AR110834A2 - MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal) - Google Patents

MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal)

Info

Publication number
AR110834A2
AR110834A2 ARP180100106A ARP180100106A AR110834A2 AR 110834 A2 AR110834 A2 AR 110834A2 AR P180100106 A ARP180100106 A AR P180100106A AR P180100106 A ARP180100106 A AR P180100106A AR 110834 A2 AR110834 A2 AR 110834A2
Authority
AR
Argentina
Prior art keywords
phenylalanine
pal
amoniacoliasa
avpal
variante
Prior art date
Application number
ARP180100106A
Other languages
English (en)
Original Assignee
Biomarin Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39868905&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR110834(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biomarin Pharm Inc filed Critical Biomarin Pharm Inc
Publication of AR110834A2 publication Critical patent/AR110834A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Fenilalanina amoniacoliasa (PAL) producida por procariotes, en donde dicha PAL de procariotes en donde la variante de PAL tiene mayor actividad convertidora de fenilalanina y/o reducida inmunogenicidad comparada con una PAL de tipo silvestre. Además composiciones de PAL bacteriana y sus fragmentos, mutantes, variantes y análogos biológicamente activos, así como métodos para la producción, purificación, y uso de dichas composiciones con fines terapéuticos e industriales.
ARP180100106A 2007-05-25 2018-01-17 MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal) AR110834A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/807,227 US7534595B2 (en) 2006-06-12 2007-05-25 Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof

Publications (1)

Publication Number Publication Date
AR110834A2 true AR110834A2 (es) 2019-05-08

Family

ID=39868905

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP080102198A AR066716A1 (es) 2007-05-25 2008-05-23 Composiciones de fenilanina amoniaco liasa procarioticas y metodos de uso de las composiciones
ARP180100106A AR110834A2 (es) 2007-05-25 2018-01-17 MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP080102198A AR066716A1 (es) 2007-05-25 2008-05-23 Composiciones de fenilanina amoniaco liasa procarioticas y metodos de uso de las composiciones

Country Status (30)

Country Link
US (1) US7534595B2 (es)
EP (2) EP2152868B1 (es)
JP (1) JP5670183B2 (es)
KR (2) KR101603796B1 (es)
CN (1) CN101842482B (es)
AR (2) AR066716A1 (es)
AU (1) AU2008263190B2 (es)
BR (1) BRPI0811267B8 (es)
CA (1) CA2687450C (es)
CL (1) CL2008001497A1 (es)
CY (2) CY1116894T1 (es)
DK (1) DK2152868T3 (es)
EA (1) EA018443B1 (es)
ES (1) ES2551315T3 (es)
HK (1) HK1135141A1 (es)
HR (1) HRP20151268T1 (es)
HU (2) HUE025784T2 (es)
IL (1) IL202132A (es)
LT (1) LTC2152868I2 (es)
LU (1) LUC00133I2 (es)
MX (1) MX2009012453A (es)
MY (1) MY151413A (es)
NL (1) NL301011I2 (es)
NO (1) NO2019037I1 (es)
PE (1) PE20090315A1 (es)
PL (1) PL2152868T3 (es)
PT (1) PT2152868E (es)
SI (1) SI2152868T1 (es)
TW (1) TWI418633B (es)
WO (1) WO2008153776A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7531341B1 (en) 2006-06-12 2009-05-12 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7534595B2 (en) * 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US7560263B2 (en) 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof
US20110201022A1 (en) * 2008-07-30 2011-08-18 Biomarin Pharmaceutical Inc. Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase
ES2582459T3 (es) 2010-02-04 2016-09-13 Biomarin Pharmaceutical Inc. Composiciones de variantes de fenilalanina amoníaco-liasa de procariotas y métodos de uso de sus composiciones
EP3222288A1 (en) * 2012-07-27 2017-09-27 University of North Texas Genetically modified probiotic for the treatment of phenylketonuria (pku) disease
PT2986722T (pt) 2013-04-18 2019-06-21 Codexis Inc Polipéptidos de fenilalanina amoníaco-liase modificados
JP6702866B2 (ja) 2013-11-18 2020-06-03 ルビウス セラピューティクス， インコーポレイテッド 合成膜−レシーバー複合体
JP6735233B2 (ja) 2014-04-01 2020-08-05 ルビウス セラピューティクス， インコーポレイテッド 免疫調節方法及び組成物
WO2015161019A1 (en) 2014-04-16 2015-10-22 Codexis, Inc. Engineered tyrosine ammonia lyase
WO2016105889A1 (en) 2014-12-22 2016-06-30 Codexis, Inc. Human alpha-galactosidase variants
TW202330904A (zh) 2015-08-04 2023-08-01 美商再生元醫藥公司 補充牛磺酸之細胞培養基及用法
JP6994018B2 (ja) 2016-07-26 2022-01-14 バイオマリン ファーマシューティカル インコーポレイテッド 新規アデノ随伴ウイルスキャプシドタンパク質
CN109844127B (zh) 2016-08-30 2023-09-19 三菱化学株式会社 突变型酶的制造方法及突变型醇酰基转移酶
CN106497905A (zh) * 2016-12-14 2017-03-15 江南大学 一株鱼腥藻来源的苯丙氨酸脱氨酶的突变体
AU2018217495B2 (en) * 2017-02-13 2021-03-04 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides
CN107653275A (zh) * 2017-10-30 2018-02-02 安徽工程大学 D‑苯丙氨酸的制备方法
CN108004225B (zh) * 2017-12-19 2020-05-08 江南大学 一种成团泛菌来源的苯丙氨酸氨基变位酶的突变体
CN113164762A (zh) 2018-05-09 2021-07-23 生物马林药物股份有限公司 苯丙酮尿症的治疗方法
TW202005978A (zh) 2018-05-14 2020-02-01 美商拜奧馬林製藥公司 新穎肝靶向腺相關病毒載體
EP3807409A4 (en) * 2018-06-12 2022-08-03 Codexis, Inc. MODIFIED TYROSINE AMMONIA-LYASE
WO2020013951A1 (en) * 2018-07-12 2020-01-16 Codexis, Inc. Engineered phenylalanine ammonia lyase polypeptides
EP3893860A4 (en) 2018-12-14 2023-03-29 Codexis, Inc. ENGINEERED TYROSINE AMMONIA LYASE
AU2019403323A1 (en) 2018-12-20 2021-07-01 Codexis, Inc. Human alpha-galactosidase variants
CN110456056A (zh) * 2019-07-22 2019-11-15 浙江大学 一种新生儿苯丙酮尿症无创筛查试纸的制备方法
MX2022002473A (es) 2019-08-30 2022-08-02 Codexis Inc Variantes de lipasa modificadas geneticamente.
US11970722B2 (en) 2019-12-20 2024-04-30 Codexis, Inc. Engineered acid alpha-glucosidase variants
US20230183712A1 (en) * 2020-02-19 2023-06-15 Trustees Of Tufts College Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained
TW202144575A (zh) 2020-04-03 2021-12-01 美商拜奧馬林製藥公司 使用ａａｖ及治療調配物之苯酮尿症治療
US11959108B2 (en) 2020-08-28 2024-04-16 Codexis, Inc. Engineered protease variants
MX2023002421A (es) 2020-08-28 2023-05-18 Codexis Inc Variantes de amilasa modificadas geneticamente.
JP2024519847A (ja) * 2021-05-19 2024-05-21 ビオマリン プハルマセウトイカル インコーポレイテッド 原核生物フェニルアラニンアンモニアリアーゼの組成物及び青年対象を治療する方法
BR112023024198A2 (pt) 2021-05-21 2024-01-30 Codexis Inc Fragmento de metionina gama liase recombinante e/ou de metionina gama liase recombinante biologicamente ativo, fragmento de metionina gama liase m recombinante e/ou biologicamente ativo do mesmo, metionina gama liase recombinante, polinucleotídeo recombinante, vetor de expressão, célula hospedeira, métodos para produzir uma metionina gama liase recombinante e para tratar e/ou prevenir os sintomas de homocistinúria em um indivíduo, composição farmacêutica, e, uso de um polipeptídeo de metionina gama liase recombinante ou da composição
WO2023044381A1 (en) * 2021-09-16 2023-03-23 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
CN117417925A (zh) * 2022-07-18 2024-01-19 浙江泽科塔生物医药有限公司 Pal变体、包含该pal变体的药物组合物以及用于制备该pal变体的方法
CN116478975B (zh) * 2023-06-16 2023-09-01 苏州优信合生技术有限公司 高活性苯丙氨酸解氨酶突变体及其表达菌株

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252822A (en) 1979-12-26 1981-02-24 Children's Hospital Medical Center Method for treating phenylketonuria
US4562151A (en) 1983-09-06 1985-12-31 Monsanto Company Stabilization of L-phenylalanine ammonia-lyase enzyme
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5766897A (en) 1990-06-21 1998-06-16 Incyte Pharmaceuticals, Inc. Cysteine-pegylated proteins
ES2184756T3 (es) 1992-11-19 2003-04-16 Anticancer Inc Uso de metioninasa como agente antitumoral en quimioterapia antimetionina.
ATE361984T1 (de) 1992-12-04 2007-06-15 Me Medical Enzymes Ag Gentechnologisch hergestellte glutaminase und ihre verwendung in therapie
DK75593D0 (es) 1993-06-25 1993-06-25 Novo Nordisk As
EP1188448A3 (en) * 1994-03-15 2002-04-17 Prizm Pharmaceuticals, Inc. Heparin-binding growth factors for gene therapy and anterior eye disorders
ES2190388T3 (es) 1995-09-21 2006-04-01 Genentech, Inc. Variantes de la hormona de crecimiento humana.
CU22585A1 (es) * 1995-11-17 1999-11-03 Centro Inmunologia Molecular Anticuerpos monoclonales antiidiótipos (ab2) de tipo igg con alta conectividad idiotípica y composiciones farmacéuticas que los contienen. su uso como inmunoreguladores de la respuesta inmune.
US6548644B1 (en) 1997-03-10 2003-04-15 Immunex Corporation Site protected protein modification
US6183738B1 (en) 1997-05-12 2001-02-06 Phoenix Pharamacologics, Inc. Modified arginine deiminase
US5981239A (en) 1997-09-24 1999-11-09 Great Lakes Chemical Corp. Synthesis of optically active phenylalanine analogs using Rhodotorula graminis
EP1042459A4 (en) * 1997-12-24 2003-07-23 Diatech Pty Ltd BIFUNCTIONAL MOLECULES
TWI227241B (en) * 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
US6451986B1 (en) 1998-06-22 2002-09-17 Immunex Corporation Site specific protein modification
US6461849B1 (en) 1998-10-13 2002-10-08 Novozymes, A/S Modified polypeptide
US6403312B1 (en) 1998-10-16 2002-06-11 Xencor Protein design automatic for protein libraries
US6686164B1 (en) 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
IL138990A0 (en) 1999-02-12 2001-11-25 Biostream Inc Matrices for drug delivery and methods for making and using the same
AU783208B2 (en) * 1999-12-09 2005-10-06 Novartis Vaccines And Diagnostics, Inc. Method for administering a cytokine to the central nervous system and the lymphatic system
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
JP2003530850A (ja) 2000-04-14 2003-10-21 ユニバーシティー オブ サウス カロライナ リサーチ ファウンデーション 生物活性ヒスチジンアンモニアリアーゼのクローニング、過剰発現および治療用途
US6967097B2 (en) 2000-07-24 2005-11-22 Pcbu Services, Inc. Phenylalainine ammonia lyase polypeptide and polynucleotide sequences and methods of obtaining and using same
JP2004523205A (ja) * 2000-07-25 2004-08-05 イムノメディクス， インコーポレイテッド 多価標的結合タンパク質
WO2002026028A2 (en) * 2000-09-26 2002-04-04 The Regents Of The University Of California Characterization of phenylalanine ammonia-lyase (pal) gene in wounded lettuce
CA2428114C (en) * 2000-11-10 2013-07-23 Proteopharma Aps Apolipoprotein analogues
KR20040088538A (ko) 2002-02-26 2004-10-16 이 아이 듀폰 디 네모아 앤드 캄파니 유전 인자의 재조합 방법
BR0312935A (pt) * 2002-07-17 2005-06-21 Cytos Biotechnology Ag Partìcula semelhante a vìrus, muteìna, vetores para produzir a referida partìcula e proteìna recombinante, composição, processo para produção de fileira ordena e repetitva de antìgeno, molécula de ácido nucléico, célula hospedeira, método para produção da referida partìcula e uso da composição de vacina
JP2006516095A (ja) 2002-11-14 2006-06-22 ザ スクリップス リサーチ インスティテュート 脂肪酸アミドヒドロラーゼ（ｆａａｈ）の結晶形
KR20060022261A (ko) * 2003-06-11 2006-03-09 와이어쓰 혈소판 당단백질 ｉｂ 알파 변이체 융합 폴리펩티드 및이의 사용 방법
FR2868318B1 (fr) * 2004-04-01 2012-11-16 Commissariat Energie Atomique Antigene tat stabilise et ses applications pour la vaccination anti-vih
US7670595B2 (en) * 2004-06-28 2010-03-02 Merck Patent Gmbh Fc-interferon-beta fusion proteins
JP2008513027A (ja) 2004-09-17 2008-05-01 バイオマリン ファーマシューティカル インコーポレイテッド フェニルアラニンアンモニアーリアーゼの改変体および化学的に修飾された改変体
EP1869174B1 (en) 2005-03-10 2015-02-18 BASF Enzymes LLC Lyase enzymes, nucleic acids encoding them and methods for making and using them
US7534595B2 (en) 2006-06-12 2009-05-19 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof
US20090011400A1 (en) 2006-12-01 2009-01-08 The Salk Institute for Biological Studies and The Regents of the University of California Substrate switched ammonia lyases and mutases
US7560263B2 (en) 2007-08-17 2009-07-14 Biomarin Pharmaceutical Inc. Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof

Also Published As

Publication number Publication date
PE20090315A1 (es) 2009-03-19
IL202132A (en) 2017-06-29
KR101603796B1 (ko) 2016-03-17
ES2551315T3 (es) 2015-11-18
PT2152868E (pt) 2015-11-13
US7534595B2 (en) 2009-05-19
MY151413A (en) 2014-05-30
BRPI0811267A2 (pt) 2014-10-07
AR066716A1 (es) 2009-09-09
TWI418633B (zh) 2013-12-11
AU2008263190A1 (en) 2008-12-18
CY1116894T1 (el) 2017-04-05
CL2008001497A1 (es) 2009-01-09
HK1135141A1 (zh) 2010-05-28
NO2019037I1 (no) 2019-10-16
EA200970980A1 (ru) 2010-04-30
IL202132A0 (en) 2010-06-16
CY2019039I1 (el) 2020-05-29
NL301011I1 (nl) 2019-10-16
SI2152868T1 (sl) 2015-12-31
CN101842482B (zh) 2014-10-22
LTPA2019517I1 (lt) 2019-10-25
CY2019039I2 (el) 2020-05-29
WO2008153776A8 (en) 2009-07-30
CA2687450C (en) 2019-03-26
NL301011I2 (nl) 2020-05-13
JP2010529835A (ja) 2010-09-02
BRPI0811267B1 (pt) 2020-11-10
EP2152868A1 (en) 2010-02-17
AU2008263190B2 (en) 2014-04-17
EA018443B1 (ru) 2013-08-30
WO2008153776A1 (en) 2008-12-18
KR20150038753A (ko) 2015-04-08
TW200902052A (en) 2009-01-16
CN101842482A (zh) 2010-09-22
HRP20151268T1 (hr) 2015-12-18
PL2152868T3 (pl) 2016-01-29
LTC2152868I2 (lt) 2020-09-25
HUS1900049I1 (hu) 2019-11-28
KR20100024437A (ko) 2010-03-05
LUC00133I2 (es) 2020-07-16
BRPI0811267B8 (pt) 2021-05-25
DK2152868T3 (en) 2015-11-16
MX2009012453A (es) 2010-01-25
US20080008695A1 (en) 2008-01-10
HUE025784T2 (en) 2016-05-30
CA2687450A1 (en) 2008-12-18
JP5670183B2 (ja) 2015-02-18
EP2152868B1 (en) 2015-09-02
LUC00133I1 (es) 2019-10-16
EP2657335A1 (en) 2013-10-30

Similar Documents

Publication Publication Date Title
AR110834A2 (es) MOLÉCULA DE UNA VARIANTE AISLADA DE FENILALANINA AMONIACOLIASA DE ANABAENA VARIABILIS (AvPal)
CA2782444C (en) Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof
CY1118222T1 (el) Συνθεσεις λυασης φαινυλαλανινης αμμωνιας προκαρυωτικων και μεθοδοι αγωγης καρκινου χρησιμοποιωντας συνθεσεις εξ' αυτης
CL2008000670A1 (es) Compuestos derivados de tiazolidindionas y oxazolidindionas sustituidas; composicion farmaceutica; proceso de preparacion de la composicion farmaceutica; y uso en el tratamiento de enfermedades tales como artritis reumatoide, epoc, cancer, entre otras.
MX2009001203A (es) Muteinas de lipocalina lacrimosa y metodos para obtener las mismas.
IN2012DN00801A (es)
TW200722079A (en) Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
CL2011000668A1 (es) Compuestos derivados de pirazolopiridina; proceso de preparacion; composicion farmaceutica y uso en el tratamiento de enfermedades tales como artritis reumatoide, psoriasis, esclerosis multiple, entre otras.
CL2007001283A1 (es) Compuestos derivados de pirazinona
CL2011001427A1 (es) Compuestos derivados de 4-azetidinil-1-heteroaril-ciclohexanol; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, aterosclerosis, artritis reumatoide, entre otras.
TW200800968A (en) Sulfoximine-substituted pyrimidines, processes for production thereof and use thereof as drugs
WO2008080003A3 (en) Generation of oncolytic adenoviruses and uses thereof
BR112012017345A2 (pt) "composições e métodos de pgl para a produção aumentada de isopreno e outros produtos com 6-fosfogliconolactonase (pgl)"
CL2007003326A1 (es) Compuestos derivados de pirrol[2,3-b]piridina, moduladores de la actividad del c-fms y/o el c-kit; composicion farmaceutica; y uso para el tratamiento de tumores de celulas mamarias, asma, artritis reumatoide, enfermedad de parkinson, entre otras.
WO2013078170A8 (en) Purification of anti-c-met antibodies
PE20160507A1 (es) Diferenciacion de celulas madre mesenquimales
NZ700181A (en) Plant cytochrome p450
GB2461659A (en) Structured compositions comprising a clay
BR112014002173A2 (pt) proteínas purificadas
MX2009011999A (es) Extruidos con enmascaramiento del sabor mejorado.
UY29189A1 (es) Nonadepsipeptidos acilados ii
UY28313A1 (es) Nonadepsipeptidos acilados
MY159790A (en) Highly bridged peptides from actinomadura namibiensis
ATE410443T1 (de) Heterocyclyl-substituierte nonadepsipeptide
WO2009108898A3 (en) Production and uses of type 1 ribosome inactivating proteins

Legal Events

Date Code Title Description
FB Suspension of granting procedure