SI3025728T1 - Metoda za čiščenje prokariontskih fenilalanin amonij-liaznih variant - Google Patents
Metoda za čiščenje prokariontskih fenilalanin amonij-liaznih variantInfo
- Publication number
- SI3025728T1 SI3025728T1 SI201131589T SI201131589T SI3025728T1 SI 3025728 T1 SI3025728 T1 SI 3025728T1 SI 201131589 T SI201131589 T SI 201131589T SI 201131589 T SI201131589 T SI 201131589T SI 3025728 T1 SI3025728 T1 SI 3025728T1
- Authority
- SI
- Slovenia
- Prior art keywords
- phenylalanine ammonia
- lyase variants
- prokaryotic phenylalanine
- purifying
- purifying prokaryotic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y403/00—Carbon-nitrogen lyases (4.3)
- C12Y403/01—Ammonia-lyases (4.3.1)
- C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30147810P | 2010-02-04 | 2010-02-04 | |
| EP15202466.7A EP3025728B1 (en) | 2010-02-04 | 2011-02-03 | Method for purifying prokaryotic phenylalanine ammonia-lyase variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3025728T1 true SI3025728T1 (sl) | 2018-11-30 |
Family
ID=44356065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201131589T SI3025728T1 (sl) | 2010-02-04 | 2011-02-03 | Metoda za čiščenje prokariontskih fenilalanin amonij-liaznih variant |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20130039898A1 (sl) |
| EP (4) | EP4062928A3 (sl) |
| JP (1) | JP5828844B2 (sl) |
| CN (2) | CN102753566A (sl) |
| AU (1) | AU2011212929B2 (sl) |
| CA (1) | CA2782444C (sl) |
| CY (1) | CY1120768T1 (sl) |
| DK (1) | DK3025728T3 (sl) |
| ES (2) | ES2582459T3 (sl) |
| HK (1) | HK1225299B (sl) |
| HR (1) | HRP20181602T1 (sl) |
| HU (1) | HUE039516T2 (sl) |
| IL (2) | IL221099B (sl) |
| LT (1) | LT3025728T (sl) |
| PL (1) | PL3025728T3 (sl) |
| PT (1) | PT3025728T (sl) |
| SI (1) | SI3025728T1 (sl) |
| WO (1) | WO2011097335A2 (sl) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319601D0 (en) † | 2003-08-20 | 2003-09-24 | Sandoz Ag | Production process |
| US20110201022A1 (en) | 2008-07-30 | 2011-08-18 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| ES2582459T3 (es) | 2010-02-04 | 2016-09-13 | Biomarin Pharmaceutical Inc. | Composiciones de variantes de fenilalanina amoníaco-liasa de procariotas y métodos de uso de sus composiciones |
| DK2986722T3 (da) | 2013-04-18 | 2019-05-13 | Codexis Inc | Manipulerede phenylalaninammoniak-lyasepolypeptider |
| EP3145536B1 (en) * | 2014-04-16 | 2021-10-27 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| TWI743023B (zh) * | 2014-05-21 | 2021-10-21 | 日商Ｋｍ生物醫藥股份有限公司 | 基質金屬蛋白酶 7(mmp-7)聚集體之單體化方法 |
| PT3237621T (pt) | 2014-12-22 | 2023-07-20 | Codexis Inc | Variantes da alfa-galactosidase humana |
| CA2972638C (en) * | 2015-01-09 | 2023-11-28 | Mcmaster University | Allosteric activators for treatment of phenylketonuria, and method for identifying allosteric activators |
| CN106636048A (zh) * | 2016-12-14 | 2017-05-10 | 江南大学 | 一株酶活提高的苯丙氨酸脱氨酶突变体 |
| CA3051262A1 (en) | 2017-02-13 | 2018-08-16 | Codexis, Inc. | Engineered phenylalanine ammonia lyase polypeptides |
| CN108424897B (zh) * | 2018-03-13 | 2020-08-14 | 广州铭康生物工程有限公司 | 一种rhTNK-tPA细胞收获液的纯化方法 |
| CN108315338A (zh) * | 2018-04-18 | 2018-07-24 | 山东省果树研究所 | 一种石榴苯丙氨酸解氨酶pal及其表达基因与应用 |
| US10900055B2 (en) | 2018-06-12 | 2021-01-26 | Codexis, Inc. | Engineered tyrosine ammonia lyase |
| SG11202105668PA (en) | 2018-12-14 | 2021-06-29 | Codexis Inc | Engineered tyrosine ammonia lyase |
| BR112021011750A2 (pt) | 2018-12-20 | 2021-08-31 | Codexis, Inc. | Alfa-galactosidase a recombinante e/ou fragmento de alfa-galactosidase a recombinante, composição, sequência de polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa-galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições |
| KR20220106738A (ko) | 2019-08-30 | 2022-07-29 | 코덱시스, 인코포레이티드 | 조작된 리파제 변이체 |
| BR112022011760A2 (pt) | 2019-12-20 | 2022-08-30 | Codexis Inc | Fragmento de alfa glicosidase ácida recombinante e/ou de alfa glicosidase ácida recombinante biologicamente ativa, alfa glicosidase ácida recombinante, composição, sequência polinucleotídica recombinante, vetor de expressão, vetor de expressão pdh, célula hospedeira, método para produzir uma variante de alfa glicosidase ácida recombinante, variante de alfa glicosidase ácida recombinante, composição farmacêutica para o tratamento da doença de pompe, composição farmacêutica, método para tratar e/ou prevenir os sintomas da doença de pompe em um indivíduo, e, uso das composições |
| WO2021168060A1 (en) * | 2020-02-19 | 2021-08-26 | Trustees Of Tufts College | Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained |
| US11767519B2 (en) | 2020-08-28 | 2023-09-26 | Codexis, Inc. | Engineered amylase variants |
| EP4204554A1 (en) | 2020-08-28 | 2023-07-05 | Codexis, Inc. | Engineered protease variants |
| CN112662606A (zh) * | 2021-01-06 | 2021-04-16 | 中国科学院分子植物科学卓越创新中心 | 用于治疗苯丙酮尿症的工程益生菌 |
| US11918633B2 (en) | 2021-05-19 | 2024-03-05 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating adolescent subjects |
| WO2024032012A1 (zh) * | 2022-08-10 | 2024-02-15 | 百葵锐(深圳)生物科技有限公司 | 苯丙氨酸解氨酶突变体及其应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4252822A (en) | 1979-12-26 | 1981-02-24 | Children's Hospital Medical Center | Method for treating phenylketonuria |
| US4562151A (en) | 1983-09-06 | 1985-12-31 | Monsanto Company | Stabilization of L-phenylalanine ammonia-lyase enzyme |
| DE3581238D1 (de) | 1984-07-05 | 1991-02-14 | Mitsubishi Chem Ind | Mikrobiologische herstellung von l-phenylalanin. |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| US6893625B1 (en) * | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5466781A (en) * | 1991-05-24 | 1995-11-14 | Chiron Therapeutics | Process for purifying bacterially produced M-CSF |
| PT668933E (pt) | 1992-11-19 | 2003-02-28 | Anticancer Inc | Utilizacao de metioninase como agente anti-tumor em qimioterapia anti-metionina |
| AU3235893A (en) | 1992-12-04 | 1994-07-04 | Me Medical Enzymes Ag | Genetically engineered glutaminase and its use in antiviral and anticancer therapy |
| DK75593D0 (sl) | 1993-06-25 | 1993-06-25 | Novo Nordisk As | |
| CA2658039A1 (en) | 1995-09-21 | 1997-03-27 | Genentech, Inc. | Human growth hormone variants |
| CU22585A1 (es) | 1995-11-17 | 1999-11-03 | Centro Inmunologia Molecular | Anticuerpos monoclonales antiidiótipos (ab2) de tipo igg con alta conectividad idiotípica y composiciones farmacéuticas que los contienen. su uso como inmunoreguladores de la respuesta inmune. |
| US6548644B1 (en) | 1997-03-10 | 2003-04-15 | Immunex Corporation | Site protected protein modification |
| US6183738B1 (en) | 1997-05-12 | 2001-02-06 | Phoenix Pharamacologics, Inc. | Modified arginine deiminase |
| US5981239A (en) | 1997-09-24 | 1999-11-09 | Great Lakes Chemical Corp. | Synthesis of optically active phenylalanine analogs using Rhodotorula graminis |
| US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| US6461849B1 (en) | 1998-10-13 | 2002-10-08 | Novozymes, A/S | Modified polypeptide |
| US6686164B1 (en) | 1998-10-30 | 2004-02-03 | Novozymes A/S | Low allergenic protein variants |
| IL138990A0 (en) | 1999-02-12 | 2001-11-25 | Biostream Inc | Matrices for drug delivery and methods for making and using the same |
| US6596849B1 (en) | 1999-05-28 | 2003-07-22 | Academia Sinica | Monoclonal-antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001257032A1 (en) | 2000-04-14 | 2001-10-30 | University Of South Carolina Research Foundation | Cloning, overexpression and therapeutic uses of bioactive histidine ammonia lyase |
| US6967097B2 (en) | 2000-07-24 | 2005-11-22 | Pcbu Services, Inc. | Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same |
| AU2002259281A1 (en) | 2001-05-21 | 2002-12-03 | Nektar Therapeutics Al, Corporation | Antibodies specific for poly(ethylene glycol) |
| US6939941B2 (en) | 2001-09-12 | 2005-09-06 | Toray Fine Chemicals Co., Ltd. | Preparation of polysulfide compositions |
| US7879582B2 (en) | 2002-02-26 | 2011-02-01 | E. I. Du Pont De Nemours And Company | Method for the recombination of genetic elements |
| WO2004024125A1 (en) * | 2002-09-16 | 2004-03-25 | Wyeth | Delayed release formulations for oral administration of a polypeptide therapeutic agent and methods of using same |
| US20080124275A1 (en) | 2002-11-14 | 2008-05-29 | The Scripps Research Institute | Crystalline Form of Fatty Acid Amide Hydrolase (Faah) |
| US7141544B2 (en) * | 2003-10-10 | 2006-11-28 | Baxter International, Inc. | Stabilization of pharmaceutical protein formulations with small peptides |
| US8114958B2 (en) * | 2004-02-11 | 2012-02-14 | Amylin Pharmaceuticals, Inc. | Amylin family peptides |
| US7553653B2 (en) | 2004-09-17 | 2009-06-30 | Biomarin Pharmaceutical Inc. | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
| US20090038023A1 (en) | 2005-03-10 | 2009-02-05 | Verenium Corporation | Lyase Enzymes, Nucleic Acids Encoding Them and Methods For Making and Using Them |
| TW200806317A (en) * | 2006-03-20 | 2008-02-01 | Wyeth Corp | Methods for reducing protein aggregation |
| US7534595B2 (en) * | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US7531341B1 (en) * | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US20090011400A1 (en) | 2006-12-01 | 2009-01-08 | The Salk Institute for Biological Studies and The Regents of the University of California | Substrate switched ammonia lyases and mutases |
| US7537923B2 (en) | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
| US20110201022A1 (en) | 2008-07-30 | 2011-08-18 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| ES2582459T3 (es) | 2010-02-04 | 2016-09-13 | Biomarin Pharmaceutical Inc. | Composiciones de variantes de fenilalanina amoníaco-liasa de procariotas y métodos de uso de sus composiciones |
-
2011
- 2011-02-03 ES ES11740323.8T patent/ES2582459T3/es active Active
- 2011-02-03 EP EP22158491.5A patent/EP4062928A3/en active Pending
- 2011-02-03 PT PT15202466T patent/PT3025728T/pt unknown
- 2011-02-03 EP EP15202466.7A patent/EP3025728B1/en active Active
- 2011-02-03 SI SI201131589T patent/SI3025728T1/sl unknown
- 2011-02-03 US US13/576,625 patent/US20130039898A1/en not_active Abandoned
- 2011-02-03 ES ES15202466T patent/ES2690542T3/es active Active
- 2011-02-03 HU HUE15202466A patent/HUE039516T2/hu unknown
- 2011-02-03 DK DK15202466.7T patent/DK3025728T3/en active
- 2011-02-03 EP EP18187522.0A patent/EP3479842A3/en not_active Withdrawn
- 2011-02-03 PL PL15202466T patent/PL3025728T3/pl unknown
- 2011-02-03 CA CA2782444A patent/CA2782444C/en active Active
- 2011-02-03 JP JP2012552071A patent/JP5828844B2/ja active Active
- 2011-02-03 CN CN2011800090746A patent/CN102753566A/zh active Pending
- 2011-02-03 WO PCT/US2011/023534 patent/WO2011097335A2/en active Application Filing
- 2011-02-03 EP EP11740323.8A patent/EP2531209B1/en active Active
- 2011-02-03 AU AU2011212929A patent/AU2011212929B2/en active Active
- 2011-02-03 LT LTEP15202466.7T patent/LT3025728T/lt unknown
- 2011-02-03 CN CN201710117140.0A patent/CN106834261B/zh active Active
-
2012
- 2012-07-24 IL IL221099A patent/IL221099B/en active IP Right Grant
-
2016
- 2016-04-15 US US15/130,694 patent/US10221408B2/en active Active
- 2016-11-30 HK HK16113671A patent/HK1225299B/zh unknown
-
2018
- 2018-02-08 IL IL257437A patent/IL257437B/en active IP Right Grant
- 2018-10-04 HR HRP20181602TT patent/HRP20181602T1/hr unknown
- 2018-10-17 CY CY181101068T patent/CY1120768T1/el unknown
-
2019
- 2019-01-11 US US16/246,300 patent/US11505790B2/en active Active
-
2022
- 2022-10-19 US US18/047,824 patent/US20240035013A1/en active Pending
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