JP2010533736A - ５員複素環アミドおよび関連化合物 - Google Patents

５員複素環アミドおよび関連化合物 Download PDF

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JP2010533736A
JP2010533736A JP2010517200A JP2010517200A JP2010533736A JP 2010533736 A JP2010533736 A JP 2010533736A JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010533736 A JP2010533736 A JP 2010533736A
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alkyl
amino
mono
aminosulfonyl
aminocarbonyl
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JP2010533736A5 (Direct
Inventor
リー・ホンビン
ユアン・ジュン
バクサバッチャラム・ラジャゴパル
ホッドゲッツ・ケビン・ジェイ
キャピトスティ・スコット・エム
マオ・ジャンミン
ウストロウ・デイビッド・ジェイ
ギュオ・クィン
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ハー・ルンドベック・アクチエゼルスカベット
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Publication of JP2010533736A5 publication Critical patent/JP2010533736A5/ja
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
JP2010517200A 2007-07-19 2008-07-21 ５員複素環アミドおよび関連化合物 Pending JP2010533736A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95062507P 2007-07-19 2007-07-19
PCT/US2008/070613 WO2009012482A2 (en) 2007-07-19 2008-07-21 5-membered heterocyclic amides and related compounds

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JP2010533736A true JP2010533736A (ja) 2010-10-28
JP2010533736A5 JP2010533736A5 (Direct) 2011-09-08

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JP2010517200A Pending JP2010533736A (ja) 2007-07-19 2008-07-21 ５員複素環アミドおよび関連化合物
JP2013243253A Expired - Fee Related JP5813734B2 (ja) 2007-07-19 2013-11-25 ５員複素環アミドおよび関連化合物

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US (2) US20100292236A1 (Direct)
EP (1) EP2178865B1 (Direct)
JP (2) JP2010533736A (Direct)
KR (2) KR20150118197A (Direct)
CN (2) CN104844578B (Direct)
AU (1) AU2008275891B2 (Direct)
BR (1) BRPI0813426A2 (Direct)
CA (1) CA2691507C (Direct)
CO (1) CO6251318A2 (Direct)
CY (1) CY1116809T1 (Direct)
DK (1) DK2178865T3 (Direct)
EA (1) EA017250B1 (Direct)
ES (1) ES2551095T3 (Direct)
HK (1) HK1213879A1 (Direct)
HR (1) HRP20151052T1 (Direct)
HU (1) HUE026446T2 (Direct)
IL (1) IL202499A (Direct)
MX (1) MX2009014159A (Direct)
MY (1) MY154668A (Direct)
NZ (1) NZ582057A (Direct)
PH (1) PH12014501677A1 (Direct)
PL (1) PL2178865T3 (Direct)
PT (1) PT2178865E (Direct)
RS (1) RS54303B1 (Direct)
SG (1) SG187396A1 (Direct)
SI (1) SI2178865T1 (Direct)
UA (1) UA105758C2 (Direct)
WO (1) WO2009012482A2 (Direct)
ZA (1) ZA200908447B (Direct)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011524349A (ja) * 2008-06-13 2011-09-01 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト 殺有害生物剤としての新規ヘテロ芳香族アミド及びチオアミド
JP2013538825A (ja) * 2010-09-21 2013-10-17 エーザイ・アール・アンド・ディー・マネジメント株式会社 医薬組成物
JP2016510325A (ja) * 2013-01-22 2016-04-07 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
JP2017522306A (ja) * 2014-07-31 2017-08-10 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法
JP2017523168A (ja) * 2014-07-31 2017-08-17 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法
JP2017523163A (ja) * 2014-07-31 2017-08-17 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの製造方法
JP2018529739A (ja) * 2015-09-30 2018-10-11 マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ヴィッセンシャフテン エーファウ −ジェネラルフェルヴァルトゥング セピアプテリン還元酵素としてのヘテロアリール誘導体
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CA2691507C (en) 2016-06-21
AU2008275891B2 (en) 2013-10-10
KR20100032861A (ko) 2010-03-26
WO2009012482A2 (en) 2009-01-22
MY154668A (en) 2015-07-15
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ZA200908447B (en) 2011-05-25
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RS54303B1 (sr) 2016-02-29
US9133204B2 (en) 2015-09-15
PH12014501677B1 (en) 2015-08-03
CN104844578B (zh) 2018-06-19
WO2009012482A3 (en) 2009-04-30
HRP20151052T1 (xx) 2015-11-06
CY1116809T1 (el) 2017-03-15
JP2014058545A (ja) 2014-04-03
AU2008275891A1 (en) 2009-01-22
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US20100292236A1 (en) 2010-11-18
UA105758C2 (uk) 2014-06-25
ES2551095T3 (es) 2015-11-16
EA017250B1 (ru) 2012-11-30
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IL202499A (en) 2017-05-29
CA2691507A1 (en) 2009-01-22
PH12014501677A1 (en) 2015-08-03
PT2178865E (pt) 2015-11-16
SI2178865T1 (sl) 2015-11-30
HUE026446T2 (en) 2016-05-30
PL2178865T3 (pl) 2015-12-31
EP2178865B1 (en) 2015-08-19
IL202499A0 (en) 2010-06-30
EA200971084A1 (ru) 2010-04-30
JP5813734B2 (ja) 2015-11-17
BRPI0813426A2 (pt) 2014-12-23
KR20150118197A (ko) 2015-10-21
SG187396A1 (en) 2013-02-28
HK1213879A1 (zh) 2016-07-15
CN104844578A (zh) 2015-08-19
KR101593237B1 (ko) 2016-02-12

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