JP2015533376A5 - - Google Patents

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Publication number
JP2015533376A5
JP2015533376A5 JP2015538149A JP2015538149A JP2015533376A5 JP 2015533376 A5 JP2015533376 A5 JP 2015533376A5 JP 2015538149 A JP2015538149 A JP 2015538149A JP 2015538149 A JP2015538149 A JP 2015538149A JP 2015533376 A5 JP2015533376 A5 JP 2015533376A5
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JP
Japan
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conjugate
blood cells
conjugate according
antigen
peripheral blood
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JP2015538149A
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English (en)
Japanese (ja)
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JP6430949B2 (ja
JP2015533376A (ja
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Priority claimed from PCT/US2013/066261 external-priority patent/WO2014066443A1/en
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Publication of JP2015533376A5 publication Critical patent/JP2015533376A5/ja
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Publication of JP6430949B2 publication Critical patent/JP6430949B2/ja
Expired - Fee Related legal-status Critical Current
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JP2015538149A 2012-10-23 2013-10-23 Gm−csfとil−4のコンジュゲート、組成物、ならびにそれに関連する方法 Expired - Fee Related JP6430949B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717129P 2012-10-23 2012-10-23
US61/717,129 2012-10-23
PCT/US2013/066261 WO2014066443A1 (en) 2012-10-23 2013-10-23 Gm-csf and il-4 conjugates, compositions, and methods related thereto

Publications (3)

Publication Number Publication Date
JP2015533376A JP2015533376A (ja) 2015-11-24
JP2015533376A5 true JP2015533376A5 (enExample) 2016-12-08
JP6430949B2 JP6430949B2 (ja) 2018-11-28

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ID=50545195

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JP2015538149A Expired - Fee Related JP6430949B2 (ja) 2012-10-23 2013-10-23 Gm−csfとil−4のコンジュゲート、組成物、ならびにそれに関連する方法

Country Status (5)

Country Link
US (4) US9657076B2 (enExample)
EP (2) EP3587455A1 (enExample)
JP (1) JP6430949B2 (enExample)
CN (2) CN109134640A (enExample)
WO (1) WO2014066443A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2780361B1 (en) 2011-11-14 2018-01-17 Emory University Conjugates of gm-csf and il-7, compositions and methods related thereto
US9657076B2 (en) 2012-10-23 2017-05-23 Emory University GM-CSF and IL-4 conjugates, compositions, and methods related thereto
US10072058B2 (en) 2015-04-29 2018-09-11 Emory University Chimeric virus-like particles incorporating fusion GPI anchored GM-CSF and IL-4 conjugates
WO2017027866A1 (en) * 2015-08-13 2017-02-16 University Of Florida Research Foundation, Inc. Aav6 vectors for immunotherapy
CN105647970A (zh) * 2016-02-22 2016-06-08 河北利同康生物科技有限公司 前列腺癌特异性pap-gm-csf-il-6基因重组融合蛋白及其制备方法
MX2018011306A (es) * 2016-03-18 2019-08-16 Nantcell Inc Vector multimodal para infeccion de celulas dentriticas.
US11267859B2 (en) 2017-06-09 2022-03-08 The Regents Of The University Of Colorado, A Body Corporate GM-CSF mimetics and methods of making and using same
CN109735566B (zh) * 2018-12-13 2023-02-28 中国科学院广州生物医药与健康研究院 一种增强腺病毒载体生物制品感染靶细胞的方法
EP4545139A3 (en) 2019-04-19 2025-07-09 Synerkine Pharma B.V. A fusion protein comprising il13
EP4121095A4 (en) * 2020-03-20 2024-04-03 The Regents of the University of Colorado, a body corporate METHODS AND COMPOSITIONS FOR TREATING VIRUS DISEASES WITH GRANULOCYTE MACROPHAGE COLONIA STIMULATING FACTOR (GM-CSF)
WO2023072854A1 (en) * 2021-10-25 2023-05-04 Ellennbe Gmbh Injectable dosage form and kit comprising an immunomodulatory substance for treating diseases
US20240166706A1 (en) * 2022-11-21 2024-05-23 Wisconsin Alumni Research Foundation Synthetic il6-il1beta fusion cytokine for promoting t cell cytotoxic function, t cell proliferation, and tumoricidal activity

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
FI861417A0 (fi) 1985-04-15 1986-04-01 Endotronics Inc Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav.
FR2583429B1 (fr) 1985-06-18 1989-11-03 Transgene Sa Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
FR2606029B2 (fr) 1986-04-08 1989-02-03 Transgene Sa Vecteur viral et adn recombinant codant pour une glycoproteine du virus agent causal du s.i.d.a., culture cellulaire infectee par ce vecteur, procede de preparation de la glycoproteine, glycoproteine obtenue, vaccin et anticorps obtenus
FR2643817B1 (fr) 1989-03-06 1993-12-17 Transgene Sa Composition pharmaceutique, utile a titre preventif ou curatif contre les tumeurs induites par les papillomavirus
EP0304578B1 (en) 1987-06-22 2001-10-24 Medeva Holdings Bv Peptide comprising hepatitis B surface antigen
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
FR2632863B2 (fr) 1987-10-29 1990-08-31 Transgene Sa Virus du fowlpox recombinant et vaccins derives de ces virus
GB8819209D0 (en) 1988-08-12 1988-09-14 Research Corp Ltd Polypeptide & dna encoding same
SG48175A1 (en) 1989-07-25 1998-04-17 Smithkline Beecham Biolog Novel antigens and method for their preparation
FR2650838A1 (fr) 1989-08-09 1991-02-15 Transgene Sa Vecteurs d'expression du facteur ix dans une cellule eucaryote superieure, procede de preparation de facteur ix par des animaux transgeniques et facteur ix obtenu
US5108910A (en) 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5670488A (en) 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
FR2668064B1 (fr) 1990-10-23 1994-12-16 Transgene Sa Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne.
GB9105383D0 (en) 1991-03-14 1991-05-01 Immunology Ltd An immunotherapeutic for cervical cancer
DK1298211T3 (da) 1991-07-19 2006-11-13 Univ Queensland Polynukleotidsegment af HPV16-genom
WO1993010152A1 (en) 1991-11-16 1993-05-27 Smithkline Beecham Biologicals S.A. HYBRID PROTEIN BETWEEN CS FROM PLASMODIUM AND HBsAG
WO1994000152A1 (en) 1992-06-25 1994-01-06 Georgetown University Papillomavirus vaccines
US5786148A (en) 1996-11-05 1998-07-28 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a novel prostate-specific kallikrein
GB9223084D0 (en) 1992-11-04 1992-12-16 Imp Cancer Res Tech Compounds to target cells
EP0673431A1 (en) 1992-12-03 1995-09-27 Genzyme Corporation Gene therapy for cystic fibrosis
US5747323A (en) 1992-12-31 1998-05-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Retroviral vectors comprising a VL30-derived psi region
US5846945A (en) 1993-02-16 1998-12-08 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
DE122007000089I1 (de) 1993-03-09 2008-03-27 Univ Rochester Herstellung von menschlichem papillomavirus hüllprotein und virus-ähnlichen teilchen
US6133028A (en) 1993-05-28 2000-10-17 Transgene S.A. Defective adenoviruses and corresponding complementation lines
FR2705686B1 (fr) 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
FR2707091B1 (fr) 1993-06-30 1997-04-04 Cohen Haguenauer Odile Vecteur rétroviral pour le transfert et l'expression de gènes dans des cellules eucaryotes.
FR2711523B1 (fr) 1993-10-26 1996-02-16 Transgene Sa Procédé de préparation d'un aérosol viral.
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
CA2193488A1 (en) 1994-05-20 1995-11-30 Michele P. Calos An autonomous replication system for mammalian cells
US6638762B1 (en) 1994-11-28 2003-10-28 Genetic Therapy, Inc. Tissue-vectors specific replication and gene expression
US5998205A (en) 1994-11-28 1999-12-07 Genetic Therapy, Inc. Vectors for tissue-specific replication
FR2727689A1 (fr) 1994-12-01 1996-06-07 Transgene Sa Nouveau procede de preparation d'un vecteur viral
FR2730735B1 (fr) 1995-02-20 1997-05-09 Pasteur Institut Sequences amplificatrices, vecteurs portant ces sequences et leurs utilisations dans des compositions pour l'expression de sequences nucleotidiques dans des cellules transfectees, applications therapeutiques et vaccinales
US5837520A (en) 1995-03-07 1998-11-17 Canji, Inc. Method of purification of viral vectors
US5759776A (en) 1995-06-05 1998-06-02 California Pacific Medical Center Targets for breast cancer diagnosis and treatment
AU705035B2 (en) 1995-06-07 1999-05-13 Baylor College Of Medicine Nucleic acid transporters for delivery of nucleic acids into a cell
UA68327C2 (en) 1995-07-04 2004-08-16 Gsf Forschungszentrum Fur Unwe A recombinant mva virus, an isolated eukaryotic cell, infected with recombinant mva virus, a method for production in vitro of polypeptides with use of said cell, a method for production in vitro of virus parts (variants), vaccine containing the recombinant mva virus, a method for immunization of animals
FR2737222B1 (fr) 1995-07-24 1997-10-17 Transgene Sa Nouveaux vecteurs viraux et lignee pour la therapie genique
US6090618A (en) 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
US6225446B1 (en) * 1995-12-06 2001-05-01 Schering Corporation Mutational variants of mammalian proteins
FR2746815A1 (fr) 1996-03-26 1997-10-03 Pasteur Institut Sequences en amont du gene sm 22, vecteurs les contenant et leurs utilisations therapeutiques, notamment dans le traitement des maladies vasculaires
US5776683A (en) 1996-07-11 1998-07-07 California Pacific Medical Center Methods for identifying genes amplified in cancer cells
US6485958B2 (en) 1996-07-01 2002-11-26 Gencell Sa Method for producing recombinant adenovirus
CA2264482A1 (en) 1996-09-06 1998-03-12 The Trustees Of The University Of Pennsylvania An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
US5955306A (en) 1996-09-17 1999-09-21 Millenium Pharmaceuticals, Inc. Genes encoding proteins that interact with the tub protein
US5994132A (en) 1996-10-23 1999-11-30 University Of Michigan Adenovirus vectors
EP0968284B1 (en) 1996-11-20 2006-12-13 Introgen Therapeutics, Inc. An improved method for the production and purification of adenoviral vectors
AU5370598A (en) 1996-12-13 1998-07-03 Schering Corporation Methods for purifying viruses
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
FR2763958A1 (fr) 1997-05-29 1998-12-04 Transgene Sa Produit de combinaison associant un acide nucleique a une substance desorganisant la matrice extracellulaire pour la therapie genique
FR2763959A1 (fr) 1997-06-02 1998-12-04 Transgene Sa Nouveaux vecteurs adenoviraux recombinants comprenant une sequence d'epissage
WO1998056415A1 (en) 1997-06-11 1998-12-17 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
CA2242035C (en) 1997-07-01 2004-11-23 Transgene S.A. Compositions useful for transferring therapeutically active substances into a target cell, and their use in gene therapy
FR2766091A1 (fr) 1997-07-18 1999-01-22 Transgene Sa Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee
AU1606999A (en) 1997-11-26 1999-06-15 Albert Einstein College Of Medicine Of Yeshiva University Mouse telomerase reverse transcriptase
EP1035867A1 (en) 1997-12-02 2000-09-20 Powderject Vaccines, Inc. Transdermal delivery of particulate vaccine compositions
JP4768121B2 (ja) 1998-02-05 2011-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Mageファミリーからの腫瘍関連抗原及びそれらをコードする核酸配列、融合タンパク質の及びワクチン接種のための組成物の調製のための使用
US6838081B1 (en) 1998-04-02 2005-01-04 The Regents Of The University Of California Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient
AU748850B2 (en) * 1998-04-02 2002-06-13 Regents Of The University Of California, The Methods for enhancing antigen-presenting cells and anti-tumor responses in a human patient
AU3560399A (en) 1998-04-15 1999-11-01 Ludwig Institute For Cancer Research Tumor associated nucleic acids and uses therefor
WO1999056784A2 (en) 1998-05-06 1999-11-11 Transgene S.A. Inprovements in gene therapy using compositions comprising a polynucleotide and a nuclease inhibitor or interleukin-10
CN1107604C (zh) * 1998-05-15 2003-05-07 李振东 防夜间会车眩目的后灯侧灯车体灯
JP3864610B2 (ja) 1998-05-21 2007-01-10 旭硝子株式会社 水分散型撥水撥油剤組成物およびその製造方法
ES2210081T3 (es) 1998-07-07 2004-07-01 Transgene S.A. Utilizacion de los marcos de lectura de la region e4 para la mejora de la expresion de genes.
TW200728465A (en) 1998-07-14 2007-08-01 Corixa Corp Compositions and methods for the therapy and diagnosis of prostate cancer
FR2782732A1 (fr) 1998-08-28 2000-03-03 Transgene Sa Systeme d'expression inductible
US6900049B2 (en) 1998-09-10 2005-05-31 Cell Genesys, Inc. Adenovirus vectors containing cell status-specific response elements and methods of use thereof
EP0998945A1 (en) 1998-09-30 2000-05-10 Transgene S.A. Use of magnesium (Mg2+) for the enhancement of gene delivery in gene therapy
US20020037274A1 (en) 1998-10-26 2002-03-28 Angelica Williams Single agent method for killing tumor and tumor associated endothelial cells using adenoviral mutants
US7217421B1 (en) 1998-11-03 2007-05-15 Cell Genesys, Inc. Cancer-associated antigens and methods of their identification and use
FR2787465A1 (fr) 1998-12-21 2000-06-23 Transgene Sa Procede d'inactivation des virus enveloppes dans une preparation virale de virus non enveloppes
CN1258738A (zh) * 1998-12-31 2000-07-05 上海华晨生物技术研究所 表达人粒细胞巨噬细胞集落刺激因子的重组腺病毒及其制法和用途
NZ512504A (en) 1998-12-31 2004-01-30 Aventis Pharma Sa Method for separating viral particles
ATE266720T1 (de) 1999-02-04 2004-05-15 Geron Corp Replikativer virus gesteuert von dem promotor der reversen telomerase transkriptase zur behandlung von krebs
WO2000050573A1 (fr) 1999-02-22 2000-08-31 Transgene S.A. Procede d'obtention d'une preparation virale purifiee
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
BR0013231A (pt) 1999-08-09 2002-07-23 Lexigen Pharm Corp Complexos citocina-anticorpo múltiplos
CN1382218A (zh) 1999-11-15 2002-11-27 昂尼克斯药物公司 溶瘤腺病毒
CA2363180A1 (en) 1999-12-28 2001-07-05 Transgene S.A. Use of lithium (li+) for the preparation of a composition for transfection of a polynucleotide into a cell and compositions useful in gene therapy
CA2341356C (en) 2000-04-14 2011-10-11 Transgene S.A. Poxvirus with targeted infection specificity
AU2002230958A1 (en) 2000-12-18 2002-07-16 Geron Corporation Chimeric cytolytic viruses for cancer treatment
WO2002096939A2 (en) 2001-05-30 2002-12-05 Transgene S.A. Adenovirus protein ix, its domains involved in capsid assembly, transcriptional activity and nuclear reorganization
WO2003035105A2 (en) * 2001-10-23 2003-05-01 Centre For Translational Research In Cancer A synthetic chimeric fusion protein with immuno-therapeutic uses
EP1310561A1 (en) 2001-11-09 2003-05-14 Transgene S.A. Chimeric promoters for controlling expression in skeletal muscle cells
GB0201679D0 (en) * 2002-01-25 2002-03-13 Asterion Ltd Polypeptide variants
WO2005026820A1 (en) 2003-09-06 2005-03-24 Donald Bennett Hilliard Pellicle
FR2862866B1 (fr) 2003-11-28 2006-12-15 Gilles Voydeville Prothese discale intervertebrale postero-laterale
ES2305886T3 (es) 2003-12-30 2008-11-01 Merck Patent Gmbh Proteinas de fusion de il-7 con porciones de anticuerpo, su preparacion y su empleo.
CN101141979B (zh) * 2005-03-18 2013-05-08 赛托斯生物技术公司 猫变应原融合蛋白及其用途
WO2008014612A1 (en) 2006-08-02 2008-02-07 Mcgill University Fusion proteins and methods for modulation of immune response
WO2008053573A1 (fr) 2006-10-30 2008-05-08 National University Corporation Hokkaido University Remède pour néoplasme malin
WO2009062001A1 (en) * 2007-11-08 2009-05-14 Dana-Farber Cancer Institute, Inc. Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28
JP4761173B2 (ja) 2008-11-21 2011-08-31 Dic株式会社 ポリアリ−レンスルフィド樹脂の製造方法
CA2799081C (en) * 2009-05-15 2018-10-30 Irx Therapeutics, Inc. Compositions comprising primary cell-derived biologics for enhancing immune responses in patients
EP2613773A2 (en) * 2010-09-09 2013-07-17 Trifoilium ApS Airway administration of angiogenesis inhibitors
US9657076B2 (en) 2012-10-23 2017-05-23 Emory University GM-CSF and IL-4 conjugates, compositions, and methods related thereto

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