JP2015529676A5 - - Google Patents
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- Publication number
- JP2015529676A5 JP2015529676A5 JP2015531646A JP2015531646A JP2015529676A5 JP 2015529676 A5 JP2015529676 A5 JP 2015529676A5 JP 2015531646 A JP2015531646 A JP 2015531646A JP 2015531646 A JP2015531646 A JP 2015531646A JP 2015529676 A5 JP2015529676 A5 JP 2015529676A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- cells expressing
- cell antigen
- antigen
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003795 chemical substances by application Substances 0.000 claims 20
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- 241000709661 Enterovirus Species 0.000 claims 1
- 101100207070 Homo sapiens TNFSF8 gene Proteins 0.000 claims 1
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 101100207071 Mus musculus Tnfsf8 gene Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 108010001441 Phosphopeptides Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 102100032100 Tumor necrosis factor ligand superfamily member 8 Human genes 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 150000003408 sphingolipids Chemical class 0.000 claims 1
- 229960000814 tetanus toxoid Drugs 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201216649A GB201216649D0 (en) | 2012-09-18 | 2012-09-18 | Agents and methods |
| GB1216649.2 | 2012-09-18 | ||
| PCT/GB2013/052427 WO2014045022A2 (en) | 2012-09-18 | 2013-09-17 | Agents and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015529676A JP2015529676A (ja) | 2015-10-08 |
| JP2015529676A5 true JP2015529676A5 (enExample) | 2016-12-22 |
Family
ID=47144453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531646A Withdrawn JP2015529676A (ja) | 2012-09-18 | 2013-09-17 | 作用物質および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20150297745A1 (enExample) |
| EP (1) | EP2897642A2 (enExample) |
| JP (1) | JP2015529676A (enExample) |
| CN (1) | CN104812413A (enExample) |
| AU (1) | AU2013319980C1 (enExample) |
| CA (1) | CA2885133A1 (enExample) |
| GB (1) | GB201216649D0 (enExample) |
| WO (1) | WO2014045022A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9402916B2 (en) * | 2011-03-17 | 2016-08-02 | The University Of Birmingham | Re-directed immunotherapy |
| WO2016023040A1 (en) * | 2014-08-08 | 2016-02-11 | Alexo Therapeutics International | Sirp-alpha variant constructs and uses thereof |
| CN117964732A (zh) | 2015-08-07 | 2024-05-03 | Alx肿瘤生物技术公司 | 具有SIRP-α结构域或其变体的构建体 |
| PT3377103T (pt) * | 2015-11-19 | 2021-05-26 | Revitope Ltd | Complementação de fragmento de anticorpo funcional para um sistema de dois componentes para exterminação redirecionada de células indesejadas |
| JP2017141172A (ja) * | 2016-02-08 | 2017-08-17 | 日本全薬工業株式会社 | 抗イヌｃｄ７０モノクローナル抗体 |
| CN113201071A (zh) * | 2017-03-28 | 2021-08-03 | 礼进生物医药科技（上海）有限公司 | 用于增强肿瘤微环境中免疫应答的治疗剂和方法 |
| CN112118858A (zh) * | 2018-05-15 | 2020-12-22 | 默克专利有限公司 | 用于未经治疗对象中癌症治疗的靶向tgf-β抑制的给药方案 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020132091A2 (en) | 2018-12-19 | 2020-06-25 | Humabs Biomed Sa | Antibodies that neutralize hepatitis b virus and uses thereof |
| DK4285929T3 (da) | 2018-12-20 | 2025-12-22 | Humabs Biomed Sa | Kombinationsterapi mod hbv |
| AU2020282791A1 (en) | 2019-05-31 | 2021-12-09 | ALX Oncology Inc. | Methods of treating cancer with SIRP alpha Fc fusion in combination with an immune checkpoint inhibitor |
| AU2020321953A1 (en) * | 2019-07-29 | 2022-02-24 | Deverra Therapeutics Inc. | NK cell composition and preparations for immunotherapy and methods for their production |
| BR112022008817A2 (pt) | 2019-11-27 | 2022-07-26 | Alx Oncology Inc | Terapias combinadas para tratamento de câncer |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2131003A1 (en) * | 1992-05-26 | 1993-12-09 | Raymond G. Goodwin | Novel cytokine that binds cd30 |
| EP0659438A1 (en) * | 1993-12-23 | 1995-06-28 | Boehringer Mannheim Gmbh | Conjugates consisting of peptidic T cell antigens and cell binding groups, and their use for therapy |
| JP2000503003A (ja) * | 1995-12-22 | 2000-03-14 | イムノメディクス，インコーポレイテッド | 多段階カスケード増強ワクチンの効果を高めるための免疫接合体の使用 |
| ATE477276T1 (de) * | 2002-03-01 | 2010-08-15 | Immunomedics Inc | Internalisierung von anti cd74 monoklonalen antikörpern und deren verwendungen |
| US9402916B2 (en) * | 2011-03-17 | 2016-08-02 | The University Of Birmingham | Re-directed immunotherapy |
| CN104168918A (zh) * | 2012-03-19 | 2014-11-26 | 德国癌症研究中心 | 含有t-细胞表位的b细胞受体复合体结合蛋白质 |
-
2012
- 2012-09-18 GB GB201216649A patent/GB201216649D0/en not_active Ceased
-
2013
- 2013-09-17 US US14/428,449 patent/US20150297745A1/en not_active Abandoned
- 2013-09-17 JP JP2015531646A patent/JP2015529676A/ja not_active Withdrawn
- 2013-09-17 EP EP13782809.1A patent/EP2897642A2/en not_active Withdrawn
- 2013-09-17 CN CN201380059696.9A patent/CN104812413A/zh active Pending
- 2013-09-17 WO PCT/GB2013/052427 patent/WO2014045022A2/en not_active Ceased
- 2013-09-17 CA CA 2885133 patent/CA2885133A1/en not_active Abandoned
- 2013-09-17 AU AU2013319980A patent/AU2013319980C1/en not_active Expired - Fee Related
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