JP2010533736A5 - - Google Patents
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- JP2010533736A5 JP2010533736A5 JP2010517200A JP2010517200A JP2010533736A5 JP 2010533736 A5 JP2010533736 A5 JP 2010533736A5 JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010517200 A JP2010517200 A JP 2010517200A JP 2010533736 A5 JP2010533736 A5 JP 2010533736A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- mono
- cycloalkyl
- aminosulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 0 CC(*)(C1(CC(C2)C3)CC3CC2C1)NC(C)=O Chemical compound CC(*)(C1(CC(C2)C3)CC3CC2C1)NC(C)=O 0.000 description 17
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95062507P | 2007-07-19 | 2007-07-19 | |
| PCT/US2008/070613 WO2009012482A2 (en) | 2007-07-19 | 2008-07-21 | 5-membered heterocyclic amides and related compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013243253A Division JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | 5員複素環アミドおよび関連化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010533736A JP2010533736A (ja) | 2010-10-28 |
| JP2010533736A5 true JP2010533736A5 (Direct) | 2011-09-08 |
Family
ID=40260407
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010517200A Pending JP2010533736A (ja) | 2007-07-19 | 2008-07-21 | 5員複素環アミドおよび関連化合物 |
| JP2013243253A Expired - Fee Related JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | 5員複素環アミドおよび関連化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013243253A Expired - Fee Related JP5813734B2 (ja) | 2007-07-19 | 2013-11-25 | 5員複素環アミドおよび関連化合物 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20100292236A1 (Direct) |
| EP (1) | EP2178865B1 (Direct) |
| JP (2) | JP2010533736A (Direct) |
| KR (2) | KR20150118197A (Direct) |
| CN (2) | CN104844578B (Direct) |
| AU (1) | AU2008275891B2 (Direct) |
| BR (1) | BRPI0813426A2 (Direct) |
| CA (1) | CA2691507C (Direct) |
| CO (1) | CO6251318A2 (Direct) |
| CY (1) | CY1116809T1 (Direct) |
| DK (1) | DK2178865T3 (Direct) |
| EA (1) | EA017250B1 (Direct) |
| ES (1) | ES2551095T3 (Direct) |
| HK (1) | HK1213879A1 (Direct) |
| HR (1) | HRP20151052T1 (Direct) |
| HU (1) | HUE026446T2 (Direct) |
| IL (1) | IL202499A (Direct) |
| MX (1) | MX2009014159A (Direct) |
| MY (1) | MY154668A (Direct) |
| NZ (1) | NZ582057A (Direct) |
| PH (1) | PH12014501677A1 (Direct) |
| PL (1) | PL2178865T3 (Direct) |
| PT (1) | PT2178865E (Direct) |
| RS (1) | RS54303B1 (Direct) |
| SG (1) | SG187396A1 (Direct) |
| SI (1) | SI2178865T1 (Direct) |
| UA (1) | UA105758C2 (Direct) |
| WO (1) | WO2009012482A2 (Direct) |
| ZA (1) | ZA200908447B (Direct) |
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| AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| AR069798A1 (es) | 2007-12-20 | 2010-02-17 | Novartis Ag | Derivados de 1, 3-tiazol, metodos para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la manufactura de medicamentos para el tratamiento de enfermedades mediadas por la fosfatidilinositol 3-cinasa. |
| ES2524045T3 (es) * | 2008-06-13 | 2014-12-03 | Bayer Cropscience Ag | Nuevas amidas y tioamidas heteroaromáticas como plaguicidas |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| KR101712576B1 (ko) | 2008-11-10 | 2017-03-06 | 버텍스 파마슈티칼스 인코포레이티드 | Atr 키나제의 억제제로서 유용한 화합물 |
| NZ593969A (en) | 2008-12-19 | 2013-11-29 | Vertex Pharma | Pyrazine derivatives useful as inhibitors of atr kinase |
| US8293753B2 (en) | 2009-07-02 | 2012-10-23 | Novartis Ag | Substituted 2-carboxamide cycloamino ureas |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| KR20130056244A (ko) | 2010-04-22 | 2013-05-29 | 버텍스 파마슈티칼스 인코포레이티드 | 시클로알킬카르복스아미도-인돌 화합물의 제조 방법 |
| US9062008B2 (en) | 2010-05-12 | 2015-06-23 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2011143399A1 (en) | 2010-05-12 | 2011-11-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP2013526540A (ja) | 2010-05-12 | 2013-06-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| SG185524A1 (en) | 2010-05-12 | 2012-12-28 | Vertex Pharma | Compounds useful as inhibitors of atr kinase |
| US8962631B2 (en) | 2010-05-12 | 2015-02-24 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| AU2011253021A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | 2 -aminopyridine derivatives useful as inhibitors of ATR kinase |
| NZ605627A (en) | 2010-06-23 | 2015-06-26 | Vertex Pharma | Pyrrolo-pyrazine derivatives useful as inhibitors of atr kinase |
| EP2595962B1 (en) * | 2010-07-23 | 2018-07-11 | Solvay Sa | Process for the preparation of esters of 1-substituted-3-fluoroalkyl-pyrazole-4-carboxylic acids |
| CN101921268B (zh) * | 2010-08-27 | 2016-08-03 | 中山大学肿瘤防治中心 | 5-噻唑酰胺类化合物及生物学应用 |
| JP2013249256A (ja) * | 2010-09-15 | 2013-12-12 | Astellas Pharma Inc | 脂肪性肝疾患治療薬 |
| KR101911105B1 (ko) | 2010-09-21 | 2018-10-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 제약 조성물 |
| EP2694498B1 (en) | 2011-04-05 | 2016-03-30 | Vertex Pharmaceuticals Incorporated | Aminopyrazine compounds useful as inhibitors of tra kinase |
| JP2014522818A (ja) | 2011-06-22 | 2014-09-08 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
| WO2012178123A1 (en) | 2011-06-22 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2723746A1 (en) | 2011-06-22 | 2014-04-30 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
| BR112014000887A2 (pt) * | 2011-07-15 | 2016-09-13 | Basf Se | método para o combate ou o controle das pragas de invertebrados, método para a proteção das culturas, vegetais, material de propagação dos vegetais e/ou crescimento de vegetais do ataque ou infestação por pragas de invertebrados, método para o tratamento, controle, prevenção e proteção dos animais contra a infestação e infecção por parasitas, compostos de tiazol de 3-piridila, composto intermediário, processo para a preparação dos compostos de fórmula i, utilização de um composto de fórmula i-4, composição agrícola ou veterinária e semente |
| ES2574840T3 (es) | 2011-07-22 | 2016-06-22 | Actelion Pharmaceuticals Ltd. | Derivados de amidas heterocíclicas como antagonistas de receptores p2x7 |
| US8853217B2 (en) | 2011-09-30 | 2014-10-07 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| WO2013049722A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| WO2013049859A1 (en) | 2011-09-30 | 2013-04-04 | Vertex Pharmaceuticals Incorporated | Treating pancreatic cancer and non-small cell lung cancer with atr inhibitors |
| MX353461B (es) | 2011-09-30 | 2018-01-15 | Vertex Pharma | PROCESOS PARA PREPARAR COMPUESTOS ÚTILES COMO INHIBIDORES DE CINASA ATAXIA TELANGIECTASIA MUTADA Y Rad3 RELACIONADOS (ATR). |
| US8765751B2 (en) | 2011-09-30 | 2014-07-01 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| EP2776429A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| JP2015502925A (ja) | 2011-11-09 | 2015-01-29 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用なピラジン化合物 |
| EP2776422A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
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| EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
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| CA2863228C (en) | 2012-01-20 | 2020-07-21 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
| PT2833973T (pt) | 2012-04-05 | 2017-12-21 | Vertex Pharma | Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos |
| WO2013186089A2 (en) | 2012-06-14 | 2013-12-19 | Basf Se | Pesticidal methods using substituted 3-pyridyl thiazole compounds and derivatives for combating animal pests |
| EP2897953B8 (en) * | 2012-09-19 | 2019-06-26 | Cyclerion Therapeutics, Inc. | Sgc stimulators |
| AU2013326600B2 (en) | 2012-10-02 | 2017-03-30 | Bayer Cropscience Ag | Heterocyclic compounds as pesticides |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| US8912198B2 (en) | 2012-10-16 | 2014-12-16 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| US8871754B2 (en) | 2012-11-19 | 2014-10-28 | Irm Llc | Compounds and compositions for the treatment of parasitic diseases |
| ME03042B (me) | 2012-11-19 | 2018-10-20 | Novartis Ag | Jedinjenja i kompozicije za tretman parazitskih oboljenja |
| HK1209746A1 (en) | 2012-12-07 | 2016-04-08 | 沃泰克斯药物股份有限公司 | Compounds useful as inhibitors of atr kinase |
| BR112015013463B1 (pt) | 2012-12-12 | 2022-06-14 | Idorsia Pharmaceuticals Ltd | Derivados de carboxamida indol como antagonistas do receptor de p2x7 |
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| WO2014115078A1 (en) * | 2013-01-22 | 2014-07-31 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
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| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| ES2768678T3 (es) | 2013-12-06 | 2020-06-23 | Vertex Pharma | Compuesto de 2-amino-6-fluoro-N-[5-fluoro-piridin-3-il]pirazolo[1,5-a]pirimidin-3-carboxamida útil como inhibidor de la ATR quinasa, su preparación, diferentes formas sólidas y derivados radiomarcados de las mismas |
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| KR102447581B1 (ko) | 2014-04-15 | 2022-09-28 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막전도 조절자 매개 질환 치료용 약제학적 조성물 |
| HRP20200186T1 (hr) | 2014-06-05 | 2020-05-29 | Vertex Pharmaceuticals Inc. | Radioaktivno obilježeni derivati 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]-pirazolo[1,5-a]pirimidin-3-karboksamid spojeva koji se koriste kao inhibitori atr kinaze, priprava navedenih spojeva i njihovi različiti čvrsti oblici |
| PT3157566T (pt) | 2014-06-17 | 2019-07-11 | Vertex Pharma | Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr |
| JP2017523168A (ja) * | 2014-07-31 | 2017-08-17 | ダウ アグロサイエンシィズ エルエルシー | 3−(3−クロロ−1h−ピラゾール−1−イル)ピリジンの製造方法 |
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| AU2007333194A1 (en) * | 2006-12-08 | 2008-06-19 | Exelixis, Inc. | LXR and FXR modulators |
| CL2008000836A1 (es) | 2007-03-26 | 2008-11-07 | Actelion Pharmaceuticals Ltd | Compuestos derivados de tiazolidina, antagonistas del receptor de orexina; composicion farmaceutica que los comprende; y su uso en el tratamiento de neurosis emocional, depresion grave, trastornos psicoticos, alzheimer, parkinson, dolor, entre otras. |
| WO2008138876A1 (en) | 2007-05-10 | 2008-11-20 | Glaxo Group Limited | Pyrazole derivatives as p2x7 modulators |
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2008
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- 2008-07-21 JP JP2010517200A patent/JP2010533736A/ja active Pending
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