JP2010529835A5 - - Google Patents

Download PDF

Info

Publication number
JP2010529835A5
JP2010529835A5 JP2010509405A JP2010509405A JP2010529835A5 JP 2010529835 A5 JP2010529835 A5 JP 2010529835A5 JP 2010509405 A JP2010509405 A JP 2010509405A JP 2010509405 A JP2010509405 A JP 2010509405A JP 2010529835 A5 JP2010529835 A5 JP 2010529835A5
Authority
JP
Japan
Prior art keywords
avpal
avpal variant
variant
subject
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2010509405A
Other languages
English (en)
Japanese (ja)
Other versions
JP5670183B2 (ja
JP2010529835A (ja
Filing date
Publication date
Priority claimed from US11/807,227 external-priority patent/US7534595B2/en
Application filed filed Critical
Publication of JP2010529835A publication Critical patent/JP2010529835A/ja
Publication of JP2010529835A5 publication Critical patent/JP2010529835A5/ja
Application granted granted Critical
Publication of JP5670183B2 publication Critical patent/JP5670183B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2010509405A 2007-05-25 2008-05-23 原核生物フェニルアラニンアンモニアリアーゼの組成物、及び、その組成物の使用方法 Active JP5670183B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/807,227 US7534595B2 (en) 2006-06-12 2007-05-25 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US11/807,227 2007-05-25
PCT/US2008/006661 WO2008153776A1 (en) 2007-05-25 2008-05-23 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using said compositions

Publications (3)

Publication Number Publication Date
JP2010529835A JP2010529835A (ja) 2010-09-02
JP2010529835A5 true JP2010529835A5 (https=) 2011-07-07
JP5670183B2 JP5670183B2 (ja) 2015-02-18

Family

ID=39868905

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010509405A Active JP5670183B2 (ja) 2007-05-25 2008-05-23 原核生物フェニルアラニンアンモニアリアーゼの組成物、及び、その組成物の使用方法

Country Status (29)

Country Link
US (1) US7534595B2 (https=)
EP (2) EP2152868B1 (https=)
JP (1) JP5670183B2 (https=)
KR (2) KR101603796B1 (https=)
CN (1) CN101842482B (https=)
AR (2) AR066716A1 (https=)
AU (1) AU2008263190B2 (https=)
BR (1) BRPI0811267B8 (https=)
CA (1) CA2687450C (https=)
CL (1) CL2008001497A1 (https=)
CY (2) CY1116894T1 (https=)
DK (1) DK2152868T3 (https=)
EA (1) EA018443B1 (https=)
ES (1) ES2551315T3 (https=)
HR (1) HRP20151268T1 (https=)
HU (2) HUE025784T2 (https=)
IL (1) IL202132A (https=)
LT (1) LTC2152868I2 (https=)
LU (1) LUC00133I2 (https=)
MX (1) MX2009012453A (https=)
MY (1) MY151413A (https=)
NL (1) NL301011I2 (https=)
NO (1) NO2019037I1 (https=)
PE (1) PE20090315A1 (https=)
PL (1) PL2152868T3 (https=)
PT (1) PT2152868E (https=)
SI (1) SI2152868T1 (https=)
TW (1) TWI418633B (https=)
WO (1) WO2008153776A1 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531341B1 (en) 2006-06-12 2009-05-12 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7534595B2 (en) * 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7560263B2 (en) * 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
WO2010014225A2 (en) * 2008-07-30 2010-02-04 Biomarin Pharmaceutical Inc. Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase
ES2690542T3 (es) * 2010-02-04 2018-11-21 Biomarin Pharmaceutical Inc. Método para purificar variantes de fenilalanina amoníaco-liasa procariotas
AU2013295621A1 (en) * 2012-07-27 2015-03-12 University Of North Texas Genetically modified probiotic for the treatment of phenylketonuria (PKU) disease
NZ713396A (en) 2013-04-18 2020-06-26 Codexis Inc Engineered phenylalanine ammonia lyase polypeptides
CA2930665A1 (en) * 2013-11-18 2015-05-21 Rubius Therapeutics, Inc. Synthetic membrane-receiver complexes
MA39819A (fr) 2014-04-01 2017-02-08 Rubius Therapeutics Inc Méthodes et compositions d'immunomodulation
WO2015161019A1 (en) 2014-04-16 2015-10-22 Codexis, Inc. Engineered tyrosine ammonia lyase
LT3237621T (lt) 2014-12-22 2023-09-25 Codexis, Inc. Žmogaus alfa-galaktozidazės variantai
TWI870789B (zh) * 2015-08-04 2025-01-21 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
IL305149A (en) 2016-07-26 2023-10-01 Biomarin Pharm Inc Novel adeno-associated virus capsid proteins
MY190749A (en) 2016-08-30 2022-05-12 Mitsubishi Chem Corp Method for producing mutant enzyme, and mutant alcohol acyltransferase
CN106497905A (zh) * 2016-12-14 2017-03-15 江南大学 一株鱼腥藻来源的苯丙氨酸脱氨酶的突变体
MX2019009615A (es) 2017-02-13 2019-10-14 Codexis Inc Polipeptidos dise?ados de fenilalanina amonio liasa.
CN107653275A (zh) * 2017-10-30 2018-02-02 安徽工程大学 D‑苯丙氨酸的制备方法
CN108004225B (zh) * 2017-12-19 2020-05-08 江南大学 一种成团泛菌来源的苯丙氨酸氨基变位酶的突变体
TW202016314A (zh) 2018-05-09 2020-05-01 美商拜奧馬林製藥公司 治療苯丙酮尿症之方法
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
US10900055B2 (en) 2018-06-12 2021-01-26 Codexis, Inc. Engineered tyrosine ammonia lyase
JP2021531749A (ja) * 2018-07-12 2021-11-25 コデクシス， インコーポレイテッド 操作されたフェニルアラニンアンモニアリアーゼポリペプチド
CA3122524A1 (en) 2018-12-14 2020-06-18 Codexis, Inc. Engineered tyrosine ammonia lyase
AU2019403323B2 (en) 2018-12-20 2026-02-26 Codexis, Inc. Human alpha-galactosidase variants
CN110456056A (zh) * 2019-07-22 2019-11-15 浙江大学 一种新生儿苯丙酮尿症无创筛查试纸的制备方法
EP4501403A3 (en) 2019-08-30 2025-05-14 Société des Produits Nestlé S.A. Engineered lipase variants
JP2023507575A (ja) 2019-12-20 2023-02-24 コデクシス， インコーポレイテッド 操作された酸性アルファ－グルコシダーゼバリアント
JP2023512683A (ja) 2020-02-04 2023-03-28 コデクシス， インコーポレイテッド 操作されたロイシンデカルボキシラーゼ
WO2021168060A1 (en) * 2020-02-19 2021-08-26 Trustees Of Tufts College Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained
TW202144575A (zh) 2020-04-03 2021-12-01 美商拜奧馬林製藥公司 使用ａａｖ及治療調配物之苯酮尿症治療
CN116897205A (zh) 2020-08-28 2023-10-17 科德克希思公司 工程化淀粉酶变体
AU2021334371A1 (en) 2020-08-28 2023-03-09 Codexis, Inc. Engineered protease variants
EP4341394A4 (en) * 2021-05-19 2025-04-09 BioMarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia lyase and methods for treating adolescent patients
CA3220735A1 (en) 2021-05-21 2022-11-24 Codexis, Inc. Engineered methionine gamma lyase variants
WO2023044381A1 (en) * 2021-09-16 2023-03-23 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
JP2024540358A (ja) 2021-11-01 2024-10-31 シンティス バイオ，インコーポレイティド 工学操作ロイシン脱炭酸酵素
CN117417925A (zh) * 2022-07-18 2024-01-19 浙江泽科塔生物医药有限公司 Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN118931888A (zh) * 2023-05-09 2024-11-12 重庆派金生物科技有限公司 苯丙氨酸裂解酶突变体及其偶联物或其药学上可接受的盐
GB202307239D0 (en) 2023-05-15 2023-06-28 Evox Therapeutics Ltd Gene therapies for Phenylketonuria
CN116478975B (zh) * 2023-06-16 2023-09-01 苏州优信合生技术有限公司 高活性苯丙氨酸解氨酶突变体及其表达菌株
US20250161466A1 (en) 2023-11-17 2025-05-22 Biomarin Pharmaceutical Inc. Conjugates of phenylalanine ammonia-lyase and poegma and methods for their use

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252822A (en) * 1979-12-26 1981-02-24 Children's Hospital Medical Center Method for treating phenylketonuria
US4562151A (en) * 1983-09-06 1985-12-31 Monsanto Company Stabilization of L-phenylalanine ammonia-lyase enzyme
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5766897A (en) * 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
JP2930723B2 (ja) * 1992-11-19 1999-08-03 アンティキャンサー インコーポレーテド 抗メチオニン化学療法における抗腫瘍薬としてのメチオニナーゼの使用
EP0692029B1 (en) * 1992-12-04 2007-05-09 Me Medical Enzymes Ag Genetically engineered glutaminase and its use in therapy
DK75593D0 (https=) * 1993-06-25 1993-06-25 Novo Nordisk As
JPH09510352A (ja) * 1994-03-15 1997-10-21 プリズム ファーマシューティカルズ，インコーポレイティド 遺伝子療法及び前部の眼疾患のためのヘパリン結合成長因子
DK0851925T3 (da) * 1995-09-21 2005-11-28 Genentech Inc Humane Væksthormonvarianter
CU22585A1 (es) * 1995-11-17 1999-11-03 Centro Inmunologia Molecular Anticuerpos monoclonales antiidiótipos (ab2) de tipo igg con alta conectividad idiotípica y composiciones farmacéuticas que los contienen. su uso como inmunoreguladores de la respuesta inmune.
US6548644B1 (en) * 1997-03-10 2003-04-15 Immunex Corporation Site protected protein modification
US6183738B1 (en) * 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
US5981239A (en) * 1997-09-24 1999-11-09 Great Lakes Chemical Corp. Synthesis of optically active phenylalanine analogs using Rhodotorula graminis
US7026446B1 (en) * 1997-12-24 2006-04-11 Diatech Pty Ltd. Bifunctional molecules
TWI227241B (en) * 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
US6451986B1 (en) * 1998-06-22 2002-09-17 Immunex Corporation Site specific protein modification
US6461849B1 (en) * 1998-10-13 2002-10-08 Novozymes, A/S Modified polypeptide
US6403312B1 (en) 1998-10-16 2002-06-11 Xencor Protein design automatic for protein libraries
US6686164B1 (en) * 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
US6395299B1 (en) * 1999-02-12 2002-05-28 Biostream, Inc. Matrices for drug delivery and methods for making and using the same
WO2001041782A2 (en) * 1999-12-09 2001-06-14 Chiron Corporation Method for administering a cytokine to the central nervous system and the lymphatic system
US6586398B1 (en) * 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
AU2001257032A1 (en) * 2000-04-14 2001-10-30 University Of South Carolina Research Foundation Cloning, overexpression and therapeutic uses of bioactive histidine ammonia lyase
US6967097B2 (en) * 2000-07-24 2005-11-22 Pcbu Services, Inc. Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same
WO2002008293A2 (en) * 2000-07-25 2002-01-31 Immunomedics Inc. Multivalent target binding protein
AU2001294774A1 (en) * 2000-09-26 2002-04-08 The Regents Of The University Of California Characterization of phenylalanine ammonia-lyase (pal) gene in wounded lettuce
BR0115257A (pt) * 2000-11-10 2003-08-12 Proteopharma Aps Análogos de apolipoproteìna
KR20040088538A (ko) 2002-02-26 2004-10-16 이 아이 듀폰 디 네모아 앤드 캄파니 유전 인자의 재조합 방법
US7138252B2 (en) * 2002-07-17 2006-11-21 Cytos Biotechnology Ag Molecular antigen arrays
JP2006516095A (ja) 2002-11-14 2006-06-22 ザ スクリップス リサーチ インスティテュート 脂肪酸アミドヒドロラーゼ（ｆａａｈ）の結晶形
JP2007537710A (ja) * 2003-06-11 2007-12-27 ワイス 血小板糖タンパク質ＩＢα改変体融合ポリペプチドおよびその使用法
FR2868318B1 (fr) * 2004-04-01 2012-11-16 Commissariat Energie Atomique Antigene tat stabilise et ses applications pour la vaccination anti-vih
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
WO2006034373A2 (en) 2004-09-17 2006-03-30 Biomarin Pharmaceutical Inc. Variants and chemically-modified variants of phenylalanine ammonia-lyase
EP2886658A1 (en) * 2005-03-10 2015-06-24 BASF Enzymes LLC Lyase enzymes, nucleic acids encoding them and methods for making and using them
US7534595B2 (en) * 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US20090011400A1 (en) 2006-12-01 2009-01-08 The Salk Institute for Biological Studies and The Regents of the University of California Substrate switched ammonia lyases and mutases
US7560263B2 (en) * 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof

Similar Documents

Publication Publication Date Title
JP2010529835A5 (https=)
HRP20151268T1 (hr) Pripravci prokariotske fenilalanin amonijak liaze i postupci upotrebe navedenog pripravka
Lai et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen—positive chronic hepatitis B
Perrillo Therapy of hepatitis B—viral suppression or eradication?
ES2932498T3 (es) Composiciones que comprenden el péptido WKDEAGKPLVK
WO2005023083A3 (en) Compositions and methods for the treatment of severe acute respiratory syndrome (sars)
TW200524626A (en) Treatment of HCV disorders
JP2008540565A5 (https=)
NZ617196A (en) Activin-actrii antagonists and uses for increasing red blood cell levels
JP2009537143A5 (https=)
TW200914617A (en) Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
HRP20160368T1 (hr) Sublingvalni i bukalni filmom obložen pripravak
WO2005021707A3 (en) Severe acute respiratory syndrome dna vaccine compositions and methods of use
JP2011515349A5 (https=)
JP2018515101A5 (https=)
JP2006506942A5 (https=)
RU2017143580A (ru) Улучшенные последовательности уриказы и способы лечения
JP2004534503A5 (https=)
JP2014500722A5 (https=)
US20220287347A1 (en) Peptides for treating muscle atrophy
HRP20161560T1 (hr) Varijanta, rekombinantnih proteina beta-glukocerebrozidaze s povećanom stabilnošću i povećanom zadržanom katalitičkom aktivnošću
JP2014529399A5 (https=)
JP2011522864A5 (https=)
NZ611145A (en) Peg or peg block copolymers for treating colorectal cancer
CN102453089B (zh) 重组集成干扰素变异体聚乙二醇偶联物的制备和应用