pacific Arrow Limited | Anticancer biangeloyl saponins |
| US8614197B2 (en) * | 2003-10-09 | 2013-12-24 | Pacific Arrow Limited | Anti-tumor compounds with angeloyl groups |
| US7488753B2 (en) * | 2003-10-09 | 2009-02-10 | Pacific Arrow Limited | Composition comprising triterpene saponins and compounds with angeloyl functional group, methods for preparing same and uses thereof |
| JP4815558B2 (ja) * | 2003-10-09 | 2011-11-16 | パシフィック アロー リミテッド | Ｘａｎｔｈｏｃｅｒａｓｓｏｒｂｉｆｏｌｉａ抽出物を含む組成物、該抽出物から単離された化合物、それらを調製する方法、およびそれらの使用 |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| DE102004022200B4 (de) | 2004-05-05 | 2006-07-20 | Actinium Pharmaceuticals, Inc. | Radium-Target sowie Verfahren zu seiner Herstellung |
| US8735558B2 (en) * | 2005-02-14 | 2014-05-27 | Pacific Arrow Limited | Blocking the migration or metastasis of cancer cells by affecting adhesion proteins and the uses of new compounds thereof |
| US9382285B2 (en) | 2004-09-07 | 2016-07-05 | Pacific Arrow Limited | Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells |
| US8586719B2 (en) * | 2005-04-27 | 2013-11-19 | Pacific Arrow Limited | Triterpenes for modulating gene expression and cell membrane, and as antiprotozoal agents |
| DE102006008023B4 (de) | 2006-02-21 | 2008-05-29 | Actinium Pharmaceuticals, Inc. | Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets |
| CA2662932C (en) | 2006-09-08 | 2017-06-06 | Actinium Pharmaceuticals, Inc. | Method for the purification of radium from different sources |
| EP2129394B1 (en) * | 2007-03-09 | 2012-06-20 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
| ES2588705T3 (es) | 2007-09-27 | 2016-11-04 | Immunovaccine Technologies Inc. | Uso de liposomas en un vehículo que comprende una fase hidrófoba continua para la entrega de polinucleótidos in vivo |
| US20100209452A1 (en) * | 2007-10-03 | 2010-08-19 | Immunovaccine Technologies, Inc | Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof |
| US8741313B2 (en) | 2008-01-11 | 2014-06-03 | Emory University | Polypeptide vaccine and vaccination strategy against mycobacterium |
| CA2723918C (en) | 2008-06-05 | 2018-01-09 | Immunovaccine Technologies Inc. | Compositions comprising liposomes, an antigen, a polynucleotide and a carrier comprising a continuous phase of a hydrophobic substance |
| CN102076358B (zh) * | 2008-06-27 | 2016-08-17 | 硕腾有限责任公司 | 新颖的佐剂组合物 |
| TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
| WO2010147268A1 (ko) * | 2009-06-19 | 2010-12-23 | 아이진 주식회사 | 자궁경부암 백신 |
| US20120277308A1 (en) | 2010-07-16 | 2012-11-01 | Pacific Arrow Limited | compounds for treating cancer and other diseases |
| US9499577B2 (en) | 2009-07-16 | 2016-11-22 | Pacific Arrow Limited | Natural and synthetic compounds for treating cancer and other diseases |
| US9434677B2 (en) | 2009-07-16 | 2016-09-06 | Pacific Arrow Limited | Natural and synthetic compounds for treating cancer and other diseases |
| HRP20161608T1 (hr) * | 2010-01-27 | 2017-01-13 | Glaxosmithkline Biologicals Sa | Modificirani tuberkulozni antigeni |
| BR112012030337B1 (pt) * | 2010-05-28 | 2021-04-27 | Coley Pharmaceutical Group, Inc | Vacina compreendendo um ou mais oligonucleotídeo(s) de cpg isolado(s) ou um agonista de tlr e colesterol, e uso da mesma |
| GB201016471D0 (en) * | 2010-09-30 | 2010-11-17 | Isis Innovation | Viral vector immunogenic compositions |
| RU2482866C2 (ru) * | 2010-10-07 | 2013-05-27 | Общество с ограниченной ответственностью "Аллоферон" | Способ лечения папилломавирусных инфекций, реализуемый через индукцию интерлейкина-18 |
| IN2014CN02581A (enExample) | 2011-10-06 | 2015-08-07 | Immunovaccine Technologies Inc | |
| GB201205361D0 (en) * | 2012-03-27 | 2012-05-09 | Univ Nottingham Trent | Breast cancer assay |
| EP2941436B1 (en) * | 2013-01-04 | 2020-12-02 | OBI Pharma, Inc. | Vaccines with higher carbohydrate antigen density and novel saponin adjuvant |
| CN106794263A (zh) * | 2014-10-01 | 2017-05-31 | 宾夕法尼亚大学理事会 | 具有抗原和作为佐剂的白细胞介素‑21的疫苗 |
| US10456459B2 (en) | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
| GB201522329D0 (en) * | 2015-12-17 | 2016-02-03 | Glaxosmithkline Biolog S A And Inst Nat De La Sante Et De La Rech Medicale Inserm And Université Pie | Use of adjuvants for the prevention and/or treatment of autoimmune diseases |
| US10874733B2 (en) | 2016-10-31 | 2020-12-29 | Eyegene Inc. | Composition for enhancing immunity comprising immune modulator and cationic liposome, and use of same |
| CU24534B1 (es) * | 2017-11-06 | 2021-07-02 | Ct Inmunologia Molecular | Adyuvantes nano-particulados que contienen variantes sintéticas del gangliósido gm3 |
| CN107952069A (zh) * | 2017-11-24 | 2018-04-24 | 长春百克生物科技股份公司 | 重组疫苗及其应用 |
| EP3669890A1 (en) * | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
| TR201907085A2 (tr) | 2019-05-10 | 2020-11-23 | Univ Yeditepe | Parazi̇tleri̇n ve parazi̇tlerden elde edi̇len ekstraselüler vezi̇külleri̇n kanser tedavi̇si̇nde kullanimi |
| WO2021048081A1 (en) * | 2019-09-09 | 2021-03-18 | Glaxosmithkline Biologicals Sa | Immunotherapeutic compositions |
| CN112972671B (zh) * | 2019-12-13 | 2024-04-19 | 远大赛威信生命科学(南京)有限公司 | 药物组合物及其用途 |
| WO2022034555A1 (en) * | 2020-08-13 | 2022-02-17 | Janssen Biopharma, Inc. | Polynucleotide constructs and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ253137A (en) * | 1992-06-25 | 1996-08-27 | Smithkline Beecham Biolog | Vaccine comprising antigen and/or antigenic composition, qs21 (quillaja saponaria molina extract) and 3 de-o-acylated monophosphoryl lipid a. |
| US5869445A (en) * | 1993-03-17 | 1999-02-09 | University Of Washington | Methods for eliciting or enhancing reactivity to HER-2/neu protein |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6355256B1 (en) * | 1994-09-30 | 2002-03-12 | Ludwig Institute For Cancer Research | Compositions containing a p53 derived protein or peptide, an adjuvant, and interleukin-12 and uses thereof |
| GB9712347D0 (en) * | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| WO1999056775A1 (en) * | 1998-05-07 | 1999-11-11 | Akzo Nobel N.V. | Use of interleukin-18 as vaccine adjuvant |
| US6562798B1 (en) * | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
| CN1227030C (zh) * | 1999-04-19 | 2005-11-16 | 史密丝克莱恩比彻姆生物有限公司 | 包含皂甙和免疫刺激寡核苷酸的佐剂组合物 |
| AU2001233212A1 (en) * | 2000-02-02 | 2001-08-14 | Schering Corporation | Mammalian cytokines; receptors; related reagents and methods |
| TWI373343B (en) * | 2000-02-10 | 2012-10-01 | Abbott Gmbh & Co Kg | Antibodies that bind human interleukin-18 and methods of making and using |
-
2003
- 2003-10-13 GB GBGB0323965.4A patent/GB0323965D0/en not_active Ceased
-
2004
- 2004-10-11 US US10/575,838 patent/US20070212329A1/en not_active Abandoned
- 2004-10-11 CN CNA2004800363071A patent/CN1889977A/zh active Pending
- 2004-10-11 AU AU2004283457A patent/AU2004283457A1/en not_active Abandoned
- 2004-10-11 BR BRPI0415304-9A patent/BRPI0415304A/pt not_active Application Discontinuation
- 2004-10-11 CA CA002541695A patent/CA2541695A1/en not_active Abandoned
- 2004-10-11 RU RU2006111847/13A patent/RU2006111847A/ru not_active Application Discontinuation
- 2004-10-11 KR KR1020067009283A patent/KR20070054136A/ko not_active Withdrawn
- 2004-10-11 JP JP2006530155A patent/JP2007508272A/ja active Pending
- 2004-10-11 EP EP04790465A patent/EP1687025A1/en not_active Withdrawn
- 2004-10-11 WO PCT/EP2004/011620 patent/WO2005039634A1/en not_active Ceased
-
2006
- 2006-03-23 IL IL174544A patent/IL174544A0/en unknown
- 2006-03-27 IS IS8374A patent/IS8374A/is unknown
- 2006-04-07 CO CO06034535A patent/CO5700790A2/es not_active Application Discontinuation
- 2006-04-11 ZA ZA200602950A patent/ZA200602950B/xx unknown
- 2006-04-28 NO NO20061912A patent/NO20061912L/no not_active Application Discontinuation
- 2006-05-04 MA MA29002A patent/MA28149A1/fr unknown
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