CL2008001497A1 - Variante de liasa amoniacal de fenilalanina (pal) procariota con sustituciones en las cisteinas de posiciones 503 y/o 565 por serina; composicion farmaceutica que la comprende; y su uso para tratar una enfermedad causada en todo o en parte por una deficiencia de fenilalanina hidroxilasa (pah) como la fenilcetonuria. - Google Patents
Variante de liasa amoniacal de fenilalanina (pal) procariota con sustituciones en las cisteinas de posiciones 503 y/o 565 por serina; composicion farmaceutica que la comprende; y su uso para tratar una enfermedad causada en todo o en parte por una deficiencia de fenilalanina hidroxilasa (pah) como la fenilcetonuria.Info
- Publication number
- CL2008001497A1 CL2008001497A1 CL2008001497A CL2008001497A CL2008001497A1 CL 2008001497 A1 CL2008001497 A1 CL 2008001497A1 CL 2008001497 A CL2008001497 A CL 2008001497A CL 2008001497 A CL2008001497 A CL 2008001497A CL 2008001497 A1 CL2008001497 A1 CL 2008001497A1
- Authority
- CL
- Chile
- Prior art keywords
- phenylalanine
- pah
- pal
- serine
- deficiency
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
VARIANTE DE LIASA AMONIACAL DE FENILALANINA (PAL) PROCARIOTA CON SUSTITUCIONES EN LAS CISTEINAS DE POSICIONES 503 Y/O 565 POR SERINA;<br /> COMPOSICIÓN FARMACÉUTICA QUE LA COMPRENDE; Y SU USO PARA TRATAR UNA ENFERMEDAD CAUSADA EN TODO O EN PARTE POR UNA DEFICIENCIA<br /> DE FENILALANINA HIDROXILASA (PAH) COMO LA FENILCETANURIA.<br />
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/807,227 US7534595B2 (en) | 2006-06-12 | 2007-05-25 | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008001497A1 true CL2008001497A1 (es) | 2009-01-09 |
Family
ID=39868905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008001497A CL2008001497A1 (es) | 2007-05-25 | 2008-05-23 | Variante de liasa amoniacal de fenilalanina (pal) procariota con sustituciones en las cisteinas de posiciones 503 y/o 565 por serina; composicion farmaceutica que la comprende; y su uso para tratar una enfermedad causada en todo o en parte por una deficiencia de fenilalanina hidroxilasa (pah) como la fenilcetonuria. |
Country Status (30)
Country | Link |
---|---|
US (1) | US7534595B2 (es) |
EP (2) | EP2152868B1 (es) |
JP (1) | JP5670183B2 (es) |
KR (2) | KR20150038753A (es) |
CN (1) | CN101842482B (es) |
AR (2) | AR066716A1 (es) |
AU (1) | AU2008263190B2 (es) |
BR (1) | BRPI0811267B8 (es) |
CA (1) | CA2687450C (es) |
CL (1) | CL2008001497A1 (es) |
CY (2) | CY1116894T1 (es) |
DK (1) | DK2152868T3 (es) |
EA (1) | EA018443B1 (es) |
ES (1) | ES2551315T3 (es) |
HK (1) | HK1135141A1 (es) |
HR (1) | HRP20151268T1 (es) |
HU (2) | HUE025784T2 (es) |
IL (1) | IL202132A (es) |
LT (1) | LTC2152868I2 (es) |
LU (1) | LUC00133I2 (es) |
MX (1) | MX2009012453A (es) |
MY (1) | MY151413A (es) |
NL (1) | NL301011I2 (es) |
NO (1) | NO2019037I1 (es) |
PE (1) | PE20090315A1 (es) |
PL (1) | PL2152868T3 (es) |
PT (1) | PT2152868E (es) |
SI (1) | SI2152868T1 (es) |
TW (1) | TWI418633B (es) |
WO (1) | WO2008153776A1 (es) |
Families Citing this family (34)
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US7534595B2 (en) | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7537923B2 (en) | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
US20110201022A1 (en) | 2008-07-30 | 2011-08-18 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
SI3025728T1 (sl) * | 2010-02-04 | 2018-11-30 | Biomarin Pharmaceutical Inc. | Metoda za čiščenje prokariontskih fenilalanin amonij-liaznih variant |
US20150246083A1 (en) * | 2012-07-27 | 2015-09-03 | University Of North Texas | Genetically modified probiotic for the treatment of phenylketonuria (pku) disease |
ES2729048T3 (es) * | 2013-04-18 | 2019-10-30 | Codexis Inc | Polipéptidos de fenilalanina amoníaco-liasa modificados |
EP3071515A2 (en) | 2013-11-18 | 2016-09-28 | Rubius Therapeutics, Inc. | Synthetic membrane-receiver complexes |
AU2015241422B2 (en) | 2014-04-01 | 2020-12-03 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
HUE056444T2 (hu) | 2014-04-16 | 2022-02-28 | Codexis Inc | Génmódosított tirozin-ammónia-liáz |
HUE062016T2 (hu) | 2014-12-22 | 2023-09-28 | Codexis Inc | Humán alfa-galaktozidáz variánsok |
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EP3579867A4 (en) * | 2017-02-13 | 2021-03-10 | Codexis, Inc. | MANIPULATED PHENYLALANINE AMMONIA LYASE POLYPEPTIDES |
CN107653275A (zh) * | 2017-10-30 | 2018-02-02 | 安徽工程大学 | D‑苯丙氨酸的制备方法 |
CN108004225B (zh) * | 2017-12-19 | 2020-05-08 | 江南大学 | 一种成团泛菌来源的苯丙氨酸氨基变位酶的突变体 |
CN113164762A (zh) | 2018-05-09 | 2021-07-23 | 生物马林药物股份有限公司 | 苯丙酮尿症的治疗方法 |
TW202005978A (zh) | 2018-05-14 | 2020-02-01 | 美商拜奧馬林製藥公司 | 新穎肝靶向腺相關病毒載體 |
WO2019241132A1 (en) | 2018-06-12 | 2019-12-19 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
CN112672989A (zh) * | 2018-07-12 | 2021-04-16 | 科德克希思公司 | 工程化苯丙氨酸氨裂合酶多肽 |
SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
CA3123598A1 (en) | 2018-12-20 | 2020-06-25 | Codexis, Inc. | Human alpha-galactosidase variants |
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2007
- 2007-05-25 US US11/807,227 patent/US7534595B2/en active Active
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2008
- 2008-05-23 CL CL2008001497A patent/CL2008001497A1/es unknown
- 2008-05-23 DK DK08754717.0T patent/DK2152868T3/en active
- 2008-05-23 CN CN200880016898.4A patent/CN101842482B/zh active Active
- 2008-05-23 AR ARP080102198A patent/AR066716A1/es active IP Right Grant
- 2008-05-23 EP EP08754717.0A patent/EP2152868B1/en active Active
- 2008-05-23 KR KR20157007821A patent/KR20150038753A/ko not_active Application Discontinuation
- 2008-05-23 SI SI200831540T patent/SI2152868T1/sl unknown
- 2008-05-23 ES ES08754717.0T patent/ES2551315T3/es active Active
- 2008-05-23 HU HUE08754717A patent/HUE025784T2/en unknown
- 2008-05-23 EP EP13169362.4A patent/EP2657335A1/en not_active Withdrawn
- 2008-05-23 AU AU2008263190A patent/AU2008263190B2/en active Active
- 2008-05-23 EA EA200970980A patent/EA018443B1/ru unknown
- 2008-05-23 BR BRPI0811267A patent/BRPI0811267B8/pt active IP Right Grant
- 2008-05-23 WO PCT/US2008/006661 patent/WO2008153776A1/en active Application Filing
- 2008-05-23 KR KR1020097027018A patent/KR101603796B1/ko active IP Right Grant
- 2008-05-23 PT PT87547170T patent/PT2152868E/pt unknown
- 2008-05-23 MY MYPI20094868 patent/MY151413A/en unknown
- 2008-05-23 PE PE2008000889A patent/PE20090315A1/es active IP Right Grant
- 2008-05-23 CA CA2687450A patent/CA2687450C/en active Active
- 2008-05-23 PL PL08754717T patent/PL2152868T3/pl unknown
- 2008-05-23 TW TW097119178A patent/TWI418633B/zh active
- 2008-05-23 MX MX2009012453A patent/MX2009012453A/es active IP Right Grant
- 2008-05-23 JP JP2010509405A patent/JP5670183B2/ja active Active
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2009
- 2009-11-15 IL IL202132A patent/IL202132A/en active IP Right Grant
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2010
- 2010-04-01 HK HK10103366.8A patent/HK1135141A1/zh unknown
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2015
- 2015-11-06 CY CY20151100997T patent/CY1116894T1/el unknown
- 2015-11-24 HR HRP20151268TT patent/HRP20151268T1/hr unknown
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2018
- 2018-01-17 AR ARP180100106A patent/AR110834A2/es unknown
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2019
- 2019-10-09 NL NL301011C patent/NL301011I2/nl unknown
- 2019-10-10 LT LTPA2019517C patent/LTC2152868I2/lt unknown
- 2019-10-14 LU LU00133C patent/LUC00133I2/fr unknown
- 2019-10-16 NO NO2019037C patent/NO2019037I1/no unknown
- 2019-10-17 CY CY2019039C patent/CY2019039I2/el unknown
- 2019-10-18 HU HUS1900049C patent/HUS1900049I1/hu unknown
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