LUC00133I2 - - Google Patents
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- Publication number
- LUC00133I2 LUC00133I2 LU00133C LUC00133C LUC00133I2 LU C00133 I2 LUC00133 I2 LU C00133I2 LU 00133 C LU00133 C LU 00133C LU C00133 C LUC00133 C LU C00133C LU C00133 I2 LUC00133 I2 LU C00133I2
- Authority
- LU
- Luxembourg
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/807,227 US7534595B2 (en) | 2006-06-12 | 2007-05-25 | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
LU2008006661 | 2008-05-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
LUC00133I1 LUC00133I1 (fr) | 2019-10-16 |
LUC00133I2 true LUC00133I2 (fr) | 2020-07-16 |
Family
ID=39868905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LU00133C LUC00133I2 (fr) | 2007-05-25 | 2019-10-14 |
Country Status (30)
Country | Link |
---|---|
US (1) | US7534595B2 (fr) |
EP (2) | EP2152868B1 (fr) |
JP (1) | JP5670183B2 (fr) |
KR (2) | KR20150038753A (fr) |
CN (1) | CN101842482B (fr) |
AR (2) | AR066716A1 (fr) |
AU (1) | AU2008263190B2 (fr) |
BR (1) | BRPI0811267B8 (fr) |
CA (1) | CA2687450C (fr) |
CL (1) | CL2008001497A1 (fr) |
CY (2) | CY1116894T1 (fr) |
DK (1) | DK2152868T3 (fr) |
EA (1) | EA018443B1 (fr) |
ES (1) | ES2551315T3 (fr) |
HK (1) | HK1135141A1 (fr) |
HR (1) | HRP20151268T1 (fr) |
HU (2) | HUE025784T2 (fr) |
IL (1) | IL202132A (fr) |
LT (1) | LTC2152868I2 (fr) |
LU (1) | LUC00133I2 (fr) |
MX (1) | MX2009012453A (fr) |
MY (1) | MY151413A (fr) |
NL (1) | NL301011I2 (fr) |
NO (1) | NO2019037I1 (fr) |
PE (1) | PE20090315A1 (fr) |
PL (1) | PL2152868T3 (fr) |
PT (1) | PT2152868E (fr) |
SI (1) | SI2152868T1 (fr) |
TW (1) | TWI418633B (fr) |
WO (1) | WO2008153776A1 (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7537923B2 (en) * | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
WO2010014225A2 (fr) | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Dosages permettant la détection de la phénylalanine ammoniac-lyase et des anticorps contre la phénylalanine ammoniac-lyase |
CA2782444C (fr) * | 2010-02-04 | 2018-10-23 | Biomarin Pharmaceutical Inc. | Compositions de variants procaryotes de phenylalanine ammonia-lyase et procedes d'utilisation de compositions les comprenant |
WO2014018832A1 (fr) * | 2012-07-27 | 2014-01-30 | University Of North Texas | Probiotique génétiquement modifié (gmp) pour le traitement de la phénylcétonurie (pku) |
MY193198A (en) | 2013-04-18 | 2022-09-26 | Codexis Inc | Engineered phenylalanine ammonia lyase polypeptides |
WO2015073587A2 (fr) | 2013-11-18 | 2015-05-21 | Rubius Therapeutics, Inc. | Complexes membrane synthétique- récepteur |
MA39819A (fr) | 2014-04-01 | 2017-02-08 | Rubius Therapeutics Inc | Méthodes et compositions d'immunomodulation |
HUE056444T2 (hu) | 2014-04-16 | 2022-02-28 | Codexis Inc | Génmódosított tirozin-ammónia-liáz |
KR102438885B1 (ko) | 2014-12-22 | 2022-09-01 | 코덱시스, 인코포레이티드 | 인간 알파-갈락토시다제 변이체 |
TW202340452A (zh) * | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
WO2018022608A2 (fr) | 2016-07-26 | 2018-02-01 | Biomarin Pharmaceutical Inc. | Nouvelles protéines de capside de virus adéno-associés |
MY190749A (en) * | 2016-08-30 | 2022-05-12 | Mitsubishi Chem Corp | Method for producing mutant enzyme, and mutant alcohol acyltransferase |
CN106497905A (zh) * | 2016-12-14 | 2017-03-15 | 江南大学 | 一株鱼腥藻来源的苯丙氨酸脱氨酶的突变体 |
BR112019016634A2 (pt) | 2017-02-13 | 2020-04-07 | Codexis Inc | polipeptídeos, sequência de polinucleotídeos modificados por engenharia, vetor de expressão, célula hospedeira, métodos para produzir um polipeptídeo de fenilalanina amônia liase modificado por engenharia em uma célula hospedeira e para tratar e/ou prevenir os sintomas de fenilcetonúria em um indivíduo, composição, e, uso |
CN107653275A (zh) * | 2017-10-30 | 2018-02-02 | 安徽工程大学 | D‑苯丙氨酸的制备方法 |
CN108004225B (zh) * | 2017-12-19 | 2020-05-08 | 江南大学 | 一种成团泛菌来源的苯丙氨酸氨基变位酶的突变体 |
EP3790627A2 (fr) | 2018-05-09 | 2021-03-17 | BioMarin Pharmaceutical Inc. | Méthodes de traitement de la grippe |
TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
WO2019241132A1 (fr) | 2018-06-12 | 2019-12-19 | Codexis, Inc. | Tyrosine ammonia-lyase modifiée |
US11198861B2 (en) * | 2018-07-12 | 2021-12-14 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
EP3898960A4 (fr) | 2018-12-20 | 2022-11-30 | Codexis, Inc. | Variants d'alpha-galactosidase humaine |
CN110456056A (zh) * | 2019-07-22 | 2019-11-15 | 浙江大学 | 一种新生儿苯丙酮尿症无创筛查试纸的制备方法 |
AR122409A1 (es) | 2020-04-03 | 2022-09-07 | Biomarin Pharm Inc | Tratamiento de la fenilcetonuria con aav y formulaciones terapéuticas |
BR112023003643A2 (pt) | 2020-08-28 | 2023-03-28 | Codexis Inc | Amilase recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma amilase recombinante e para tratar e/ou prevenir os sintomas de insuficiência pancreática, composição farmacêutica para o tratamento de insuficiência pancreática, e, uso |
US11959108B2 (en) | 2020-08-28 | 2024-04-16 | Codexis, Inc. | Engineered protease variants |
EP4341394A1 (fr) * | 2021-05-19 | 2024-03-27 | BioMarin Pharmaceutical Inc. | Compositions de phénylalanine ammonia-lyase procaryotique et méthodes de traitement de sujets adolescents |
WO2023044381A1 (fr) * | 2021-09-16 | 2023-03-23 | Arcturus Therapeutics, Inc. | Compositions et procédés de traitement de la phénylcétonurie |
CN117417925A (zh) * | 2022-07-18 | 2024-01-19 | 浙江泽科塔生物医药有限公司 | Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法 |
CN116478975B (zh) * | 2023-06-16 | 2023-09-01 | 苏州优信合生技术有限公司 | 高活性苯丙氨酸解氨酶突变体及其表达菌株 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4252822A (en) | 1979-12-26 | 1981-02-24 | Children's Hospital Medical Center | Method for treating phenylketonuria |
US4562151A (en) | 1983-09-06 | 1985-12-31 | Monsanto Company | Stabilization of L-phenylalanine ammonia-lyase enzyme |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
DK0668933T3 (da) | 1992-11-19 | 2003-02-10 | Anticancer Inc | Anvendelse af methioninase som antitumormiddel i antimethioninkemoterapi |
EP0692029B1 (fr) | 1992-12-04 | 2007-05-09 | Me Medical Enzymes Ag | Glutaminase produite par génie génetique et son utilisation en thérapie |
DK75593D0 (fr) | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
EP1188448A3 (fr) * | 1994-03-15 | 2002-04-17 | Prizm Pharmaceuticals, Inc. | Facteurs de croissance de fibroplastes pour la thérapie génétique et le traitement de troubles du segment antérieur de l'oeil |
DE69635026T2 (de) | 1995-09-21 | 2006-05-24 | Genentech Inc., San Francisco | Varianten des menschlichen wachstumshormons |
CU22585A1 (es) * | 1995-11-17 | 1999-11-03 | Centro Inmunologia Molecular | Anticuerpos monoclonales antiidiótipos (ab2) de tipo igg con alta conectividad idiotípica y composiciones farmacéuticas que los contienen. su uso como inmunoreguladores de la respuesta inmune. |
US6548644B1 (en) | 1997-03-10 | 2003-04-15 | Immunex Corporation | Site protected protein modification |
US6183738B1 (en) | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
US5981239A (en) | 1997-09-24 | 1999-11-09 | Great Lakes Chemical Corp. | Synthesis of optically active phenylalanine analogs using Rhodotorula graminis |
WO1999033965A1 (fr) * | 1997-12-24 | 1999-07-08 | Diatech Pty. Ltd. | Molecules bifonctionnelles |
TWI227241B (en) * | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
US6461849B1 (en) | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
US6403312B1 (en) | 1998-10-16 | 2002-06-11 | Xencor | Protein design automatic for protein libraries |
US6686164B1 (en) | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
CA2328614C (fr) | 1999-02-12 | 2012-06-26 | Biostream, Inc. | Matrices d'administration de medicaments et procedes de fabrication et d'utilisation de ces dernieres |
IL150109A0 (en) * | 1999-12-09 | 2002-12-01 | Chiron Corp | Method for administering a cytokine to the central nervous system and the lymphatic system |
US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
CA2406390A1 (fr) | 2000-04-14 | 2001-10-25 | University Of South Carolina Research Foundation | Clonage, surexpression et utilisation therapeutique de l'histidine ammoniac lyase bioactive |
US6967097B2 (en) | 2000-07-24 | 2005-11-22 | Pcbu Services, Inc. | Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same |
AU2001283496A1 (en) * | 2000-07-25 | 2002-02-05 | Immunomedics, Inc. | Multivalent target binding protein |
WO2002026028A2 (fr) * | 2000-09-26 | 2002-04-04 | The Regents Of The University Of California | Caracterisation du gene de la phenylalanine ammonia-lyase (pal) dans un tissu de laitue blesse |
WO2002038609A2 (fr) * | 2000-11-10 | 2002-05-16 | Proteopharma Aps | Analogues d'apolipoproteine |
US7879582B2 (en) | 2002-02-26 | 2011-02-01 | E. I. Du Pont De Nemours And Company | Method for the recombination of genetic elements |
ATE542828T1 (de) * | 2002-07-17 | 2012-02-15 | Cytos Biotechnology Ag | Molekulare antigen-anordnung durch verwendung eines virus-ähnlichen partikels vom virus ap205 |
US20080124275A1 (en) | 2002-11-14 | 2008-05-29 | The Scripps Research Institute | Crystalline Form of Fatty Acid Amide Hydrolase (Faah) |
RU2403262C2 (ru) * | 2003-06-11 | 2010-11-10 | Уайт | Выделенный полипептид ib альфа гликопротеина тромбоцитов человека, слитый белок, молекула днк (варианты), экспрессирующий вектор (варианты), клетка (варианты), способ экспрессии полипептида, способ экспрессии слитого белка, фармацевтическая композиция (варианты), способ ингибирования прикрепления клетки крови к биологической ткани в биологической системе, способ ингибирования прикрепления белка к биологической ткани в биологической системе и способ лечения нарушения |
FR2868318B1 (fr) * | 2004-04-01 | 2012-11-16 | Commissariat Energie Atomique | Antigene tat stabilise et ses applications pour la vaccination anti-vih |
US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
US7553653B2 (en) | 2004-09-17 | 2009-06-30 | Biomarin Pharmaceutical Inc. | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
US20090038023A1 (en) | 2005-03-10 | 2009-02-05 | Verenium Corporation | Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them |
US7534595B2 (en) | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
WO2008069958A2 (fr) | 2006-12-01 | 2008-06-12 | The Salk Institute For Biological Studies | Ammonia lyases et mutases à substrat modifié |
US7537923B2 (en) | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
-
2007
- 2007-05-25 US US11/807,227 patent/US7534595B2/en active Active
-
2008
- 2008-05-23 EP EP08754717.0A patent/EP2152868B1/fr active Active
- 2008-05-23 CL CL2008001497A patent/CL2008001497A1/es unknown
- 2008-05-23 PT PT87547170T patent/PT2152868E/pt unknown
- 2008-05-23 KR KR20157007821A patent/KR20150038753A/ko not_active Application Discontinuation
- 2008-05-23 AR ARP080102198A patent/AR066716A1/es active IP Right Grant
- 2008-05-23 CN CN200880016898.4A patent/CN101842482B/zh active Active
- 2008-05-23 CA CA2687450A patent/CA2687450C/fr active Active
- 2008-05-23 TW TW097119178A patent/TWI418633B/zh active
- 2008-05-23 EA EA200970980A patent/EA018443B1/ru unknown
- 2008-05-23 MX MX2009012453A patent/MX2009012453A/es active IP Right Grant
- 2008-05-23 KR KR1020097027018A patent/KR101603796B1/ko active IP Right Grant
- 2008-05-23 PL PL08754717T patent/PL2152868T3/pl unknown
- 2008-05-23 EP EP13169362.4A patent/EP2657335A1/fr not_active Withdrawn
- 2008-05-23 PE PE2008000889A patent/PE20090315A1/es active IP Right Grant
- 2008-05-23 ES ES08754717.0T patent/ES2551315T3/es active Active
- 2008-05-23 WO PCT/US2008/006661 patent/WO2008153776A1/fr active Application Filing
- 2008-05-23 AU AU2008263190A patent/AU2008263190B2/en active Active
- 2008-05-23 JP JP2010509405A patent/JP5670183B2/ja active Active
- 2008-05-23 DK DK08754717.0T patent/DK2152868T3/en active
- 2008-05-23 MY MYPI20094868 patent/MY151413A/en unknown
- 2008-05-23 SI SI200831540T patent/SI2152868T1/sl unknown
- 2008-05-23 HU HUE08754717A patent/HUE025784T2/en unknown
- 2008-05-23 BR BRPI0811267A patent/BRPI0811267B8/pt active IP Right Grant
-
2009
- 2009-11-15 IL IL202132A patent/IL202132A/en active IP Right Grant
-
2010
- 2010-04-01 HK HK10103366.8A patent/HK1135141A1/zh unknown
-
2015
- 2015-11-06 CY CY20151100997T patent/CY1116894T1/el unknown
- 2015-11-24 HR HRP20151268TT patent/HRP20151268T1/hr unknown
-
2018
- 2018-01-17 AR ARP180100106A patent/AR110834A2/es unknown
-
2019
- 2019-10-09 NL NL301011C patent/NL301011I2/nl unknown
- 2019-10-10 LT LTPA2019517C patent/LTC2152868I2/lt unknown
- 2019-10-14 LU LU00133C patent/LUC00133I2/fr unknown
- 2019-10-16 NO NO2019037C patent/NO2019037I1/no unknown
- 2019-10-17 CY CY2019039C patent/CY2019039I1/el unknown
- 2019-10-18 HU HUS1900049C patent/HUS1900049I1/hu unknown
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